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Fecal Microbiota Transplantation In Recurrent Clostridium Difficile Infection: A Retrospective Single‐center Chart Review

Pamela Kim, Akash Gadani, Heitham Abdul-Baki, Ricardo Mitre, Marcia Mitre
Published 2019 · Medicine

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Background and Aim Fecal microbiota transplantation (FMT) has been proposed as a treatment option for patients with recurrent Clostridium difficile (C. difficile) infection but remains a novel option. We examined if FMT is an effective means of treating recurrent C. difficile infection. Methods A retrospective review of 35 patients who underwent FMT was completed. Demographics and other variables, including the use of proton pump inhibitor therapy and history of inflammatory bowel disease, were collected. Results Twenty‐five patients (71.4%) belonged to a high‐risk population (working in a hospital setting, rehabilitation center, or nursing facility) and a total of 74.3% of patients (n = 26 patients) had no history of proton pump inhibitor use. Twenty‐five patients (71.4%) had used metronidazole prior to transplantation, 35 patients (100%) had used vancomycin, and 7 patients (20%) had used fidaxomicin for prior infection. Four patients (11.4%) had used all three antibiotics during prior treatment. Of the eight patients who had a history of inflammatory bowel disease, six (75%) experienced resolution of symptoms after transplantation. A total of 30 patients (85.7%) had resolution of their symptoms 6–8 weeks’ posttransplant, while 5 patients (14.3%) continued to have symptoms. Conclusions Our retrospective chart review supports that patients benefit from FMT in the setting of recurrent C. difficile infection.
This paper references
10.1111/apt.14443
The long‐term effects of faecal microbiota transplantation for gastrointestinal symptoms and general health in patients with recurrent Clostridium difficile infection
J. Jalanka (2018)
10.1097/MCG.0000000000000410
The Long-term Efficacy and Safety of Fecal Microbiota Transplant for Recurrent, Severe, and Complicated Clostridium difficile Infection in 146 Elderly Individuals
M. Agrawal (2016)
10.1111/apt.14201
Systematic review with meta‐analysis: the efficacy of faecal microbiota transplantation for the treatment of recurrent and refractory Clostridium difficile infection
M. N. Quraishi (2017)
10.1093/cid/ciy149
Clinical Practice Guidelines for Clostridium difficile Infection in Adults and Children: 2017 Update by the Infectious Diseases Society of America (IDSA) and Society for Healthcare Epidemiology of America (SHEA).
L. McDonald (2018)
10.1007/s00384-015-2396-2
Fecal transplant is as effective and safe in immunocompromised as non-immunocompromised patients for Clostridium difficile
A. Mandalia (2015)
Clinical practice guidelines for Clostridium dif fi cile infection in adults :
SH Cohen (2010)
10.7326/M16-2810
Methods and Reporting Studies Assessing Fecal Microbiota Transplantation
Aïda Bafeta (2017)
10.1177/1756283X12453637
Fecal microbiota transplantation in relapsing Clostridium difficile infection
Faith Rohlke (2012)
10.1186/s12879-016-1786-6
Cost of hospital management of Clostridium difficile infection in United States—a meta-analysis and modelling study
Shuailong Zhang (2016)
10.4103/1947-2714.114163
Fecal Transplantation for the Treatment of Recurrent Clostridium Difficile Infection
Zeid Karadsheh (2013)
10.1001/jamainternmed.2013.7056
Epidemiology of community-associated Clostridium difficile infection, 2009 through 2011.
A. Chitnis (2013)
10.1111/j.1365-2036.2011.04737.x
Review article: faecal transplantation therapy for gastrointestinal disease
J. Landy (2011)
10.1056/NEJMoa1408913
Burden of Clostridium difficile infection in the United States.
F. Lessa (2015)
10.1001/jamainternmed.2015.42
Continuous Proton Pump Inhibitor Therapy and the Associated Risk of Recurrent Clostridium difficile Infection.
E. McDonald (2015)
10.1111/apt.13868
Consensus report: faecal microbiota transfer – clinical applications and procedures
J. König (2017)
10.1111/j.1572-0241.2002.05839.x
Breaking the cycle: treatment strategies for 163 cases of recurrent Clostridium difficile disease
L. Mcfarland (2002)
10.1056/NEJMoa1205037
Duodenal infusion of donor feces for recurrent Clostridium difficile.
E. van Nood (2013)
10.1093/ofid/ofy045
Is a Single Fecal Microbiota Transplant a Promising Treatment for Recurrent Clostridium difficile Infection?
S. Hota (2018)
10.1038/ajg.2014.133
Fecal Microbiota Transplant for Treatment of Clostridium difficile Infection in Immunocompromised Patients
C. Kelly (2014)
10.1086/651706
Clinical practice guidelines for Clostridium difficile infection in adults: 2010 update by the society for healthcare epidemiology of America (SHEA) and the infectious diseases society of America (IDSA).
S. Cohen (2010)
10.3201/eid1309.061116
Increase in Clostridium difficile–related Mortality Rates, United States, 1999–2004
Matthew D. Redelings (2007)
10.1016/j.mayocp.2012.07.016
Clostridium difficile infection: new insights into management.
S. Khanna (2012)
Clinical practice guidelines for Clostridium difficile infection in adults:2010 update by the Society for Healthcare Epidemiology of America(SHEA)and the Infectious Diseases Society of America(IDSA)
Li Guang-hu (2011)
Fecal Microbiota transplantation for recurrent or refractory clostridium Difficile infection in inflammatory bowel disease
Y. Cheng (2017)



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