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MiR‐134 Targets PDCD7 To Reduce E‐cadherin Expression And Enhance Oral Cancer Progression
Shih-Yuan Peng, H. Tu, Cheng-Chieh Yang, Cheng-Hsien Wu, Chung-Ji Liu, Kuo-Wei Chang, Shu-Chun Lin
Published 2018 · Biology, Medicine
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Oral squamous cell carcinoma (OSCC) is a common malignancy worldwide. This study clarified the oncogenic role of miR‐134 in OSCC. Reporter assays, using both wild‐type and mutant constructs, confirmed that Programmed Cell Death 7 (PDCD7) gene was a potential target of miR‐134. The OSCC cells exogenously expressed miR‐134 exhibited reduced PDCD7 expression. As expected, exogenous miRZip‐134 expression increased PDCD7 expression in the OSCC cells; additionally, PDCD7 expression suppressed the oncogenicity of the OSCC cells. By contrast, PDCD7 knockout through gene editing increased in vitro oncogenicity and neck nodal metastasis in mice, and reduced E‐cadherin (E‐cad) expression. PDCD7 transactivated E‐cad expression via the GC‐box in the promoter. Moreover, miR‐134‐associated cellular transformation and E‐cad downregulation was attenuated by PDCD7. Downregulation of both PDCD7 and E‐cad and high levels miR‐134 expression was observed in OSCC tumor tissues. Activation of the miR‐134‐PDCD7‐E‐cad pathogenesis cascade occurred early during the human and murine oral carcinogenesis process. In conclusion, the oncogenic effect of miR‐134 in oral carcinoma is mediated by reducing PDCD7 and E‐cad expression.
This paper references
Isolation of a novel mouse gene MA-3 that is induced upon programmed cell death.
K. Shibahara (1995)
Isolation of a novel mouse gene MA-3 that is induced upon programmed cell death
柴原 慶一 (1996)
Differentially expressed protein Pdcd4 inhibits tumor promoter-induced neoplastic transformation.
J. Cmarik (1999)
Characterization of a novel mouse cDNA, ES18, involved in apoptotic cell death of T-cells.
E. Park (1999)
MicroRNAs Genomics, Biogenesis, Mechanism, and Function
D. Bartel (2004)
The U11/U12 snRNP 65K protein acts as a molecular bridge, binding the U12 snRNA and U11‐59K protein
H. Benecke (2005)
A brain-specific microRNA regulates dendritic spine development
G. Schratt (2006)
MicroRNAs to Nanog, Oct4 and Sox2 coding regions modulate embryonic stem cell differentiation
Y. Tay (2008)
Mature miR-184 as Potential Oncogenic microRNA of Squamous Cell Carcinoma of Tongue
T. Wong (2008)
Areca nut extract induced oxidative stress and upregulated hypoxia inducing factor leading to autophagy in oral cancer cells
H. Lu (2010)
miR-31 ablates expression of the HIF regulatory factor FIH to activate the HIF pathway in head and neck carcinoma.
Chung-Ji Liu (2010)
Down-regulation of E-cadherin is an essential event in activating β-catenin/Tcf dependent transcription and expression of its target genes in Pdcd4 knock-down cells
Q. Wang (2010)
A novel pathway regulates memory and plasticity via SIRT1 and miR-134
Jun Gao (2010)
Multifactorial Regulation of E-Cadherin Expression: An Integrative Study
W. Reinhold (2010)
in oral cancer cells
YY Kao (2010)
Downregulation of E-cadherin is an essential event in activating beta-catenin/Tcf-dependent transcription and expression of its target genes in Pdcd4 knockdown cells
Q Wang (2010)
Cooperative Transcriptional Activation by Klf4, Meis2, and Pbx1
Glen A Bjerke (2011)
Pdcd4 knockdown up-regulates MAP4K1 expression and activation of AP-1 dependent transcription through c-Myc.
Qing Wang (2012)
MiR-134 functions as a regulator of cell proliferation, apoptosis, and migration involving lung septation
X. Zhang (2012)
Is E-cadherin immunoexpression a prognostic factor for head and neck squamous cell carcinoma (HNSCC)? A systematic review and meta-analysis.
Z. Zhao (2012)
Stem Cell Marker (Nanog) and Stat-3 Signaling Promote MicroRNA-21 Expression and Chemoresistance in Hyaluronan/CD44-activated Head and Neck Squamous Cell Carcinoma Cells
L. Bourguignon (2012)
The cBio cancer genomics portal: an open platform for exploring multidimensional cancer genomics data.
