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Resistance To Taxanes
L. Greenberger, D. Sampath
Published 2006 · Chemistry
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Time to take this seriously.
Resistance to two taxanes, paclitaxel and docetaxel, is frequently observed in cancer patients and limits successful therapy. In experimental systems, resistance to paclitaxel and docetaxel are mediated by alterations in tubulin (the primary site of action of taxanes), proteins that interact with microtubules, energy-dependent efflux pumps, apoptotic proteins, and signal transduction pathways. Clinical correlations with some of these alterations exist, but have not been fully elucidated. Strategies to overcome or circumvent resistance to paclitaxel or docetaxel include inhibition of efflux pumps (which have largely proven to be unsuccessful), the use of novel taxanes or other chemically distinct classes of polymerizing agents that do not interact with drug efflux pumps (currently in clinical trials), and regulation of apoptotic or signal transduction pathways that would restore sensitivity to taxanes. Understanding the basis of resistance at the clinical level is likely to be difficult and complex, but holds the promise of providing a therapeutic opportunity specific to taxane-resistant cancer cells.
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Y. Kim (2019)
Highlights in Resistance Mechanism Pathways for Combination Therapy
João M A Delou (2019)
The transcription factor ZEB1 promotes chemoresistance in prostate cancer cell lines
O. Orellana-Serradell (2019)
The potential role of miRNAs and exosomes in chemotherapy in ovarian cancer.
Mona Alharbi (2018)
Clinical benefit of nanoparticle albumin-bound-paclitaxel in recurrent/metastatic head and neck squamous cell carcinoma resistant to cremophor-based paclitaxel or docetaxel
J. Ley (2017)
Recent findings and future directions for interpolar mitotic kinesin inhibitors in cancer therapy
S. Myers (2016)
Efficacy of cabazitaxel in mouse models of pediatric brain tumors.
Emily J. Girard (2015)
Telomere and Microtubule Targeting in Treatment-Sensitive and Treatment-Resistant Human Prostate Cancer Cells
B. Zhang (2012)
Preclinical Pharmacologic Evaluation of MST-997, an Orally Active Taxane with Superior In vitro and In vivo Efficacy in Paclitaxel- and Docetaxel-Resistant Tumor Models
D. Sampath (2006)