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The Sirtuins: Markers Of Metabolic Health.

J. Covington, S. Bajpeyi
Published 2016 · Medicine, Biology

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The sirtuins represent a class of proteins first discovered orthologus to the yeast silent information regulator 2 protein that have been retained in mammalian species. Currently, seven sirtuins have been identified in humans, and their functions currently surpass their originally identified role as histone deacetylase and chromatin silencers to encompass nutrient sensing and metabolic function. All seven sirtuins require NAD(+) in order to carry out their enzymatic activity, and thus become activated in conditions of nutrient depletion, starvation, and cellular stress. Caloric restriction and increased physical activity have been postulated, though perhaps controversially, to mediate sirtuin function. Here, we review the current literature surrounding the functions of the seven human sirtuins, mediators of their function, and the roles they play in metabolic health related to dietary and physical activity interventions. Despite the controversy surrounding sirtuin function with regard to longevity, we have aimed to show that regardless of its effects on aging, sirtuin function is pivotal to pathways involving metabolic health, and should therefore be investigated with regard to improving metabolic diseases such as obesity and type 2 diabetes.
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10.3389/fendo.2018.00093
Circadian and Metabolic Perspectives in the Role Played by NADPH in Cancer
Isabel Méndez (2018)
10.1007/s13105-016-0492-6
The role of sirtuins in cellular homeostasis
Wioleta Kupis (2016)
Potential of Phytonutrients to act as Mimetics for Caloric Restriction – Identification of the Transcriptional and Functional Overlap in silico
Stefanie Rieper (2017)
10.1016/j.dsx.2018.11.011
Altered levels of sirtuin genes (SIRT1, SIRT2, SIRT3 and SIRT6) and their target genes in adipose tissue from individual with obesity.
V. Martínez-Jiménez (2019)
10.1371/journal.pone.0174759
Characterization and mutational analysis of a nicotinamide mononucleotide deamidase from Agrobacterium tumefaciens showing high thermal stability and catalytic efficiency
Ana Belén Martínez-Moñino (2017)
10.1080/17512433.2018.1546119
Functional and therapeutic potential of mitochondrial SIRT3 deacetylase in disease conditions
Abhinav Kanwal (2018)
10.1089/DNA.2016.3280
Role of Sirtuins in Maintenance of Genomic Stability: Relevance to Cancer and Healthy Aging.
Xiayu Wu (2016)
10.1007/s11064-016-2110-y
Sirtuins and Their Roles in Brain Aging and Neurodegenerative Disorders
H. Jęśko (2016)
10.1016/j.numecd.2017.05.009
Epicardial fat thickness correlates with P-wave duration, left atrial size and decreased left ventricular systolic function in morbid obesity.
A. Fernandes-Cardoso (2017)
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