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Mammalian Gastrointestinal Tract Parameters Modulating The Integrity, Surface Properties, And Absorption Of Food‐relevant Nanomaterials
Susann Bellmann, D. Carlander, A. Fasano, D. Momcilović, J. Scimeca, W. Waldman, L. Gombau, Lyubov Tsytsikova, Richard Canady, Dora I. A. Pereira, D. E. Lefebvre
Published 2015 · Materials Science, Medicine
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Many natural chemicals in food are in the nanometer size range, and the selective uptake of nutrients with nanoscale dimensions by the gastrointestinal (GI) tract is a normal physiological process. Novel engineered nanomaterials (NMs) can bring various benefits to food, e.g., enhancing nutrition. Assessing potential risks requires an understanding of the stability of these entities in the GI lumen, and an understanding of whether or not they can be absorbed and thus become systemically available. Data are emerging on the mammalian in vivo absorption of engineered NMs composed of chemicals with a range of properties, including metal, mineral, biochemical macromolecules, and lipid‐based entities. In vitro and in silico fluid incubation data has also provided some evidence of changes in particle stability, aggregation, and surface properties following interaction with luminal factors present in the GI tract. The variables include physical forces, osmotic concentration, pH, digestive enzymes, other food, and endogenous biochemicals, and commensal microbes. Further research is required to fill remaining data gaps on the effects of these parameters on NM integrity, physicochemical properties, and GI absorption. Knowledge of the most influential luminal parameters will be essential when developing models of the GI tract to quantify the percent absorption of food‐relevant engineered NMs for risk assessment. WIREs Nanomed Nanobiotechnol 2015, 7:609–622. doi: 10.1002/wnan.1333 For further resources related to this article, please visit the WIREs website.
This paper references
Presence of nano-sized silica during in vitro digestion of foods containing silica as a food additive.
R. Peters (2012)
Colloidal stability of aqueous nanofibrillated cellulose dispersions.
Andreas B. Fall (2011)
Tight Junctions. 2nd ed
M Cereijido (2001)
The role of bile salts in digestion.
J. Maldonado-Valderrama (2011)
The gut microbiota and the metabolic health of the host
S. Joyce (2014)
The potential of asymmetric flow field-flow fractionation hyphenated to multiple detectors for the quantification and size estimation of silica nanoparticles in a food matrix
J. Heroult (2014)
Methods to Evaluate Uptake of Engineered Nanomaterials by the Alimentary Tract
Heather M. Alger (2014)
Adsorption of bile salts to particles allows penetration of intestinal mucus
A. Macierzanka (2011)
Volume 7, September/October 2015 © 2015 The Authors. WIREs Nanomedicine and Nanobiotechnology published by Wiley Periodicals, Inc
T Yatsunenko (2012)
Protein analysis by time-resolved measurements with an electro-switchable DNA chip
A. Langer (2013)
Engineered Nanoscale Food Ingredients: Evaluation of Current Knowledge on Material Characteristics Relevant to Uptake from the Gastrointestinal Tract
R. Yada (2014)
Upper Gastrointestinal pH in Seventy-Nine Healthy, Elderly, North American Men and Women
T. Russell (2004)
Nanoparticles as potential oral delivery systems of proteins and vaccines: a mechanistic approach.
A. des Rieux (2006)
WIREs Nanomedicine and Nanobiotechnology Nanomaterial gastrointestinal absorption
The role of porous nanostructure in controlling lipase-mediated digestion of lipid loaded into silica particles.
P. Joyce (2014)
Molecular targeting of liposomal nano-particles to lymphatic system.
N. Cuong (2011)
Measurement Methods to Detect, Characterize, and Quantify Engineered Nanomaterials in Foods
G. Singh (2014)
Mucins in the mucosal barrier to infection
S. Lindén (2008)
[Persorption of microparticles].
G. Volkheimer (1993)
Distribution of silver in rats following 28 days of repeated oral exposure to silver nanoparticles or silver acetate
K. Loeschner (2010)
Minimal intestinal epithelial cell toxicity in response to short- and long-term food-relevant inorganic nanoparticle exposure.
christie Mccracken (2013)
Biorelevant media simulating fed state intestinal fluids: colloid phase characterization and impact on solubilization capacity.
