Online citations, reference lists, and bibliographies.

Diabetes And Pancreatic Cancer.

Donghui Li
Published 2012 · Biology, Medicine
Cite This
Download PDF
Analyze on Scholarcy
Share
Type 2 diabetes mellitus is likely the third modifiable risk factor for pancreatic cancer after cigarette smoking and obesity. Epidemiological investigations have found that long-term type 2 diabetes mellitus is associated with a 1.5-fold to 2.0-fold increase in the risk of pancreatic cancer. A causal relationship between diabetes and pancreatic cancer is also supported by findings from prediagnostic evaluations of glucose and insulin levels in prospective studies. Insulin resistance and associated hyperglycemia, hyperinsulinemia, and inflammation have been suggested to be the underlying mechanisms contributing to development of diabetes-associated pancreatic cancer. Signaling pathways that regulate the metabolic process also play important roles in cell proliferation and tumor growth. Use of the antidiabetic drug metformin has been associated with reduced risk of pancreatic cancer in diabetics and recognized as an antitumor agent with the potential to prevent and treat this cancer. On the other hand, new-onset diabetes may indicate subclinical pancreatic cancer, and patients with new-onset diabetes may constitute a population in whom pancreatic cancer can be detected early. Biomarkers that help define high-risk individuals for clinical screening for pancreatic cancer are urgently needed. Why pancreatic cancer causes diabetes and how diabetes affects the clinical outcome of pancreatic cancer have yet to be fully determined. Improved understanding of the pathological mechanisms shared by diabetes and pancreatic cancer would be the key to the development of novel preventive and therapeutic strategies for this cancer.
This paper references
Modification of pancreatic carcinogenesis in the hamster model. 3. Inhibitory effect of alloxan.
Parviz Moradi Pour (1983)
10.6092/1590-8577/1656
Diabetes and pancreatic cancer.
Najla H El-Jurdi (2013)
10.1093/jnci/87.12.930
Risk of pancreatic cancer following diabetes mellitus: a nationwide cohort study in Sweden.
W. H. Chow (1995)
10.1001/jama.283.19.2552
Abnormal glucose metabolism and pancreatic cancer mortality.
Susan M Gapstur (2000)
10.1016/j.molcel.2008.03.003
AMPK phosphorylation of raptor mediates a metabolic checkpoint.
Dana M. Gwinn (2008)
10.1007/s10620-009-0944-8
Colorectal Cancer Outcomes, Recurrence, and Complications in Persons With and Without Diabetes Mellitus: A Systematic Review and Meta-Analysis
Kelly B. Stein (2009)
10.1053/gast.2001.23258
Prevention of pancreatic cancer induction in hamsters by metformin.
Matthias B. Schneider (2001)
10.1080/13813450801954451
Hyper-insulinaemia and cancer, meta-analyses of epidemiological studies.
Paola Pisani (2008)
10.1001/jama.294.22.2872
Insulin, glucose, insulin resistance, and pancreatic cancer in male smokers.
Rachael Stolzenberg-Solomon (2005)
10.1056/NEJM199407143310203
Diabetes and the risk of pancreatic cancer.
Lucio Gullo (1999)
10.1038/bjc.1986.185
Diabetes, gall stone disease, and pancreatic cancer.
Staffan E. Norell (1986)
10.6092/1590-8577/3617
Clinical outcome of pancreatic cancer patients with diabetes mellitus: is diabetes a poor prognostic factor? Highlights from the "2010 ASCO Annual Meeting". Chicago, IL, USA. June 4-8, 2010.
Soonmo Peter Kang (2010)
10.1158/1078-0432.CCR-09-1942
New Strategies in Pancreatic Cancer: Emerging Epidemiologic and Therapeutic Concepts
Donghui Li (2010)
10.1158/1940-6207.CAPR-10-0157
Metformin and Cancer Risk in Diabetic Patients: A Systematic Review and Meta-analysis
Andrea Decensi (2010)
10.1016/S0025-7125(16)33598-2
Abnormal carbohydrate metabolism in pancreatic carcinoma.
R. Murphy (1963)
10.1016/j.ejca.2006.01.027
Association between diabetes mellitus and adverse characteristics of breast cancer at presentation.
Ido Wolf (2006)
10.1046/j.1440-1622.2000.01940.x
Pancreatic cancer and diabetes: is there a relationship? A case-controlled study.
J. N. R. Frye (2000)
10.1053/j.gastro.2009.04.013
Antidiabetic therapies affect risk of pancreatic cancer.
