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Anti/genotoxic, Longevity Inductive, Cytotoxic, And Clastogenic‐related Bioactivities Of Tomato And Lycopene

Zahira Fernández-Bedmar, Jaouad Anter, Ángeles Alonso Moraga
Published 2018 · Biology, Medicine
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The aim of this study was to evaluate some biological activities of tomato as well as lycopene and to consider a new nutraceutic value for this fruit regarding to the protection against genetic damage and as a chemopreventive agent. Genotoxicity, DNA-protection against hydrogen peroxide, and lifespan properties of tomato and lycopene were assessed through wing spot test and longevity assay using the Drosophila in vivo model. Additionally, chemopreventive activity was investigated through cytotoxicity, DNA-fragmentation comet and annexin V FITC/PI assays using HL60 in vitro model. Results showed that: (i) tomato and lycopene are not genotoxic and protect against H2 O2 -induced damage; (ii) with respect to the lifespan, tomato and lycopene are harmless at the lowest concentration; (iii) tomato is cytotoxic in a dose-dependent manner, but not lycopene; (iv) tomato and lycopene do not induce internucleosomal DNA-fragmentation although they induce significant clastogenic activity at low level in the leukemia cells. To sum up, tomato is a good candidate to be considered as a nutraceutical substance. Furthermore, synergistic action among other components within tomato matrix could be the cause of the health effects observed in this vegetable, which are not fully explained by lycopene. Environ. Mol. Mutagen. 59:427-437, 2018. © 2018 Wiley Periodicals, Inc.
This paper references
10.1016/j.tiv.2007.11.002
Antigenotoxicity and antimutagenicity of lycopene in HepG2 cell line evaluated by the comet assay and micronucleus test.
Clarissa Scolastici (2008)
10.1534/genetics.107.072959
The flare Gene, Which Encodes the AIP1 Protein of Drosophila, Functions to Regulate F-Actin Disassembly in Pupal Epidermal Cells
Nan Ren (2007)
10.1093/mutage/9.4.383
Antigenotoxicity of coffee in the Drosophila assay for somatic mutation and recombination.
Suresh K. Abraham (1994)
10.1016/j.mrgentox.2005.05.004
Genotoxicity and anti-genotoxicity of some traditional medicinal herbs.
Magdalena Romero-Jiménez (2005)
10.1016/j.biopha.2007.02.015
Lycopene affects proliferation and apoptosis of four malignant cell lines.
H. Salman (2007)
10.1002/em.20078
Genotoxicity of vegetable cooking oils in the Drosophila wing spot test.
Mar Rojas-Molina (2005)
10.1016/j.arr.2005.08.001
How should we assess the impact of genetic changes on ageing in model species?
Nadège Minois (2006)
10.1016/0022-1759(95)00072-I
A novel assay for apoptosis. Flow cytometric detection of phosphatidylserine expression on early apoptotic cells using fluorescein labelled Annexin V.
István Vermes (1995)
10.1016/S1383-5718(98)00017-5
In vitro antimutagenic and in vivo anticlastogenic effects of carotenoids and solvent extracts from fruits and vegetables rich in carotenoids.
Raymond Rauscher (1998)
10.1590/S1415-47572009005000008
Effect of organic tomato (Lycopersicon esculentum) extract on the genotoxicity of doxorubicin in the Drosophila wing spot test
Elaine Sílvia Dutra (2009)
Genotoxicity of vegetable cooking oils
A. Alonso-Moraga (2005)
10.1016/j.foodres.2004.10.016
Antioxidant activity in different fractions of tomatoes
Ramandeep Kaur Toor (2005)
Lycopene affects
H Salman (2007)
10.1007/s11130-008-0099-3
Antioxidant Capacity and Antimutagenic Activity of Natural Oleoresin from Greenhouse Grown Tomatoes (Lycopersicon esculentum)
Eustolia Rodríguez-Muñoz (2009)
Anticarcinogenic effects of Solanum lycopersicum fruit extract on Swiss albino and C57 Bl mice.
R. C. Agrawal (2009)
10.1002/biof.5520230302
The effect of lycopene on cell growth and oxidative DNA damage of Hep3B human hepatoma cells.
