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Control Of Lipoprotein Lipase Secretion By Macrophages: Effect Of Macrophage Differentiation Agents

R. Goldman
Published 1990 · Biology, Medicine

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The effect of macrophage differentiation agents on lipoprotein lipase (LPL) secretion by macrophages at different stages of differentiation/maturation was investigated. Phorbol myristate acetate (TPA) had an augmenting effect on LPL secretion by in vitro‐derived bone marrow macrophages (BMMs), thioglycollate‐elicited peritoneal macrophages (Tg‐M⊘), and resident macrophages. Augmentation was time dependent and reached ~ twofold and ~ threefold increase over control cells within 16 and 96 hr, respectively. TPA did not affect LPL secretion from J774.1 cells treated with the agent for 16–72 hr. L‐cell conditioned medium (L‐CM), a source of macrophage colony‐stimulating activity, augmented LPL secretion by BMMs and Tg‐M⊘, and when added together with TPA had an additive augmenting effect on LPL secretion in these cells. Retinoic acid (RA) exerted a time‐dependent suppressive effect on LPL secretion by BMMs (46% within 16 hr and 83% within 6 d), had a relatively small effect on secretion from J774.1 cells (~ 20% in 72 hr) and had no effect on LPL secretion by Tg‐M⊘. Dexamethasone suppressed LPL secretion by BMMs, Tg‐M⊘, and J774.1 cells. Optimal suppression of LPL secretion by BMMs required more than 24 hr. Thus, TPA and L‐CM, agents that exert a mitogenic effect on BMMs and Tg‐M⊘, augmented the secretion of LPL in these cell types, and RA and dexamethasone, agents which induce differentiation patterns in myeloid cells, suppressed LPL secretion.
This paper references
Methods for the purification, assay, characterization and target cell binding of a colony stimulating factor (CSF-1).
E. R. Stanley (1981)
Heparin decreases the degradation rate of lipoprotein lipase in adipocytes.
M. Cupp (1987)
Retinoids. Structure-function relationship in normal and leukemic hematopoiesis in vitro.
A. Tobler (1986)
The nature of 12‐O‐tetradecanoylphorbol‐13‐acetate (TPA)‐stimulated hemopoiesis, colony stimulating factor (CSF) requirement for colony formation, and the effect of TPA on [125I]CSF‐1 binding to macrophages
L. Guilbert (1983)
A stable, radioactive substrate emulsion for assay of lipoprotein lipase.
P. Nilsson-ehle (1976)
Phagocytosis and cytolysis by a macrophage tumour and its cloned cell line
P. Ralph (1975)
Regulation of Iipoprotein lipase synthesis by recombinant tumor necrosis factorthe primary regulatory role of the hormone in 3T3-Ll adipocytes
Price (1986)
Bacterial lipopolysaccharide suppresses the expression of lipoprotein lipase in murine macrophages: a process independent of tumor necrosis factor or interleukin 1.
O. Sopher (1987)
The nature of 12 - 0 - tetradecanoyl phorbol - 13 - acetate ( TPA ) - stimulated hemopoiesis . colony stimulating factor ( CSF ) requirement for colony formation and the effect of TPA on macrophages
L. J. Guilbert (1983)
The molecular basis of retinoic acid action. Transcriptional regulation of tissue transglutaminase gene expression in macrophages.
E. Chiocca (1988)
Synthesis and secretion of lipoprotein lipase in 3T3-L1 adipocytes. Demonstration of inactive forms of lipase in cells.
T. Olivecrona (1987)
Retinoic acid-induced expression of tissue transglutaminase in mouse peritoneal macrophages.
W. Moore (1984)
Regulation of lipoprotein lipase synthesis by recombinant tumor necrosis factor--the primary regulatory role of the hormone in 3T3-L1 adipocytes.
S. Price (1986)
Activation and proliferation signals in murine macrophages: synergistic interactions between the hematopoietic growth factors and with phorbol ester for DNA synthesis.
J. Hamilton (1988)
Control of lipoprotein lipase secretion in mouse macrophages.
R. Goldman (1989)
Induction of Macrophage DNA Synthesis by phorbol esters
J. Hamilton (1981)
Opposing effects of dexamethasone on the clonal growth of granulocyte and macrophage progenitor cells and on the phagocytic capability of mononuclear phagocytes at different stages of differentiation
E. Shezen (1985)
Identification of a receptor for the morphogen retinoic acid
V. Giguère (1987)
Inhibition of yeast phagocytosis and cell spreading by glucocorticoids in cultures of resident murine peritoneal macrophages.
R. Grasso (1981)
Tissue lipoprotein lipase activity and its action in lipoprotein metabolism.
A. Cryer (1981)
Heart and skeletal muscle lipoprotein lipase
J. Borensztajn (1987)
Secretion of lipoprotein lipase by macrophages in culture.
J. C. Khoo (1981)
Effect of retinoic acid on the proliferation and phagocytic capability of murine macrophage‐like cell lines
R. Goldman (1984)
Biochemical actions of glucocorticoids on macrophages in culture. Specific inhibition of elastase, collagenase, and plasminogen activator secretion and effects on other metabolic functions
Z. Werb (1978)
Glucocorticoids and prostaglandins inhibit the induction of macrophage DNA synthesis by macrophage growth factor and phorbol ester
J. Hamilton (1983)
Activation and proliferation signals in murine macrophages: Stimulation of glucose uptake by hemopoietic growth factors and other agents
J. Hamilton (1988)
The correlation between plasminogen activator activity and thymidine incorporation in mouse bone marrow-derived macrophages. Opposing actions of colony-stimulating factor, phorbol myristate acetate, dexamethasone and prostaglandin E.
D. Hume (1984)
Retinoic acid - induced expression of tissue transglutaminase in mouse pert - toneal macrophages
W. T. Moore (1984)
Lipoprotein lipase in mouse peritoneal macrophages: the effects of insulin and dexamethasone.
M. Kawakami (1986)
Comparative biochemistry and physiology of lipoprotein lipase
A. Cryer
Human monocytes in culture synthesize and secrete lipoprotein lipase.
P. Wang-Iverson (1982)
Expression of cellular homologues of retroviral onc genes in human hematopoietic cells.
E. Westin (1982)
Lipolytic enzymes and plasma lipoprotein metabolism.
P. Nilsson-ehle (1980)
Modification of low density lipoprotein by lipoprotein lipase or hepatic lipase induces enhanced uptake and cholesterol accumulation in cells.
M. Aviram (1988)
Recombinant interleukin I suppresses lipoprotein lipase activity in 3 T 3 - LI cells
B. A. Beutler (1985)
Enhancement of colony‐stimulating‐factor–dependent clonal growth of murine macrophage progenitors and their phagocytic activity by retinoic acid
R. Goldman (1985)
Modulation of transglutaminase activity in mononuclear phagocytes and macrophage-like tumor cell lines by differentiation agents.
R. Goldman (1987)
A human retinoic acid receptor which belongs to the family of nuclear receptors
M. Petkovich (1987)
Regulation of the secretion of lipoprotein lipase by mouse macrophages.
S. Behr (1986)
Recombinant interleukin 1 suppresses lipoprotein lipase activity in 3T3-L1 cells.
B. Beutler (1985)

