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DOI: 10.1002/jcb.28626

CeNETs Analysis Reveals The Prognostic Value Of A Signature Integration From Five LncRNAs In Breast Cancer.

K. Wang, Caihua Liao, Qiong Zhong, H. Dong, T. Zhang, Rongzhong Jin
Published 2019 · Biology, Medicine

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BACKGROUND The competitive endogenous RNA (ceRNA) hypothesis is a novel effective theory that can enable us to deeply understand the mechanisms of comprehensive diseases. METHODS In this study, we first downloaded RNAseq data and microRNA (miRNA) seq data of breast cancer from The Cancer Genome Atlas and further explored the regulation of ceRNA network in breast cancer using comprehensive bioinformatics tools. RESULTS The results revealed that five miRNAs, including hsa-miR-10b, hsa-miR-21, hsa-miR-183, hsa-miR-1258, and hsa-miR-3200 formed the core of ceRNA network. Moreover, five long noncoding RNAs that could competitively bind with miR-10b, respectively, named ACTA2-AS1, RP11-384P7.7, RP11-327J17.9, RP11-124N14.3, and RP11-645C24.5, were discovered as an integration signature with great potential in the prediction of survival outcomes in patients with different stages of breast cancer. CONCLUSIONS This indicates that these five long noncoding RNAs may be potential novel diagnostic and prognostic biomarkers of breast cancer.
This paper references
10.1038/nature12986
The multilayered complexity of ceRNA crosstalk and competition
Y. Tay (2014)
10.1016/j.biopha.2014.03.001
Enhanced expression of long non-coding RNA ZXF1 promoted the invasion and metastasis in lung adenocarcinoma.
L. Zhang (2014)
10.1016/j.cell.2009.02.006
Evolution and Functions of Long Noncoding RNAs
C. Ponting (2009)
10.1371/journal.pone.0141042
Cancer Specific Long Noncoding RNAs Show Differential Expression Patterns and Competing Endogenous RNA Potential in Hepatocellular Carcinoma
J. Zhang (2015)
10.1186/s12864-017-3790-7
High-throughput validation of ceRNA regulatory networks
H. Chiu (2017)
10.18632/oncotarget.6745
E2F1-induced upregulation of long noncoding RNA LINC00668 predicts a poor prognosis of gastric cancer and promotes cell proliferation through epigenetically silencing of CKIs
Erbao Zhang (2016)
10.1186/gb-2010-11-10-r106
Differential expression analysis for sequence count data
S. Anders (2010)
10.1158/2159-8290.CD-13-0202
ceRNA cross-talk in cancer: when ce-bling rivalries go awry.
F. Karreth (2013)
10.1093/hmg/ddu502
LncRNA-HOST2 regulates cell biological behaviors in epithelial ovarian cancer through a mechanism involving microRNA let-7b.
Y. Gao (2015)
10.1158/0008-5472.CAN-13-0023
TGF-β modulates ovarian cancer invasion by upregulating CAF-derived versican in the tumor microenvironment.
Tsz-Lun Yeung (2013)
10.18632/oncotarget.10142
Long non-coding RNA UCA1 is a predictive biomarker of cancer
Han-han Hong (2016)
10.1038/srep06088
Long noncoding RNA associated-competing endogenous RNAs in gastric cancer
Tian Xia (2014)
10.1038/onc.2008.373
GAS5, a non-protein-coding RNA, controls apoptosis and is downregulated in breast cancer
M. Mourtada-Maarabouni (2009)
10.1016/j.ccr.2014.03.010
A long noncoding RNA activated by TGF-β promotes the invasion-metastasis cascade in hepatocellular carcinoma.
J. Yuan (2014)
10.1016/j.celrep.2014.02.042
Iron Metabolism Regulates p53 Signaling through Direct Heme-p53 Interaction and Modulation of p53 Localization, Stability, and Function
J. Shen (2014)
10.1089/dna.2017.3862
Circular RNA hsa_circ_0001982 Promotes Breast Cancer Cell Carcinogenesis Through Decreasing miR-143.
Yi-Yin Tang (2017)
10.1073/pnas.0530291100
Prospective identification of tumorigenic breast cancer cells
M. Al-Hajj (2003)
10.1016/S0092-8674(04)00045-5
MicroRNAs Genomics, Biogenesis, Mechanism, and Function
D. Bartel (2004)
10.3892/mmr.2017.7304
Identification of an lncRNA-miRNA-mRNA interaction mechanism in breast cancer based on bioinformatic analysis
Y. Zhang (2017)
10.1186/s13046-014-0084-7
A four-long non-coding RNA signature in predicting breast cancer survival
J. Meng (2014)
10.1158/2159-8290.CD-11-0209
The emergence of lncRNAs in cancer biology.
John R. Prensner (2011)
10.1371/journal.pone.0013984
Enrichment Map: A Network-Based Method for Gene-Set Enrichment Visualization and Interpretation
D. Merico (2010)
10.1517/14712598.2014.920812
MicroRNAs and ceRNAs: therapeutic implications of RNA networks
D. Giza (2014)
10.3748/wjg.v21.i41.11680
Competing endogenous RNA networks and gastric cancer.
Lei-Lei Guo (2015)
10.1016/j.cell.2011.07.014
A ceRNA Hypothesis: The Rosetta Stone of a Hidden RNA Language?
L. Salmena (2011)
10.3390/ijms14034655
Long Non-Coding RNA in Cancer
N. Hauptman (2013)
10.1158/0008-5472.CAN-15-3284
Transcriptome Analysis of Triple-Negative Breast Cancer Reveals an Integrated mRNA-lncRNA Signature with Predictive and Prognostic Value.
Y. Jiang (2016)
10.18632/oncotarget.8063
Long noncoding RNA H19 indicates a poor prognosis of colorectal cancer and promotes tumor growth by recruiting and binding to eIF4A3
D. Han (2016)
10.1038/nature08975
Long noncoding RNA HOTAIR reprograms chromatin state to promote cancer metastasis
R. Gupta (2010)
10.1186/s13046-017-0624-z
Circular RNAs: emerging cancer biomarkers and targets
Y. Zhang (2017)
10.1049/iet-syb.2013.0025
Construction and investigation of breast-cancer-specific ceRNA network based on the mRNA and miRNA expression data.
Xionghui Zhou (2014)
10.1186/1471-2164-16-S4-S1
Parameter optimization for constructing competing endogenous RNA regulatory network in glioblastoma multiforme and other cancers
Yu-Chiao Chiu (2015)
10.1016/j.molmed.2014.03.005
Long noncoding RNAs and prostate carcinogenesis: the missing 'linc'?
Anna L. Walsh (2014)
10.1186/s13046-017-0614-1
circGFRA1 and GFRA1 act as ceRNAs in triple negative breast cancer by regulating miR-34a
R. He (2017)



This paper is referenced by
10.1186/s12935-020-01471-w
A novel mechanism by which ACTA2-AS1 promotes cervical cancer progression: acting as a ceRNA of miR-143-3p to regulate SMAD3 expression
Lingli Luo (2020)
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