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Boswellic Acids And Their Role In Chronic Inflammatory Diseases.

H. Ammon
Published 2016 · Medicine

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Boswellic acids, which are pentacyclic triterpenes belong to the active pharmacological compounds of the oleogum resin of different Boswellia species. In the resin, more than 12 different boswellic acids have been identified but only KBA and AKBA received significant pharmacological interest. Biological Activity: In an extract of the resin of Boswellia species multiple factors are responsible for the final outcome of a therapeutic effect, be it synergistic or antagonistic. Moreover, the anti-inflammatory actions of BAs are caused by different mechanisms of action. They include inhibition of leukotriene synthesis and to a less extend prostaglandin synthesis. Furthermore inhibition of the complement system at the level of conversion of C3 into C3a and C3b. A major target of BAs is the immune system. Here, BEs as well as BAs including KBA and AKBA, have been shown to decrease production of proinflammatory cytokines including IL-1, IL-2, IL-6, IFN-γ and TNF-α which finally are directed to destroy tissues such as cartilage, insulin producing cells, bronchial, intestinal and other tissues. NFĸB is considered to be the target of AKBA. The complex actions of BEs and BAs in inflamed areas may be completed by some effects that are localized behind the inflammatory process as such tissue destruction. In this case, in vitro- and animal studies have shown that BAs and BEs suppress proteolytic activity of cathepsin G, human leucocyte elastase, formation of oxygen radicals and lysosomal enzymes. PHARMACOKINETICS Whereas KBA is absorbed reaching blood levels being close to in vitro IC50, AKBA which is more active in in vitro studies than KBA, but undergoes much less absorption than KBA. However, absorption of both is increased more than twice when taken together with a high-fat meal.Clinical Studies There are a variety of chronic inflammatory diseases which respond to treatment with extracts from the resin of Boswellia species. Though, the number of cases is small in related clinical studies, their results are convincing and supported by the preclinical data. These studies include rheumatoid arthritis, osteoarthritis, chronic colitis, ulcerative colitis, collagenous colitis, Crohn's disease and bronchial asthma. It can not be expected that there is cure from these diseases but at least improvement of symptoms in about 60-70 % of the cases. Side Effects The number and severity of side effects is extremely low. The most reported complaints are gastrointestinal symptoms. Allergic reactions are rare. And most authors report, that treatment with BEs is well tolerated and the registered side effects in BE- and placebo groups are similar.
This paper references
10.1002/PTR.1858
Phytochemical screening and antiviral activity of some medicinal plants from the island Soqotra
R. A. Mothana (2006)
10.1016/j.phymed.2011.06.035
Prevention of multiple low-dose streptozotocin (MLD-STZ) diabetes in mice by an extract from gum resin of Boswellia serrata (BE).
A. M. Shehata (2011)
10.1002/ibd.21345
Randomized, placebo‐controlled, double‐blind trial of Boswellia serrata in maintaining remission of Crohn's disease: Good safety profile but lack of efficacy
W. Holtmeier (2011)
10.1124/mol.106.024836
Boswellic Acids Stimulate Arachidonic Acid Release and 12-Lipoxygenase Activity in Human Platelets Independent of Ca2+ and Differentially Interact with Platelet-Type 12-Lipoxygenase
Daniel Poeckel (2006)
10.1007/s003930050051
Ist H15 (Harzextrakt von Boswellia serrata, „Weihrauch“) eine sinnvolle Ergänzung zur etablierten medikamentösen Therapie der chronischen Polyarthritis? – Ergebnisse einer doppelblinden Pilotstudie
O. Sander (1998)
10.19182/REMVT.8831
Screening of some Nigerian plants for molluscicidal activity.
S. L. Kela (1989)
10.1111/j.0105-1873.2004.0396d.x
Allergic contact dermatitis from Boswellia serrata extract in a naturopathic cream
E. Acebo (2004)
10.1111/j.1476-5381.1996.tb15235.x
Acetyl‐11‐keto‐β‐boswellic acid (AKBA): structure requirements for binding and 5‐lipoxygenase inhibitory activity
E. Sailer (1996)
Inhibition by boswellic acids of human leukocyte elastase.