Donghui Li (2009)
10.1007/BF00051670
Cancer risk in patients with diabetes mellitus
Hans-Olov Adami (1991)
10.2337/diacare.29.02.06.dc05-1558
Increased cancer-related mortality for patients with type 2 diabetes who use sulfonylureas or insulin.
Samantha L. Bowker (2006)
10.1002/cncr.25465
Obesity adversely affects survival in pancreatic cancer patients.
Robert R McWilliams (2010)
10.4049/jimmunol.178.7.4129
Peroxisome Proliferator-Activated Receptor γ (PPARγ) and Immunoregulation: Enhancement of Regulatory T Cells through PPARγ-Dependent and -Independent Mechanisms
Elizabeth A. Wohlfert (2007)
10.1007/s002680020344
Diabetes: Risk Factor for the Development of Pancreatic Cancer or Manifestation of the Disease?
William E. Fisher (2001)
10.1016/S0895-7061(02)03253-3
Lipoic acid prevents hypertension, hyperglycemia, and the increase in heart mitochondrial superoxide production.
Adil El Midaoui (2003)
10.1002/ijc.2910410603
Pancreatic cancer, blood glucose and beverage consumption.
Robert A. Hiatt (1988)
10.1002/ijc.2910580109
A prospective study of pancreatic cancer in the elderly.
Atsuko Shibata (1994)
10.1111/j.1440-1746.2004.03219.x
Clinical usefulness of carbohydrate antigen 19-9 as a screening test for pancreatic cancer in an asymptomatic population.
Jee-Eun Kim (2004)
10.1038/414813a
Biochemistry and molecular cell biology of diabetic complications
Michael A. Brownlee (2001)
10.1001/jama.2008.824
Long-term all-cause mortality in cancer patients with preexisting diabetes mellitus: a systematic review and meta-analysis.
Bethany B. Barone (2008)
10.3945/ajcn.2008.26823
Glycemic index, glycemic load, and risk of digestive tract neoplasms: a systematic review and meta-analysis.
Helen G. Mulholland (2009)
Diabetes and pancreatic carcinoma.
Beverley Balkau (1993)
Pancreatic cancer is associated with impaired glucose metabolism.
Johan Permert (1993)
10.1074/jbc.274.15.10595
Oxidative Stress Disrupts Insulin-induced Cellular Redistribution of Insulin Receptor Substrate-1 and Phosphatidylinositol 3-Kinase in 3T3-L1 Adipocytes
Amir Tirosh (1999)
10.1093/oxfordjournals.jjco.a039304
Epidemiology of pancreatic cancer in Japan.
Takeshi Thomas Hirayama (1989)
10.1007/s10552-004-1050-z
Diabetes status and post-load plasma glucose concentration in relation to site-specific cancer mortality: findings from the original Whitehall study
G. D. Batty (2004)
10.1053/j.gastro.2008.01.039
Prevalence and clinical profile of pancreatic cancer-associated diabetes mellitus.
Rahul Pannala (2008)
10.2337/diab.46.6.1081
Novel Mutations and a Mutational Hotspot in the M0DY3 Gene
Maria Alexandra Glucksmann (1997)
10.1038/sj.bjc.6603826
Circulating insulin-like growth factor axis and the risk of pancreatic cancer in four prospective cohorts
Brian Wolpin (2007)
Metformin: New understandings, new uses. Drugs 2003;63:1879–1894
RS Hundal (2003)
10.1016/0021-9681(85)90139-0
Diabetes mellitus and cancer risk: a multisite case-control study.
B A O'Mara (1985)
[Clinical characteristics of pancreatic cancer according to the presence of diabetes mellitus].
Tae Dong Kim (2004)
The pancreatic cancer cell line MIA PaCa2 produces one or more factors able to induce hyperglycemia in SCID mice.
Daniela Basso (1995)
10.1002/ijc.2910450504
Risk of pancreatic cancer in relation to medical history and the use of tobacco, alcohol and coffee.
Diana C. Farrow (1990)
10.1016/j.tcb.2008.01.008
LKB1 and AMPK in cell polarity and division.
Tyisha Williams (2008)
10.1161/01.ATV.0000201938.78044.75
Metformin Inhibits Proinflammatory Responses and Nuclear Factor-&kgr;B in Human Vascular Wall Cells
Kikuo Isoda (2006)
10.1002/ijc.2910430312
Pancreatic cancer, alcohol, diabetes mellitus and gall-bladder disease.
