Online citations, reference lists, and bibliographies.
← Back to Search

Intrinsic Laryngeal Muscles Are Spared From Myonecrosis In The Mdx Mouse Model Of Duchenne Muscular Dystrophy

M. J. Marques, R. Ferretti, V. Vomero, Elaine Minatel, H. S. Neto
Published 2007 · Medicine

Cite This
Download PDF
Analyze on Scholarcy
Share
Intrinsic laryngeal muscles share many anatomical and physiological properties with extraocular muscles, which are unaffected in both Duchenne muscular dystrophy and mdx mice. We hypothesized that intrinsic laryngeal muscles are spared from myonecrosis in mdx mice and may serve as an additional tool to understand the mechanisms of muscle sparing in dystrophinopathy. Intrinsic laryngeal muscles and tibialis anterior (TA) muscle of adult and aged mdx and control C57Bl/10 mice were investigated. The percentage of central nucleated fibers, as a sign of muscle fibers that had undergone injury and regeneration, and myofiber labeling with Evans blue dye, as a marker of myofiber damage, were studied. Except for the cricothyroid muscle, none of the intrinsic laryngeal muscles from adult and old mdx mice showed signs of myofiber damage or Evans blue dye labeling, and all appeared to be normal. Central nucleation was readily visible in the TA of the same mdx mice. A significant increase in the percentage of central nucleated fibers was observed in adult cricothyroid muscle compared to the other intrinsic laryngeal muscles, which worsened with age. Thus, we have shown that the intrinsic laryngeal muscles are spared from the lack of dystrophin and may serve as a useful model to study the mechanisms of muscle sparing in dystrophinopathy. Muscle Nerve, 2006
This paper references
Adult mouse intrinsic laryngeal muscles express high levels of the myogenic regulatory factor, MYF-5
N. Bain (2001)
Muscles of a different color: the unusual properties of the extraocular muscles may predispose or protect them in neurogenic and myogenic disease
JD Porter (1996)
10.1016/S0039-6257(05)80055-4
Extraocular muscles: basic and clinical aspects of structure and function.
J. Porter (1995)
10.1152/PHYSIOLGENOMICS.00234.2004
Distinctive morphological and gene/protein expression signatures during myogenesis in novel cell lines from extraocular and hindlimb muscle.
J. Porter (2006)
10.1016/0022-510X(94)00276-T
mdx mice show progressive weakness and muscle deterioration with age
C. Pastoret (1995)
10.1016/0092-8674(87)90579-4
Dystrophin: The protein product of the duchenne muscular dystrophy locus
E. Hoffman (1987)
10.1073/PNAS.81.4.1189
X chromosome-linked muscular dystrophy (mdx) in the mouse.
G. Bulfield (1984)
10.1007/BF00114502
Expression of extraocular myosin heavy chain in rabbit laryngeal muscle
C. Lucas (2004)
10.1084/JEM.182.2.467
Absence of extraocular muscle pathology in Duchenne's muscular dystrophy: role for calcium homeostasis in extraocular muscle sparing
T. Khurana (1995)
Extraocular and laryngeal muscles exhibit differential amplification of protein involved in calcium homeostasis
JM Blank (1999)
10.1007/s00405-003-0702-z
Age-related changes in human thyroarytenoid muscles: a histological and histochemical study
W. Kersing (2003)
10.1111/j.1365-2990.1988.tb00866.x
THE mdx MOUSE SKELETAL MUSCLE MYOPATHY: I. A HISTOLOGICAL, MORPHOMETRIC AND BIOCHEMICAL INVESTIGATION
G. Coulton (1988)
Analysis of gene expression differences between utrophin/dystrophin-deficient vs mdx skeletal muscles reveals a specific upregulation of slow muscles genes in limb muscles. Neurogenetics 2006;7:81–91
PE Baker (2006)
10.1007/s10048-006-0031-7
Analysis of gene expression differences between utrophin/dystrophin-deficient vs mdx skeletal muscles reveals a specific upregulation of slow muscle genes in limb muscles
P. E. Baker (2006)
10.1111/J.1365-201X.2004.01402.X
Laryngeal muscle fibre types.
J. F. Hoh (2005)
10.1093/BRAIN/110.2.269
The mutant mdx: inherited myopathy in the mouse. Morphological studies of nerves, muscles and end-plates.
L. Torres (1987)
10.1038/293300A0
Calcium-binding protein parvalbumin as a neuronal marker
M. Celio (1981)
10.1177/000348940511400711
Myonuclear Addition to Uninjured Laryngeal Myofibers in Adult Rabbits
G. Goding (2005)
10.1002/mus.20012
Continuous myofiber remodeling in uninjured extraocular myofibers: Myonuclear turnover and evidence for apoptosis
L. McLoon (2004)
What is muscular dystrophy? Forty years of progressive ignorance.
V. Dubowitz (2000)
10.1016/j.nmd.2004.10.002
Extraocular muscles have fundamentally distinct properties that make them selectively vulnerable to certain disorders
C. Man (2005)
10.1177/002215540405200503
Fiber Types in Rat Laryngeal Muscles and Their Transformations After Denervation and Reinnervation
H. Rhee (2004)
10.1002/AR.1092420109
Phenotype of dystrophinopathy in old MDX mice
J. P. Lefaucheur (1995)
10.1001/ARCHOTOL.126.7.851
Age-related changes in muscle fiber regeneration in the human thyroarytenoid muscle.
L. Malmgren (2000)
10.1152/PHYSIOLGENOMICS.00191.2004
Layer-specific differences of gene expression in extraocular muscles identified by laser-capture microscopy.
M. T. Budak (2004)
10.1046/j.0021-8782.2001.00008.x
Evans Blue Dye as an in vivo marker of myofibre damage: optimising parameters for detecting initial myofibre membrane permeability
P. W. Hamer (2002)
10.1002/(SICI)1097-0029(20000201/15)48:3/4<192::AID-JEMT7>3.0.CO;2-J
Eye muscle sparing by the muscular dystrophies: Lessons to be learned?
F. H. Andrade (2000)