H. Safayhi (1997)
10.1007/BF01965005
Pharmacology of an extract of salai guggal ex-Boswellia serrata, a new non-steroidal anti-inflammatory agent
G. B. Singh (2005)
10.1212/WNL.56.9.1219
Response of radiochemotherapy-associated cerebral edema to a phytotherapeutic agent, H15
J. Streffer (2001)
10.1016/S1570-0232(03)00555-5
Analysis of 12 different pentacyclic triterpenic acids from frankincense in human plasma by high-performance liquid chromatography and photodiode array detection.
B. Buechele (2003)
10.1515/znc-2003-3-416
Chemistry and Immunomodulatory Activity of Frankincense Oil
Botros R Mikhaeil (2003)
10.2337/DIABETES.54.SUPPL_2.S97
Mechanisms of pancreatic beta-cell death in type 1 and type 2 diabetes: many differences, few similarities.
M. Cnop (2005)
10.1016/j.fct.2011.06.079
Anti-inflammatory, antinociceptive and antioxidant activities of the endemic Soqotraen Boswellia elongata Balf. f. and Jatropha unicostata Balf. f. in different experimental models.
R. A. Mothana (2011)
10.1055/S-2001-15802
Effects of gum resin of Boswellia serrata in patients with chronic colitis.
I. Gupta (2001)
10.1016/j.intimp.2011.02.011
Immunological adjuvant effect of Boswellia serrata (BOS 2000) on specific antibody and cellular response to ovalbumin in mice.
A. Gupta (2011)
10.1186/1756-0500-4-406
Acetyl-11-keto-β-boswellic acid (AKBA); targeting oral cavity pathogens
A. F. Raja (2011)
10.1358/DOT.1996.32.2.354254
ALCOHOLIC EXTRACT OF SALAI-GUGGAL EX-BOSWELLIA SERRATA, A NEW NATURAL SOURCE NSAID
G. Singh (1996)
10.1124/mol.107.038810
Incensole Acetate, a Novel Anti-Inflammatory Compound Isolated from Boswellia Resin, Inhibits Nuclear Factor-κB Activation
A. Moussaieff (2007)
10.1016/j.bcp.2012.06.016
A novel C(28)-hydroxylated lupeolic acid suppresses the biosynthesis of eicosanoids through inhibition of cytosolic phospholipase A(2).
M. Verhoff (2012)
10.4049/jimmunol.174.1.498
Acetyl-Boswellic Acids Inhibit Lipopolysaccharide-Mediated TNF-α Induction in Monocytes by Direct Interaction with IκB Kinases1
T. Syrovets (2005)
10.7150/IJMS.7.366
Comparative Efficacy and Tolerability of 5-Loxin® and Aflapin® Against Osteoarthritis of the Knee: A Double Blind, Randomized, Placebo Controlled Clinical Study
K. Sengupta (2010)
10.1016/S1570-0232(03)00160-0
Analysis of pentacyclic triterpenic acids from frankincense gum resins and related phytopharmaceuticals by high-performance liquid chromatography. Identification of lupeolic acid, a novel pentacyclic triterpene.
B. Buechele (2003)
10.1016/j.phymed.2007.11.019
Boswellic acids: A leukotriene inhibitor also effective through topical application in inflammatory disorders.
S. Singh (2008)
10.4049/jimmunol.176.5.3127
Acetyl-11-Keto-β-Boswellic Acid Potentiates Apoptosis, Inhibits Invasion, and Abolishes Osteoclastogenesis by Suppressing NF-κB and NF-κB-Regulated Gene Expression1
Y. Takada (2006)
10.1016/j.bmcl.2009.05.034
Synthesis of novel triterpenoid (lupeol) derivatives and their in vivo antihyperglycemic and antidyslipidemic activity.
K. Papi Reddy (2009)
10.1055/S-2005-919835
Boswellia serrata Extrakt bei kollagener Kolitis-Eine randomisierte, placebo-kontrollierte, doppelblinde Multicenterstudie
A. Madisch (2005)
10.1002/cncr.25945
Boswellia serrata acts on cerebral edema in patients irradiated for brain tumors
S. Kirste (2011)
[Therapy of Crohn diseases--results of a Consensus Conference of the German Society of Digestive and Metabolic Diseases].