Jack Cuzick (1989)
Insulin-like growth factor I and transforming growth factor alpha as autocrine growth factors in human pancreatic cancer cell growth.
Eiji Ohmura (1990)
10.1002/cncr.20071
Relation between the duration of remission and hyperglycemia during induction chemotherapy for acute lymphocytic leukemia with a hyperfractionated cyclophosphamide, vincristine, doxorubicin, and dexamethasone/methotrexate-cytarabine regimen.
Mary Ann Weiser (2004)
10.1079/BJNBJN2002524
Short-term consumption of a high-sucrose diet has a pro-oxidant effect in rats.
Jérĵme Busserolles (2002)
10.1007/BF02576207
Glucose tolerance and insulin secretion in experimental pancreatic cancer in the Syrian hamster
Bo Ahrén (1993)
10.1016/0021-9681(83)90059-0
Early precursors of pancreatic cancer in college men.
Alice S. Whittemore (1983)
10.1053/j.gastro.2005.05.007
Probability of pancreatic cancer following diabetes: a population-based study.
Suresh T. Chari (2005)
10.1007/s00125-004-1391-x
Oxidative stress induces insulin resistance by activating the nuclear factor-κB pathway and disrupting normal subcellular distribution of phosphatidylinositol 3-kinase
Takehide Ogihara (2004)
10.1007/s00125-009-1440-6
The influence of glucose-lowering therapies on cancer risk in type 2 diabetes
Craig J Currie (2009)
10.1002/1097-0142(19850115)55:2<460::AID-CNCR2820550229>3.0.CO;2-V
Diet and other risk factors for cancer of the pancreas.
Ellen B. Gold (1985)
10.1023/A:1015729615148
A prospective study of medical conditions, anthropometry, physical activity, and pancreatic cancer in male smokers (Finland)
Rachael Z. Stolzenberg-Solomon (2004)
10.1002/ijc.10402
Risk of pancreatic cancer in relation to alcohol drinking, coffee consumption and medical history: findings from the Japan collaborative cohort study for evaluation of cancer risk.
Yingsong Lin (2002)
10.1056/NEJM198103123041102
Coffee and cancer of the pancreas.
Brian Macmahon (1981)
10.14670/HH-25.423
Morphometric studies in human pancreatic cancer argues against the etiological role of type 2 diabetes in pancreatic cancer.
Murat Saruç (2010)
10.1097/00006676-199708000-00004
An Unidentified Pancreatic Cancer Cell Product Alters Some Intracellular Pathways of Glucose Metabolism in Isolated Rat Hepatocytes
Daniela Basso (1997)
10.1093/oxfordjournals.aje.a116576
Post-challenge glucose concentration, impaired glucose tolerance, diabetes, and cancer mortality in men.
Geoffrey D. Smith (1992)
10.1097/00006676-199411000-00005
CA19‐9 as a Screening and Diagnostic Tool in Symptomatic Patients: The Japanese Experience
Katsusuke Satake (1994)
10.7326/0003-4819-137-1-200207020-00009
Metformin: An Update
Dmitri Kirpichnikov (2002)
10.1016/S0002-9440(10)63460-8
Regulation of hypoxia-inducible factor-1alpha, vascular endothelial growth factor, and angiogenesis by an insulin-like growth factor-I receptor autocrine loop in human pancreatic cancer.
Oliver Stoeltzing (2003)
10.1097/00006676-200201000-00002
Putative Pancreatic Cancer-Associated Diabetogenic Factor: 2030 MW Peptide
Daniela Basso (2002)
10.1136/bmj.38415.708634.F7
Metformin and reduced risk of cancer in diabetic patients
Josie M. M. Evans (2005)
10.1007/s00125-009-1441-5
Does diabetes therapy influence the risk of cancer?
Ulf Smith (2009)
10.1158/0008-5472.CAN-07-0373
Circulating insulin-like growth factor binding protein-1 and the risk of pancreatic cancer.
Brian Wolpin (2007)
10.1097/00006676-199905000-00012
Dissociated insulin and islet amyloid polypeptide secretion from isolated rat pancreatic islets cocultured with human pancreatic adenocarcinoma cells.
Feng Ze Wang (1999)
10.1007/s00592-008-0083-2
Sulphonylureas and cancer: a case–control study
Matteo Monami (2008)
10.4161/cc.8.6.7933
Metformin inhibits breast cancer cell growth, colony formation and induces cell cycle arrest in vitro
Irina N Alimova (2009)
10.1097/ACI.0b013e3282f1dc99
Genetic determinants of diabetes are similarly associated with other immune-mediated diseases
David L. Duffy (2007)
10.1111/j.1440-1746.1996.tb00296.x
Risk factors for pancreatic cancer in orientals.
