Online citations, reference lists, and bibliographies.

Quadrupole Time-of-flight Versus Triple-quadrupole Mass Spectrometry For The Determination Of Non-steroidal Antiinflammatory Drugs In Surface Water By Liquid Chromatography/tandem Mass Spectrometry.

S. Marchese, A. Gentili, D. Perret, Giuseppe D' Ascenzo, F. Pastori
Published 2003 · Chemistry, Medicine
Cite This
Download PDF
Analyze on Scholarcy
Share
A triple-quadrupole instrument and a hybrid quadrupole/time-of-flight (TOF) mass spectrometer were compared for the determination of pharmaceutical compounds in water samples. The drugs investigated were the analgesics Ibuprofen, Fenoprofen, Ketoprofen, Naproxen, and Diclofenac. The recently introduced Q2-pulsing function, which enhances the transmission of fragment ions of a selected m/z window from the collision cell into the TOF analyzer, improved the sensitivity of product ion scans on the quadrupole/TOF instrument. The selectivity is much better on quadrupole/TOF systems than on triple quadrupoles because the high resolving power of the reflectron-TOF mass analyzer permits high-accuracy fragment ion selection. This minimizes interferences from environmental matrices and allows acquisition of full spectra for selected analytes with better signal-to-noise characteristics than comparable spectra obtained with a scanned quadrupole. The qualitative information obtained (mass accuracy, resolution and full-scan spectra) by hybrid quadrupole/TOF mass spectrometry allows a more certain identification of analytes in environmental matrices at trace levels. Sample enrichment of water samples was achieved by a solid-phase extraction procedure. Average recoveries for loading 1 L of samples varied from 88 to 110%, and the quantification limits were less than 1.2 ng/L for the triple-quadrupole instrument (in MRM mode) and less than 3 ng/L for the quadrupole/TOF instrument.



This paper is referenced by
10.5985/JEC.18.511
Automated Analysis of Non-steroidal Anti-inflammatory Drugs in Environmental Water by On-line In-tube Solid-phase Microextraction Coupled with Liquid Chromatography-Tandem Mass Spectrometry
Kurie Ohcho (2008)
10.1007/s11356-014-2885-9
Survey of the occurrence of pharmaceuticals in Spanish finished drinking waters
M. Boleda (2014)
10.1016/J.CHERD.2016.11.024
Removal of naproxen from water by ionic liquid-modified polymer sorbents
Karolina Wieszczycka (2017)
10.1016/J.TRAC.2013.05.007
Fate of drugs during wastewater treatment
Bruce Petrie (2013)
10.1080/03067319.2015.1046059
Occurrence of non-steroidal anti-inflammatory drugs in surface waters of Central Italy by liquid chromatography–tandem mass spectrometry
Lucia Mainero Rocca (2015)
10.1039/b819464e
JEM spotlight: recent advances in analysis of pharmaceuticals in the aquatic environment.
Charles S Wong (2009)
10.1002/mas.20332
Fragmentation of toxicologically relevant drugs in positive-ion liquid chromatography-tandem mass spectrometry.
Wilfried M. A. Niessen (2011)
10.1002/jssc.201101099
Pre-concentration of non-steroidal anti-inflammatory drugs in water using dispersive liquid-liquid and single-drop microextraction with high-performance liquid chromatography.
Ali Sarafraz-yazdi (2012)
10.1016/J.TRAC.2014.08.003
Investigation of pharmaceuticals and illicit drugs in waters by liquid chromatography-high-resolution mass spectrometry
Félix Hernández (2014)
10.1016/j.chroma.2008.09.093
Chemometric assisted solid-phase microextraction for the determination of anti-inflammatory and antiepileptic drugs in river water by liquid chromatography-diode array detection.
L. Vera-Candioti (2008)
10.1007/s00344-007-9023-6
Hormone Profiling by LC-QToF-MS/MS in Dormant Macadamia integrifolia: Correlations with Abnormal Vertical Growth
Andrew T. Fletcher (2007)
10.1007/978-3-540-36253-1_9
Liquid Chromatography—Mass Spectrometry Methods for Analysis of Endocrine-Disrupting Chemicals in Wastewaters
C. Postigo (2009)
10.1080/10643389.2019.1705723
A review of extraction methods for the analysis of pharmaceuticals in environmental waters
Kevin D. Daniels (2020)
Proteomic and metabolomic studies on milk during bovine mastitis
Rozaihan Mansor (2012)
10.1016/j.jpba.2015.12.055
Comparison of a triple-quadrupole and a quadrupole time-of-flight mass analyzer to quantify 16 opioids in human plasma.
J. Viaene (2016)
Pharmaceuticals in sewage: Sources, concentrations and degradation
A. Y. C. Tong (2013)
10.1002/rcm.4336
Rapid separation and identification of major constituents in Pseudolarix kaempferi by ultra-performance liquid chromatography coupled with electrospray and quadrupole time-of-flight tandem mass spectrometry.
Xia Ye (2009)
10.1016/j.chroma.2008.11.014
Serial mixed-mode cation- and anion-exchange solid-phase extraction for separation of basic, neutral and acidic pharmaceuticals in wastewater and analysis by high-performance liquid chromatography-quadrupole time-of-flight mass spectrometry.
Martin Lavén (2009)
10.1016/j.jpba.2011.03.014
Simultaneous determination of non-steroidal anti-inflammatory drugs in river water samples by liquid chromatography-tandem mass spectrometry using molecularly imprinted polymers as a pretreatment column.
Kaori Hoshina (2011)
Enhancing the removal of a diverse range of hazardous chemicals from wastewaters
Bruce J. Petrie (2014)
10.1007/s11419-010-0096-8
Determination of nonsteroidal anti-inflammatory drugs in human plasma by LC-MS-MS with a hydrophilic polymer column
Xiao-Pen Lee (2010)
10.1002/mas.20359
Fragmentation of toxicologically relevant drugs in negative-ion liquid chromatography-tandem mass spectrometry.
Wilfried M. A. Niessen (2012)
10.1515/pthp-2018-0027
Investigation of Drug-Packaging Interactions with Mass Spectroscopy Detectors: A Meta-Synthesis of the Literature
Camille Fauchere (2019)
10.1021/pr4004213
Targeted quantitative proteomics for the analysis of 14 UGT1As and -2Bs in human liver using NanoUPLC-MS/MS with selected reaction monitoring.
John K Fallon (2013)
Techniques and Methods: Detection of antibiotics in environmental samples
Debdeep Dasgupta (2015)
10.1186/1477-5956-4-15
Phosphoprotein analysis: from proteins to proteomes
F. Delom (2006)
10.3724/SP.J.1123.2010.00435
[Applications of chromatography-mass spectrometry for the analysis of emerging organic pollutants].
Xiaofeng Zhao (2010)
Semantic Scholar Logo Some data provided by SemanticScholar