Online citations, reference lists, and bibliographies.

Impact Of Reclassifying Noninvasive Follicular Variant Of Papillary Thyroid Carcinoma On The Risk Of Malignancy In The Bethesda System For Reporting Thyroid Cytopathology.

William C Faquin, L. Q. Wong, Amir H Afrogheh, Syed Zulfiqar Ali, Justin A. Bishop, Massimo Bongiovanni, Marc P Pusztaszeri, Christopher J. VandenBussche, Jolanta Gourmaud, Louis J. Vaickus, Zubair W Baloch
Published 2016 · Medicine
Cite This
Download PDF
Analyze on Scholarcy
Share
BACKGROUND Recent discussions have focused on redefining noninvasive follicular variant of papillary thyroid carcinoma (NI-FVPTC) as a neoplasm rather than a carcinoma. This study assesses the potential impact of such a reclassification on the implied risk of malignancy (ROM) for the diagnostic categories of The Bethesda System for Reporting Thyroid Cytopathology (TBSRTC). METHODS The study consisted of consecutive fine-needle aspiration biopsy (FNAB) cases collected between January 1, 2013 and June 30, 2014 from 5 academic institutions. Demographic information, cytology diagnoses, and surgical pathology follow-up were recorded. The ROM was calculated with and without NI-FVPTC and was presented as a range: all cases (ie, overall risk of malignancy [OROM]) versus those with surgical follow-up only. RESULTS The FNAB cohort consisted of 6943 thyroid nodules representing 5179 women and 1409 men with an average age of 54 years (range, 9-94 years). The combined average ROM and OROM for the diagnostic categories of TBSRTC were as follows: nondiagnostic, 4.4% to 25.3%; benign, 0.9% to 9.3%; atypia of undetermined significance/follicular lesion of undetermined significance (AUS/FLUS), 12.1% to 31.2%; follicular neoplasm (FN), 21.8% to 33.2%; suspicious for malignancy (SM), 62.1% to 82.6%; and malignant, 75.9% to 99.1%. The impact of reclassifying NI-FVPTC on the ROM and OROM was most pronounced and statistically significant in the 3 indeterminate categories: the AUS/FLUS category had a decrease of 5.2% to 13.6%, the FN category had a decrease of 9.9% to 15.1%, and the SM category had a decrease of 17.6% to 23.4% (P < .05), whereas the benign and malignant categories had decreases of 0.3% to 3.5% and 2.5% to 3.3%, respectfully. The trend of the effect on the ROM and OROM was similar for all 5 institutions. CONCLUSIONS The results from this multi-institutional cohort indicate that the reclassification of NI-FVPTC will have a significant impact on the ROM for the 3 indeterminate categories of TBSRTC.
This paper references
Encapsulated follicular variant of papillary thyroid carcinoma.
Zubair Baloch (2002)
10.1002/cncy.21333
"Colloid-rich" follicular neoplasm/suspicious for follicular neoplasm thyroid fine-needle aspiration specimens: cytologic, histologic, and molecular basis for considering an alternate view.
N Paul Ohori (2013)
10.1111/j.1349-7006.2010.01769.x
Encapsulated follicular thyroid tumor with equivocal nuclear changes, so-called well-differentiated tumor of uncertain malignant potential: a morphological, immunohistochemical, and molecular appraisal.
Zhiyan Liu (2011)
10.1002/dc.21718
The triage efficacy of fine needle aspiration biopsy for follicular variant of papillary thyroid carcinoma using the Bethesda reporting guidelines.
Elizabeth M. Kurian (2012)
10.1097/PAS.0b013e3181dbee07
Encapsulated Well-differentiated Follicular-patterned Thyroid Carcinomas Do Not Play a Significant Role in the Fatality Rates From Thyroid Carcinoma
Simonetta Piana (2010)
10.1002/cncr.21825
Prognostic factors of recurrence in encapsulated Hurthle cell carcinoma of the thyroid gland: a clinicopathologic study of 50 cases.
