Vascular Action Of Polyphenols.
D. Ghosh, A. Scheepens
Published 2009 · Medicine
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Dietary patterns are widely recognised as contributors to cardiovascular and cerebrovascular disease. Endothelial function, the elastic properties of large arteries and the magnitude and timing of wave reflections are important determinants of cardiovascular performance. Several epidemiological studies suggest that the regular consumption of foods and beverages rich in flavonoids is associated with a reduction in the risk of several pathological conditions ranging from hypertension to coronary heart disease, stroke and dementia. The impairment of endothelial function is directly related to ageing and an association between decreased cerebral perfusion and dementia has been shown to exist. Cerebral blood flow (CBF) must be maintained to ensure a constant delivery of oxygen and glucose as well as the removal of waste products. Increasing blood flow is one potential way for improving brain function and the prospect for increasing CBF with dietary polyphenols is extremely promising. The major polyphenols shown to have some of these effects in humans are primarily from cocoa, wine, grape seed, berries, tea, tomatoes (polyphenolics and nonpolyphenolics), soy and pomegranate. There has been a significant paradigm shift in polyphenol research during the last decade. This review summarises our current knowledge in this area and points the way for the development of new types of functional foods targeted to brain health through improving vascular health.
This paper references
Dietary antioxidants in preventing atherogenesis, Atherosclerosis
A. C. Kaliora (2006)
Resveratrol or higher arterial blood pressure protects the spinal cord from ischemia-reperfusion injury?
I. Toumpoulis (2006)
MegaNatural((R)) Gold Grapeseed Extract: In Vitro Antioxidant and In Vivo Human Supplementation Studies.
J. Vinson (2001)
Blackberry anthocyanins are slightly bioavailable in rats.
C. Felgines (2002)
Soy phytoestrogens and cardiovascular disease
T. B. Clarkson (2002)
Absorption and urinary excretion of procyanidin B2 [epicatechin-(4beta-8)-epicatechin] in rats.
S. Baba (2002)
Isoflavones, equol and cardiovascular disease: pharmacological and therapeutic insights.
K. Jackman (2007)
Protective effect of anthocyanins in middle cerebral artery occlusion and reperfusion model of cerebral ischemia in rats.
Won-Ho Shin (2006)
Potential Drug–Food Interactions with Pomegranate Juice
K. M. Summers (2006)
Antiatherogenic potential of red wine: clinician update.
P. Szmitko (2005)
Fruit and vegetable consumption and risk of stroke
L. Dauchet (2005)
Effect of cocoa and tea intake on blood pressure: a meta-analysis.
D. Taubert (2007)
Improvement of shade ring under the eyes by blackcurrant polyphenol intake
H. Matsumoto (2005)
Flavonoid-Rich Dark Chocolate Improves Endothelial Function and Increases Plasma Epicatechin Concentrations in Healthy Adults
M. Engler (2004)
Inverse association of tea and flavonoid intakes with incident myocardial infarction: the Rotterdam Study.
J. Geleijnse (2002)
Red wine polyphenols enhance endothelial nitric oxide synthase expression and subsequent nitric oxide release from endothelial cells.
N. Hollenberg (2003)
Factors affecting the bioavailability of soy isoflavones in humans after ingestion of physiologically relevant levels from different soy foods.
A. Cassidy (2006)
[The neuroprotection of resveratrol in the experimental cerebral ischemia].
Y. Wang (2003)
Body mass index and ischemic and hemorrhagic stroke: A perspective study in Korean men, Stroke
Y. M. Song (2003)
Dietary antioxidants in preventing atherogenesis.
A. Kaliora (2006)
Red Wine Polyphenols Enhance Endothelial Nitric Oxide Synthase Expression and Subsequent Nitric Oxide Release From Endothelial Cells
J. Leikert (2002)
A comparison of the effects of 2 doses of soy protein or casein on serum lipids, serum lipoproteins, and plasma total homocysteine in hypercholesterolemic subjects.
S. Tonstad (2002)
Anthocyanins and anthocyanin-rich extracts: role in diabetes and eye function.
D. Ghosh (2007)
Effects of olive oil and tomato lycopene combination on serum lycopene, lipid profile, and lipid oxidation.
K. Ahuja (2006)
Lycopene synergistically inhibits LDL oxidation in combination with vitamin E, glabridin, rosmarinic acid, carnosic acid, or garlic.
B. Fuhrman (2000)
Administration of wine and grape juice inhibits in vivo platelet activity and thrombosis in stenosed canine coronary arteries.
H. S. Demrow (1995)
Phytoestrogens and cardiovascular disease
A. Cassidy (2006)
Protective effect of resveratrol, a red wine constituent polyphenol, on rats subjected to portal vein thrombosis.