Yun Ok Park (2005)
10.1016/j.mad.2007.08.004
Dietary restriction in Drosophila is dependent on mitochondrial efficiency and constrained by pre-existing extended longevity
Jung Won Soh (2007)
10.1016/j.fct.2016.10.011
In vivo and in vitro evaluation for nutraceutical purposes of capsaicin, capsanthin, lutein and four pepper varieties.
Zahira Fernández-Bedmar (2016)
10.1101/gr.169101
A systematic analysis of human disease-associated gene sequences in Drosophila melanogaster.
Lawrence T. Reiter (2001)
10.1534/genetics.108.091314
The multiple-wing-hairs Gene Encodes a Novel GBD–FH3 Domain-Containing Protein That Functions Both Prior to and After Wing Hair Initiation
Jie Yan (2008)
10.1186/1475-2867-12-36
Effect of lycopene on cell viability and cell cycle progression in human cancer cell lines
Anderson Junger Teodoro (2012)
10.1080/10408690390826437
Tomatoes and Cardiovascular Health
Joye K Willcox (2003)
EFFECT OF LYCOPENE ON LIFESPAN OF DROSOPHILA AND ITS UNDERLYING MOLECULAR MECHANISM
Xu Si-hong (2008)
10.1016/S0027-5107(97)00298-4
Antigenotoxicity studies in Drosophila melanogaster.
Uwe Graf (1998)
Protective effect of S-allylcysteine and lycopene in combination against N-methyl-N'-nitro-N-nitrosoguanidine-induced genotoxicity.
Balaiya Velmurugan (2004)
10.1016/S0963-9969(99)00053-8
Lycopene content of tomatoes and tomato products and their contribution to dietary lycopene
A. V. N. Rao (1998)
10.1016/0165-1161(95)90018-7
Optimal experimental design and sample size for the statistical evaluation of data from somatic mutation and recombination tests (SMART) in Drosophila
Hansjörg Frei (1995)
10.1089/jmf.2010.0139
Antigenotoxicity, cytotoxicity, and apoptosis induction by apigenin, bisabolol, and protocatechuic acid.
Jaouad Anter (2011)
10.1016/j.atherosclerosis.2017.01.009
Tomato and lycopene supplementation and cardiovascular risk factors: A systematic review and meta-analysis.
Ho Ming Cheng (2017)
10.1177/153537020523000303
Physiologically Attainable Concentrations of Lycopene Induce Mitochondrial Apoptosis in LNCaP Human Prostate Cancer Cells
Holly L Hantz (2005)
Genotoxicity and anti-genotoxicity
A. Alonso-Moraga (2005)
10.1017/S0007114507787445
Tomato juice decreases LDL cholesterol levels and increases LDL resistance to oxidation.
M L Silaste (2007)
10.1016/j.nut.2004.05.003
Protective effect of tomato against N-methyl-N'-nitro-N-nitrosoguanidine-induced in vivo clastogenicity and oxidative stress.
Balaiya Velmurugan (2004)
10.1007/BF02639429
Necrotic dna degradation mimics apoptotic nucleosomal fragmentation comet tail length
D. W. Fairbairn (2007)
10.1007/s11010-006-9403-4
In-vitro cytotoxic and genotoxic effects of arsenic trioxide on human leukemia (HL-60) cells using the MTT and alkaline single cell gel electrophoresis (Comet) assays
Clement G Yedjou (2006)
10.1016/j.archger.2013.07.007
Lutein extends the lifespan of Drosophila melanogaster.
Zesheng Zhang (2014)
10.1038/nmeth.2899
Quantifying Drosophila food intake: comparative analysis of current methodology
Sonali A. Deshpande (2014)
10.1016/S0308-8146(03)00165-1
Antioxidants in tomato (Lycopersium esculentum) as a function of genotype
Binoy George (2004)
10.1371/journal.pone.0056986
Protective Effect of Borage Seed Oil and Gamma Linolenic Acid on DNA: In Vivo and In Vitro Studies
Inmaculada Tasset-Cuevas (2013)
10.1155/2016/7574843
In Vivo and In Vitro Genotoxic and Epigenetic Effects of Two Types of Cola Beverages and Caffeine: A Multiassay Approach
Marcos Mateo-Fernández (2016)
10.1042/bj2860331
Key morphological features of apoptosis may occur in the absence of internucleosomal DNA fragmentation.
Gerald M. Cohen (1992)
10.1016/S0271-5317(03)00105-2
Lycopene content of foods and lycopene intake in two groups of the Hungarian population
Andrea Lugasi (2003)
10.1016/S0273-2300(03)00004-7
Summary of safety studies conducted with synthetic lycopene.