E. Cerami (2012)
Hepatocyte nuclear factor‐4α reverses malignancy of hepatocellular carcinoma through regulating miR‐134 in the DLK1‐DIO3 region
C. Yin (2013)
Diagnostic microRNA markers to screen for sporadic human colon cancer in stool: I. Proof of principle.
F. E. Ahmed (2013)
MicroRNA Array Analysis Finds Elevated Serum miR-1290 Accurately Distinguishes Patients with Low-Stage Pancreatic Cancer from Healthy and Disease Controls
A. Li (2013)
Expression and clinical significance of the programmed cell death 5 gene and protein in laryngeal squamous cell carcinoma
F. Xu (2013)
miR‐134 induces oncogenicity and metastasis in head and neck carcinoma through targeting WWOX gene
Chung-Ji Liu (2014)
E-cadherin expression and prognosis of oral cancer: a meta-analysis
Sheng-lei Luo (2014)
Downregulated miR329 and miR410 promote the proliferation and invasion of oral squamous cell carcinoma by targeting Wnt-7b.
S. Shiah (2014)
EGF Up-Regulates miR-31 through the C/EBPβ Signal Cascade in Oral Carcinoma
Wen-cheng Lu (2014)
High‐throughput screens identify microRNAs essential for HER2 positive breast cancer cell growth
Suvi-Katri Leivonen (2014)
Highthroughput screens identify microRNAs essential for HER2 positive breast cancer cell growth
SK Leivonen (2014)
MicroRNA-21 links epithelial-to-mesenchymal transition and inflammatory signals to confer resistance to neoadjuvant trastuzumab and chemotherapy in HER2-positive breast cancer patients
L. De Mattos-Arruda (2015)
Epigenetic and Genetic Alterations Affect the WWOX Gene in Head and Neck Squamous Cell Carcinoma
S. Ekizoğlu (2015)
The miR-134 attenuates the expression of transcription factor FOXM1 during pluripotent NT2/D1 embryonal carcinoma cell differentiation.
Y. Chen (2015)
E-cadherin, β-catenin, and α2β1 and α3β1 integrin expression in primary oral squamous cell carcinoma and its regional metastasis.
Mariana Quirino Silveira Soares (2015)
Comprehensive genomic characterization of head and neck squamous cell carcinomas
M. Lawrence (2015)
The increase of oncogenic miRNA expression in tongue carcinogenesis of a mouse model.
Yu-Yu Kao (2015)
MicroRNA‐134 suppresses endometrial cancer stem cells by targeting POGLUT1 and Notch pathway proteins
Y. Gao (2015)
Ecadherin, beta-catenin, and alpha2beta1 and alpha3beta1 integrin expression in primary oral squamous cell carcinoma and its regional metastasis
MQ Soares (2015)
E - cadherin , beta - catenin , and alpha 2 beta 1 and alpha 3 beta 1 integrin expression in primary oral squamous cell carcinoma and its regional metasta
MQ Soares (2015)
Comprehen - sive genomic characterization of head and neck squamous cell carcinomas
DS Chandrashekar (2015)
The Cancer Genome Atlas Network. Comprehensive genomic characterization of head and neck squamous cell carcinomas
Cellular functions of programmed cell death 5.
Ge Li (2016)
MicroRNA-211 Enhances the Oncogenicity of Carcinogen-Induced Oral Carcinoma by Repressing TCF12 and Increasing Antioxidant Activity.
Yi-Fen Chen (2016)
miR‐134 inhibits non‐small cell lung cancer growth by targeting the epidermal growth factor receptor
Q. Qin (2016)
Hsa-miR-134 suppresses non-small cell lung cancer (NSCLC) development through down-regulation of CCND1
C. Sun (2016)
Clinico-Pathological Association of Delineated miRNAs in Uveal Melanoma with Monosomy 3/Disomy 3 Chromosomal Aberrations
N. Venkatesan (2016)
Two lung development-related microRNAs, miR-134 and miR-187, are differentially expressed in lung tumors.
F. Mirzadeh Azad (2016)
A central role for cadherin signaling in cancer.
Antonis Kourtidis (2017)
Reexamining cancer metabolism: lactate production for carcinogenesis could be the purpose and explanation of the Warburg Effect
Iñigo San-Millán (2017)
PDCD1 (PD-1) promoter methylation predicts outcome in head and neck squamous cell carcinoma patients
D. Goltz (2017)
Competing causes of death in the head and neck cancer population.
Sean T Massa (2017)
UALCAN: A Portal for Facilitating Tumor Subgroup Gene Expression and Survival Analyses1
D. Chandrashekar (2017)
CRISPR/Cas9-mediated PD-1 disruption enhances anti-tumor efficacy of human chimeric antigen receptor T cells
Levi J. Rupp (2017)
Prognostic Prediction of Oral Squamous Cell Carcinoma by E-Cadherin and N-Cadherin Expression in Overall Cells in Tumor Nests or Tumor Cells at the Invasive Front
Yuu Ozaki-Honda (2017)
miR-134: A Human Cancer Suppressor?
