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Vitamin E And Cancer: An Insight Into The Anticancer Activities Of Vitamin E Isomers And Analogs

C. Constantinou, A. Papas, A. Constantinou
Published 2008 · Chemistry, Medicine

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Current observations in the literature suggest that vitamin E may be a suitable candidate for the adjuvant treatment of cancer. Even though historically most research focused on α‐tocopherol, more recent evidence suggests that the other isomers of vitamin E (β‐, γ‐ and δ‐tocopherols and α‐, β‐, γ‐ and δ‐tocotrienols) differ in their proapoptotic potencies. The main focus of this communication is the current understanding of the molecular mechanisms regulated by vitamin E isomers and their analogs during the induction of apoptosis. This review highlights that the mitochondria are the major target for the induction of apoptosis by vitamin E isomers and analogs and that the various signaling pathways regulated by these agents are likely to contribute towards maximizing the intrinsic pathway of apoptosis triggered initially by the mitochondria. Overall, the presentation of recent studies from the literature in this communication allows the drawing of the following important conclusions: (i) no direct link exists between the antioxidant activity of each isomer/derivative and proapoptotic potency, (ii) tocotrienols are more effective proapoptotic agents than tocopherols, (iii) synthetic modifications of the naturally occurring compounds may improve their apoptotic potency and (iv) vitamin E isomers and derivatives regulate caspase‐independent pathways of apoptosis. The latter combined with the evidence presented in this review regarding the additive or synergistic anticarcinogenic effects obtained when vitamin E analogs are used in combination with other cancer chemotherapeutic agents, supports further research to design the most promising vitamin E derivatives and clinically test them in adjuvant chemotherapeutic treatments. © 2008 Wiley‐Liss, Inc.
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In vitro screening of synergistic ascorbate-drug combinations for the treatment of malignant mesothelioma.
S. Martinotti (2011)
A pH sensitive polymeric micelle for co-delivery of doxorubicin and α-TOS for colon cancer therapy.
T. Debele (2017)
Modulation of PPAR-γ by Nutraceutics as Complementary Treatment for Obesity-Related Disorders and Inflammatory Diseases
Daniel Ortuño Sahagún (2012)
Vitamin E supplementation and mammalian lifespan.
Ruth Banks (2010)
S0Synergistic effect of selected anticancer drugs with Vitamin - E against HT29 human adenocarcinoma cell lines
Karthi Natesan (2014)
alpha-Tocopherol attenuates the cytotoxic effect of delta-tocotrienol in human colorectal adenocarcinoma cells.
Akira Shibata (2010)
Targeting mitochondria for cancer therapy
S. Fulda (2010)
Potent Inhibitory Effect of δ-Tocopherol on Prostate Cancer Cells Cultured in Vitro and Grown As Xenograft Tumors in Vivo
H. Huang (2014)
Physiobiochemical Significance of Vitamin E and other Tocopherols in the U.S. Diet: Cancer Promoters or Preventers?
L. Gerber (2012)
Development and application of web-based open source drug discovery platforms
Yuri Pevzner (2015)
Vitamin E Transporters in Cancer Therapy
S. Alqahtani (2014)
Synergistic actions of atorvastatin with γ‐tocotrienol and celecoxib against human colon cancer HT29 and HCT116 cells
Z. Yang (2010)
Vitamin E-based micelles enhance the anticancer activity of doxorubicin.
F. Danhier (2014)
Pro-apoptotic Properties of Chemopreventive Agents
C. Neophytou (2020)
α-Tocopherol suppresses antiangiogenic effect of δ-tocotrienol in human umbilical vein endothelial cells.
Akira Shibata (2015)
Thiolated chitosan-modified PLA-PCL-TPGS nanoparticles for oral chemotherapy of lung cancer
L. Jiang (2013)
Role of Antioxidant Phytochemicals in Prevention, Formation and Treatment of Cancer
A. Kocyigit (2017)
Comparing extraction methods for the determination of tocopherols and tocotrienols in seeds and germinating seeds of soybean transformed with OsHGGT
Y. Lee (2012)
Vitamin E intake and the lung cancer risk among female nonsmokers: A report from the Shanghai Women's Health Study
Q. Wu (2015)
Vitamin E Family of Compounds and Cancer Prevention
Kimberly Kline (2013)
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