R Michael McClain (2003)
10.1002/ijc.30027
Lycopene, tomato products and prostate cancer-specific mortality among men diagnosed with nonmetastatic prostate cancer in the Cancer Prevention Study II Nutrition Cohort.
Ying Wang (2016)
10.1080/15287394.2011.582306
Role of Citrus Juices and Distinctive Components in the Modulation of Degenerative Processes: Genotoxicity, Antigenotoxicity, Cytotoxicity, and Longevity in Drosophila
Zahira Fernández-Bedmar (2011)
Effect of b-carotene-rich tomato lycopene b-cyclase (tlcy-b) on cell growth inhibition in HT-29 colon adenocarcinoma cells
Paola Palozza (2009)
Tomato lycopene and its role in human health and chronic diseases.
Sanjiv K Agarwal (2000)
10.1016/0003-9861(89)90467-0
Lycopene as the most efficient biological carotenoid singlet oxygen quencher.
Paolo Di Mascio (1989)
In vivo and in vitro genotoxic and epigenetic effects of two types of cola beverages and caffeine: A multi-assay approach
RM McClain (2016)
10.1016/j.redox.2013.12.020
OpenComet: An automated tool for comet assay image analysis
Benjamin M. Gyori (2014)
10.1073/pnas.0702726104
Prandiology of Drosophila and the CAFE assay
William W Ja (2007)
10.1093/jn/131.12.3303
Carotenoids affect proliferation of human prostate cancer cells.
Eiichi Kotake-Nara (2001)
10.1002/em.2860060206
Somatic mutation and recombination test in Drosophila melanogaster.
Ulrich Graf (1984)
10.1093/jxb/erf044
Increasing antioxidant levels in tomatoes through modification of the flavonoid biosynthetic pathway.
Martine Elisa Verhoeyen (2002)
10.1515/BC.2006.012
Aflatoxin B1-induced toxicity in HepG2 cells inhibited by carotenoids: morphology, apoptosis and DNA damage
Lalini Reddy (2006)
10.3136/fstr.19.513
Extension of Life Span and Improvement of Vitality in Drosophila melanogaster by Supplementation with Lycopene Mycelium Powder from Blakeslea trispora
Weilian Hu (2013)
10.1017/S0007114508169902
Effect of beta-carotene-rich tomato lycopene beta-cyclase ( tlcy-b) on cell growth inhibition in HT-29 colon adenocarcinoma cells.
Paola Palozza (2008)
10.1007/s11010-011-0743-3
A Drosophila model for the screening of bioavailable NADPH oxidase inhibitors and antioxidants
Nguyen Thi Tu Anh (2011)
10.1093/jn/135.5.1226
The tomato as a functional food.
Kirstie Canene-Adams (2005)
10.1002/biof.5520230203
Effects of tomato paste extracts on cell proliferation, cell-cycle arrest and apoptosis in LNCaP human prostate cancer cells.
Eun-Sun Hwang (2005)
10.1080/01635589909514756
Lycopene and 1,25-dihydroxyvitamin D3 cooperate in the inhibition of cell cycle progression and induction of differentiation in HL-60 leukemic cells.
Hermansyah Amir (1999)
10.1016/j.exger.2010.08.012
Drosophila as a model for age-related impairment in locomotor and other behaviors
Melanie A. Jones (2011)
10.1590/S0100-879X2004000700012
Tomato and garlic by gavage modulate 7,12-dimethylbenz[a]anthracene-induced genotoxicity and oxidative stress in mice.
Vaidhyanathan Bhuvaneswari (2004)
10.1021/jf904015f
Tomato ( Lycopersicon esculentum ) seeds: new flavonols and cytotoxic effect.
Federico Ferreres (2010)
Lack of modulatory effect of asparagus, tomato, and grape juice on cyclophosphamide-induced genotoxicity in mice
Asita Okorie Asita (2008)
10.1021/jf900364j
Tomatine-containing green tomato extracts inhibit growth of human breast, colon, liver, and stomach cancer cells.
Mendel Friedman (2009)
10.1093/mutage/gen043
In vivo assessment of DNA damage and protective effects of extracts from Miconia species using the comet assay and micronucleus test.
Juliana Mara Serpeloni (2008)



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