Ronald A. Ghossein (2006)
10.1002/dc.21292
Fine-needle aspiration of follicular patterned lesions of the thyroid: Diagnosis, management, and follow-up according to National Cancer Institute (NCI) recommendations.
William C Faquin (2010)
10.1002/dc.20827
Indications for thyroid FNA and pre-FNA requirements: a synopsis of the National Cancer Institute Thyroid Fine-Needle Aspiration State of the Science Conference.
Edmund S Cibas (2008)
10.1309/AJCPI41QOQUSKDGP
Atypia of undetermined significance and nondiagnostic rates in The Bethesda System for Reporting Thyroid Cytopathology are inversely related.
Paul A VanderLaan (2012)
10.1089/thy.2015.0116
The Impact of Diagnostic Changes on the Rise in Thyroid Cancer Incidence: A Population-Based Study in Selected High-Resource Countries.
Salvatore Vaccarella (2015)
10.1158/1078-0432.CCR-12-1253
New Strategies in Diagnosing Cancer in Thyroid Nodules: Impact of Molecular Markers
Yuri E Nikiforov (2013)
Encapsulated follicular variant of papillary thyroid carcinoma.
Jennifer Leigh Hunt (2002)
10.1089/thy.2014.0612
The Impact of Noninvasive Follicular Variant of Papillary Thyroid Carcinoma on Rates of Malignancy for Fine-Needle Aspiration Diagnostic Categories.
Kyle C. Strickland (2015)
10.1001/archoto.2011.1466
Follicular variant of papillary thyroid cancer: encapsulated, nonencapsulated, and diffuse: distinct biologic and clinical entities.
Sachin Gupta (2012)
10.4158/EP10060.OR
Encapsulated classic and follicular variants of papillary thyroid carcinoma: comparative clinicopathologic study.
Zubair W Baloch (2010)
10.1309/AJCP5N4MTHPAFXFB
Malignancy risk for fine-needle aspiration of thyroid lesions according to the Bethesda System for Reporting Thyroid Cytopathology.
Vickie Y. Jo (2010)
10.1002/cncr.29038
Highly accurate diagnosis of cancer in thyroid nodules with follicular neoplasm/suspicious for a follicular neoplasm cytology by ThyroSeq v2 next-generation sequencing assay.
Yuri E Nikiforov (2014)
10.1002/hed.21373
Diminishing diagnosis of follicular thyroid carcinoma.
Kristen J. Otto (2010)
10.1159/000322365
Thyroid Cytopathology: Bethesda and Beyond
Syed Zulfiqar Ali (2010)
10.1089/thy.2009.0110
Revised American Thyroid Association management guidelines for patients with thyroid nodules and differentiated thyroid cancer.
David S. Cooper (2009)
10.1089/thy.2009.0274
The Bethesda System for Reporting Thyroid Cytopathology.
Edmund S Cibas (2009)
10.1056/NEJMoa1203208
Preoperative diagnosis of benign thyroid nodules with indeterminate cytology.
Erik K. Alexander (2012)
10.1089/thy.2012.0180
The impact of benign gene expression classifier test results on the endocrinologist-patient decision to operate on patients with thyroid nodules with indeterminate fine-needle aspiration cytopathology.
Daniel S. Duick (2012)
10.1159/000339959
The Bethesda System for Reporting Thyroid Cytopathology: A Meta-Analysis
Massimo Bongiovanni (2012)
10.1016/j.humpath.2014.03.010
Molecular testing for oncogenic gene mutations in thyroid lesions: a case-control validation study in 413 postsurgical specimens.
Thomas J. Giordano (2014)
10.1186/1742-6413-5-6
The National Cancer Institute Thyroid fine needle aspiration state of the science conference: a summation
Zubair W Baloch (2008)
10.1016/j.surg.2014.10.004
Evidence for overestimation of the prevalence of malignancy in indeterminate thyroid nodules classified as Bethesda category III.
