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Antibacterial Activity Of Flavonoids And Their Structure–activity Relationship: An Update Review

F. Farhadi, B. Khameneh, M. Iranshahi, Milad Iranshahy
Published 2019 · Biology, Medicine

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Based on World Health Organization reports, resistance of bacteria to well‐known antibiotics is a major global health challenge now and in the future. Different strategies have been proposed to tackle this problem including inhibition of multidrug resistance pumps and biofilm formation in bacteria and development of new antibiotics with novel mechanism of action. Flavonoids are a large class of natural compounds, have been extensively studied for their antibacterial activity, and more than 150 articles have been published on this topic since 2005. Over the past decade, some promising results were obtained with the antibacterial activity of flavonoids. In some cases, flavonoids (especially chalcones) showed up to sixfold stronger antibacterial activities than standard drugs in the market. Some synthetic derivatives of flavonoids also exhibited remarkable antibacterial activities with 20‐ to 80‐fold more potent activity than the standard drug against multidrug‐resistant Gram‐negative and Gram‐positive bacteria (including Escherichia coli, Pseudomonas aeruginosa, and Staphylococcus aureus). This review summarizes the ever changing information on antibacterial activity of flavonoids since 2005, with a special focus on the structure–activity relationship and mechanisms of actions of this broad class of natural compounds.
This paper references
10.1159/000134754
Préface, Vorwort, Foreword
H. Selye (1959)
10.1097/00000446-200005000-00042
Drug-drug interactions.
S. Preskorn (1996)
10.1016/S0944-7113(00)80089-6
Reduction of membrane fluidity by antibacterial sophoraflavanone G isolated from Sophora exigua.
H. Tsuchiya (2000)
10.1076/phbi.39.5.388.5894
Chemical and Antimicrobial Studies of Platycladus orientalis Essential Oils
M. Hassanzadeh (2001)
10.1007/s00203-005-0063-7
Differential antibacterial activity of genistein arising from global inhibition of DNA, RNA and protein synthesis in some bacterial strains
Katarzyna Ulanowska (2005)
10.1016/J.JEP.2005.04.014
Detection of galangin-induced cytoplasmic membrane damage in Staphylococcus aureus by measuring potassium loss.
T. P. T. Cushnie (2005)
10.1016/j.ijantimicag.2005.09.002
Antimicrobial activity of flavonoids
Tim Cushnie (2005)
10.1128/AAC.49.7.2914-2920.2005
Antifolate Activity of Epigallocatechin Gallate against Stenotrophomonas maltophilia
M. D. Navarro-Martínez (2005)
10.1016/J.JEP.2006.06.001
Flavonoids with anti-Helicobacter pylori activity from Cistus laurifolius leaves.
O. Ustün (2006)
10.1016/J.PHYMED.2004.07.003
Assessment of the antibacterial activity of galangin against 4-quinolone resistant strains of Staphylococcus aureus.
T. P. T. Cushnie (2006)
10.1139/O06-047
Inactivation mechanism of the beta-ketoacyl-[acyl carrier protein] reductase of bacterial type-II fatty acid synthase by epigallocatechin gallate.
B. Li (2006)
10.1016/J.PHYTOCHEM.2006.03.019
Antimycobacterial flavonoids from Derris indica.
S. Koysomboon (2006)
10.1111/j.1365-2672.2006.02912.x
Guaijaverin – a plant flavonoid as potential antiplaque agent against Streptococcus mutans
G. R. Prabu (2006)
10.1529/BIOPHYSJ.106.097105
Single GUV method reveals interaction of tea catechin (-)-epigallocatechin gallate with lipid membranes.
Y. Tamba (2007)
10.1590/S0102-695X2007000300003
Bioactive flavone dimers from Ouratea multiflora (Ochnaceae)
C. A. Carbonezi (2007)
10.1016/J.JEP.2007.03.008
Antimicrobial activity of the methanolic extract, fractions and four flavonoids from the twigs of Dorstenia angusticornis Engl. (Moraceae).
V. Kuete (2007)
10.1002/PTR.2061
Antibacterial activity of flavonoids and phenylpropanoids from Marrubium globosum ssp. libanoticum
D. Rigano (2007)
10.1111/j.1365-2672.2007.03393.x
Aggregation of Staphylococcus aureus following treatment with the antibacterial flavonol galangin
T. P. T. Cushnie (2007)
10.2478/s11756-007-0042-3
Assessment of antibacterial effects of flavonoids by estimation of generation times in liquid bacterial cultures
Katarzyna Ulanowska (2007)
10.1016/J.BMC.2007.03.045
Polyphenols based on isoflavones as inhibitors of Helicobacter pylori urease.
Zhu-Ping Xiao (2007)
10.1016/J.JEP.2006.09.022
Antibacterial pterocarpans from Erythrina subumbrans.
Thitima Rukachaisirikul (2007)
10.1016/J.EJMECH.2006.10.013
Synthesis, SAR and antibacterial studies on novel chalcone oxazolidinone hybrids.
