Online citations, reference lists, and bibliographies.

Studies On Digitalis; X. Digitoxin Metabolites In Human Myocardium And Relationship Between Myocardial And Serum Concentrations Of Digitoxin In Patients On Maintenance Treatment

L. Storstein
Published 1977 · Medicine

Cite This
Download PDF
Analyze on Scholarcy
Share
The levels of digitoxin and cardioactive metabolites were measured in 42 atrial biopsies with a 86Rb method mod(fiedfor analysis of myocardial sampies. The mean value was 91.0 ng/gm wet weight (SD 54.4). Myocardial and serum concentrations were compared in 23 patients; there was no significant correlation. The ratio of total drug concentration in myocardium and serum ranged from 1 to 38 with a mean value of 5.4. Calculated from the free drug concentrations, the mean myocardial serum ratio was 200, which reflects the high affinity of digitoxin and cardioactive metabolites to the myocardium. The metabolic pattern of cardioactive and inactive metabolites (conjugates with glucuronic and sulfuric acid) was studied in autopsy samples from left ventricular myocardium from 7 patients. Significant differences between the myocardial and serum patterns of cardioactive and inactive metabolites were demonstrated. The myocardium contained less unchanged digitoxin (25.7%) and more hydrolyzed (55.4%) and conjugated (54.1%) metabolites than serum (57.6%, 31.0%, and 33.1%, respeetively). Hydroxylated metabolites in myocardium (15.8%) were not significantly changed compared to serum (10.0%).
This paper references
10.1016/S0021-9673(00)81069-9
Studies on digitalis. IV. A method for thin-layer chromatographic separation and determination of digitoxin and cardioactive metabolites in human blood and urine.
L. Storstein (1976)
10.1172/JCI106060
Binding of digitoxin and some related cardenolides to human plasma proteins.
D. S. Lukas (1969)
Digitoxin pharmacokinetics in chronic active hepatitis
L Storstein (1975)
10.1016/s0016-5085(19)34700-6
THE METABOLISM OF TRITIATED DIGOXIN IN CIRRHOTIC PATIENTS.
F. Marcus (1964)
10.1016/0002-9149(63)90060-2
Effect of total cardiopulmonary bypass on myocardial and blood digoxin concentration in man
A. Beall (1963)
Metabolism and distribution of digitoxin in the rat.
M. C. Castle (1973)
The inftuence of impaired renal function, hemodialysis, and drug interaction on serum protein binding of digitoxin and digoxin
L Storstein (1976)
10.1161/01.CIR.49.3.517
The Onset and Magnitude of the Contractile Response to Commonly Used Digitalis Glycosides in Normal Subjects
W. Forester (1974)
10.1016/0002-9149(72)90414-6
The relation between myocardial 3 H-digoxin concentration and its hemodynamic effects.
R. N. Deutscher (1972)
10.1002/cpt1976202158
Studies on digitalis; VII. Influence of nephrotic syndrome on protein binding, pharmacokinetics, and renal excretion of digitoxin and cardioactive metabolites
L. Storstein (1976)
Metabolism of digoxin: role of the liver in tritiated digoxin degradation.
R. J. Abel RM LUCHI (1965)
Interruption of digitoxin by choles - tyramine . 11 . Effect on metabolic disposition of tritium - Iabeled digitoxin and cardiac systolic intervals in man
P. R. Carroll (1971)
10.1111/J.1600-0773.1974.TB03534.X
Tissue concentrations of digoxin in an autopsy material.
J. Karjalainen (1974)
10.1016/0002-9149(75)90828-0
Dose-response relation between therapeutic levels of serum digoxin and systolic time intervals.
R. Hoeschen (1975)
10.1002/cpt19762016
Studies on digitalis. V. The influence of impaired renal function, hemodialysis, and drug interaction on serum protein binding of digitoxin and digoxin
L. Storstein (1976)
Metabolic fate of radioactive digitoxin in human subjects.
G. Okita (1955)
10.1002/cpt1977212125
Studies on digitalis; VIII. Digitoxin metabolism on a maintenance regimen and after a single dose
