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Biological Effects Of Hydroxytyrosol, A Polyphenol From Olive Oil Endowed With Antioxidant Activity.

C. Manna, F. della Ragione, V. Cucciolla, A. Borriello, S. D'Angelo, P. Galletti, V. Zappia
Published 1999 · Biology, Medicine
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A number of epidemiological studies indicate that dietary factors may influence the development of some types of cancer and degenerative pathologies, including cardiovascular diseases and cataract. In this respect, it is well documented that daily consumption of fruits and vegetables is associated with a lowered risk of these diseases.1 Polyphenols are bioactive substances that are widely distributed in the vegetable kingdom2,3 and therefore are present in high concentrations in typical components of the Mediterranean diet, such as fruit, vegetables, red wine, and olive oil. The aim of this article is to overview the most recent data on the nutritional value of the phenolic fraction of virgin olive oil in the ongoing studies on its beneficial effects on human health.
This paper references
10.1172/JCI112196
Effect of hydrogen peroxide exposure on normal human erythrocyte deformability, morphology, surface characteristics, and spectrin-hemoglobin cross-linking.
L. Snyder (1985)
10.1093/ajcn/66.6.1557S
Specific fatty acids and risks of breast and prostate cancer: dietary intake.
W. Willett (1997)
10.1016/0891-5849(96)00051-2
Redox modulation of tyrosine phosphorylation-dependent signal transduction pathways.
H. Monteiro (1996)
10.1016/S0070-2137(97)80005-2
Gene regulation by reactive oxygen species.
F. Cimino (1997)
How to eat well and stay well the Mediterranean way
A. Keys (1975)
Suppression of hydroperoxide-induced cytotoxicity by polyphenols.
T. Nakayama (1994)
Enhancement of antioxidant and phase II enzymes by oral feeding of green tea polyphenols in drinking water to SKH-1 hairless mice: possible role in cancer chemoprevention.
S. Khan (1992)
10.1016/S0891-5849(98)00231-7
Inhibition of peroxynitrite dependent DNA base modification and tyrosine nitration by the extra virgin olive oil-derived antioxidant hydroxytyrosol.
M. Deiana (1999)
10.1016/S0016-5085(89)80072-1
Characterization of the human colon carcinoma cell line (Caco-2) as a model system for intestinal epithelial permeability.
I. Hidalgo (1989)
Oxidative denaturation of red blood cells in thalassemia.
E. Shinar (1990)
10.1016/0021-9150(95)05656-4
Dietary non-tocopherol antioxidants present in extra virgin olive oil increase the resistance of low density lipoproteins to oxidation in rabbits.
S. Wiseman (1996)
10.1097/00041433-199302000-00003
An update on monounsaturated fatty acids
G. Riccardi (1993)
10.1093/JN/127.2.286
The protective effect of the olive oil polyphenol (3,4-dihydroxyphenyl)-ethanol counteracts reactive oxygen metabolite-induced cytotoxicity in Caco-2 cells.
C. Manna (1997)
10.1073/pnas.87.10.3894
Low density lipoprotein rich in oleic acid is protected against oxidative modification: implications for dietary prevention of atherosclerosis.
S. Parthasarathy (1990)
10.1007/978-1-4615-2942-2_15
Protective aspects of the Mediterranean diet.
A. Ferro-Luzzi (1993)
10.1016/S0140-6736(94)92346-9
The oxidation hypothesis of atherosclerosis
J. Witztum (1994)
10.1021/jf00021a019
Simple and hydrolyzable phenolic compounds in virgin olive oil. 1. Their extraction, separation, and quantitative and semiquantitative evaluation by HPLC
G. F. Montedoro (1992)
10.1080/10408399509527682
Free radicals and antioxidants in food and in vivo: what they do and how they work.
B. Halliwell (1995)
10.1172/JCI110724
Spontaneous oxygen radical generation by sickle erythrocytes.
R. Hebbel (1982)
The generation of superoxide radical during the autoxidation of hemoglobin.
H. Misra (1971)
10.1016/0278-6915(84)90033-4
Antioxidant actions of thymol, carvacrol, 6-gingerol, zingerone and hydroxytyrosol.
R. Aeschbach (1994)
10.1002/(SICI)1097-0142(19980201)82:3<448::AID-CNCR4>3.0.CO;2-L
Olive oil, other seasoning fats, and the risk of colorectal carcinoma
C. Braga (1998)
10.1073/pnas.90.17.7915
Oxidants, antioxidants, and the degenerative diseases of aging.
B. Ames (1993)
10.1016/0891-5849(95)02186-8
Hemoglobin: a mechanism for the generation of hydroxyl radicals.
B. V. Van Dyke (1996)
10.1111/J.1753-4887.1998.TB01670.X
Polyphenols: chemistry, dietary sources, metabolism, and nutritional significance.
L. Bravo (1998)
10.1111/J.1753-4887.1998.TB01739.X
The effect of minor constituents of olive oil on cardiovascular disease: new findings.