N. Selvakumar (2007)
10.1016/J.FITOTE.2007.03.015
Bacteriostatic effect of flavonoids isolated from leaves of Psidium guajava on fish pathogens.
P. Rattanachaikunsopon (2007)
10.1021/JM060817O
Green tea catechins inhibit bacterial DNA gyrase by interaction with its ATP binding site.
H. Gradišar (2007)
10.1016/J.PHYTOCHEM.2007.04.015
Isoflavanones from Uraria picta and their antimicrobial activity.
M. Rahman (2007)
10.1007/s12223-008-0003-4
Antimicrobial activity and synergism of some substituted flavonoids
M. Álvarez (2008)
10.1016/j.jep.2007.12.017
Antimicrobial activity of the crude extracts and five flavonoids from the twigs of Dorstenia barteri (Moraceae).
A. Mbaveng (2008)
10.1016/j.phytochem.2008.02.022
Antimicrobial acylphloroglucinols and dibenzyloxy flavonoids from flowers of Helichrysum gymnocomum.
S. Drewes (2008)
10.1124/pr.107.07110
Sortase as a Target of Anti-Infective Therapy
A. Maresso (2008)
10.1007/s00253-008-1406-5
Virtual screening for novel quorum sensing inhibitors to eradicate biofilm formation of Pseudomonas aeruginosa
Z. Zeng (2008)
10.1016/j.phytochem.2008.05.003
Flavonols and an oxychromonol from Piliostigma reticulatum.
O. J. Babajide (2008)
10.1016/J.PHYTOL.2008.01.002
Modulation of isoniazid susceptibility by flavonoids in Mycobacterium
D. Lechner (2008)
10.1080/10412905.2008.9699986
High Content of Polysulphides in the Volatile Oil of Ferula latisecta Rech. F. et Aell. Fruits and Antimicrobial Activity of the Oil
M. Iranshahi (2008)
10.1016/j.ijantimicag.2008.06.010
D-Alanine:D-alanine ligase as a new target for the flavonoids quercetin and apigenin.
Dalei Wu (2008)
10.1111/j.1365-2672.2008.03881.x
Investigation of the antibacterial activity of 3‐O‐octanoyl‐(–)‐epicatechin
T. P. T. Cushnie (2008)
10.1110/ps.036186.108
Three flavonoids targeting the β‐hydroxyacyl‐acyl carrier protein dehydratase from Helicobacter pylori: Crystal structure characterization with enzymatic inhibition assay
L. Zhang (2008)
10.1021/np070446u
Antibacterial C-geranylflavonoids from Paulownia tomentosa Fruits.
K. Šmejkal (2008)
10.1177/1934578X0800300929
In Vitro Antifungal Activity of Polysulfides-Rich Essential Oil of Ferula Latisecta Fruits against Human Pathogenic Dermatophytes
M. Iranshahi (2008)
10.1016/J.BBRC.2007.10.190
Epigallocatechin gallate inhibits intracellular survival of Listeria monocytogenes in macrophages.
C. Kohda (2008)
10.1016/j.jep.2008.05.041
Cholinesterase inhibitory and anti-amnesic activity of alkaloids from Corydalis turtschaninovii.
T. Hùng (2008)
10.1016/j.jep.2009.05.004
Antimicrobial activity of the methanolic extract and compounds from Morus mesozygia stem bark.
V. Kuete (2009)
10.1021/np800698d
Screening of flavonoids as candidate antibiotics against Enterococcus faecalis.
Ki-woong Jeong (2009)
10.1002/ptr.2540
Antibacterial activity of sophoraflavanone G Isolated from the roots of Sophora flavescens against methicillin‐resistant Staphylococcus aureus
Jeong-Dan Cha (2009)
10.1016/j.micpath.2009.08.004
Beta-naphthoflavone causes an AhR-independent inhibition of invasion and intracellular multiplication of Listeria monocytogenes in murine hepatocytes.
L. Shi (2009)
10.1002/ptr.3014
Inhibitory effect of quercetin on periodontal pathogens in vitro
F. Geoghegan (2010)
10.1007/s00203-010-0617-1
Antibacterial mechanism of soybean isoflavone on Staphylococcus aureus
Q. Wang (2010)
10.3839/JKSABC.2010.045
Antibacterial and synergistic activity of prenylated chalcone isolated from the roots of Sophora flavescens
Guem-San Lee (2010)
10.1016/j.micres.2009.09.002
Antibacterial, antifungal, and antiviral activities of some flavonoids.
D. D. Orhan (2010)
10.1016/j.phymed.2010.09.003
Reversing β-lactam antibiotic resistance of Staphylococcus aureus with galangin from Alpinia officinarum Hance and synergism with ceftazidime.
G. Eumkeb (2010)
10.1016/j.ijbiomac.2010.03.009
Dietary bioflavonoids inhibit Escherichia coli ATP synthase in a differential manner.