Mazen E. Iskandar (2015)
10.1007/s00268-002-6612-1
Papillary Thyroid Carcinoma Managed at the Mayo Clinic during Six Decades (1940–1999): Temporal Trends in Initial Therapy and Long-term Outcome in 2444 Consecutively Treated Patients
Ian D. Hay (2002)
10.1002/cncy.21229
BRAF mutation detection in indeterminate thyroid cytology specimens: underlying cytologic, molecular, and pathologic characteristics of papillary thyroid carcinoma.
N Paul Ohori (2013)
10.1089/thy.2008.0303
Encapsulated papillary thyroid carcinoma: a clinico-pathologic study of 106 cases with emphasis on its morphologic subtypes (histologic growth pattern).
M. Rivera (2009)
10.1043/2010-0664-RAIR.1
Molecular diagnostics of thyroid tumors.
Yuri E Nikiforov (2011)
10.1111/j.1365-2303.2012.00966.x
Thyroid Bethesda reporting category, 'suspicious for papillary thyroid carcinoma', pitfalls and clues to optimize the use of this category.
Aparna N. Mahajan (2013)
10.1097/00000478-200211000-00014
Observer Variation of Encapsulated Follicular Lesions of the Thyroid Gland
Mitsuyoshi Hirokawa (2002)
10.4158/EP14466.DSCR
AMERICAN ASSOCIATION OF CLINICAL ENDOCRINOLOGISTS AND AMERICAN COLLEGE OF ENDOCRINOLOGY DISEASE STATE CLINICAL REVIEW: THE INCREASING INCIDENCE OF THYROID CANCER.
Louise Davies (2015)



This paper is referenced by
10.1159/000451020
The Bethesda System for Reporting Thyroid Cytopathology: Proposed Modifications and Updates for the Second Edition from an International Panel
Marc P Pusztaszeri (2016)
Follicular Variant of Papillary Thyroid
Gilbert H. Daniels (2016)
10.1007/s12105-019-01032-2
Noninvasive Follicular Thyroid Neoplasm with Papillary-Like Nuclear Features is Rare: A Population Based Study of Incidence
Rasmus H Reinke (2019)
10.1530/EC-19-0566
Noninvasive follicular thyroid neoplasm with papillary-like nuclear features: a problematic entity
Klaudia Zajkowska (2020)
10.1089/thy.2016.0244
Follicular Variant of Papillary Thyroid Carcinoma: Hybrid or Mixture?
Gilbert H. Daniels (2016)
10.1002/dc.24309
Cytologic and clinical features of NIFTP: Can we diagnose based on preoperative fine-needle aspiration.
Lei Yan (2019)
10.1089/thy.2016.0628
American Thyroid Association Guidelines on the Management of Thyroid Nodules and Differentiated Thyroid Cancer Task Force Review and Recommendation on the Proposed Renaming of Encapsulated Follicular Variant Papillary Thyroid Carcinoma Without Invasion to Noninvasive Follicular Thyroid Neoplasm with
Bryan R. Haugen (2017)
10.1007/978-3-319-54493-9_4
Pathologic Diagnosis of Thyroid Cancer
Xiaoyin “Sara” Jiang (2017)
10.1016/J.SUC.2019.04.002
Decision Making in Indeterminate Thyroid Nodules and the Role of Molecular Testing.