Karen Kleberg (2010)
Studies of the pH gradient across the mucus on rat gastric mucosa in vivo and across mucus on human gastric mucosa in vitro.
I. Ross (1982)
Intestinal fluid volumes and transit of dosage forms as assessed by magnetic resonance imaging
C. Schiller (2005)
Alterations in intestinal permeability
M. C. Arrieta (2006)
pH of the microclimate lining human gastric and duodenal mucosa in vivo. Studies in control subjects and in duodenal ulcer patients.
E. Quigley (1987)
Distribution of thiolated mucoadhesive nanoparticles on intestinal mucosa.
S. Dünnhaupt (2011)
A porous defense: the leaky epithelial barrier in intestinal disease
Daniel R. Clayburgh (2004)
Studies in control subjects and in duodenal ulcer patients
Paracellular porosity and pore size of the human intestinal epithelium in tissue and cell culture models.
Johanna Linnankoski (2010)
Sub-chronic toxicity study in rats orally exposed to nanostructured silica
M. van der Zande (2013)
The Oral Absorption of Micro- and Nanoparticulates: Neither Exceptional Nor Unusual
A. Florence (2004)
Measurement Methods to Evaluate Engineered Nanomaterial Release from Food Contact Materials
G. Noonan (2014)
Apical membrane receptors on intestinal M cells: potential targets for vaccine delivery.
D. Brayden (2004)
The comparative physiology of food deprivation: from feast to famine.
T. Wang (2006)
The oral microbiota: living with a permanent guest.
M. Ávila (2009)
An experimental study on the aggregation of TiO2 nanoparticles under environmentally relevant conditions.
Marina Belen Romanello (2013)
A standardised static in vitro digestion method suitable for food - an international consensus.
M. Minekus (2014)
TEMPO-oxidized cellulose nanofibers.
A. Isogai (2011)
Titan-Blutspiegel vor und nach Belastungsversuchen mit Titandioxid
J. Böckmann (2000)
Caco-2 intestinal epithelial cells absorb soybean ferritin by mu2 (AP2)-dependent endocytosis.
Carol D San Martin (2008)
Influence of Material Properties on TiO2 Nanoparticle Agglomeration
Dongxu Zhou (2013)
Comparative absorption, distribution, and excretion of titanium dioxide and zinc oxide nanoparticles after repeated oral administration
W. Cho (2012)
Manipulating Digestion with Foods Designed to Change the Physical Characteristics of Digesta
R. Lentle (2010)
Novel insights into the risk assessment of the nanomaterial synthetic amorphous silica, additive E551, in food
P. C. E. van Kesteren (2015)
Gastrointestinal persorption and tissue distribution of differently sized colloidal gold nanoparticles.
J. F. Hillyer (2001)
Yersinia pseudotuberculosis induces transcytosis of nanoparticles across human intestinal villus epithelium via invasin-dependent macropinocytosis
E. Ragnarsson (2008)
Physicochemical properties and in vitro intestinal permeability properties and intestinal cell toxicity of silica particles, performed in simulated gastrointestinal fluids.
K. Sakai-Kato (2014)
Nanoemulsion-based oral delivery systems for lipophilic bioactive components: nutraceuticals and pharmaceuticals.
D. J. Mcclements (2013)
Light microscopic observation on luminally administered dyes, dextrans, nanospheres and microspheres in the pre-epithelial mucus gel layer of the rat distal colon
L. Szentkuti (1997)
Intestinal microbiota in health and disease
Christina Tobin Kåhrström (2016)
Particle uptake by Peyer’s patches: a pathway for drug and vaccine delivery
Monjed Shakweh (2004)
In vitro lipolysis tests on lipid nanoparticles: comparison between lipase/co-lipase and pancreatic extract
V. Jannin (2015)
The targeting of surface modified silica nanoparticles to inflamed tissue in experimental colitis.
B. Moulari (2008)
Lamellar structures of MUC2-rich mucin: a potential role in governing the barrier and lubricating functions of intestinal mucus.