N. Chinnam (2010)
10.1111/J.1365-2621.2010.02267.X
Characterisation of anti-Staphylococcus aureus activity of quercetin
I. Hirai (2010)
10.1002/cbdv.201000264
Evaluation of the Antimicrobial Potential of Two Flavonoids Isolated from Limnophila Plants
G. Brahmachari (2011)
10.1002/HLCA.201100173
Isoprenoids and Flavonoids with Antimicrobial Activity from Ficus conrauiWarburg (Moraceae)
Rodrigue T. Kengap (2011)
10.1016/j.phymed.2011.02.013
Antibacterial and synergy of a flavanonol rhamnoside with antibiotics against clinical isolates of methicillin-resistant Staphylococcus aureus (MRSA).
J. An (2011)
10.1016/j.jep.2011.06.039
Synergistic effects of baicalein with ciprofloxacin against NorA over-expressed methicillin-resistant Staphylococcus aureus (MRSA) and inhibition of MRSA pyruvate kinase.
Ben C L Chan (2011)
Methanolic activities of selected weeds on bacteria isolated from Macrobrachium rosenbergii larvae.
N. Musa (2011)
10.1016/j.ijantimicag.2011.02.014
Recent advances in understanding the antibacterial properties of flavonoids.
T. P. T. Cushnie (2011)
10.1002/ptr.3159
Antibacterial activity of flavonoids from the stem bark of Erythrina caffra thunb.
J. Chukwujekwu (2011)
10.5012/BKCS.2011.32.9.3219
Antimicrobial Flavonoid, 3,6-Dihydroxyflavone, Have Dual Inhibitory Activity against KAS III and KAS I
J. Lee (2011)
10.1371/journal.pone.0025681
Development of Non-Natural Flavanones as Antimicrobial Agents
Zachary L. Fowler (2011)
10.1007/s12272-011-0206-0
In vitro sortase a inhibitory and antimicrobial activity of flavonoids isolated from the roots of Sophora flavescens
Ikhoon Oh (2011)
10.1080/14786410802496911
Acetylcholinesterase inhibitors from Corydalis yanhusuo
Hai-tao Xiao (2011)
10.1002/cbdv.201000367
New Flavanones from the Leaves of Cryptocarya chinensis and Their Antituberculosis Activity
T. Chou (2011)
10.1097/OLQ.0b013e3181f0bdbd
Antimicrobial Activity of Flavonoids From Piper lanceaefolium and Other Colombian Medicinal Plants Against Antibiotic Susceptible and Resistant Strains of Neisseria gonorrhoeae
P. Ruddock (2011)
10.2298/JSC100406027K
Antimicrobial activity screening of isolated flavonoids from Azadirachta indica leaves
Qudsia Kanwal (2011)
10.1021/np200174h
Comparative evaluation of two structurally related flavonoids, isoliquiritigenin and liquiritigenin, for their oral infection therapeutic potential.
M. Feldman (2011)
Two novel flavonoids from Bryophyllum pinnatum and their antimicrobial Activity
D. E. Okwu (2011)
10.1002/ptr.4660
Antibacterial and Antimycobacterial Lignans and Flavonoids from Larrea tridentata
J. M. Favela-Hernández (2012)
10.1177/1934578X1200701216
Ochnaflavone and Ochnaflavone 7-O-Methyl Ether two Antibacterial Biflavonoids from Ochna pretoriensis (Ochnaceae)
T. Makhafola (2012)
10.3390/molecules17066684
Synthesis and Antibacterial Activity of Some Heterocyclic Chalcone Analogues Alone and in Combination with Antibiotics
Thanh-Dao Tran (2012)
10.3109/13880209.2012.662235
Investigation of optimal extraction, antioxidant, and antimicrobial activities of Achillea biebersteinii and A. wilhelmsii
D. S. Bashi (2012)
10.5530/PJ.2012.27.10
Antimicrobial Activity of the Crude Extracts of Withania somnifera and Cenchrus setigerus In-vitro
P. Singariya (2012)
10.1177/1934578X1200700712
Corylucinine, a new Alkaloid from Corydalis cava (Fumariaceae), and its Cholinesterase Activity
Z. Novak (2012)
10.1002/JHET.942
Synthesis, Characterization, and In Vitro Antibacterial Activities of Macromolecules Derived from Bis‐Chalcone
A. Asiri (2012)
10.1080/14786411003675667
Antimicrobial flavonoids from the twigs of Populus nigra × Populus deltoides
Lingyun Zhong (2012)
10.1016/j.fitote.2012.04.011
Phytochemical and antimicrobial investigations of stilbenoids and flavonoids isolated from three species of Combretaceae.
D. Katerere (2012)
10.1007/978-94-007-3926-0_1
An Overview of Antimicrobial Properties of Different Classes of Phytochemicals
A. Patra (2012)
10.1016/j.bmcl.2012.05.112
Synthesis and anti Methicillin resistant Staphylococcus aureus activity of substituted chalcones alone and in combination with non-beta-lactam antibiotics.
Thanh-Dao Tran (2012)
10.1007/978-94-007-3926-0
Dietary Phytochemicals and Microbes
A. Patra (2012)
10.1016/j.jep.2012.01.019
Potentiality of standardized extract and isolated flavonoids from Zuccagnia punctata for the treatment of respiratory infections by Streptococcus pneumoniae: in vitro and in vivo studies.