C. T. Lee (1996)
10.1016/j.diabres.2008.02.006
The effect of metformin treatment on VEGF and PAI-1 levels in obese type 2 diabetic patients.
Canan Özyardımcı Ersoy (2008)
10.1210/mend.6.12.1283442
Insulin rapidly decreases insulin-like growth factor-binding protein-1 gene transcription in streptozotocin-diabetic rats.
Guck T. Ooi (1992)
10.1002/bjs.1800800841
Improved glucose metabolism after subtotal pancreatectomy for pancreatic cancer.
Johan Permert (1993)
10.1053/gast.2000.20228
Very high risk of cancer in familial Peutz-Jeghers syndrome.
Francis M. Giardiello (2000)
10.1054/bjoc.1999.1105
Socio-economic and lifestyle factors associated with the risk of prostate cancer
Tom Ivar Lund Nilsen (2000)
10.1016/S0006-291X(03)00107-4
Requirement of different signaling pathways mediated by insulin-like growth factor-I receptor for proliferation, invasion, and VPF/VEGF expression in a pancreatic carcinoma cell line.
Huiyan Zeng (2003)
10.1016/j.exger.2005.07.007
Effect of metformin on life span and on the development of spontaneous mammary tumors in HER-2/neu transgenic mice
Vladimir Anisimov (2005)
10.1038/ncb1537
The energy sensing LKB1–AMPK pathway regulates p27kip1 phosphorylation mediating the decision to enter autophagy or apoptosis
Jiyong Liang (2007)
10.1007/s00423-004-0469-8
Diabetes mellitus: a risk factor for pancreatic cancer?
Mehmet Yalnız (2004)
10.1158/1940-6207.CAPR-10-0055
Metformin Prevents Tobacco Carcinogen–Induced Lung Tumorigenesis
Regan M. Memmott (2010)
10.1093/ajcn/75.4.767
Both lipid and protein intakes stimulate increased generation of reactive oxygen species by polymorphonuclear leukocytes and mononuclear cells.
Priya Mohanty (2002)
10.1093/jnci/44.3.673
Cancer mortality among diabetics.
Irving I. Kessler (1970)
10.1001/jama.2009.886
Body mass index and risk, age of onset, and survival in patients with pancreatic cancer.
Donghui Li (2009)
10.1002/1097-0142(197303)31:3<641::AID-CNCR2820310323>3.0.CO;2-1
A case control study of cancer of the pancreas.
Ernst L. Wynder (1973)
Stimulation of islet cell proliferation enhances pancreatic ductal carcinogenesis in the hamster model.
Parviz Moradi Pour (1996)
10.1097/00006676-200405000-00018
Diabetes and pancreatic cancer.
Lucio Gullo (2004)
10.1038/sj.bjc.6690607
Diabetes mellitus, other medical conditions and familial history of cancer as risk factors for pancreatic cancer
Debra T. Silverman (1999)
10.1093/aje/kwh161
Diabetes mellitus as a predictor of cancer mortality in a large cohort of US adults.
Steven Scott Coughlin (2004)
10.1200/JCO.2003.07.125
Impact of diabetes mellitus on outcomes in patients with colon cancer.
Jeffrey A. Meyerhardt (2003)
10.1002/1097-0142(19880615)61:12<2578::AID-CNCR2820611232>3.0.CO;2-0
Dietary habits and past medical history as related to fatal pancreas cancer risk among Adventists.
Paul K. Mills (1988)
10.1016/j.cca.2006.03.027
Pancreatic cancer-derived S-100A8 N-terminal peptide: a diabetes cause?
Daniela Basso (2006)
10.1001/jama.1995.03520440059037
Diabetes mellitus as a risk factor for pancreatic cancer. A meta-analysis.
James E. Everhart (1995)
10.1038/sj.bjc.6602619
Type-II diabetes and pancreatic cancer: a meta-analysis of 36 studies
R Huxley (2005)
10.1093/ije/22.1.30
Risk factors for pancreatic cancer: an exploratory study.
Gary D. Friedman (1993)
C-peptide pattern in patients with pancreatic cancer.
Paola Fogar (1993)
10.1056/NEJM199402033300503
Islet amyloid polypeptide in patients with pancreatic cancer and diabetes.
Johan Permert (1994)
10.1053/j.gastro.2007.10.040
Pancreatic cancer-associated diabetes mellitus: prevalence and temporal association with diagnosis of cancer.
