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Recovery From Facial Paralysis Following Crush Injury Of The Facial Nerve In Hamsters: Differential Effects Of Gender And Androgen Exposure

K. J. Jones
Published 1993 · Biology, Medicine

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In recent studies, we have shown that administration of androgens to male hamsters enhances functional recovery from facial paralysis induced by facial nerve crush at the level of the stylomastoid foramen. Furthermore, we have established that the mechanism behind this enhancement of regeneration involves an acceleration of the rate of regeneration, without a shortening in the delay of sprout formation. From those studies, several unexpected findings of inherent sex differences emerged. First, intact (nongonadectomized) females have a faster facial nerve regeneration rate than males and, second, testosterone has a less dramatic effect on the rate of regeneration in females compared to males. In the present study, we explored these novel findings of sex differences in the response of motor neurons to injury. Adult intact female hamsters were subjected to right facial nerve crush axotomy at the level of stylomastoid foramen and either implanted with two or four silastic capsules containing 5 alpha-dihydrotestosterone, or sham-implanted for controls. A group of adult intact male hamsters was also subjected to right facial nerve crush axotomy. Animals were observed daily, beginning on Day 1 postoperatively and continuing throughout a 3-week recovery period for signs of functional recovery from facial paralysis. The average day of return of each of four behavioral components (semi-blink, blink reflex, full vibrissae movement, and complete recovery) was calculated for all four experimental groups. The results indicate that intact females recover functional return of movement following crush injury significantly faster than intact males. In contrast to our previous findings in male hamsters, administration of exogenous steroids does not accelerate recovery from facial paralysis in adult female hamsters.(ABSTRACT TRUNCATED AT 250 WORDS)

This paper is referenced by
Posttraumatic facial nerve regeneration in rabbits.
H. J. Z. R. Costa (2006)
The neurosteroid 3α,5α-THP has antiseizure and possible neuroprotective effects in an animal model of epilepsy
C. Frye (1995)
Mechanisms and significance of nuclear receptor auto- and cross-regulation.
P. Bagamasbad (2011)
Females remyelinate more efficiently than males following demyelination in the aged but not young adult CNS
W. Li (2006)
Longitudinal study of risk for facial nerve injury in mandibular condyle fracture surgery: marginal mandibular branch-traversing classification of percutaneous approaches
T. Imai (2019)
Agmatine treatment and vein graft reconstruction enhance recovery after experimental facial nerve injury
L. Berenholz (2005)
Gonadal Steroids in Regeneration and Repair of Neuromuscular Systems
Eileen M. Foecking (2015)
Open reduction and internal fixation of mandibular angle fractures using temporary Kirschner wire fixation.
A. Perry (2012)
Molecular Changes at the Post-Synapse and Improved Motor Function Suggest Accelerated Recovery with SARM Treatment in an Androgen-Depleted Animal Model of Nerve Injury
John Bryant (2017)
Sex Steroids and the Brain: Lessons from Animal Studies
J. Chowen (2000)
Experimental study on the influence of facial muscle activity on the facial mesostructure bones in rabbits.
Andre Ricardo Mateus (2008)
Androgen regulates neuritin mRNA levels in an in vivo model of steroid-enhanced peripheral nerve regeneration.
K. Fargo (2008)
Anatomical but not functional recovery from a sciatic nerve crush is enhanced by treatment with testosterone.
R. Swallow (1999)
Gonadal hormones as promoters of structural synaptic plasticity: Cellular mechanisms
L. García-segura (1994)
Chemotherapy-Induced Neuropathic Pain
R. Raffa (2012)
Neuroprotective actions of androgens on motoneurons
K. Fargo (2009)
Sex-related differences in cisplatin-induced neuropathy in rats.
T. Wongtawatchai (2009)
Androgen Receptor Overexpression Is Neuroprotective in Experimental Stroke
P. Ayala (2011)
Evaluation of the systemic use of riluzole in post-traumatic facial nerve regeneration: experimental study in rabbits
H. J. Z. R. Costa (2007)
Effects of electrical stimulation and gonadal steroids on rat facial nerve regenerative properties.
N. Sharma (2009)
Sex differences in androgen receptor mRNA levels and regulation in hamster facial motoneurons.
S. Drengler (1996)
Standardization of techniques used in facial nerve section and facial movement evaluation in rats.
Simone Damasceno de Faria (2006)
Hyperbaric oxygen versus steroid in facial nerve injury: an experimental animal study.
S. Toros (2013)
Influência do AMP cíclico na regeneração do nervo facial em ratos
A. Borin (2008)
Influence of cyclic AMP on facial nerve regeneration in rats.
A. Borin (2008)
Androgenic Enhancement of Motor Neuron Regeneration
K. Jones (1994)
Regeneração pós-traumática do nervo facial em coelhos
H. J. Z. R. Costa (2006)
The Role of BDNF in Peripheral Nerve Regeneration: Activity-Dependent Treatments and Val66Met
Claire McGregor (2019)
Sex-related difference in collateral sprouting of nociceptive axons after peripheral nerve injury in the rat
U. Kovačič (2003)
Retrospective study of the functional recovery of men compared with that of women with long-term facial paralysis.
B. Hontanilla (2013)
Cellular localization of androgen and estrogen receptors in mouse‐derived motoneuron hybrid cells and mouse facial motoneurons
J. Tetzlaff (2007)
Estudo experimental da influência da atividade muscular da face sobre o esqueleto da mesoestrutura facial em coelhos
Andre Ricardo Mateus (2008)
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