I. C. Zampini (2012)
10.1080/14786419.2011.616504
A flavanone and antimicrobial activities of the constituents of extracts from Mundulea sericea
O. Mazimba (2012)
10.1016/j.fitote.2012.02.003
Acylated flavonol glycosides from Epimedium elatum, a plant endemic to the Western Himalayas.
M. Tantry (2012)
Synergy of flavone with vancomycin and oxacillin against vancomycin-intermediate Staphyloccus aureus.
Nur Salwani Bakar (2012)
10.1016/J.FOODCHEM.2011.09.021
Biological activities of flavonoids from pathogenic-infected Astragalus adsurgens
J. Chen (2012)
10.3390/molecules17067284
Antibacterial, Antifungal and Cytotoxic Activities of Two Flavonoids from Retama raetam Flowers
H. Edziri (2012)
Synthesis and antibacterial activity of some heterocyclic chalcone analogues alone and in combinationwith antibiotics
T. ‐ D. Tran (2012)
Synthesis and antibacterial activity of some heterocyclic chalcone analogues alone and in combinationwith antibiotics.Molecules
Tran (2012)
Antibacterial, antifungal and cytotoxic activities of two flavonoids from Retama raetam
H. Edziri (2012)
A flavanone and
O. Mazimba (2012)
10.3390/molecules181012633
Antimicrobial and Selected In Vitro Enzyme Inhibitory Effects of Leaf Extracts, Flavonols and Indole Alkaloids Isolated from Croton menyharthii
M. A. Aderogba (2013)
10.1007/s11274-013-1288-2
Antimicrobial activity of Calotropis procera Ait. (Asclepiadaceae) and isolation of four flavonoid glycosides as the active constituents
Gomah E. Nenaah (2013)
10.1080/08927014.2013.788692
Anti-biofilm activities of quercetin and tannic acid against Staphylococcus aureus
J. Lee (2013)
10.1007/s00044-013-0876-x
Synthesis and antimicrobial screening of some novel chalcones and flavanones substituted with higher alkyl chains
U. V. Mallavadhani (2013)
10.1016/j.ejmech.2013.03.016
Synthesis, structure-activity relationship analysis and kinetics study of reductive derivatives of flavonoids as Helicobacter pylori urease inhibitors.
Zhu-Ping Xiao (2013)
Comparative study on the antibacterial activity of some flavonoids and their sulfonic derivatives.
E. Woźnicka (2013)
10.3390/ijerph10115459
Antimicrobial Effect of 7-O-Butylnaringenin, a Novel Flavonoid, and Various Natural Flavonoids against Helicobacter pylori Strains
Sun Hee Moon (2013)
10.1016/j.ijmm.2013.06.003
Antibiotic resistance.
W. Witte (2013)
10.1007/s10600-013-0631-z
A novel flavonoid compound from Farsetia aegyptia and its antimicrobial activity
E. Atta (2013)
10.1155/2013/963248
Review on Natural Coumarin Lead Compounds for Their Pharmacological Activity
K. N. Venugopala (2013)
10.3390/ijms141019434
Systematic Exploration of Natural and Synthetic Flavonoids for the Inhibition of Staphylococcus aureus Biofilms
Suvi Manner (2013)
10.5582/DDT.2013.V7.2.66
Antimicrobial action mechanism of flavonoids from Dorstenia species.
J. P. Dzoyem (2013)
10.1155/2013/823794
Combination Therapy of Sophoraflavanone B against MRSA: In Vitro Synergy Testing
S. Mun (2013)
10.1016/j.phymed.2012.10.008
Synergistic activity and mechanism of action of ceftazidime and apigenin combination against ceftazidime-resistant Enterobacter cloacae.
G. Eumkeb (2013)
10.1016/J.JORGANCHEM.2013.05.009
Ferrocenylvinyl-flavones: Synthesis, structure, anticancer and antibacterial activity studies
K. Kowalski (2013)
10.1016/j.ejmech.2012.09.004
Synthesis and antibacterial and antifungal evaluation of some chalcone based sulfones and bisulfones.
N. Konduru (2013)
10.1016/j.bbamem.2013.07.029
A structure-activity relationship study of flavonoids as inhibitors of E. coli by membrane interaction effect.
T. Wu (2013)
10.1007/s10068-013-0272-9
Antibacterial activity of a novel flavonoid, 7-O-butyl naringenin, against methicillin-resistant Staphylococcus aureus (MRSA)
K. A. Lee (2013)
10.1155/2013/162750
Chemistry and Biological Activities of Flavonoids: An Overview
S. Kumar (2013)
Foodborne Pathogens and Disease
234–239. Mun (2013)
10.1016/j.ejmech.2014.04.037
Design, synthesis, and evaluation of novel fluoroquinolone-flavonoid hybrids as potent antibiotics against drug-resistant microorganisms.