Suresh Chari (2008)
10.1158/1055-9965.EPI-06-0188
Diabetes Mellitus and Pancreatic Cancer in a Population-Based Case-Control Study in the San Francisco Bay Area, California
Furong Wang (2006)
Oxidative stress induces insulin resistance by activating the nuclear factor-kappa B pathway and disrupting normal subcellular distribution of phosphatidylinositol 3-kinase.
Toshio Ogihara (2004)
10.1097/00006676-200010000-00014
Physiological Concentrations of Insulin Augment Pancreatic Cancer Cell Proliferation and Glucose Utilization By Activating MAP Kinase, PI3 Kinase and Enhancing GLUT-1 Expression
Xian Zhong Ding (2000)
10.1124/pr.109.002469
Insulin-Like Growth Factor-I Regulation of Immune Function: A Potential Therapeutic Target in Autoimmune Diseases?
Terry J. Smith (2010)
10.1385/IJGC:31:1-3:123
The specificity of amylin for the diagnosis of pancreatic adenocarcinoma
Randall E Brand (2002)
10.1007/BF00051341
Tobacco, ethanol, coffee, pancreatitis, diabetes mellitus, and cholelithiasis as risk factors for pancreatic carcinoma
Victoria Kalapothaki (2004)
10.1007/s10552-010-9686-3
Diabetes and risk of pancreatic cancer: a pooled analysis of three large case–control studies
Donghui Li (2010)
10.1053/gast.2001.27210
Islet amyloid polypeptide is not a satisfactory marker for detecting pancreatic cancer.
Suresh Chari (2001)
10.1210/jcem.79.5.7962312
Clinical review 63: Diabetes and pancreatic cancer: clues to the early diagnosis of pancreatic malignancy.
Ariela Noy (1994)
Insulin-like Growth Factor I and Transforming Growth Factor α as Autocrine Growth Factors in Human Pancreatic Cancer Cell Growth
Eiji Ohmura (1990)
10.1073/pnas.062605899
Profound defects in pancreatic β-cell function in mice with combined heterozygous mutations in Pdx-1, Hnf-1α, and Hnf-3β
David Q Shih (2002)
10.1158/1940-6207.CAPR-10-0186
Metformin Suppresses Colorectal Aberrant Crypt Foci in a Short-term Clinical Trial
Kunihiro Hosono (2010)
Insulin-like growth factor I overexpression in human pancreatic cancer: evidence for autocrine and paracrine roles.
Uwe Bergmann (1995)
10.2165/00003495-200363180-00001
Metformin: new understandings, new uses.
Ripudaman S Hundal (2003)
10.2337/dc09-1380
Metformin Associated With Lower Cancer Mortality in Type 2 Diabetes
Gijs W D Landman (2009)
4 – 8 , 2010
D Li
10.1093/ajcn/80.1.51
Glucose intake induces an increase in activator protein 1 and early growth response 1 binding activities, in the expression of tissue factor and matrix metalloproteinase in mononuclear cells, and in plasma tissue factor and matrix metalloproteinase concentrations.
Ahmad Aljada (2004)
10.1093/jnci/71.5.1059
Modification of pancreatic carcinogenesis in the hamster model. X. Effect of streptozotocin.
Parviz Moradi Pour (1983)
Improved endothelial function with metformin in type 2 diabetes mellitus
N. Norman Chan Mb Mrcp Dch (2001)
[Prediction of resectability and of surgical risk in pancreatic carcinoma; conditioning factors of survival after resective intervention].
Sergio Pedrazzoli (1994)
Recent advances in the relationship between obesity, inflammation, and insulin resistance.
Jean-Philippe Bastard (2006)
[Diabetes mellitus and pancreatic cancer: a case-control study in greater Montreal, Quebec, Canada].
J. M. Ekoe (1992)
10.1002/mc.20637
Metformin suppresses azoxymethane-induced colorectal aberrant crypt foci by activating AMP-activated protein kinase.
Kunihiro Hosono (2010)
Influence of insulin deprivation on growth of the 7,12-dimethylbenz(a)anthracene-induced mammary carcinoma in rats subjected to alloxan diabetes and food restriction.
J. C. Heuson (1972)
10.1016/j.coph.2009.06.011
Inflammation and pancreatic cancer: an evidence-based review.
Julia B. Greer (2009)
10.1038/ncponc0062
Therapy Insight: influence of type 2 diabetes on the development, treatment and outcomes of cancer
Lisa C. Richardson (2005)
10.1038/bjc.1994.427
A case-control study of diabetes mellitus and cancer risk.