E. Stange (1997)
10.1078/094471103321648593
Efficacy and tolerability of Boswellia serrata extract in treatment of osteoarthritis of knee--a randomized double blind placebo controlled trial.
N. Kimmatkar (2003)
10.1111/j.1476-5381.2010.01020.x
Inhibition of microsomal prostaglandin E2 synthase‐1 as a molecular basis for the anti‐inflammatory actions of boswellic acids from frankincense
U. Siemoneit (2011)
10.1016/j.phrs.2010.02.007
Discovery of cyclooxygenase inhibitors from medicinal plants used to treat inflammation.
Hongmei Cao (2010)
10.4049/jimmunol.0803574
Identification of Human Cathepsin G As a Functional Target of Boswellic Acids from the Anti-Inflammatory Remedy Frankincense1
L. Tausch (2009)
10.1016/J.BCP.2007.09.010
Identification and functional analysis of cyclooxygenase-1 as a molecular target of boswellic acids.
U. Siemoneit (2008)
10.1002/ptr.3055
Boswellia frereana (frankincense) suppresses cytokine‐induced matrix metalloproteinase expression and production of pro‐inflammatory molecules in articular cartilage
E. Blain (2010)
10.1124/dmd.107.018424
Metabolism of Boswellic Acids in Vitro and in Vivo
P. Krueger (2008)
Mechanism of 5-lipoxygenase inhibition by acetyl-11-keto-beta-boswellic acid.
H. Safayhi (1995)
10.1016/j.ejphar.2009.01.044
On the interference of boswellic acids with 5-lipoxygenase: mechanistic studies in vitro and pharmacological relevance.
U. Siemoneit (2009)
10.1055/S-2004-835844
Effect of food intake on the bioavailability of boswellic acids from a herbal preparation in healthy volunteers.
V. Sterk (2004)
10.1111/j.1472-765X.2008.02469.x
In vitro anti‐biofilm activity of Boswellia spp. oleogum resin essential oils
D. Schillaci (2008)
10.1046/J.1432-1327.1998.2560364.X
Characterization of an acetyl-11-keto-beta-boswellic acid and arachidonate-binding regulatory site of 5-lipoxygenase using photoaffinity labeling.
E. Sailer (1998)
10.1089/ACM.2005.11.323
Effects of an acetone extract of Boswellia carterii Birdw. (Burseraceae) gum resin on rats with persistent inflammation.
A. Fan (2005)
Effects of Boswellia serrata gum resin in patients with bronchial asthma: results of a double-blind, placebo-controlled, 6-week clinical study.
I. Gupta (1998)
10.1016/J.JEP.2004.09.006
Antimicrobial activity of some medicinal plants of the island Soqotra.
R. A. Mothana (2005)
10.1016/0192-0561(92)90048-P
Anticomplementary activity of boswellic acids--an inhibitor of C3-convertase of the classical complement pathway.
A. Kapil (1992)
10.1016/j.phymed.2014.02.001
Boswellia serrata extract attenuates inflammatory mediators and oxidative stress in collagen induced arthritis.
S. Umar (2014)
10.2165/00003495-199447010-00002
Leukotrienes as a Target in Asthma Therapy
N. Chanarin (2012)
10.1016/j.phymed.2014.02.004
Extract from gum resin of Boswellia serrata decreases IA(2)-antibody in a patient with "Late onset Autoimmune Diabetes of the Adult" (LADA).
E. Schrott (2014)
10.1016/1056-8719(92)90060-E
A sensitive and relevant model for evaluating anti-inflammatory activity-papaya latex-induced rat paw inflammation.
O. P. Gupta (1992)
10.1002/(SICI)1099-1573(199603)10:2<107::AID-PTR780>3.0.CO;2-3
Immunomodulatory Activity of Boswellic Acids (Pentacyclic Triterpene Acids) from Boswellia serrata
M. L. Sharma (1996)
10.1128/CDLI.12.5.575-580.2005
Boswellia carterii Extract Inhibits TH1 Cytokines and Promotes TH2 Cytokines In Vitro
M. R. Chevrier (2005)
Wirksamkeit und Unbedenklichkeit der H15 Ayurmedica-Therapie bei chronisch entzündlichen Erkrankungen
P. Buvari (2001)
10.1002/MRC.1212
Structural analysis of 3‐α‐acetyl‐20(29)‐lupene‐24‐oic acid, a novel pentacyclic triterpene isolated from the gum resin of Boswellia serrata, by NMR spectroscopy
K. Belsner (2003)
10.1016/S0944-7113(96)80019-5
Special extract of BOSWELLIA serrata (H 15) in the treatment of rheumatoid arthritis.