L. Storstein (1977)
10.1111/j.1445-5994.1973.tb03113.x
Digoxin concentrations in the serum and myocardium of digitalised patients.
P. Carroll (1973)
The ratio between myocardial and plasma levels of digoxin in man, in Storstein, 0
H. Schülier (1973)
Inftuence of nephrotic syndrome on protein binding, pharmacokinetics, and renal excretion of digitoxin and cardioactive metabolites, CUN
L. Studies on digitalis. VII (1976)
Metabolie fate of radioactive digitoxin in human subjects , 1
G. T. Okita (1955)
10.1152/ajplegacy.1971.220.4.906
Relationship between myocardial oubain content and inotropic activity.
R. Luchi (1971)
Digitoxin metabolites in human myocardium 407
10.1016/0014-2999(71)90213-5
The cardioactivity of digitoxin metabolites.
H. Mann (1971)
10.1056/NEJM197105062841801
Digitalis intoxication. A prospective clinical study with serum level correlations.
G. Beller (1971)
Correlation of the subcellular distribution of digoxin with the positive inotropic effect.
N. Kim (1972)
10.1161/01.CIR.42.6.1065
Relationship of Plasma Digitoxin and Digoxin to Cardiac Response Following Intravenous Digitalization in Man
W. Shapiro (1970)
The inftuence of cardiopulmonary bypass on digitoxin concentrations in serum, in Storstein, 0
S. Nitter-Hauge (1973)
The ratio between myocardial and plasma levels of digoxin in man
A Redfors (1973)
10.1161/01.CIR.50.4.653
Correlation of Serum Concentrations with Heart Concentrations of Digoxin in Human Subjects
H. Güllner (1974)
10.1111/j.1476-5381.1969.tb09505.x
The distribution of 3H‐labelled cardenolides between isolated guinea‐pig atrial tissue and circulating, oxygenated whole blood
H. Luellmann (1969)
10.1161/01.CIR.49.6.1053
Comparison of Serum Digoxin Level Measurement with Acetyl Strophanthidin Tolerance Testing
M. Klein (1974)
The ratio between myocardial and Clinical Pharmacology and Therapeutics serum levels of digitoxin
L Storstein (1973)
10.1136/bmj.2.5809.318
Myocardial and Skeletal Muscle Concentrations of Digoxin in Patients on Long-term Therapy
J. Coltart (1972)
10.1111/J.0954-6820.1970.TB02958.X
Determination of digitalis in blood.
K. Gjerdrum (1970)
Correlation of the electrophysiologic action of digoxin with serum digoxin concentration.
I. Barr (1972)
Studies on digitalis. XIII. A prospective study of 649 patients on maintenance treatment with digitoxin.
O. Storstein (1977)
The pharmacokinetics and metabolism of digitoxin in man
D S Lukas (1973)
10.1016/0002-9149(66)90370-5
Assay of digitalis glycosides in man
A. Weissler (1966)
10.1161/01.CIR.49.6.1047
Serum, Atrial, and Urinary Digoxin Levels During Cardiopulmonary Bypass in Children
R. Krasula (1974)
10.1111/j.1476-5381.1972.tb08137.x
Species and ionic influences on the accumulation of digitalis glycosides by isolated perfused hearts
S. Dutta (1972)
Relative potency of digitoxin and digoxin in relation with their binding to isolated cardiac and smooth muscles.
T. Godfriand (1968)
10.1136/bmj.4.5947.733
Physiological Distribution of Digoxin in Human Heart
D. Coltart (1974)
10.1016/0006-2952(67)90148-7
The uptake and content of digitoxin and its metabolites in the heart muscle of rats and guinea-pigs after acute and chronic application.
W. Foerster (1967)
The inftuence of cardiopulmonary bypass on digitoxin concentrations in serum
S Nitter-Hauge (1973)
The inftuence of renal function on the pharmacokinetics of digitoxin
L Storstein (1973)
The distribution of 3 H - Iabelled cardenolides between isolated guinea - pig atrial tissue and circulating , oxygenated whole blood , Br . 1
H. LülImann (1969)
Inftuence of nephrotic syndrome on protein binding, pharmacokinetics, and renal excretion of digitoxin and cardioactive metabolites
L Storstein (1976)



This paper is referenced by
Semantic Scholar Logo Some data provided by SemanticScholar