V. Kirimlioğlu (2008)
Interactive relations of central versus total obesity and blood pressure to cognitive function
S. Waldstein (2006)
Soy Protein, Isoflavones, and Cardiovascular Health: A Summary of a Statement for Professionals From the American Heart Association Nutrition Committee
F. Sacks (2006)
Cellular mechanisms of the protective effect of polyphenols on the neurovascular unit in strokes.
Y. Curin (2006)
[Alcohol consumption and risk of stroke].
A. Peter (2000)
Regular ingestion of black tea improves brachial vasodilator function, Clin
J. M. Hodgson (2002)
Can dementia be prevented? Brain aging in a population-based context.
M. Haan (2004)
The Effect of Flavanol-rich Cocoa on the fMRI Response to a Cognitive Task in Healthy Young People
S. Francis (2006)
Resveratrol in cardioprotection: a therapeutic promise of alternative medicine.
D. Das (2006)
Pomegranate juice consumption for 3 years by patients with carotid artery stenosis reduces common carotid intima-media thickness, blood pressure and LDL oxidation.
M. Aviram (2004)
Tea consumption and the prevalence of coronary heart disease in Saudi adults: results from a Saudi national study.
I. A. Hakim (2003)
Potential health benefits from the flavonoids in grape products on vascular disease.
J. Folts (2002)
Change in Body Mass Index and Its Impact on Blood Pressure: A Prospective Population StudyDloyvold WB, Midthjell K, Nilsen TIL, et al (Norwegian Univ of Science and Technology, Trondheim, Norway) Int J Obes 29:650-655, 2005§
W. Elliott (2006)
Soy Protein, Isoflavones, and Cardiovascular Health: An American Heart Association Science Advisory for Professionals From the Nutrition Committee
F. Sacks (2006)
Processing effects on lycopene content and antioxidant activity of tomatoes.
G. Takeoka (2001)
Does tea affect cardiovascular disease? A meta-analysis.
U. Peters (2001)
Direct intestinal absorption of red fruit anthocyanins, cyanidin-3-glucoside and cyanidin-3,5-diglucoside, into rats and humans.
T. Miyazawa (1999)
Preventive effects of green tea catechins on spontaneous stroke in rats.
M. Ikeda (2007)
Alcohol consumption and risk of stroke: a meta-analysis.
K. Reynolds (2003)
A moderate dose of red wine, but not de-alcoholized red wine increases coronary flow reserve.
T. Kiviniemi (2007)
Effects of a pomegranate fruit extract rich in punicalagin on oxidation-sensitive genes and eNOS activity at sites of perturbed shear stress and atherogenesis.
F. de Nigris (2007)
Effects of blackcurrant anthocyanin intake on peripheral muscle circulation during typing work in humans
H. Matsumoto (2004)
Plasma Carotenoid and Malondialdehyde Levels in Ischemic Stroke Patients: Relationship to Early Outcome
M. C. Polidori (2002)
Regular ingestion of black tea improves brachial artery vasodilator function.
J. Hodgson (2002)
Health: Endothelin-1 synthesis reduced by red wine
R. Corder (2001)
Soy, soy phytoestrogens and cardiovascular disease.
T. Clarkson (2002)
Does Flavanol Intake Influence Mortality from Nitric Oxide-Dependent Processes? Ischemic Heart Disease, Stroke, Diabetes Mellitus, and Cancer in Panama
Vicente Bayard (2007)
Consumption of flavanol-rich cocoa acutely increases microcirculation in human skin
Karin Neukam (2007)
Tea consumption. relationship to cholesterol, blood pressure, and coronary and total mortality.
I. Stensvold (1992)
Inverse association between carotid intima-media thickness and the antioxidant lycopene in atherosclerosis.
J. Gianetti (2002)
Macrophage paraoxonase 2 (PON2) expression is up-regulated by pomegranate juice phenolic anti-oxidants via PPARgamma and AP-1 pathway
M. Shiner (2007)
Vasorelaxant and antioxidant activity of the isoflavone metabolite equol in carotid and cerebral arteries
K. Jackman (2007)
Cocoa intake, blood pressure, and cardiovascular mortality: the Zutphen Elderly Study.
B. Buijsse (2006)
Resveratrol, a natural red wine polyphenol, reduces ischemia-reperfusion-induced spinal cord injury.
S. Kaplan (2005)
The effect of chronic consumption of red wine polyphenols on vascular function in postmenopausal women
M. Naissides (2006)
Bioavailability and bioefficacy of polyphenols in humans. II. Review of 93 intervention studies.
G. Williamson (2005)
Does tea affect cardiovascular disease
U. Peters (2001)
The Flavonoids Advances in Research Since 1986
J. Harborne (1988)
Vascular protection by dietary polyphenols.