A. Round (2012)
Organizer and regulatory role of colonic isolated lymphoid follicles in inflammation.
M. Constantinovits (2012)
Food grade titanium dioxide disrupts intestinal brush border microvilli in vitro independent of sedimentation
J. Faust (2014)
Titanium dioxide (rutile) particle uptake from the rat GI tract and translocation to systemic organs after oral administration
P. U. Jani (1994)
Fine control over the size of surfactant-polyelectrolyte nanoparticles by hydrodynamic flow focusing.
G. Tresset (2013)
Transport of two metal oxide nanoparticles in saturated granular porous media: role of water chemistry and particle coating.
A. R. Petosa (2012)
Stabilization of TiO2 nanoparticles in complex medium through a pH adjustment protocol.
C. Guiot (2013)
associated lymphoid tissue
A Fasano (1996)
Titanium dioxide nanoparticle impact and translocation through ex vivo, in vivo and in vitro gut epithelia
E. Brun (2013)
Alterations in physiology and anatomy during pregnancy.
E. K. Tan (2013)
Origin and fate of dietary nanoparticles and microparticles in the gastrointestinal tract.
J. Powell (2010)
Lactic acid bacteria as reducing and capping agent for the fast and efficient production of silver nanoparticles
L. Sintubin (2009)
Changes in macromolecular transport appear early in Caco-2 cells infected with a human rotavirus
A. Catto-Smith (2008)
Characterisation of inorganic microparticles in pigment cells of human gut associated lymphoid tissue.
J. Powell (1996)
Influence of surface potential on aggregation and transport of titania nanoparticles.
K. Guzmán (2006)
Study of enzymatic degradation and water absorption of composites carboxymethyl cellulose and poly (ϵ-caprolactone) containing SiO2nanoparticle by cellulase
M. Alikarami (2013)
Volatile release and structural stability of β-lactoglobulin primary and multilayer emulsions under simulated oral conditions.
O. Benjamin (2013)
Intestinal barrier function in health and gastrointestinal disease
M. Camilleri (2012)
Vascular distribution of nanomaterials.
P. Stapleton (2014)
Pathophysiology of gastrointestinal mucosal permeability
K. Crissinger (1990)
Surface area of the digestive tract – revisited
H. Helander (2014)
Clay minerals and layered double hydroxides for novel biological applications
Jin-Ho Choy (2007)
Dietary fiber: the effect of particle size of wheat bran on colonic function in young adult men.
S. Heller (1980)
F. Alessio (2011)
Aggregation and transport of nano-TiO2 in saturated porous media: effects of pH, surfactants and flow velocity.
I. G. Godinez (2011)
Assay of gastricsin and individual pepsins in human gastric juice.
A. Jones (1993)
The use of SmartPill for gastric monitoring
W. Hasler (2014)
L. González-Mariscal (2014)
WIREs Nanomedicine and Nanobiotechnology Nanomaterial gastrointestinal absorption Studies in control subjects and in duodenal ulcer patients
Zonulin and its regulation of intestinal barrier function: the biological door to inflammation, autoimmunity, and cancer.
A. Fasano (2011)
Microfold (M) cells: important immunosurveillance posts in the intestinal epithelium
N. A. Mabbott (2013)
Measurement Methods for the Oral Uptake of Engineered Nanomaterials from Human Dietary Sources: Summary and Outlook
C. Szakal (2014)
Utility of models of the gastrointestinal tract for assessment of the digestion and absorption of engineered nanomaterials released from food matrices
D. E. Lefebvre (2015)
Effects of glutamine supplements and radiochemotherapy on systemic immune and gut barrier function in patients with advanced esophageal cancer.
S. Yoshida (1998)
Structure of rice starch granules in nanometre scale as revealed by atomic force microscopy.
T. Ohtani (2000)
Molecular dynamics simulation of nanocolloidal amorphous silica particles: Part I.
S. Jenkins (2007)
The role of PEG on the stability in digestive fluids and in vivo fate of PEG-PLA nanoparticles following oral administration.