Carlo la Vecchia (1994)
Insulin-like growth factor (IGF)-1, IGF-binding protein-3, and pancreatic cancer in male smokers.
Rachael Stolzenberg-Solomon (2004)
Risk factors for the development of pancreatic cancer in familial pancreatic cancer
SJ Rulyak (2003)
10.1002/ijc.2910520105
Aspects of medical history and exocrine carcinoma of the pancreas: a population-based case-control study in The Netherlands.
H Bas Bueno de Mesquita (1992)
10.1002/ijc.2910470313
Coffee and alcohol as determinants of risk of pancreas cancer: a case-control study from Toronto.
Meera Jain (1991)
10.2337/diacare.27.9.2166
Effect of high-dose vitamin E on insulin resistance and associated parameters in overweight subjects.
Patrick J. Manning (2004)
10.1158/1055-9965.EPI-09-0372
Obesity and Cancer: The Role of Dysfunctional Adipose Tissue
Rob C M van Kruijsdijk (2009)
10.1385/MO:19:4:233
Predictive value of clinical features at initial presentation in pancreatic adenocarcinoma
Apar Kishor P. Ganti (2002)
10.1128/MCB.23.19.6713-6724.2003
Pancreatic-Duodenal Homeobox 1 Regulates Expression of Liver Receptor Homolog 1 during Pancreas Development
Jean-Sébastien Annicotte (2003)
10.1007/PL00012080
Clinical observations of pancreatic diabetes caused by pancreatic carcinoma, and survival period
Hideyuki Wakasugi (2001)
10.1074/jbc.M111272200
Reduction in Pancreatic Transcription Factor PDX-1 Impairs Glucose-stimulated Insulin Secretion*
Marcela Brissova (2002)
10.2337/dc08-2175
New Users of Metformin Are at Low Risk of Incident Cancer
Gillian Libby (2009)
10.1016/S0016-5085(03)00272-5
Risk factors for the development of pancreatic cancer in familial pancreatic cancer kindreds.
Stephen J. Rulyak (2003)
10.1111/j.1365-2796.2004.01420.x
Effects of short-term treatment with metformin on markers of endothelial function and inflammatory activity in type 2 diabetes mellitus: a randomized, placebo-controlled trial.
Jolien de Jager (2005)
4 The influence of glucose-lowering therapies on cancer risk
Craig J Currie (2009)
10.1093/ije/dyg062
Epidemiology of pancreatic cancer in Japan: a nested case-control study from the Hospital-based Epidemiologic Research Program at Aichi Cancer Center (HERPACC).
Manami Inoue (2003)
10.1016/j.cellimm.2007.09.004
Leptin beyond body weight regulation--current concepts concerning its role in immune function and inflammation.
Rocío Lago (2008)
10.1038/nrc2536
Insulin and insulin-like growth factor signalling in neoplasia
Michael D Pollak (2008)
10.1016/0021-9681(82)90025-X
Subsequent cancer risk in the incidence cohort of Rochester, Minnesota, residents with diabetes mellitus.
Mark W. Ragozzino (1982)
10.1002/1097-0142(19910115)67:2<486::AID-CNCR2820670228>3.0.CO;2-1
Insulin secretion and action in patients with pancreatic cancer.
Eugenio Cersosimo (1991)
10.1097/00006676-200311000-00014
Nutritional Links to Plausible Mechanisms Underlying Pancreatic Cancer: A Conference Report
R. Jean Hine (2003)
10.1097/00006676-200308000-00007
Exocrine Pancreatic Cancer, Cigarette Smoking, and Diabetes Mellitus: A Case-Control Study in Northern Italy
Luigina Bonelli (2003)
10.1053/j.gastro.2007.03.059
Obesity, inflammation, and insulin resistance.
Steven E. Shoelson (2007)
10.1245/s10434-010-0996-1
Impact of Diabetes Mellitus on the Prognosis of Patients with Oral Squamous Cell Carcinoma: A Retrospective Cohort Study
Cheng-Hsien Wu (2010)
10.1158/0008-5472.CAN-09-0418
Metformin disrupts crosstalk between G protein-coupled receptor and insulin receptor signaling systems and inhibits pancreatic cancer growth.
Krisztina Kisfalvi (2009)
10.1093/jnci/89.18.1360
Cancer incidence in a population-based cohort of patients hospitalized with diabetes mellitus in Denmark.