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Reactive oxygen species are involved in the activation of cellular phospholipase A2
R. Goldman (1992)
The ArcAB two-component regulatory system promotes resistance to reactive oxygen species and systemic infection by Salmonella Typhimurium
Coral Pardo-Esté (2018)
Physiological regulation of lipoprotein lipase.
S. Kersten (2014)
Effects of cytokines on the production of lipoprotein lipase in cultured human macrophages.
U. Querfeld (1990)
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S. Sukhanov (2011)
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R. Goldman (1990)
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M. Jin (2010)
Regulation of lipoprotein lipase by dibutyryl cAMP, cholera toxin, Hepes and heparin in F1 heart-cell cultures.
G. Friedman (1992)
Calcium and lipoprotein lipase synergistically enhance the binding and uptake of native and oxidized LDL in mouse peritoneal macrophages.
X. Wang (2000)
Effects of Chondroitin Sulfate and Its Oligosaccharides on Toll-Like Receptor-Mediated IL-6 Secretion by Macrophage-Like J774.1 Cells
M. Jin (2011)
Role of Lipoprotein Lipase and Apolipoprotein E Secretion by Macrophages in Modulating Lipoprotein Uptake: Possible Role in Acceleration of Atherosclerosis in Diabetes
F. Kraemer (1992)
Lipoprotein lipase mediates the uptake of glycated LDL in fibroblasts, endothelial cells, and macrophages.
R. Zimmermann (2001)
Effects of platelet-derived growth factor on the synthesis of lipoprotein lipase in human monocyte-derived macrophages.
T. Inaba (1995)
Chimeras of lipoprotein lipase and hepatic lipase : localization of the apolipoprotein C-II activation site of lipoprotein lipase
T. McIlhargey (2003)
The Transcription Factor ArcA Modulates Salmonella’s Metabolism in Response to Neutrophil Hypochlorous Acid-Mediated Stress
Coral Pardo-Esté (2019)
Regulation of lipoprotein lipase secretion in murine macrophages during foam cell formation in vitro. Effect of triglyceride-rich lipoproteins.
O. Sofer (1992)
Lipoprotein lipase: structure, function, regulation, and role in disease
J. R. Mead (2002)
Effects of retinoic acid on lipoprotein lipase activity and mRNA level in vitro and in vivo.
J. Oliver (1993)
High macrophage lipoprotein lipase expression and secretion are associated in inbred murine strains with susceptibility to atherosclerosis.
G. Renier (1993)
Regulation of macrophage lipoprotein lipase gene expression by interferon-gamma
S. M. Evans (2005)
Unravelling the biology of macrophage infection by gene expression profiling of intracellular Salmonella enterica
S. Eriksson (2003)
Lipoprotein lipase gene expression: physiological regulators at the transcriptional and post-transcriptional level.
S. Enerbäck (1993)
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