WIREs Nanomedicine and Nanobiotechnology
The Authors. WIREs Nanomedicine and Nanobiotechnology published by Wiley Periodicals, Inc. 621 Advanced Review wires
T Yatsunenko (2015)
Cell uptake and oral absorption of titanium dioxide nanoparticles.
G. Janer (2014)
Edible lipid nanoparticles: digestion, absorption, and potential toxicity.
D. J. Mcclements (2013)
Human gut microbiome viewed across age and geography
T. Yatsunenko (2012)
Dental plaque biofilms: communities, conflict and control.
Philip D. Marsh (2011)
pH‐Profile and regional transit times of the normal gut measured by a radiotelemetry device
J. Fallingborg (1989)
Absorption of iron from ferritin is independent of heme iron and ferrous salts in women and rat intestinal segments.
Elizabeth C. Theil (2012)
Mucus penetrating nanoparticles: biophysical tool and method of drug and gene delivery.
Laura M Ensign (2012)
Functionalized bacterial cellulose derivatives and nanocomposites.
Weili Hu (2014)
How Does Plant Cell Wall Nanoscale Architecture Correlate with Enzymatic Digestibility?
Shi-You Ding (2012)
The adherent gastrointestinal mucus gel layer: thickness and physical state in vivo.
C. Atuma (2001)
Toxicity and genotoxicity of nano-SiO2 on human epithelial intestinal HT-29 cell line.
J. Sergent (2012)
Evolution: Bacterial endocytosis uncovered
A. Jermy (2010)
Leaky Gut and Autoimmune Diseases
A. Fasano (2011)
Regulated portals of entry into the cell
S. Conner (2003)
Xylan as limiting factor in enzymatic hydrolysis of nanocellulose.
P. Penttilä (2013)
M cells in Peyer's patches of the intestine.
A. Gebert (1996)
Models for oral uptake of nanoparticles in consumer products
E. Fröhlich (2012)
Caco-2 Cell Acquisition of Dietary Iron(III) Invokes a Nanoparticulate Endocytic Pathway
Dora I. A. Pereira (2013)
Characterising the behaviour of poorly water soluble drugs in the intestine: application of biorelevant media for solubility, dissolution and transport studies
Karen Kleberg (2010)
[Blood titanium levels before and after oral administration titanium dioxide].
J. Boeckmann (2000)
Barrier properties of mucus.
Richard A. Cone (2009)
Light microscopical observations on luminally administered dyes, dextrans, nanospheres and microspheres in the pre-epithelial mucus gel layer of the rat distal colon
L. Szentkuti (1997)
Physicochemical factors that affect metal and metal oxide nanoparticle passage across epithelial barriers.
A. Elder (2009)
Lectin-modified solid lipid nanoparticles as carriers for oral administration of insulin.
N. Zhang (2006)
Transport of chitosan-DNA nanoparticles in human intestinal M-cell model versus normal intestinal enterocytes.
I. Kadiyala (2010)
Molecular dynamics simulation of nanocolloidal amorphous silica particles: part III.
S. Jenkins (2009)
Medical physiology : a cellular and molecular approach
W. Boron (2002)
Irreversible adsorption-driven assembly of nanoparticles at fluid interfaces revealed by a dynamic surface tension probe.
N. Bizmark (2014)
How bile acids confer gut mucosal protection against bacteria.
A. Hofmann (2006)
Approaches to the safety assessment of engineered nanomaterials (ENM) in food.
A. Cockburn (2012)
Exploring uptake mechanisms of oral nanomedicines using multimodal nonlinear optical microscopy.
N. Garrett (2012)
Measurement of nanomaterials in foods: integrative consideration of challenges and future prospects.
C. Szakal (2014)
Oral delivery of proteins by biodegradable nanoparticles.
