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Cytomorphological And Molecular Genetic Findings In Pediatric Thyroid Fine-needle Aspiration.

Sara E Monaco, Liron Pantanowitz, Walid E. Khalbuss, Vanessa A Benkovich, John A. Ozolek, Marina N Nikiforova, Jeffrey P Simons, Yuri E Nikiforov
Published 2012 · Medicine
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BACKGROUND The Bethesda System for Reporting Thyroid Cytopathology is largely based on data from adult studies. Although thyroid nodules in children are rare, the rate of malignancy is high. The authors' aim was to analyze the cytomorphology and mutational profiles in pediatric thyroid fine-needle aspirations (FNAs). METHODS Thyroid FNAs from patients 21 years old or younger were identified from the authors' pathology archive, categorized using the Bethesda System for Reporting Thyroid Cytopathology, and correlated with histological and molecular follow-up. RESULTS A total of 179 samples from 142 patients were identified, including 96 cases (54%) with histological follow-up and 66 cases (37%) with molecular data. The diagnoses included 21 (12%) unsatisfactory, 82 (46%) negative, 43 (24%) atypia or follicular lesion of undetermined significance, 19 (11%) suspicious for follicular neoplasm, 6 (3%) suspicious for malignancy, and 8 (4%) positive for malignancy. The rate of malignancy in each category was 0%, 7%, 28%, 58%, 100%, and 100%, respectively. Of the 66 FNAs with molecular data, there were 11 (17%) positive for mutations. All mutation-positive FNAs were papillary thyroid carcinomas (PTCs) on resection. The overall sensitivity and specificity in this population were 80% and 100%, respectively. CONCLUSIONS This study demonstrates that thyroid FNA in children is a sensitive and highly specific tool. There was a 17% positivity rate for a genetic mutation, which correlated with malignancy in all cases. In comparison to adults, there was a higher prevalence of RET/PTC mutations and lower prevalence of BRAF mutations, which may in part explain the less aggressive nature of PTCs reported in children.
This paper references
10.1002/cncr.10725
Childhood and adolescent thyroid carcinoma.
Perry Grigsby (2002)
10.1155/2011/974125
Thyroid Nodules in Children: A Single Institution's Experience
Nini Khozeimeh (2011)
10.1210/jcem.87.5.8504
Risk of malignancy in nonpalpable thyroid nodules: predictive value of ultrasound and color-Doppler features.
Enrico Papini (2002)
SEER Cancer Statistics Review, 1975-2003, National Cancer Institute. Bethesda, MD,
Ries Lag (2006)
10.4274/jcrpe.v2i2.78
Fine−Needle Aspiration Biopsy in the Diagnosis and Follow−Up of Thyroid Nodules in Childhood
Ayça Altıncık (2010)
10.1016/0002-9343(91)90153-O
Natural history of thyroid abnormalities: prevalence, incidence, and regression of thyroid diseases in adolescents and young adults.
Marvin L. Rallison (1991)
RET/PTC oncogene activation defines a subset of papillary thyroid carcinomas lacking evidence of progression to poorly differentiated or undifferentiated tumor phenotypes.
Giovanni Tallini (1998)
10.1016/j.jpedsurg.2009.07.022
Pediatric thyroid fine-needle aspiration cytology: a meta-analysis.
Christopher J Stevens (2009)
High prevalence of RET rearrangement in thyroid tumors of children from Belarus after the Chernobyl reactor accident.
Sabine Klugbauer (1995)
10.1002/dc.20830
Diagnostic terminology and morphologic criteria for cytologic diagnosis of thyroid lesions: a synopsis of the National Cancer Institute Thyroid Fine-Needle Aspiration State of the Science Conference.
Zubair W Baloch (2008)
10.1309/AJCPIX52MBOKTICP
Eliminating the "Atypia of Undetermined Significance/Follicular Lesion of Undetermined Significance" category from the Bethesda System for Reporting Thyroid Cytopathology.
Remmi S. Singh (2011)
10.1677/erc.1.00882
Pathogenesis, diagnosis and management of thyroid nodules in children.
Marek Niedziela (2006)
10.1089/thy.2009.0058
Ultrasound-guided fine-needle aspiration in the management of thyroid nodules in children and adolescents.
R. E. Martín Izquierdo (2009)
10.1634/theoncologist.2007-0212
Management of the solitary thyroid nodule.