Janeil M Mitchell (2019)
10.1093/ajcp/aqx136
Impact of the Reclassification of “Noninvasive Encapsulated Follicular Variant of Papillary Thyroid Carcinoma” to “Noninvasive Follicular Thyroid Neoplasm With Papillary-Like Nuclear Features” on the Bethesda System for Reporting Thyroid Cytopathology: A Large Academic Institution’s Experience
Ryan P. Lau (2017)
10.1371/journal.pone.0218046
Comprehensive analysis for diagnosis of preoperative non-invasive follicular thyroid neoplasm with papillary-like nuclear features
Hye Seung Lee (2019)
10.1016/J.RMCLC.2018.05.006
Citopatología de tiroides. Punción por aguja fina
Carmen Franco (2018)
10.1016/j.humpath.2016.03.014
Cytological features of "noninvasive follicular thyroid neoplasm with papillary-like nuclear features" and their correlation with tumor histology.
Francesca Maletta (2016)
10.1002/cncy.21910
Identification of distinct cytomorphologic features in the diagnosis of NIFTP at the time of preoperative FNA: Implications for patient management
Jocelyn B. Chandler (2017)
10.1002/cncy.22228
Differences in surgical resection rate and risk of malignancy in thyroid cytopathology practice between Western and Asian countries: A systematic review and meta-analysis.
Huy Gia Vuong (2019)
10.21037/GS.2018.12.01
The impact of non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) on the diagnosis of thyroid nodules.
Marc P Pusztaszeri (2019)
10.1111/cyt.12501
Pre‐operative features of non‐invasive follicular thyroid neoplasms with papillary‐like nuclear features: An analysis of their cytological, Gene Expression Classifier and sonographic findings
Sharon J Song (2017)
10.1002/cncy.21926
Noninvasive follicular thyroid neoplasm with papillary‐like nuclear features (NIFTP)
Haijun Zhou (2018)
10.1016/j.clon.2017.01.006
Recent Developments in the Pathology of Thyroid Cancer.
David Nigel Poller (2017)
10.1002/cncy.21892
The influence of the noninvasive follicular thyroid neoplasm with papillary‐like nuclear features (NIFTP) resection diagnosis on the false‐positive thyroid cytology rate relates to quality assurance thresholds and the application of NIFTP criteria
N Paul Ohori (2017)
10.1089/thy.2016.0677
Role of Ultrasound in Predicting Tumor Invasiveness in Follicular Variant of Papillary Thyroid Carcinoma.
Soo Yeon Hahn (2017)
10.1007/s00423-017-1600-y
Underestimated risk of cancer in solitary thyroid nodules ≥3 cm reported as benign
Sohail Bakkar (2017)
10.1089/thy.2017.0238
Thyroid Nodule Diagnostic Markers in the Face of the New NIFTP Category: Time for a Reset?
Zeyad T Sahli (2017)
10.1016/j.ecl.2018.11.001
Clinical Diagnostic Evaluation of Thyroid Nodules.
Carolyn Maxwell (2019)
10.5114/pjp.2016.59224
Correspondence of cytological and histopathological diagnoses in diagnostic category V of the Bethesda system: "suspicious for malignancy".
Agata Stanek-Widera (2016)
10.4322/ahns.2018.0093
Noninvasive follicular thyroid neoplasm with papillary nuclear characteristics: Clinicopathologic features and follow-up
Oscar Brunás (2018)
10.1002/cncy.22220
Refining the criteria for an atypical thyroid aspirate.
Jeffrey F Krane (2019)
10.1007/978-1-4471-2446-7_5
Head and Neck: Thyroid
Paul A VanderLaan (2014)
10.1109/TMI.2019.2913194
Combining Total Variation Regularization with Window-Based Time Delay Estimation in Ultrasound Elastography
Mehdi Mirzaei (2019)
10.1007/978-3-319-72102-6_32
Pathology of the Thyroid: A Review
Virginia A. Livolsi (2019)
10.1002/dc.24103
Standardized terminology systems in cytopathology
Kaitlin E Sundling (2019)
Noninvasive Follicular Thyroid Neoplasm with Papillary-like Nuclear Features (NIFTP): Report of an Institutional Experience with 86 Cases
Marc P Pusztaszeri (2017)
See more
Semantic Scholar Logo Some data provided by SemanticScholar