Zhu-Ping Xiao (2014)
10.1016/J.PHYTOL.2014.08.022
Isolation of diterpenes and flavonoids from a new type of propolis from Saudi Arabia
Sultan Z. AlMutairi (2014)
10.3109/13880209.2013.865241
Isolation and biological activity of compounds from Garcinia preussii
Bernadette Biloa Messi (2014)
10.1016/J.JFF.2013.11.022
Identification of flavonoids in litchi (Litchi chinensis Sonn.) leaf and evaluation of anticancer activities
Lingrong Wen (2014)
10.3390/molecules19043883
Structures of Two New Flavonoids and Effects of Licorice Phenolics on Vancomycin-Resistant Enterococcus Species
Eerdunbayaer (2014)
10.4314/AJTCAM.V11I3.14
Antioxidant and antibacterial activities of flavonoid glycosides from Ficus exasperata Vahl-Holl (moraceae) leaves.
B. J. Taiwo (2014)
10.1111/jam.12595
Artonin I inhibits multidrug resistance in Staphylococcus aureus and potentiates the action of inactive antibiotics in vitro
S. Farooq (2014)
10.1016/j.phytochem.2014.07.028
Galloylated flavonol rhamnosides from the leaves of Calliandra tergemina with antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA).
Elaine Wan Ling Chan (2014)
10.5560/znc.2014-0066
Antibacterial Flavanones and Dihydrochalcones from Macaranga trichocarpa
M. S. Fareza (2014)
10.1016/J.APSUSC.2014.03.125
Antimicrobial mechanism of flavonoids against Escherichia coli ATCC 25922 by model membrane study
Mengying He (2014)
10.1111/1348-0421.12194
A chalcone with potent inhibiting activity against biofilm formation by nontypeable Haemophilus influenzae
D. Kunthalert (2014)
10.11113/JT.V71.2699
Antimicrobial Flavonoids from Artocarpus anisophyllus Miq. and Artocarpus lowii King
S. Jamil (2014)
10.1002/ptr.5098
Flavonoids from Sophora moorcroftiana and their Synergistic Antibacterial Effects on MRSA
S. Wang (2014)
10.1016/J.SAJB.2013.11.012
Antimicrobial flavonoids and diterpenoids from Dodonaea angustifolia
L. K. Omosa (2014)
10.1080/14786419.2013.863202
A new cinnamoylglycoflavonoid, antimycobacterial and antioxidant constituents from Heritiera littoralis leaf extracts
R. Christopher (2014)
10.1089/fpd.2013.1627
The mechanism of antimicrobial activity of sophoraflavanone B against methicillin-resistant Staphylococcus aureus.
S. Mun (2014)
10.1016/J.INDCROP.2014.05.021
Antibacterial and antifungal activities of methanol extract and phenolic compounds from Diospyros virginiana L.
Khaled Rashed (2014)
10.1016/j.fitote.2014.07.011
2-(2-phenylethyl)chromone derivatives from Chinese agarwood induced by artificial holing.
W. Li (2014)
10.1089/FPD.2013.1627
The mechanism of antimicrobial activity of sophoraflavanone B against methicillin-resistant Staphylococcus aureus.
MunSu-Hyun (2014)
10.1021/jm500853v
Synthesis, Structure–Activity Relationship Studies, and Antibacterial Evaluation of 4-Chromanones and Chalcones, as Well as Olympicin A and Derivatives
Li Feng (2014)
10.1016/j.bmcl.2014.03.071
The antibacterial properties of sulfur containing flavonoids.
L. G. Bahrin (2014)
10.1111/1348-0421.12150
Anti‐quorum sensing activity of Psidium guajava L. flavonoids against Chromobacterium violaceum and Pseudomonas aeruginosa PAO1
H. S. Vasavi (2014)
10.1590/S1517-83822014000100038
Newly-synthesized chalcones-inhibition of adherence and biofilm formation of methicillin-resistant Staphylococcus aureus
Dragana Božić (2014)
10.1080/14786419.2014.886205
Flavonoids from the halophyte Apocynum venetum and their antifouling activities against marine biofilm-derived bacteria
Na-Na Kong (2014)
10.1080/14786419.2014.947488
Flavonoids with antimicrobial activity from the stem bark of Commiphora pedunculata (Kotschy & Peyr.) Engl.
N. Tajuddeen (2014)
Antioxidant and antibacterial activities of flavonoid glycosides from Ficus exasperata Vahl‐Holl (moraceae
B. J. Taiwo (2014)
Green synthesis, characterization, antibacterial activity of heterocyclic compounds from chalcone on basis of in vitro and quantum chemistry calculation
S. A. Khan (2014)
10.1080/14786419.2015.1007976
One new flavonoid from Oroxylum indicum
Qing-Fei Fan (2015)
10.3390/molecules201018128
Phytochemical and Biological Investigation of Two Diplotaxis Species Growing in Tunisia: D. virgata & D. erucoides
N. Ben Salah (2015)
10.3390/molecules200712500
Constituents of Psoralea corylifolia Fruits and Their Effects on Methicillin-Resistant Staphylococcus aureus
Y. Cui (2015)
10.1186/s40064-015-1645-8
Antibacterial activity of nineteen selected natural products against multi-drug resistant Gram-negative phenotypes
A. Mbaveng (2015)
10.1016/J.PHYTOL.2015.08.012
Lemairones A and B: Two new antibacterial tetraflavonoids from the leaves of Zanthoxylum lemairei (Rutaceae)
Gabin Thierry M. Bitchagno (2015)
10.1016/j.apsb.2015.05.005
The antiviral and antimicrobial activities of licorice, a widely-used Chinese herb
L. Wang (2015)
10.1016/j.bmcl.2015.02.051
Streptococcus mutans sortase A inhibitory metabolites from the flowers of Sophora japonica.