J. Stoclet (2004)
Short- and long-term black tea consumption reverses endothelial dysfunction in patients with coronary artery disease, Circulation
S. J. Duffy (2001)
Rapid ischemic preconditioning for spinal cord protection after transient aortic occlusion.
I. Toumpoulis (2004)
Interaction between flavonoids and the blood-brain barrier: in vitro studies.
K. Youdim (2003)
Plant polyphenols: How to translate their in vitro antioxidant actions to in vivo conditions
C. Fraga (2007)
Short-term administration of dark chocolate is followed by a significant increase in insulin sensitivity and a decrease in blood pressure in healthy persons.
D. Grassi (2005)
Effect of dark chocolate on arterial function in healthy individuals.
C. Vlachopoulos (2005)
Pomegranate juice supplementation to atherosclerotic mice reduces macrophage lipid peroxidation, cellular cholesterol accumulation and development of atherosclerosis.
M. Kaplan (2001)
Neurological diseases: Mechanisms, challenges and opportunities in stroke
E. Lo (2003)
Short- and Long-Term Black Tea Consumption Reverses Endothelial Dysfunction in Patients With Coronary Artery Disease
S. J. Duffy (2001)
Potential health benefits from the flavonoids in grape products on vascular disease, Adv
J. D. Folts (2002)
Beneficial effects of pomegranate juice on oxidation-sensitive genes and endothelial nitric oxide synthase activity at sites of perturbed shear stress.
F. de Nigris (2005)
Cancer Chemopreventive Activity of Resveratrol, a Natural Product Derived from Grapes
M. Jang (1997)
Unique Properties of Polyphenol Stilbenes in the Brain: More than Direct Antioxidant Actions; Gene/Protein Regulatory Activity
S. Doré (2005)
Dietary Polyphenols and the Prevention of Diseases
A. Scalbert (2005)
Cocoa Flavanols and Brain Perfusion
N. D. Fisher (2006)
Phenolics in food and nutraceuticals
F. Shahidi (1995)
Effect of genistein on endothelial function in postmenopausal women: a randomized, double-blind, controlled study.
F. Squadrito (2003)
Bioavailability and bioefficacy of polyphenols in humans. I. Review of 97 bioavailability studies.
C. Manach (2005)
Effects of niacin-bound chromium and grape seed proanthocyanidin extract on the lipid profile of hypercholesterolemic subjects: a pilot study.
H. Preuß (2000)
Tea intake is inversely related to blood pressure in older women.
J. Hodgson (2003)
Anthocyanins and anthocyaninrich extracts in biology and medicine : Biochemical , cellular , and medicinal properties
D. Ghosh (2005)
A moderate intake of wine is associated with reduced total mortality and reduced mortality from cardiovascular disease.
H. Theobald (2000)
(-)-Epicatechin mediates beneficial effects of flavanol-rich cocoa on vascular function in humans.
H. Schroeter (2006)
Role of oxidative modifications in atherosclerosis.
R. Stocker (2004)
Age affects ERK1/2 and NRF2 signaling in the regulation of GCLC expression
M. Li (2006)
Body Mass Index and Ischemic and Hemorrhagic Stroke: A Prospective Study in Korean Men
Y. Song (2004)
Mega natural gold grapeseed extract: In vitro antioxidant and in vivo human supplementation
J. A. Vinson (2001)
Vascular effects of cocoa rich in flavan-3-ols.
C. Heiss (2003)
Acute consumption of flavanol-rich cocoa and the reversal of endothelial dysfunction in smokers.
C. Heiss (2005)
Relation between green tea consumption and the severity of coronary atherosclerosis among Japanese men and women.
S. Sasazuki (2000)
Anthocyanins and anthocyaninrich extracts : Role in diabetes and eyefunction
D. Ghosh (2007)
How do dietary flavanols improve vascular function? A position paper.
T. Schewe (2008)
Change in body mass index and its impact on blood pressure: a prospective population study
W. Drøyvold (2005)
The Flavonoids: Advances in Research : Edited by J.B. Harborne and T.J. Mabry Chapman and Hall; London, New York, 1982 744 pages. £ 49.50
D. J. Pilbeam (1983)
Cardiovascular disease risk factors and cognitive impairment.
D. Nash (2006)
Macrophage paraoxonase 2 (PON2) expression is up-regulated by pomegranate juice phenolic anti-oxidants via PPAR gamma and AP-1 pathway activation.
M. Shiner (2007)
Resveratrol, a red wine polyphenol, protects spinal cord from ischemia-reperfusion injury.