R. Etzel (1996)
10.1016/j.ejps.2008.10.005
Permeation of Boswellia extract in the Caco-2 model and possible interactions of its constituents KBA and AKBA with OATP1B3 and MRP2.
Phillip Krüger (2009)
Effects of Boswellia serrata gum resin in patients with ulcerative colitis.
I. Gupta (1997)
10.1002/ptr.2320
Immunomodulatory activity of biopolymeric fraction BOS 2000 from Boswellia serrata
A. Khajuria (2008)
10.1016/0192-0561(89)90150-1
Anti-arthritic activity of boswellic acids in bovine serum albumin (BSA)-induced arthritis.
M. L. Sharma (1989)
10.1136/bcr-2014-203861
Holy Saturday asthma
T. O'connor (2014)
10.1046/j.1467-2494.2000.00045.x
Topical formulation of a new plant extract complex with refirming properties. Clinical and non‐invasive evaluation in a double‐blind trial
Martelli (2000)
10.1078/0944-7113-00290
Pharmacokinetic study of 11-Keto β-Boswellic Acid
S. Sharma (2004)
10.1186/ar2461
A double blind, randomized, placebo controlled study of the efficacy and safety of 5-Loxin® for treatment of osteoarthritis of the knee
K. Sengupta (2008)
10.1002/ADIC.200790068
Chemical composition and antimicrobial activity of some oleogum resin essential oils from Boswellia spp. (Burseraceae).
L. Camarda (2007)
10.1016/J.INTIMP.2006.12.003
Pure compound from Boswellia serrata extract exhibits anti-inflammatory property in human PBMCs and mouse macrophages through inhibition of TNFalpha, IL-1beta, NO and MAP kinases.
Balasubramaniam Gayathri (2007)
10.1002/1099-1573(200011)14:7<510::AID-PTR646>3.0.CO;2-B
Inhibitory effects of Sudanese medicinal plant extracts on hepatitis C virus (HCV) protease
G. Hussein (2000)
10.1016/S0367-326X(01)00313-6
Antimicrobial activity of Boswellia dalziellii stem bark.
E. Adelakun (2001)
10.1016/0024-3205(69)90153-2
Analgesic effect of the gum resin of Boswellia serata Roxb.
A. Kar (1969)
10.1055/S-2001-10708
Therapie des aktiven Morbus Crohn mit dem Boswellia-serrata-Extrakt H 15
H. Gerhardt (2001)
10.4103/0253-7613.30759
Open, randomized, controlled clinical trial of Boswellia serrata extract as compared to valdecoxib in osteoarthritis of knee
S. Sontakke (2007)
10.4049/jimmunol.0900521
Targeting NF-κB with a Natural Triterpenoid Alleviates Skin Inflammation in a Mouse Model of Psoriasis1
H. Wang (2009)
10.1055/s-0035-1547293
11-Keto-β-Boswellic Acids Prevent Development of Autoimmune Reactions, Insulitis and Reduce Hyperglycemia During Induction of Multiple Low-Dose Streptozotocin (MLD-STZ) Diabetes in Mice.
A. M. Shehata (2015)
10.1055/S-2008-1069460
[Therapy of Crohn's disease].
H. Malchow (1984)
Boswellic acids: novel, specific, nonredox inhibitors of 5-lipoxygenase.
H. Safayhi (1992)
10.1055/S-2006-960074
Inhibition of leukotriene B4 formation in rat peritoneal neutrophils by an ethanolic extract of the gum resin exudate of Boswellia serrata.
H. Ammon (1991)
10.1161/ATVBAHA.107.155606
Antiinflammatory and Antiatherogenic Effects of the NF-&kgr;B Inhibitor Acetyl-11-Keto-β-Boswellic Acid in LPS-Challenged ApoE−/− Mice
C. Cuaz-Pérolin (2007)
10.1055/s-0030-1250612
Complete structural assignment of serratol, a cembrane-type diterpene from Boswellia serrata, and evaluation of its antiprotozoal activity.