This paper is referenced by
A new model for the dystrophin associated protein complex in striated muscles
Eric K Johnson (2012)
10.1016/j.nbd.2008.03.008
Towards developing standard operating procedures for pre-clinical testing in the mdx mouse model of Duchenne muscular dystrophy
M. Grounds (2008)
10.1016/j.nmd.2007.11.011
Microarray analysis of mdx mice expressing high levels of utrophin: Therapeutic implications for dystrophin deficiency
D. Baban (2008)
10.1016/j.jvoice.2020.08.030
Laryngeal Findings in Duchenne Muscular Dystrophy.
Sara Anieli da Costa Braz Fonseca (2020)
ABSTRACT OF DISSERTATION
Lisa B. Thomas (2008)
10.1002/ar.21297
Expression of Utrophin at Dystrophin‐Deficient Neuromuscular Synapses of mdx Mice: A Study of Protected and Affected Muscles
R. Ferretti (2011)
10.1111/j.1365-2613.2009.00688.x
Calcium‐binding proteins in skeletal muscles of the mdx mice: potential role in the pathogenesis of Duchenne muscular dystrophy
A. Pertille (2010)
Proteomic Profiling of Animal Models of Motor Neuron Disease and Muscular Dystrophy
A. Holland (2015)
10.1159/000315476
Morphological and Extracellular Matrix Changes following Vocal Fold Injury in Mice
M. Yamashita (2010)
Extraocular Muscles in Patients With Infantile Nystagmus
Kathleen T. Berg (2017)
Dystrophic pathology in the intrinsic and extrinsic laryngeal muscles in the mdx mouse.
G. Smythe (2009)
10.1016/B978-0-12-374593-4.00002-4
Laryngeal muscles as highly specialized organs in airway protection, respiration and phonation
J. Hoh (2010)
10.1155/2014/246195
Proteomic Profiling of the Dystrophin-Deficient mdx Phenocopy of Dystrophinopathy-Associated Cardiomyopathy
A. Holland (2014)
10.3389/fnagi.2015.00190
A muscle stem cell for every muscle: variability of satellite cell biology among different muscle groups
Matthew E. Randolph (2015)
10.1002/mus.22235
Age‐related changes in dystrophin–glycoprotein complex and in utrophin are not correlated with intrinsic laryngeal muscles protection in mdx mice
R. Ferretti (2011)
10.1016/j.nmd.2015.09.001
Sparing of the extraocular muscles in mdx mice with absent or reduced utrophin expression: A life span analysis
Abby A. McDonald (2015)
10.1111/iep.12142
Changes in calsequestrin, TNF‐α, TGF‐β and MyoD levels during the progression of skeletal muscle dystrophy in mdx mice: a comparative analysis of the quadriceps, diaphragm and intrinsic laryngeal muscles
Juliana Barros Maranhão (2015)
10.1007/978-1-4614-4466-4_11
Laryngeal Muscle Response to Neuromuscular Diseases and Specific Pathologies
J. Stemple (2012)
10.1001/archophthalmol.2011.381
Extraocular muscles in patients with infantile nystagmus: adaptations at the effector level.
Kathleen T. Berg (2012)
10.1002/med.21279
Cardiac and Respiratory Dysfunction in Duchenne Muscular Dystrophy and the Role of Second Messengers
Matías Mosqueira (2013)
10.1002/ca.20624
Estimation of the number and size of motor units in intrinsic laryngeal muscles using morphometric methods
Humberto Santo Neto (2008)
10.15226/2372-0948/5/2/00161
Assessment of Genetic Mutations DMD, DYSF, EMD, LMNA, DUX4, DMPK, ZNF9, PABPN1 Genes Induction Duchenne Muscular Dystrophy
Shahin Asadi (2017)
10.14814/phy2.12409
Expression of calcium-buffering proteins in rat intrinsic laryngeal muscles
R. Ferretti (2015)
10.1002/cbin.11057
Sex influences diaphragm muscle response in exercised mdx mice
T. A. Hermes (2018)
10.1007/978-1-4614-4466-4_17
Comparison of the Craniofacial Muscles: A Unifying Hypothesis
Linda K McLoon (2012)
Therapeutic interventions for Duchenne Muscular Dystrophy - studies in the mdx mouse
H. Crabb (2010)
10.1142/9789812775771_0008
Myogenic precursor cells in the extraocular muscles
Kristen M Kallestad (2008)
10.3892/ijmm.2012.1006
Proteomics reveals drastic increase of extracellular matrix proteins collagen and dermatopontin in the aged mdx diaphragm model of Duchenne muscular dystrophy
Steven Carberry (2012)
From structure and dynamics to novel therapeutic development for muscular dystrophy.
Ava Yun Lin (2012)
10.1044/1092-4388(2009/09-0010)
Effect of dystrophin deficiency on selected intrinsic laryngeal muscles of the mdx mouse.
Lisa T Fry (2010)
10.1044/1092-4388(2008/042)
Laryngeal muscles are spared in the dystrophin deficient mdx mouse.
Lisa B. Thomas (2008)
Characterising and evaluating the efficacy of metabolic therapies for the treatment of Duchenne Muscular Dystrophy
Cara A. Timpani (2017)
See more
Semantic Scholar Logo Some data provided by SemanticScholar