S. Bakhru (2013)
The two mucus layers of colon are organized by the MUC2 mucin, whereas the outer layer is a legislator of host–microbial interactions
M. Johansson (2010)
This paper is referenced by
The impact of polar fraction of the fine particulate matter on redox responses in different rat tissues
Joaquim de Paula Ribeiro (2019)
Food additives can act as triggering factors in celiac disease: Current knowledge based on a critical review of the literature
C. Mancuso (2019)
Recent advances in oral delivery of biologics: nanomedicine and physical modes of delivery
D. Vllasaliu (2018)
Structural and Functional Organization of the Gastrointestinal Tract
M. Welcome (2018)
Silica Nanoparticles Provoke Cell Death Independent of p53 and BAX in Human Colon Cancer Cells
Susanne Fritsch-Decker (2019)
Critical assessment of toxicological effects of ingested nanoparticles
christie Mccracken (2016)
Investigating the hazards posed by pristine and modified copper nanomaterials using in vitro screens combined with in vivo models
D. Pantano (2018)
Progress and future of in vitro models to study translocation of nanoparticles
H. Braakhuis (2015)
Exposure to Inorganic Nanoparticles: Routes of Entry, Immune Response, Biodistribution and In Vitro/In Vivo Toxicity Evaluation
Valeria De Matteis (2017)
Guidance on risk assessment of the application of nanoscience and nanotechnologies in the food and feed chain: Part 1, human and animal health
A. Hardy (2018)
Difficulties in establishing regulations for engineered nanomaterials and considerations for policy makers: avoiding an unbalance between benefits and risks
L. G. Garduño-Balderas (2015)
Composite nanocellulose-based hydrogels with spatially oriented degradation and retarded release of macromolecules.
C. A. Maestri (2020)
Exposure to Inorganic Nanoparticles: Routes of Entry, Immune Response, Biodistribution and In Vitro/In Vivo Toxicity Evaluation.
V. D. Matteis (2017)
The Role of the Food Matrix and Gastrointestinal Tract in the assessment of biological properties of ingested engineered nanomaterials (iENMs): State of the science and knowledge gaps.
D. J. Mcclements (2016)
Effects of food‐borne nanomaterials on gastrointestinal tissues and microbiota
H. Bouwmeester (2018)
Re‐evaluation of silicon dioxide (E 551) as a food additive
M. Younes (2018)
Prediction of Oral Absorption of Nanoparticles from Biorelevant Matrices Using a Combination of Physiologically Relevant In Vitro and Ex Vivo Models
J. Westerhout (2017)
Cytotoxicity of Nanoparticles Contained in Food on Intestinal Cells and the Gut Microbiota
E. E. Fröhlich (2016)
Role of Physicochemical Properties in Nanoparticle Toxicity
S. W. Shin (2015)
Is "nano safe to eat or not"? A review of the state-of-the art in soft engineered nanoparticle (sENP) formulation and delivery in foods.
X. Liu (2019)
Laparoscopic Inguinal Hernia Repair: Technical Details, Pitfalls and Current Results
F. Altıntoprak (2018)
Safety Assessment of Nanomaterials to Eyes: An Important but Neglected Issue
S. Zhu (2019)
Short-term biodistribution and clearance of intravenously administered silica nanoparticles
N. Waegeneers (2018)
Interaction between ingested engineered nanomaterials and the gastro-intestinal tract: in vitro toxicology aspects
Laurie Laloux (2017)
The gut barrier and the fate of engineered nanomaterials: a view from comparative physiology
M. V. D. Zande (2020)
Rol de la microbiota intestinal en el desarrollo del trastorno del espectro autista
Bonivento Ortiz (2019)
TiO2 Nanoparticles and Commensal Bacteria Alter Mucus Layer Thickness and Composition in a Gastrointestinal Tract Model.
Rhodesherdeline Limage (2020)
Impact du colorant alimentaire E171 et de nanoparticules de dioxyde de titane sur des modèles cellulaires, in vitro, d'épithélium intestinal
Marie Dorier (2016)
Understanding Delivery Routes and Operational Environments of Nanosystems
U. Chude-Okonkwo (2019)
Oral Administration of Nanoparticles-Based TB Drugs
J. Magalhães (2017)
Multilayer nanocapsules as a vehicle for release of bioactive compounds
Ana Cristina Pinheiro (2016)
Effects of Nanoparticles on Gastrointestinal Disorders and Therapy
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