Louise Wideroff (1997)
10.1111/j.1572-0241.2007.01510.x
Risk Factors for Pancreatic Cancer: Case-Control Study
Manal M. Hassan (2007)
10.1016/j.metabol.2003.10.013
Differential effects of glucose and alcohol on reactive oxygen species generation and intranuclear nuclear factor-kappaB in mononuclear cells.
Sandeep Dhindsa (2004)
10.1152/ajpendo.00402.2004
Abrogation of oxidative stress improves insulin sensitivity in the Ren-2 rat model of tissue angiotensin II overexpression.
Mihaela C Blendea (2005)
10.1158/1940-6207.CAPR-10-0175
Metformin and Other Biguanides in Oncology: Advancing the Research Agenda
Michael N. Pollak (2010)
10.1001/jama.1981.03310270027018
A multifactorial model for pancreatic cancer in man. Epidemiologic evidence.
Ruey Shiung Lin (1981)
10.1371/journal.pone.0033411
Cancer Risk in Diabetic Patients Treated with Metformin: A Systematic Review and Meta-analysis
Hiroshi Noto (2012)
10.1097/00000658-198311000-00008
Factors Influencing Survival After Total Pancreatectomy in Patients with Pancreatic Cancer
Åke Andrén-Sandberg (1983)
10.1007/s11892-010-0101-y
Insulin, Insulin Resistance, Obesity, and Cancer
E. Gallagher (2010)
10.1001/jama.2010.60
Does insulin therapy promote, reduce, or have a neutral effect on cancers?
Hertzel C. Gerstein (2010)
10.1158/1055-9965.EPI-08-0514
Effect of Insulin-Like Growth Factor Gene Polymorphisms Alone or In Interaction with Diabetes on the Risk of Pancreatic Cancer
Hideo Suzuki (2008)
10.1038/nature08097
Enhancing CD8 T-cell memory by modulating fatty acid metabolism
Erika L Pearce (2009)
10.1038/ng.522
A genome-wide association study identifies pancreatic cancer susceptibility loci on chromosomes 13q22.1, 1q32.1 and 5p15.33
Gloria M Petersen (2010)
Insulin inhibits transcription of the human gene for insulin-like growth factor-binding protein-1.
D. R. Powell (1991)
10.1038/ajg.2010.32
Novel Blood Biomarkers of Pancreatic Cancer–Associated Diabetes Mellitus Identified by Peripheral Blood–Based Gene Expression Profiles
Hai Huang (2010)
10.3322/caac.20078
Diabetes and cancer: a consensus report.
Edward L. Giovannucci (2010)
10.1007/s001250051679
Oxidative stress could precede endothelial dysfunction and insulin resistance in Indian Mauritians with impaired glucose metabolism
N. K. Gopaul (2001)
Peroxisome proliferator-activated receptor gamma (PPARgamma) and immunoregulation: enhancement of regulatory T cells through PPARgamma-dependent and -independent mechanisms.
Elizabeth A. Wohlfert (2007)
Profound defects in pancreatic beta-cell function in mice with combined heterozygous mutations in Pdx-1, Hnf-1alpha, and Hnf-3beta.
David Q Shih (2002)
10.1038/460041a
Immunology: A metabolic switch to memory
Martin Prlic (2009)
10.1093/jnci/72.5.1205
Modification of pancreatic carcinogenesis in the hamster model. VIII. Inhibitory effect of exogenous insulin.
Parviz Moradi Pour (1984)



This paper is referenced by
10.15403/jgld-1282
Metabolic syndrome, insulin resistance, circadian disruption, antioxidants and pancreatic carcinoma: an overview.
Aldo M. Giudice (2014)
10.1007/s11428-012-0866-5
Krebsvorbeugung und -vorsorge bei Diabetespatienten
Regina Göke (2012)
10.1002/ijc.31271
Inflammatory potential of diet and risk of pancreatic cancer in the Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Trial
Jiali Zheng (2018)
10.4236/JCT.2013.410175
The Role of Hyperinsulenemia as a Risk Factor for Pancreatic Cancer
Giuseppe Preziosi (2013)
10.1007/s00775-016-1389-0
Bis(acetylacetonato)-oxidovanadium(IV) and sodium metavanadate inhibit cell proliferation via ROS-induced sustained MAPK/ERK activation but with elevated AKT activity in human pancreatic cancer AsPC-1 cells
Jing-Xuan Wu (2016)
Identification of Potential Biomarkers in PDAC
Rebecca L. Whittlesey (2014)
Association of DNA Repair Gene Variants with Pancreatic Cancer in Patients with Chronic Pancreatitis
Siddhartha Das (2013)
10.1016/j.pan.2013.10.009
Total pancreatectomy and islet autotransplantation in chronic pancreatitis: recommendations from PancreasFest.