Meei J. Yeung (2008)
Pediatric thyroid nodules: disease demographics and clinical management as determined by fine needle aspiration biopsy.
Stephen Spencer Raab (1995)
10.1155/2010/690108
Thyroid Fine Needle Aspiration Biopsies in Children: Study of Cytological-Histological Correlation and Immunostaining with Thyroid Peroxidase Monoclonal Antibodies
Victoria Hoperia (2010)
10.1210/jc.2008-0607
BRAF(V600E) mutation and outcome of patients with papillary thyroid carcinoma: a 15-year median follow-up study.
R. Elisei (2008)
10.1200/JCO.2008.20.1426
BRAF mutation testing of thyroid fine-needle aspiration biopsy specimens for preoperative risk stratification in papillary thyroid cancer.
Mingzhao Xing (2009)
10.1136/adc.85.4.313
Fine needle aspiration biopsy of thyroid nodules
I S Arda (2001)
10.1210/jcem.81.5.8626874
Age-related activation of the tyrosine kinase receptor protooncogenes RET and NTRK1 in papillary thyroid carcinoma.
Italia Bongarzone (1996)
10.1016/j.jpedsurg.2010.09.009
Thyroid surgery at Children's Hospital Boston: a 35-year single-institution experience.
Stefan Scholz (2011)
10.1038/sj.onc.1200206
High prevalence of activating ret proto-oncogene rearrangements, in thyroid tumors from patients who had received external radiation
Ali Bounacer (1997)
The Bethesda system for reporting thyroid cytopathology : definitions, criteria, and explanatory notes
Syed Zulfiqar Ali (2010)
10.1210/jc.2004-0172
Low frequency of BRAFT1796A mutations in childhood thyroid carcinomas.
Atsushi Kumagai (2004)
10.1210/jc.2011-1469
Impact of mutational testing on the diagnosis and management of patients with cytologically indeterminate thyroid nodules: a prospective analysis of 1056 FNA samples.
Yuri E Nikiforov (2011)
10.1016/j.surg.2011.09.023
Predictive factors of malignancy in pediatric thyroid nodules.
Rashmi Roy (2011)
10.1210/jcem.86.10.7950
Accuracy of fine needle aspiration biopsy of thyroid nodules in detecting malignancy in childhood: comparison with conventional clinical, laboratory, and imaging approaches.
Andrea Corrias (2001)
10.1507/endocrj.K07-120
High prevalence of carcinoma in ultrasonography-guided fine needle aspiration cytology of thyroid nodules.
Dong-lim Kim (2008)
10.1210/jc.2009-0247
Molecular testing for mutations in improving the fine-needle aspiration diagnosis of thyroid nodules.
Yuri E Nikiforov (2009)
10.1089/thy.2006.16.109
Management guidelines for patients with thyroid nodules and differentiated thyroid cancer.
David S. Cooper (2006)
10.1002/(SICI)1096-9896(199805)185:1<71::AID-PATH42>3.0.CO;2-S
Sporadic ret-rearranged papillary carcinoma of the thyroid: a subset of slow growing, less aggressive thyroid neoplasms?
Paula Soares (1998)
10.1007/s00268-010-0391-x
Diagnostic Utility of Fine-Needle Aspiration Cytology in Pediatric Differentiated Thyroid Cancer
Anna E Bargren (2010)



This paper is referenced by
10.1002/dc.23934
Cyto‐morphologic spectrum of thyroid lesions in children
Priya Pathak (2018)
10.4274/jcrpe.3873
Clinicopathological Characteristics of Papillary Thyroid Cancer in Children with Emphasis on Pubertal Status and Association with BRAFV600E Mutation
Şükran Poyrazoğlu (2017)
10.1210/jc.2012-1230
Clinical practice guidelines for multiple endocrine neoplasia type 1 (MEN1).
Rajesh V. Thakker (2012)
10.1002/pbc.28276
miRNA expression can classify pediatric thyroid lesions and increases the diagnostic yield of mutation testing.