F. Visioli (1998)
10.1007/BF02787808
Production of glucose and bioactive aglycone by chemical and enzymatic hydrolysis of purified oleuropein fromOlea Europea
R. Capasso (1997)
10.1002/ijc.2910580604
Dietary fat, olive oil intake and breast cancer risk
J. Martín-Moreno (1994)
10.1111/J.1753-4887.1997.TB01561.X
Reactive oxygen species and antioxidants in signal transduction and gene expression.
H. J. Palmer (1997)
10.1016/0016-5085(86)90078-8
Xanthine oxidase inhibitors attenuate ischemia-induced vascular permeability changes in the cat intestine.
D. Granger (1986)
10.1533/9780857099938
Antioxidants : In Science, Technology, Medicine and Nutrition
G. Scott (1997)
10.1007/BF02662292
Antioxidant effect of natural phenols on olive oil
G. Papadopoulos (1991)
10.1016/1043-6618(95)80032-8
Formation of F2-isoprostanes in oxidized low density lipoprotein: inhibitory effect of hydroxytyrosol.
M. Salami (1995)
10.1007/978-1-4615-2942-2
Advances in Nutrition and Cancer
V. Zappia (1993)
10.1021/jf00021a020
Simple and hydrolyzable phenolic compounds in virgin olive oil. 2. Initial characterization of the hydrolyzable fraction
G. F. Montedoro (1992)
10.1016/0021-9150(95)05546-9
Low density lipoprotein oxidation is inhibited in vitro by olive oil constituents.
F. Visioli (1995)
10.1093/jnci/87.2.110
Consumption of olive oil and specific food groups in relation to breast cancer risk in Greece.
A. Trichopoulou (1995)
10.1126/SCIENCE.275.5298.296
At What Price?
A. Lawler (1997)
Comparison of effects of dietary saturated, monounsaturated, and polyunsaturated fatty acids on plasma lipids and lipoproteins in man.
F. Mattson (1985)
10.1016/S0955-2863(98)00085-0
Olive oil hydroxytyrosol protects human erythrocytes against oxidative damages.
C. Manna (1999)
10.1056/NEJM197909063011004
Red-cell-membrane polypeptide aggregates in glucose-6-phosphate dehydrogenase mutants with chronic hemolytic disease. A clue to the mechanism of hemolysis.
G. J. Johnson (1979)
10.1016/0006-2952(93)90530-A
Ion transport ATPases as targets for free radical damage. Protection by an aminosteroid of the Ca2+ pump ATPase and Na+/K+ pump ATPase of human red blood cell membranes.
T. Rohn (1993)
The Mediterranean Diet: an attempt to define its present and past composition.
A. Ferro-Luzzi (1989)
10.1111/J.1753-4887.1995.TB01502.X
The role of phenolics, conjugated linoleic acid, carnosine, and pyrroloquinoline quinone as nonessential dietary antioxidants.
E. Decker (1995)
10.1006/BBRC.1998.8735
Free radical-scavenging properties of olive oil polyphenols.
F. Visioli (1998)
10.1016/0049-3848(95)00043-7
Inhibition of platelet aggregation and eicosanoid production by phenolic components of olive oil.
Anna Petroni (1995)
Effect of dietary oils on lipid peroxidation and on antioxidant parameters of rat plasma and lipoprotein fractions.
C. Scaccini (1992)
10.1126/SCIENCE.275.5306.1649
Mitogenic Signaling Mediated by Oxidants in Ras-Transformed Fibroblasts
K. Irani (1997)
10.1016/0308-8146(92)90025-W
Phenolic compounds and stability of virgin olive oil—Part I
M. Tsimidou (1992)
10.1113/expphysiol.1997.sp004024
Oxidative stress: oxidants and antioxidants
H. Sies (1997)
10.1073/pnas.82.3.790
Major deletions in the gene encoding the p53 tumor antigen cause lack of p53 expression in HL-60 cells.
D. Wolf (1985)
10.1016/S0024-3205(97)01150-8
Oleuropein, the bitter principle of olives, enhances nitric oxide production by mouse macrophages.
F. Visioli (1998)
10.1016/S0006-2952(98)00320-7
Inhibition of leukocyte 5-lipoxygenase by phenolics from virgin olive oil.
R. de la Puerta (1999)
10.1002/ijc.2910360103
Descriptive epidemiology of colorectal cancer
P. Boyle (1985)
10.1271/BBB.61.347
Inhibition of arachidonate lipoxygenase activities by 2-(3,4-dihydroxyphenyl)ethanol, a phenolic compound from olives.
N. Kohyama (1997)



This paper is referenced by
10.1002/9781119135340.CH19
Antioxidants of Olive Oil, Olive Leaves, and their Bioactivity
Apostolos Kiritsakis (2017)
10.1007/s11357-011-9223-7
MnSOD activity regulates hydroxytyrosol-induced extension of chronological lifespan
E. Sarsour (2011)
Resveratrol protects human lens epithelial cells against H2O2-induced oxidative stress by increasing catalase, SOD-1, and HO-1 expression
Y. Zheng (2010)
1 Antidiabetic and Antioxidant Effects of Hydroxytyrosol and 2 Oleuropein from Olive Leaves in Alloxan-Diabetic Rats 3
Hedya Jemai (2009)
10.1021/JF020565+
Protective effect of the phenolic fraction from virgin olive oils against oxidative stress in human cells.
