Online citations, reference lists, and bibliographies.

Low-frequency Subthalamic Nucleus Stimulation In Parkinson's Disease: A Randomized Clinical Trial.

Hui Ming Khoo, Haruhiko Kishima, Koichi Hosomi, Tomoyuki Maruo, Naoki Tani, Satoru Oshino, Toshio Shimokawa, Masaru Yokoe, Hideki Mochizuki, Youichi Saitoh, Toshiki Yoshimine
Published 2014 · Psychology, Medicine
Cite This
Download PDF
Analyze on Scholarcy
Share
BACKGROUND Low-frequency, bilateral stimulation of the subthalamic nucleus can improve axial symptoms of advanced Parkinson's disease (PD), but it is not particularly effective for segmental symptoms. METHODS The optimal contacts for low-frequency (60 Hz) and high-frequency (130 Hz) single monopolar stimulation were determined. Then, in a randomized, double-blind, prospective crossover manner, 60-Hz and 130-Hz stimulations via the respective optimal contacts were compared for immediate efficacy in improving the motor function of patients with PD. RESULTS The optimal contacts for 60-Hz stimulation were situated more ventrally than those for 130-Hz stimulation (P = 0.038). Under the respective optimal, single monopolar stimulation, 60 Hz provided superior efficacy over 130 Hz in improving the total Unified Parkinson's Disease Rating Scale motor score (P < 0.001) and the akinesia (P = 0.011) and axial motor signs (P = 0.012) subscores without compromising the therapeutic effect on tremor and rigidity. CONCLUSIONS Low-frequency stimulation via the optimal contacts is effective in improving overall motor function of patients with PD.
This paper references



This paper is referenced by
10.2174/1570159X14666151120123025
Current Pharmaceutical Treatments and Alternative Therapies of Parkinson's Disease
Jie Dong (2016)
10.1007/s40120-019-0140-5
A Novel Dual-Frequency Deep Brain Stimulation Paradigm for Parkinson’s Disease
Jessica A Karl (2019)
10.1002/mdc3.12681
Alternate Subthalamic Nucleus Deep Brain Stimulation Parameters to Manage Motor Symptoms of Parkinson's Disease: Systematic Review and Meta-analysis.
Zachary J. Conway (2019)
10.3389/fneur.2019.00029
Chronic Subthalamic Nucleus Stimulation in Parkinson's Disease: Optimal Frequency for Gait Depends on Stimulation Site and Axial Symptoms
Irene Di Giulio (2019)
10.1007/978-3-030-38740-2_7
Deep Brain Stimulation for Gait and Postural Disturbances in Parkinson’s Disease
Hanyan Li (2020)
10.1016/j.brainres.2019.03.013
Effects of subthalamic deep brain stimulation with gabapentin and morphine on mechanical and thermal thresholds in 6-hydroxydopamine lesioned rats
Brian C. Kaszuba (2019)
10.1371/journal.pone.0207761
Robust desynchronization of Parkinson’s disease pathological oscillations by frequency modulation of delayed feedback deep brain stimulation
Mohammad Daneshzand (2018)
10.1038/s41598-018-32161-3
Frequency-dependent effects of subthalamic deep brain stimulation on motor symptoms in Parkinson’s disease: a meta-analysis of controlled trials
Dongning Su (2018)
10.1002/mds.27863
Short Versus Conventional Pulse-Width Deep Brain Stimulation in Parkinson's Disease: A Randomized Crossover Comparison.
Viswas Dayal (2019)
CALL FOR PAPERS Neurobiology of Deep Brain Stimulation Mechanisms of deep brain stimulation
Todd M. Herrington (2015)
10.1016/j.clinph.2018.07.013
Decreasing subthalamic deep brain stimulation frequency reverses cognitive interference during gait initiation in Parkinson’s disease
Pasquale Varriale (2018)
10.1093/brain/awx296
Neuronal inhibition and synaptic plasticity of basal ganglia neurons in Parkinson's disease
Luka Milosevic (2018)
10.4103/aian.aian_11_19
The Effect of Dual Tasking and Deep Brain Stimulation Frequency Parameters on Gait in Advanced Parkinson's Disease
Swetha Reddy Tandra (2020)
10.1007/s00701-016-2942-x
Electrophysiological interpretations of the clinical response to stimulation parameters of pallidal deep brain stimulation for cervical dystonia
Ryoong Huh (2016)
10.1016/j.parkreldis.2016.01.014
Movement disorders induced by deep brain stimulation.
José Fidel Baizabal-Carvallo (2016)
10.3171/2016.2.JNS152231
Effect of low-frequency deep brain stimulation on sensory thresholds in Parkinson's disease.
Abigail Belasen (2017)
Neurobiology of Deep Brain Stimulation Mechanisms of deep brain stimulation
Todd M. Herrington (2015)
10.1002/mds.26837
Sixty‐hertz stimulation improves bradykinesia and amplifies subthalamic low‐frequency oscillations
Paul Krack (2017)
10.1007/978-3-030-38740-2
Advances in Motor Neuroprostheses
Ramana Vinjamuri (2020)
10.3233/JPD-171077
Subthalamic Nucleus Deep Brain Stimulation in Parkinson’s Disease: The Effect of Varying Stimulation Parameters
Viswas Dayal (2017)
10.1111/ene.13167
Effect of high‐frequency subthalamic neurostimulation on gait and freezing of gait in Parkinson's disease: a systematic review and meta‐analysis
Christian Schlenstedt (2017)
Subthalamic Nucleus Stimulation in Parkinson's Disease: Optimal Frequency for Gait Depends on Stimulation
Irene Di Giulio (2019)
Title: Alternate subthalamic nucleus deep brain stimulation parameters to manage motor symptoms of Parkinson’s disease: Systematic review and meta-analysis Running title: Alternate deep brain stimulation parameters
Zachary J. Conway (2019)
10.1159/000438998
The Effect of High-Frequency Stimulation on Sensory Thresholds in Chronic Pain Patients
Youngwon Youn (2015)
10.1186/s40035-017-0083-7
Effect of low versus high frequency stimulation on freezing of gait and other axial symptoms in Parkinson patients with bilateral STN DBS: a mini-review
Tao Xie (2017)
Effect of high-frequency subthalamic neurostimulation on gait and freezing of gait in Parkinson ’ s disease : a systematic review and meta-analysis
C. Schlenstedta (2016)
10.1007/s11065-015-9308-7
High Frequency Deep Brain Stimulation and Neural Rhythms in Parkinson’s Disease
Zack Blumenfeld (2015)
10.1038/s41598-018-19990-y
Haloperidol–induced catalepsy is ameliorated by deep brain stimulation of the inferior colliculus
K.-Alexander Engelhardt (2018)
10.1016/j.pneurobio.2016.07.003
Deep brain stimulation of the subthalamic nucleus in Parkinson’s disease: From history to the interaction with the monoaminergic systems
Emilie Faggiani (2017)
10.1016/j.neurol.2020.02.009
Deep brain stimulation programming in Parkinson's disease: Introduction of current issues and perspectives.
M. Aubignat (2020)
10.1017/cjn.2016.409
Establishing a Standard of Care for Deep Brain Stimulation Centers in Canada.
Michel Panisset (2017)
10.1136/jnnp-2018-318060
Long-term effect of low frequency stimulation of STN on dysphagia, freezing of gait and other motor symptoms in PD
Tao Xie (2018)
See more
Semantic Scholar Logo Some data provided by SemanticScholar