Aime T. Franco (2020)
Original Article Clinical usefulness of fine needle aspiration cytology in patients less than 20 years old: a 10-year experience at a single institution
Sunzoo Kim (2013)
10.1007/s00247-015-3478-6
Ultrasound-guided fine-needle aspiration biopsy of pediatric thyroid nodules
Pranav Moudgil (2015)
10.1007/978-3-319-59474-3_12
Surgery for Thyroid Nodules
Randall P. Scheri (2018)
10.1177/1093526616689628
Pathologic Characteristics, Natural History, and Prognostic Implications of BRAFV600E Mutation in Pediatric Papillary Thyroid Carcinoma
Steven Hardee (2017)
10.1016/j.ecl.2016.02.002
Thyroid Cancer in Pediatrics.
Josef Machac (2016)
10.1016/j.jpeds.2015.04.041
Differentiated Thyroid Cancer in Children: Prevalence and Predictors in a Large Cohort with Thyroid Nodules Followed Prospectively.
Patricia Papendieck (2015)
10.1002/cncy.21750
Pediatric thyroid FNA biopsy: Outcomes and impact on management over 24 years at a tertiary care center.
Elmira Amirazodi (2016)
10.1002/cncy.22104
Incidence and malignancy rates of indeterminate pediatric thyroid nodules
Huiying Wang (2019)
10.1002/cncy.21400
The role of thyroid fine-needle aspiration cytology in the pediatric population: an institutional experience.
Esther Diana Rossi (2014)
10.1186/s13643-015-0109-0
Diagnostic accuracy of fine needle aspiration biopsy for detection of malignancy in pediatric thyroid nodules: protocol for a systematic review and meta-analysis
Sarah W Lai (2015)
10.1016/j.jpedsurg.2015.02.067
Quality of life and clinical outcome after thyroid surgery in children: A 13 years single center experience.
Eva Stokhuijzen (2015)
10.1530/ERC-15-0381
Are we really at the dawn of understanding sporadic pediatric thyroid carcinoma?
Maria Isabel Cunha Vieira Cordioli (2015)
Clinical usefulness of fine needle aspiration cytology in patients less than 20 years old: a 10-year experience at a single institution.
Sunzoo Kim (2013)
10.1002/dc.24266
Malignant risk of indeterminate pediatric thyroid nodules-An institutional experience.
Amer Heider (2019)
10.1089/thy.2014.0312
Can malignant thyroid nodules be distinguished from benign thyroid nodules in children and adolescents by clinical characteristics? A review of 89 pediatric patients with thyroid nodules.
Melissa A Buryk (2015)
10.1002/cncy.21884
The role of thyroid FNA cytology in pediatric malignant lesions: An overview of the literature.
Esther Diana Rossi (2017)
10.7759/cureus.4693
Pediatric Differentiated Thyroid Cancer: Our Experience
Wafaa Abd Elhameed Elsayed (2019)
10.1155/2019/1829043
Recent Trends in the Clinicopathological Features of Thyroid Nodules in Pediatric Patients: A Single Tertiary Center Experience over 25 Years
Cheong-Sil Rah (2019)
10.1089/thy.2015.0401
Mutational Analysis in Pediatric Thyroid Cancer and Correlations with Age, Ethnicity, and Clinical Presentation
Maria Eleni Nikita (2016)
10.1080/09674845.2016.1144947
Fine needle aspiration cytology for lymph nodes: a three-year study
Jian Zhou (2016)
10.1002/pbc.28141
Management of pediatric differentiated thyroid cancer: An overview for the pediatric oncologist.
Pinki K Prasad (2020)
10.1016/j.jpedsurg.2014.10.046
Risk of malignancy for each Bethesda class in pediatric thyroid nodules.
Olov Norlén (2015)
10.1177/0003489419868251
Clinical Analysis of Pediatric Thyroid Cancer: A Single Medical Institution Experience of 18 Years
Hyung Kwon Byeon (2019)
10.1159/000351029
Indeterminate Pediatric Thyroid Fine Needle Aspirations: A Study of 68 Cases
Matthew A. Smith (2013)
10.1542/peds.2018-3063
Management Guidelines for Children With Thyroid Nodules and Differentiated Thyroid Cancer
Gary L. Francis (2018)
10.1002/cncy.21713
Histologic and clinical follow-up of thyroid fine-needle aspirates in pediatric patients.
Kristen L Partyka (2016)
10.1111/cyt.12171
Results of retrospective classification of thyroid FNAs according to the Bethesda system: would this have improved accuracy?
Linda Srbova (2015)
10.1016/B978-0-12-800886-7.00030-3
Molecular Testing in Thyroid Cancer
Susan J Hsiao (2017)
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