Jingyu Pan (2017)
The Molecular Landscape of Recurrent and Metastatic Head and Neck Cancers: Insights From a Precision Oncology Sequencing Platform
L. Morris (2017)
PD-1) promoter methylation predicts outcome in head and neck squamous cell carcinoma patients
D Goltz (2017)
Hyman-Walsh C Wotton D. Cooperative transcriptional activation Bjerke GA (2018)
This paper is referenced by
MicroRNA-134/MicroRNA-200a Derived Salivary Exosomes are Novel Diagnostic Biomarkers of Oral Squamous Cell Carcinoma
AminaFouad Farag (2021)
Roles of microRNAs in Regulating Cancer Stemness in Head and Neck Cancers
Melysa Fitriana (2021)
Salivary exosomal microRNAs as biomarkers for head and neck cancer detection—a literature review
C. Faur (2021)
Ruyiping formula inhibits metastasis via the microRNA-134-SLUG axis in breast cancer
Ziwei Jiang (2021)
MicroRNAs as Modulators of Oral Tumorigenesis—A Focused Review
Kumar Rishabh (2021)
MicroRNA as a Novel Biomarker in the Diagnosis of Head and Neck Cancer
J. Kabziński (2021)
Disruption of exon-bridging interactions between the minor and major spliceosomes results in alternative splicing around minor introns
Anouk M. Olthof (2021)
Cigarette Smoke Containing Acrolein Upregulates EGFR Signaling Contributing to Oral Tumorigenesis In Vitro and In Vivo
Han-Hsing Tsou (2021)
Activation of the miR-371/372/373 miRNA Cluster Enhances Oncogenicity and Drug Resistance in Oral Carcinoma Cells
S. Lin (2020)
microRNAs deregulation in head and neck squamous cell carcinoma
Juliana Carron (2020)
MicroRNA-134-3p inhibits ovarian cancer progression by targeting flap structure-specific endonuclease 1 in vitro
M. Zhao (2020)
MicroRNAs in head and neck squamous cell carcinoma: a possible challenge as biomarkers, determinants for the choice of therapy and targets for personalized molecular therapies
Mahrou Vahabi (2020)
Diagnostic and therapeutic role of microRNAs in oral cancer (Review)
J. Wang (2020)
Diagnostic and therapeutic role of microRNAs in oral cancer
J. Wang (2020)
MicroRNA profile in the squamous cell carcinoma: prognostic and diagnostic roles
S. Ghafouri-Fard (2020)
microRNAs in oral cancer: Moving from bench to bed as next generation medicine.
Wendy D'Souza (2020)
The minor and major spliceosome interact to regulate alternative splicing around minor introns
Anouk M. Olthof (2020)
The miR-372-ZBTB7A Oncogenic Axis Suppresses TRAIL-R2 Associated Drug Sensitivity in Oral Carcinoma
L. Yeh (2020)
The microRNA miR‐134‐5p induces calcium deposition by inhibiting histone deacetylase 5 in vascular smooth muscle cells
N. Choe (2020)
Epigenetic Modifications in Head and Neck Cancer
Jadwiga Gaździcka (2019)
Down-regulation of hsa_circ_0092125 is related to the occurrence and development of oral squamous cell carcinoma.
L. Gao (2019)
hsa_circ_0000745 promotes cervical cancer by increasing cell proliferation, migration, and invasion
Jun Jiao (2019)
CircZNF609/miR‐134‐5p/BTG‐2 axis regulates proliferation and migration of glioma cell
H. Tong (2019)
Targeting RNA Polymerase I with Hernandonine Inhibits Ribosomal RNA Synthesis and Tumor Cell Growth
Y. Chen (2019)
Prospective applications of microRNAs in oral cancer
C. Fang (2019)
MEHP promotes the proliferation of oral cancer cells via down regulation of miR-27b-5p and miR-372-5p.
Mengxi Wang (2019)
MicroRNA-299-3p/FOXP4 Axis Regulates the Proliferation and Migration of Oral Squamous Cell Carcinoma
Yao-xiang Xu (2019)
Cell-Free microRNAs as Potential Oral Cancer Biomarkers: From Diagnosis to Therapy
Ó. Rapado-González (2019)
Establishment of syngeneic murine model for oral cancer therapy.
Y. Chen (2019)
Acrolein Is Involved in the Synergistic Potential of Cigarette Smoking– and Betel Quid Chewing–Related Human Oral Cancer
Han-Hsing Tsou (2019)