Woo-Young Yang (2015)
10.1515/znc-2014-4195
Antibacterial, antifungal and antimycobacterial activities of some pyrazoline, hydrazone and chalcone derivatives
Begüm Evranos-Aksöz (2015)
10.3389/fphar.2015.00195
Acylated flavonol glycosides from Tagetes minuta with antibacterial activity
I. Shahzadi (2015)
10.2174/0929867321666140916113443
Antibacterial activities of flavonoids: structure-activity relationship and mechanism.
Yixi Xie (2015)
10.1515/chempap-2015-0113
Synthesis, biological evaluation, quantitative-SAR and docking studies of novel chalcone derivatives as antibacterial and antioxidant agents
Mohammad Sayed Alam (2015)
10.3109/13880209.2014.939765
Foetithiophenes C-F, thiophene derivatives from the roots of Ferula foetida
Mahsa Chitsazian-Yazdi (2015)
10.1021/np500735f
Structure and antimicrobial activity of phloroglucinol derivatives from Achyrocline satureioides.
C. Casero (2015)
10.1186/s12906-015-0580-0
Antibiotic additive and synergistic action of rutin, morin and quercetin against methicillin resistant Staphylococcus aureus
M. Amin (2015)
10.1089/fpd.2014.1923
In vitro Potential Effect of Morin in the Combination with β-Lactam Antibiotics Against Methicillin-Resistant Staphylococcus aureus.
S. Mun (2015)
10.1016/j.phytochem.2015.06.006
Flavonoids from Piper delineatum modulate quorum-sensing-regulated phenotypes in Vibrio harveyi.
A. J. Martín-Rodríguez (2015)
10.1016/j.phytochem.2015.02.022
Interconverting flavonostilbenes with antibacterial activity from Sophora alopecuroides.
C. Wan (2015)
10.1002/cbdv.201400181
Activities of Wogonin Analogs and Other Flavones against Flavobacterium columnare
Cheng-xia Tan (2015)
10.1007/s00253-015-6711-1
Antibacterial evaluation of flavonoid compounds against E. coli by microcalorimetry and chemometrics
Weijun Kong (2015)
officinarum Hance and synergism with ceftazidime. Phytomedicine
B. Evranos‐Aksöz (2015)
Phytochemical and biological investigation of two Diplotaxis species growing in Tunisia: D
N. B. Salah (2015)
Antibacterial activity of nineteen
B. T. Nagdjui (2015)
Flavonoids from Piper delineatum modulate
I. L. Bazzocchi (2015)
10.1016/j.jep.2016.02.011
Antibacterial constituents of Eremophila alternifolia: An Australian aboriginal traditional medicinal plant.
I. J. Biva (2016)
10.1186/s12866-016-0797-1
Synergistic effects of baicalein with cefotaxime against Klebsiella pneumoniae through inhibiting CTX-M-1 gene expression
Wenhui Cai (2016)
10.1186/s40360-016-0083-8
The synergy and mode of action of quercetin plus amoxicillin against amoxicillin-resistant Staphylococcus epidermidis
S. Siriwong (2016)
10.1007/s00044-016-1685-9
In vitro activity of five flavones from Scutellaria baicalensisin combination with Cefazolin against methicillin resistant Staphylococcus aureus (MRSA)
Fan Qiu (2016)
10.1080/14786419.2015.1041138
A novel antimicrobial flavonoid from the stem bark of Commiphora pedunculata (Kotschy & Peyr.) Engl.
N. Tajuddeen (2016)
10.1186/s40064-016-3463-z
Interval-valued fuzzy $$\phi$$ϕ-tolerance competition graphs
Tarasankar Pramanik (2016)
10.1007/s11356-016-6532-5
Antibiofouling potential of quercetin compound from marine-derived actinobacterium, Streptomyces fradiae PE7 and its characterization
V. Gopikrishnan (2016)
10.2147/DDDT.S97221
Baicalein attenuates the quorum sensing-controlled virulence factors of Pseudomonas aeruginosa and relieves the inflammatory response in P. aeruginosa-infected macrophages by downregulating the MAPK and NFκB signal-transduction pathways
Jing Luo (2016)
10.1016/j.micpath.2016.02.009
Breakthroughs in bacterial resistance mechanisms and the potential ways to combat them.
B. Khameneh (2016)
10.1016/j.fitote.2016.04.022
Carboxymethyl flavonoids and a chromone with antimicrobial activity from Selaginella moellendorffii Hieron.
