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Survival After BNCT In Combination With Surgery For Dogs With Spontaneous Brain Tumors

R. Bagley, P. Gavin, Moore Mp, G. Silver, M. L. Harrington, H. Kippenes
Published 2001 · Medicine

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Dogs develop spontaneous brain tumors as in humans and serve as a large animal model for evaluation of BNCT for treatment of brain tumor. In this study, 13 dogs with spontaneous brain tumors were treated surgery (SX) followed by BNCT and the median survival of was determined. The median survival was also determined for a group of dogs with spontaneous brain tumors previously treated with BNCT alone (n = 20). All dogs had histologic confirmation of tumor type either at the time of surgery or at necropsy. Of the dogs treated surgically, BNCT followed 3 to 6 weeks after surgery. Dogs of each group had various tumor types, however, the majority were meningiomas (13/20 BNCT; 9/13 SX + BNCT). Of the dogs in the surgery group, all had incomplete resections of the tumor primarily due to tumor location or infiltration of surrounding brain. In both groups, BSH or p-BPA were used for the boron agent. Peak brain dose was 10 to 12.5 Gy- equivalent.
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