U. Kızıltepe (2004)
Lycopene, Atherosclerosis, and Coronary Heart Disease
T. Rissanen (2002)
Effect of Grape Seed Extract and Quercetin on Cardiovascular and Endothelial Parameters in High-Risk Subjects
P. Clifton (2004)
Fruit and vegetable consumption and risk of stroke. A meta-analysis of cohort studies, Neurology
L. Dauchet (2005)
Effects of niacinbound chromium and grape seed proanthocyanidin extract on the lipid profile of hypercholesterolemic subjects : A pilot study
H. G. Preuss (2000)
This paper is referenced by
Phytochemicals and Hypertension
A. Kooshki (2014)
Polyphenols-rich natural products for treatment of diabetes.
S. Dragan (2015)
Advice on Lifestyle Changes (Diet, Red Wine and Physical Activity) Does Not Affect Internal Carotid and Middle Cerebral Artery Blood Flow Velocity in Patients with Carotid Arteriosclerosis in a Randomized Controlled Trial
Dirk W. Droste (2014)
Short-Term Effects of Dark Chocolate on Retinal and Choriocapillaris Perfusion in Young, Healthy Subjects Using Optical Coherence Tomography Angiography
Gianluca Scuderi (2020)
Flavonol-rich dark cocoa significantly decreases plasma endothelin-1 and improves cognition in urban children
L. Calderón‐Garcidueñas (2013)
Natural products and the aging process
Elif Burcu (2013)
Acute effects of dietary constituents on motor skill and cognitive performance in athletes.
L. Baker (2014)
Citrus aurantium L. peel extract mitigates hexavalent chromium-induced oxidative stress and cardiotoxicity in adult rats
Mariem Chaâbane (2017)
Proceso inflamatorio en la enfermedad de Alzheimer. Papel de las citoquinas
José Miguel Rubio-Pérez (2014)
Associations between flavonoids and cardiovascular disease incidence or mortality in European and US populations.
J. Peterson (2012)
Dietary Curcumin Ameliorates Aging-Related Cerebrovascular Dysfunction through the AMPK/Uncoupling Protein 2 Pathway
Yunfei Pu (2013)
Effect of dark chocolate on nitric oxide serum levels and blood pressure in prehypertension subjects.
Verawati Sudarma (2011)
Chemistry of Secondary Polyphenols Produced during Processing of Tea and Selected Foods
T. Tanaka (2009)
Laccase-based biosensor for the determination of polyphenol index in wine.
Massimo Di Fusco (2010)
(−)-Epicatechin Activation of Endothelial Cell Endothelial Nitric Oxide Synthase, Nitric Oxide, and Related Signaling Pathways
Israel Ramírez-Sánchez (2010)
Pomegranate peel extract attenuates oxidative stress by decreasing coronary angiotensin-converting enzyme (ACE) activity in hypertensive female rats
R L Dos Santos (2016)
Endothelium-dependent vasorelaxant effect of Alchemilla vulgaris methanol extract: a comparison with the aqueous extract in rat aorta
Selcuk Takir (2014)
Nutritional interventions and blood pressure : role of specific micronutrients and other food components
L. A. V. Mierlo (2010)
How Can We Cure NO / ONOO-Cycle Diseases ? Approaches to Curing Chronic Fatigue Syndrome / Myalgic Encephalomyelitis , Fibromyalgia , Multiple Chemical Sensitivity , Gulf War Syndrome and Possibly
M. Pall (2010)
Carob as cocoa substitute: a review on composition, health benefits and food applications
Andreas Loullis (2017)
Interaction of dietary flavonoids with gamma-globulin: molecular property-binding affinity relationship aspect.
Fan Yang (2011)
Pb2+, Cu2+, Zn2+, Mg2+ and Mn2+ reduce the affinities of flavone, genistein and kaempferol for human serum albumin in vitro
F. Yang (2011)
Caffeic Acid, a Phenol Found in White Wine, Modulates Endothelial Nitric Oxide Production and Protects from Oxidative Stress-Associated Endothelial Cell Injury
M. Migliori (2015)
Polyphenolic compounds and their supplementation in postmenopausal women
I. Połać (2011)
Do polyphenols enter the brain and does it matter? Some theoretical and practical considerations
S. Schaffer (2011)
Phytochemicals and health
Ian T Johnson (2013)
Efficacy of a collagen hydrolysate and antioxidants-containing nutraceutical on metrics of skin health in Indian women.
Meghna S Motwani (2020)
Health benefits of soy and soy phytochemicals
Haoqing Wu (2017)
Stroke, angiogenesis and phytochemicals.
Y. Chen (2012)
Drivers and Barriers for Marketing Innovative Functional Food Products
D. Ghosh (2016)
Natural Phytochemicals in the Treatment and Prevention of Dementia: An Overview
Rosaliana Libro (2016)
Fruit and Vegetables and Health: An Overview
Y. Desjardins (2014)See more