Zhenxing Zou (2016)
10.1016/j.fitote.2015.12.022
Ericoside, a new antibacterial biflavonoid from Erica mannii (Ericaceae).
G. Bitchagno (2016)
10.1515/biolog-2016-0073
Efflux pump inhibitory activity of flavonoids isolated from Alpinia calcarata against methicillin-resistant Staphylococcus aureus
Harmandeep Kaur Randhawa (2016)
10.1111/jam.13048
Antibacterial activity and proposed action mechanism of a new class of synthetic tricyclic flavonoids
C. Babii (2016)
10.1080/14786419.2015.1104673
Antimicrobial flavonoids isolated from Indian medicinal plant Scutellaria oblonga inhibit biofilms formed by common food pathogens
N. Rajendran (2016)
10.1371/journal.pone.0153468
Baicalein Inhibits Staphylococcus aureus Biofilm Formation and the Quorum Sensing System In Vitro
Y. Chen (2016)
10.3390/molecules21050608
Antimicrobial Activity of Xanthohumol and Its Selected Structural Analogues
M. Stompor (2016)
10.1186/s40064-016-2599-1
Antibacterial activities and structure–activity relationships of a panel of 48 compounds from Kenyan plants against multidrug resistant phenotypes
L. K. Omosa (2016)
10.3109/13880209.2015.1103755
C-Geranylated flavonoids from Paulownia tomentosa fruits with antimicrobial potential and synergistic activity with antibiotics
A. Navrátilová (2016)
DRUG-DRUG INTERACTIONS BETWEEN GRISEOFULVIN AND A NEW PRENYLATED CHALCONE FROM ELATOSTEMA PARASITICUM AND ITS ANTIBACTERIAL ACTIVITY NORTRIPTYLINE AT BINDING SITES OF BOVINE SERUM ALBUMIN
Mariani (2016)
Antimicrobial and immunomodulatory activities of flavonol glycosides isolated from Atriplex halimus L. Herb
Mona El-Aasr (2016)
10.1016/j.micres.2016.12.003
Phytochemicals for human disease: An update on plant-derived compounds antibacterial activity.
R. Barbieri (2017)
10.1016/J.MOLSTRUC.2016.09.022
Synthesis, XRD crystal structure, spectroscopic characterization (FT-IR, 1H and 13C NMR), DFT studies, chemical reactivity and bond dissociation energy studies using molecular dynamics simulations and evaluation of antimicrobial and antioxidant activities of a novel chalcone derivative, (E)-1-(4-bro
D. A. Zainuri (2017)
10.1016/J.FOODCONT.2017.03.004
Rutin inhibits mono and multi-species biofilm formation by foodborne drug resistant Escherichia coli and Staphylococcus aureus
N. A. Al-Shabib (2017)
10.1016/j.micpath.2017.03.033
Inhibitory effects of flavonoids on biofilm formation by Staphylococcus aureus that overexpresses efflux protein genes.
L. A. Lopes (2017)
10.1111/cbdd.12839
Design, synthesis, and biological evaluation of chrysin derivatives as potential FabH inhibitors
H. Li (2017)
10.1039/C6RA28061G
C-7 modified flavonoids as novel tyrosyl-tRNA synthetase inhibitors
Zhu-Ping Xiao (2017)
10.1186/s13104-017-2441-z
Cytotoxicity, antimicrobial and antioxidant activity of eight compounds isolated from Entada abyssinica (Fabaceae)
J. P. Dzoyem (2017)
10.3390/molecules22040608
Structure-Activity and Lipophilicity Relationships of Selected Antibacterial Natural Flavones and Flavanones of Chilean Flora
J. Echeverría (2017)
10.1016/J.SAJB.2016.12.019
Flavonoids from Maytenus buchananii as potential cholera chemotherapeutic agents
Perrin Lanversin Foning Tebou (2017)
10.1007/s00044-017-1837-6
Synthesis and evaluation of antibacterial and antifungal activities of 4-thiazolidinones and 2-azetidinones derivatives from chalcone
N. Patel (2017)
10.3389/fphar.2017.00379
Rutin Inhibits Streptococcus suis Biofilm Formation by Affecting CPS Biosynthesis
S. Wang (2017)
10.1016/j.archoralbio.2016.08.030
Review of flavonoids: A diverse group of natural compounds with anti-Candida albicans activity in vitro.
Dalia Seleem (2017)
10.1080/14786419.2016.1217201
Antibacterial activity of fractions from three Chumash medicinal plant extracts and in vitro inhibition of the enzyme enoyl reductase by the flavonoid jaceosidin
Brittany J. Allison (2017)
Antibacterial activity of flavonoids and their structure–activity relationship: An update review
F Farhadi (2019)
Antibiofouling potential of quercetin compound from marine-derived actinobacterium, Streptomyces fradiae PE7and its characterization. Environmental Science and Pollution Research
tual screening for novel quorum sensing inhibitors to eradicate biofilm formation of Pseudomonas aeruginosa
L. Cao



This paper is referenced by
10.3390/pharmaceutics13030402
Ballodiolic Acid A and B: Two New ROS, (•OH), (ONOO−) Scavenging and Potent Antimicrobial Constituents Isolated from Ballota pseudodictamnus (L.) Benth.