C. Manna (2002)
10.1016/j.freeradbiomed.2013.11.029
Hydroxytyrosol prevents diet-induced metabolic syndrome and attenuates mitochondrial abnormalities in obese mice.
K. Cao (2014)
10.3945/jn.109.104992
Olive leaf extract and its main component oleuropein prevent chronic ultraviolet B radiation-induced skin damage and carcinogenesis in hairless mice.
Y. Kimura (2009)
10.17077/etd.5u6y4lqp
Microrna-302 as a redox sensitive regulator of ARID4a and CCL5
Maneesh G. Kumar (2012)
10.1006/BBRC.2000.3875
Hydroxytyrosol, a natural molecule occurring in olive oil, induces cytochrome c-dependent apoptosis.
F. D. Ragione (2000)
10.3390/COATINGS9020141
Effects of Strontium-Hydroxyapatite Mediated Active Compounds from Hippocampus Kuda Bleeler (HKB) on Osteogenesis
C. Li (2019)
10.1002/jsfa.8443
Evaluation of bioactive compounds in black table olives fermented with selected microbial starters.
M. Durante (2018)
10.1016/B978-0-12-374420-3.00136-4
Effects of Hydroxytyrosol on Cyclosporine Nephrotoxicity
V. Zappia (2010)
10.1177/0748233713483191
Beneficial influence of topical extra virgin olive oil application on an experimental model of penile fracture in rats
Mustafa Gunes (2015)
10.1016/J.TETLET.2007.07.109
Chemoselective and efficient carbomethoxylation of the alcoholic chain of phenols by dimethyl carbonate (DMC)
R. Bernini (2007)
Streptozotocin Induced Diabetic Rats Olive Leaves Extract Restored the antioxidant
I. Ghanema (2012)
ydroxytyrosol , a Natural Molecule Occurring in Olive Oil , nduces Cytochrome c-Dependent Apoptosis ulvio
Della Ragione (2000)
10.1080/10715760701864492
Inhibition of Sudan I genotoxicity in human liver-derived HepG2 cells by the antioxidant hydroxytyrosol
X. Zhang (2008)
10.1016/j.foodres.2017.11.053
Hydroxytyrosol: Bioavailability, toxicity, and clinical applications.
María Robles-Almazán (2018)
10.1021/jf072589s
Lipid-lowering and antioxidant effects of hydroxytyrosol and its triacetylated derivative recovered from olive tree leaves in cholesterol-fed rats.
Hedya Jemai (2008)
Anti-diabetic effect of Murraya koenigii (L) and Olea europaea (L) leaf extracts on streptozotocin induced diabetic rats.
M. Elamin (2013)
10.1016/J.FOODRES.2010.12.010
Modulation of the superoxide anion production and MMP-9 expression in PMA stimulated THP-1 cells by olive oil minor components: Tyrosol and hydroxytyrosol
Amel Nakbi (2011)
10.1186/1476-511X-9-89
Dietary olive oil effect on antioxidant status and fatty acid profile in the erythrocyte of 2,4-D- exposed rats
A. Nakbi (2010)
10.1016/S0014-5793(02)03683-9
Antioxidants induce different phenotypes by a distinct modulation of signal transduction
F. della Ragione (2002)
10.1021/JF058110I
Protective effects of synthetic hydroxytyrosol acetyl derivatives against oxidative stress in human cells.
C. Manna (2005)
10.22159/ijpps.2016v8i12.14077
HYPOGLYCEMIC AND HYPOLIPIDEMIC EFFECTS OF PHENOLIC OLIVE TREE EXTRACT IN STREPTOZOTOCIN DIABETIC RATS
W. Laaboudi (2016)
10.1111/J.1753-4887.2005.TB00374.X
Components of olive oil and chemoprevention of colorectal cancer.
Y. Z. H. Hashim (2005)
The Dawn of Advanced Skin Care
D. Mccord (2004)
10.1093/NDT/GFH846
Diverse effects of natural antioxidants on cyclosporin cytotoxicity in rat renal tubular cells.
P. Galletti (2005)
10.1024/0300-9831.79.3.152
Antioxidant activity of olive polyphenols in humans: a review.
D. Raederstorff (2009)
Pharmacokinetics and metabolism of hydroxytyrosol, a natural antioxidant from olive oil.
S. D'angelo (2001)
10.3305/nh.2015.31.6.8997
Anti-adipogenic activity of an olive seed extract in mouse fibroblasts.
Carmen Veciana-Galindo (2015)
10.3390/foods9060800
Chemistry and Sensory Characterization of a Bakery Product Prepared with Oils from African Edible Insects
Xavier Cheseto (2020)
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