Melena D Bellin (2014)
10.1142/9789814651875_0001
The Role of Hereditary and Environmental Factors in Gastrointestinal Cancers
Beth Dudley (2016)
10.1245/s10434-014-3625-6
Association of Diabetes Mellitus and Pancreatic Adenocarcinoma: A Meta-Analysis of 88 Studies
Pikli Batabyal Mbbs (2014)
10.1053/j.seminoncol.2014.12.002
Demographics, epidemiology, and inheritance of pancreatic ductal adenocarcinoma.
Theresa Pluth Yeo (2015)
10.1016/j.ejrad.2013.06.028
A novel distinguishing system for the diagnosis of malignant pancreatic cystic neoplasm.
Xiaoyong Shen (2013)
10.1007/s13193-014-0373-9
Pancreatic Cancer in Chronic Pancreatitis
Puneet Dhar (2015)
10.1245/s10434-014-3625-6
Association of Diabetes Mellitus and Pancreatic Adenocarcinoma: A Meta-Analysis of 88 Studies
Pikli Batabyal (2014)
10.3748/wjg.v20.i32.11241
Advances in pancreatic cancer research: moving towards early detection.
Xiang-yi He (2014)
IRS-1 regulates proliferation, invasion and metastasis of pancreatic cancer cells through MAPK and PI3K signaling pathways.
Yinpeng Huang (2018)
Pancreatic ductal adenocarcinoma : The role of tumor-associated macrophages and systemic inflammatory response
Aino N.E. Salmiheimo (2017)
Inflammatory Potential of Diet And Pancreatic Cancer Risk: Interaction And Mediation Analysis In Two Prospective Cohorts
Jiali Zheng (2017)
10.3390/ijerph17051668
Application of the Key Characteristics of Carcinogens to Per and Polyfluoroalkyl Substances
Alexis Temkin (2020)
10.6092/1590-8577/1317
Duration of diabetes and pancreatic cancer in a case-control study in the Midwest and the Iowa Women's Health Study (IWHS) cohort.
Sarah A. Henry (2013)
Endocrine-Related Cancer ( 2012 ) 19 F 9 – F 26 Diabetes and pancreatic cancer
Yunfeng Cui (2012)
10.1007/978-981-32-9393-9_12
Insulin Resistance Is a Common Core Tethered to Diabetes and Pancreatic Cancer Risk
Henu Kumar Verma (2019)
10.2337/db14-1132
Metformin and Rapamycin Reduce Pancreatic Cancer Growth in Obese Prediabetic Mice by Distinct MicroRNA-Regulated Mechanisms
Vincenza Cifarelli (2015)
10.1016/j.coph.2016.07.005
Obesity and cancer: inflammation bridges the two.
Ryan Kolb (2016)
10.1016/j.canlet.2017.12.004
Diabetes as risk factor for pancreatic cancer: Hyperglycemia promotes epithelial-mesenchymal-transition and stem cell properties in pancreatic ductal epithelial cells.
Sascha Rahn (2018)
10.1007/s11428-014-1207-7
Diabetes mellitus und Krebs
Burkhard Goeke (2014)
10.1021/pr400967x
Glycoprotein Biomarker Panel for Pancreatic Cancer Discovered by Quantitative Proteomics Analysis
Song Nie (2014)
10.3892/ol.2017.5586
Association of elevated risk of pancreatic cancer in diabetic patients: A systematic review and meta-analysis
Jiaxin Tan (2017)
10.1007/978-981-32-9393-9_3
Diabetes and Pancreatic Cancer: A Bidirectional Relationship Perspective
Manoj Gupta (2019)
10.1210/en.2013-1781
Characterization of the exocrine pancreas in the male Zucker diabetic fatty rat model of type 2 diabetes mellitus following 3 months of treatment with sitagliptin.
Thomas Forest (2014)
10.1097/MED.0b013e32835eddd3
Diabetes and cancer: placing the association in perspective
Dana K. Andersen (2013)
10.1111/dme.12435
The excess mortality related to cardiovascular diseases and cancer among adults pharmacologically treated for diabetes--the 2001-2006 ENTRED cohort.
Isabelle Romon (2014)
See more
Semantic Scholar Logo Some data provided by SemanticScholar