Fozia (2021)
10.3390/molecules26082331
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Adriana Silva (2021)
10.1016/j.heliyon.2020.e05814
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Md Rabi-Ul Islam (2021)
10.1021/acsomega.1c00103
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B. Shankar (2021)
10.3389/fcimb.2021.709749
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Andrés González (2021)
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Andrhea Lozada (2021)
Assessment of the antibacterial effect of
V. Dougnon (2021)
10.3920/JIFF2020.0113
Insects as a source of phenolic compounds and potential health benefits
M. C. Nino (2021)
10.1016/J.TIFS.2021.06.020
Black chokeberry (Aronia melanocarpa) extracts in terms of geroprotector criteria
Elena Y. Platonova (2021)
10.1016/J.TIFS.2021.03.030
Food flavonols: Nutraceuticals with complex health benefits and functionalities
D. Barreca (2021)
10.1002/biof.1710
Luteolin, inflammation and cancer: Special emphasis on gut microbiota
L. Franza (2021)
10.3390/molecules26123650
LC-MS/MS Screening of Phenolic Compounds in Wild and Cultivated Grapes Vitis amurensis Rupr.
M. Razgonova (2021)
10.1016/j.foodcont.2020.107745
The effect of natural antimicrobials against Campylobacter spp. and its similarities to Salmonella spp, Listeria spp., Escherichia coli, Vibrio spp., Clostridium spp. and Staphylococcus spp
Igori Balta (2021)
10.1186/s12301-020-00111-z
Deep insights into urinary tract infections and effective natural remedies
B. S. Fazly Bazzaz (2021)
10.1007/978-981-16-0223-8_12
Encountering the Antibiotic Resistance by Bioactive Components and Therapies: Probiotics, Phytochemicals and Phages
S. A. Rasool (2021)
10.1016/J.APSUSC.2021.149774
Carbon quantum dots derived from waste acorn cups and its application as an ultraviolet absorbent for polyvinyl alcohol film
Xu Nan (2021)
10.3390/pathogens10040494
Evaluation of Essential Oils and Extracts of Rose Geranium and Rose Petals as Natural Preservatives in Terms of Toxicity, Antimicrobial, and Antiviral Activity
Chrysa Androutsopoulou (2021)
10.36547/AE.2021.3.1.20-26
Evaluation of Moringa Peregrina (Forsk) Fiori, Leaf and Seed Extract Against Multidrug Resistant Strains of Bacteria and Fungus of Clinical Origin
S. Albalawi (2021)
10.3390/ani11041039
The Use of Chinese Skullcap (Scutellaria baicalensis) and Its Extracts for Sustainable Animal Production
Baishuang Yin (2021)
10.1021/acsomega.1c00655
Hydroxyl Groups on Annular Ring-B Dictate the Affinities of Flavonol–CCL2 Chemokine Binding Interactions
Nidhi Joshi (2021)
10.1186/s43141-021-00200-8
Molecular identification and antimicrobial activities of some wild Egyptian mushrooms: Bjerkandera adusta as a promising source of bioactive antimicrobial phenolic compounds.
E. Soliman (2021)
10.1088/1755-1315/743/1/012065
Antibacterial activities of Etlingera flexuosa AD Poulsen (Zingiberaceae) from Central Sulawesi on Staphylococcus aureus and Escherichia coli
R. Pitopang (2021)
10.3390/cancers13010130
Flavonoids Targeting HIF-1: Implications on Cancer Metabolism
M. Samec (2021)
10.1021/acsomega.0c06156
Analysis of Conformational, Structural, Magnetic, and Electronic Properties Related to Antioxidant Activity: Revisiting Flavan, Anthocyanidin, Flavanone, Flavonol, Isoflavone, Flavone, and Flavan-3-ol
Sergio Antônio de Souza Farias (2021)
10.3390/antiox10020188
The Interactions between Polyphenols and Microorganisms, Especially Gut Microbiota
M. Makarewicz (2021)
10.1016/j.radphyschem.2020.109175
Influence of gamma irradiation on the biological properties of Asplenium scolopendrium L. hydroalcoholic extracts
I. Fierascu (2021)
10.1016/J.SAJB.2021.05.021
Bioactive compounds from Euphorbia schimperiana with cytotoxic and antibacterial activities
Salha M Aljubiri (2021)
10.3390/molecules26072048
Isolation, Structure Elucidation and In Silico Prediction of Potential Drug-Like Flavonoids from Onosma chitralicum Targeted towards Functionally Important Proteins of Drug-Resistant Bad Bugs
Shakeel Ahmad Khan (2021)
10.3390/molecules26123634
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V. Grumezescu (2021)
10.1007/s10681-020-02638-2
Construction of a linkage map flanking the I locus controlling dominant white bulb color and analysis of differentially expressed genes between dominant white and red bulbs in onion (Allium cepa L.)
Inho Seo (2020)
10.1016/j.foodres.2020.109134
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M. Lindén (2020)
10.3390/plants9080926
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