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Control Of Lipoprotein Lipase Secretion By Macrophages: Effect Of Macrophage Differentiation Agents

R. Goldman
Published 1990 · Biology, Medicine

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The effect of macrophage differentiation agents on lipoprotein lipase (LPL) secretion by macrophages at different stages of differentiation/maturation was investigated. Phorbol myristate acetate (TPA) had an augmenting effect on LPL secretion by in vitro‐derived bone marrow macrophages (BMMs), thioglycollate‐elicited peritoneal macrophages (Tg‐M⊘), and resident macrophages. Augmentation was time dependent and reached ~ twofold and ~ threefold increase over control cells within 16 and 96 hr, respectively. TPA did not affect LPL secretion from J774.1 cells treated with the agent for 16–72 hr. L‐cell conditioned medium (L‐CM), a source of macrophage colony‐stimulating activity, augmented LPL secretion by BMMs and Tg‐M⊘, and when added together with TPA had an additive augmenting effect on LPL secretion in these cells. Retinoic acid (RA) exerted a time‐dependent suppressive effect on LPL secretion by BMMs (46% within 16 hr and 83% within 6 d), had a relatively small effect on secretion from J774.1 cells (~ 20% in 72 hr) and had no effect on LPL secretion by Tg‐M⊘. Dexamethasone suppressed LPL secretion by BMMs, Tg‐M⊘, and J774.1 cells. Optimal suppression of LPL secretion by BMMs required more than 24 hr. Thus, TPA and L‐CM, agents that exert a mitogenic effect on BMMs and Tg‐M⊘, augmented the secretion of LPL in these cell types, and RA and dexamethasone, agents which induce differentiation patterns in myeloid cells, suppressed LPL secretion.
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