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Antibacterial Activity Of Flavonoids And Their Structure–activity Relationship: An Update Review
F. Farhadi, B. Khameneh, M. Iranshahi, Milad Iranshahy
Published 2019 · Biology, Medicine
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Time to take this seriously.
Based on World Health Organization reports, resistance of bacteria to well‐known antibiotics is a major global health challenge now and in the future. Different strategies have been proposed to tackle this problem including inhibition of multidrug resistance pumps and biofilm formation in bacteria and development of new antibiotics with novel mechanism of action. Flavonoids are a large class of natural compounds, have been extensively studied for their antibacterial activity, and more than 150 articles have been published on this topic since 2005. Over the past decade, some promising results were obtained with the antibacterial activity of flavonoids. In some cases, flavonoids (especially chalcones) showed up to sixfold stronger antibacterial activities than standard drugs in the market. Some synthetic derivatives of flavonoids also exhibited remarkable antibacterial activities with 20‐ to 80‐fold more potent activity than the standard drug against multidrug‐resistant Gram‐negative and Gram‐positive bacteria (including Escherichia coli, Pseudomonas aeruginosa, and Staphylococcus aureus). This review summarizes the ever changing information on antibacterial activity of flavonoids since 2005, with a special focus on the structure–activity relationship and mechanisms of actions of this broad class of natural compounds.
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Analysis of Conformational, Structural, Magnetic, and Electronic Properties Related to Antioxidant Activity: Revisiting Flavan, Anthocyanidin, Flavanone, Flavonol, Isoflavone, Flavone, and Flavan-3-ol
Sergio Antônio de Souza Farias (2021)
The Interactions between Polyphenols and Microorganisms, Especially Gut Microbiota
M. Makarewicz (2021)
Influence of gamma irradiation on the biological properties of Asplenium scolopendrium L. hydroalcoholic extracts
I. Fierascu (2021)
Bioactive compounds from Euphorbia schimperiana with cytotoxic and antibacterial activities
Salha M Aljubiri (2021)
Isolation, Structure Elucidation and In Silico Prediction of Potential Drug-Like Flavonoids from Onosma chitralicum Targeted towards Functionally Important Proteins of Drug-Resistant Bad Bugs
Shakeel Ahmad Khan (2021)
Isoflavonoid-Antibiotic Thin Films Fabricated by MAPLE with Improved Resistance to Microbial Colonization
V. Grumezescu (2021)
Construction of a linkage map flanking the I locus controlling dominant white bulb color and analysis of differentially expressed genes between dominant white and red bulbs in onion (Allium cepa L.)
Inho Seo (2020)
Effects of structural differences on the antibacterial activity of biflavonoids from fruits of the Brazilian peppertree (Schinus terebinthifolius Raddi).
M. Lindén (2020)
Changes in the Content of Some Groups of Phenolic Compounds and Biological Activity of Extracts of Various Parts of Heather (Calluna vulgaris (L.) Hull) at Different Growth Stages
V. Chepel (2020)See more