Online citations, reference lists, and bibliographies.

Structure, Function, And Antigenicity Of The Hemagglutinin Of Influenza Virus

S. A. Wharton, W. Weis, J. Skehel, D. Wiley
Published 1989 · Biology

Cite This
Download PDF
Analyze on Scholarcy
Share
The major surface glycoprotein of influenza virus is hemagglutinin (HA). This chapter reviews the two major functions of HA: (1) its involvement in binding to receptors on cells before their infection, and (2) its role in the fusion of viral and endosomal membranes, necessary for the release of the viral genome into the cell. In addition, HA is the viral antigen that interacts with infectivity-neutralizing antibodies; alterations in the molecule enable the virus to escape immune surveillance and cause epidemics of disease. The nature of these changes in antigenicity is discussed.



This paper is referenced by
10.1016/j.acthis.2011.11.009
Histochemical analysis of glycoproteins in the gill epithelium of an Indian major carp, Cirrhinus mrigala.
N. Srivastava (2012)
10.1099/0022-1317-78-10-2431
Variations in the neutralizing and haemagglutination-inhibiting activities of five influenza A virus-specific IgGs and their antibody fragments.
D. Schofield (1997)
10.1017/S1466252307001272
Up to new tricks - a review of cross-species transmission of influenza A viruses.
G. Landolt (2007)
10.1089/VIM.2005.18.365
Virus-like particle vaccine conferred complete protection against a lethal influenza virus challenge.
Jose M Galarza (2005)
10.1074/JBC.275.9.6469
Determination of the Disulfide Bond Arrangement of Newcastle Disease Virus Hemagglutinin Neuraminidase
J. Pitt (2000)
10.1097/01.inf.0000188160.83709.b7
Avian Influenza: An Omnipresent Pandemic Threat
D. Perez (2005)
10.1590/S1020-49891998001200008
Influenza virus epidemiological surveillance in Argentina, 1987-1993, with molecular characterization of 1990 and 1993 isolates.
O. Uez (1998)
10.1007/s00705-002-0870-y
Recombinant adenovirus encoding the HA gene from swine H3N2 influenza virus partially protects mice from challenge with heterologous virus: A/HK/1/68 (H3N2)
M. Tang (2002)
On the dynamics of infectious diseases in non-homogeneous populations
R. Ramírez (2008)
10.1016/j.acthis.2013.09.009
Histological and histochemical investigations of the pharyngeal jaw apparatus of a carp Cirrhinus mrigala.
Usha Kumari (2014)
10.1016/S0168-7069(02)07004-0
Influenza virus antigens and ‘antigenic drift’
A. Hampson (2002)
10.1016/S0753-3322(00)89026-5
Influenza virus genetics.
E. Brown (2000)
10.1006/VIRO.2000.0507
Varicella-zoster virus gE escape mutant VZV-MSP exhibits an accelerated cell-to-cell spread phenotype in both infected cell cultures and SCID-hu mice.
R. A. Santos (2000)
10.1016/j.tice.2012.08.004
Histochemical analysis of glycoproteins in the secretory cells in the epidermis of the head skin of Indian Major Carp, Labeo rohita.
A. K. Rai (2012)
10.1038/s41467-020-14579-4
Glycan repositioning of influenza hemagglutinin stem facilitates the elicitation of protective cross-group antibody responses
Seyhan Boyoglu-Barnum (2020)
and A Portela particles obtained from recombinant plasmids . acetyltransferase RNA into influenza virus-like Rescue of a synthetic chloramphenicol
I. Mena (1996)
10.1089/vim.2005.18.244
Virus-like particle (VLP) vaccine conferred complete protection against a lethal influenza virus challenge.
Jose M Galarza (2005)
Insilico Prediction of Immunogenic Peptide of Hemagglutinin Protein in H1N1 Influenza Virus
Banpreet Gujral (2011)
10.1590/S0100-879X2000001200010
Production and characterization of monoclonal antibodies to Brazilian isolates of bovine viral diarrhea virus.
L. C. Kreutz (2000)
10.1002/9780470015902.A0023618
A Perspective of Influenza Pandemics
John S. Oxford (2014)
10.1007/978-1-4757-9504-2
Biology of the Sialic Acids
A. Rosenberg (1995)
Identification of Peptide Containing T Cell Epitope Of Hemagglutinin Protein In H5n1 Influenza Virus
N. Kumari (2014)
10.1016/J.ACTHIS.2007.03.002
Histochemical characterization of glycoproteins in the buccal epithelium of the catfish, Rita rita.
M. Yashpal (2007)
10.1111/j.1439-0264.2007.00816.x
Glycoproteins in the Epithelium of Lips and Associated Structures of a Hill Stream Fish Garra lamta (Cyprinidae, Cypriniformes): A Histochemical Investigation
S. Mittal (2008)
Semantic Scholar Logo Some data provided by SemanticScholar