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Synthesis And Cytotoxicity Of Arene-Ru Compounds Containing 4-Nitroaniline Or 2-Halogenated 4-Nitroaniline

An-liang Chen, F. Huang, Maolin Hu, Zhi-min Jin, Q. Miao, B. Tian
Published 2017 · Chemistry

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The compounds [(η6-p-cymene)RuCl2(4-nitroaniline)] and [(η6-p-cymene)RuCl2(2-halogen-4-nitroaniline)] were synthesized and characterized by various means. The [(η6-p-cymene)RuCl2(4-nitroaniline)] and [(η6-p-cymene)RuCl2(2-fluoro-4-nitroaniline)] compounds were determined by X-ray diffraction, appearing in a distorted piano-stool type of arrangement with similar bond lengths and angles around the ruthenium. The compounds exhibited moderate to strong in vitro cytotoxicity against A549 and MCF-7 human cancer cells. Substitution of heavy halogen atom on the ortho position of para-nitroaniline weakened the cytotoxicity against both of MCF-7 and A549, except the cases of fluorine substitution for hydrogen atom regarding A549 and bromine substitution for chlorine atom regarding MCF-7, which showed minor deviation.
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