T. Schmidt (2011)



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10.1007/s10787-019-00627-z
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S. M. Baram (2019)
10.1016/j.jpha.2019.09.007
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Kumar Katragunta (2019)
10.3390/ijms21051822
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X. Gao (2020)
10.1055/a-0889-5569
Boswelliaextrakte/Boswelliasäuren bei malignen Tumoren: Eine Übersicht
Hpt Ammon (2019)
10.1016/j.phymed.2019.153002
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H. Ammon (2019)
10.29252/QUMS.22.1.81
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Soheila Noroozi (2018)
Effect of Boswellia serrata Resin Extract on Cell-Mediated and Humoral Immune Response in Mice
Megha Jha (2020)
A Systematic Review on Frankincense (Boswellia species)
S. Yadav (2018)
10.1016/j.jddst.2020.101881
Dendrosome-encapsulated beta-Boswellic acid boosts expression of the memory-related genes in the B65 cell line
Mohammad Khalaj-kondori (2020)
10.4172/1747-0862.1000376
Targeting cytokines in the 5-Lox pro-inflammatory pathway for treatment-resistant anorexia nervosa
S. J. Brooks (2018)
10.1002/ptr.6338
A pilot, randomized, double‐blind, placebo‐controlled trial to assess the safety and efficacy of a novel Boswellia serrata extract in the management of osteoarthritis of the knee
M. Majeed (2019)
10.1021/acs.jafc.7b04203
Improvement of Human-Oral-Epithelial-Barrier Function and of Tight Junctions by Micronutrients.
E. Rybakovsky (2017)
10.22038/IJBMS.2020.35288.8419
Genus Boswellia as a new candidate for neurodegenerative disorders
A. Rajabian (2020)
10.1016/j.jcot.2018.07.015
Current status of top 10 nutraceuticals used for Knee Osteoarthritis in India.
Raju Vaishya (2018)
10.1155/2018/2504305
Anti-Inflammatory Activity of Boswellia serrata Extracts: An In Vitro Study on Porcine Aortic Endothelial Cells
Martina Bertocchi (2018)
10.1016/j.pharmthera.2018.02.015
Nutraceuticals and osteoarthritis pain
A. Wang (2018)
10.1055/s-0043-107884
Defined Structure-Activity Relationships of Boswellic Acids Determine Modulation of Ca2+ Mobilization and Aggregation of Human Platelets by Boswellia serrata Extracts.
U. Siemoneit (2017)
10.2174/1381612826666200406093257
The anti-inflammatory potential of selected plant-derived compounds in respiratory diseases.
J. Wieczfinska (2020)
10.1177/1091581819858069
Toxicological Assessment of a Standardized Boswellia serrata Gum Resin Extract
Venkata Krishnaraju Alluri (2019)
10.1002/ptr.6517
Herbal medicinal products for inflammatory bowel disease: A focus on those assessed in double‐blind randomised controlled trials
G. Holleran (2019)
10.3390/nu12103186
The Beneficial Effect of Boswellic Acid on Bone Metabolism and Possible Mechanisms of Action in Experimental Osteoporosis
Bandar E Aldhubiab (2020)
10.3390/medsci7120105
Role of Jumpstart Nutrition®, a Dietary Supplement, to Ameliorate Calcium-to-Phosphorus Ratio and Parathyroid Hormone of Patients with Osteoarthritis
A. Ganguly (2019)
10.3390/nu11102341
Comparative Investigation of Frankincense Nutraceuticals: Correlation of Boswellic and Lupeolic Acid Contents with Cytokine Release Inhibition and Toxicity against Triple-Negative Breast Cancer Cells
M. Schmiech (2019)
10.1016/j.semcancer.2020.01.015
Anti-inflammatory and anti-cancer activities of frankincense: Targets, treatments and toxicities.
Thomas Efferth (2020)
10.1016/j.sjbs.2019.05.010
Repeat oral dose safety study of standardized methanolic extract of Boswellia sacra oleo gum resin in rats
A. AL-Yahya (2020)
10.1016/j.abb.2020.108656
Boswellic acids and their derivatives as potent regulators of glucocorticoid receptor actions.
Aikaterini G Karra (2020)
10.1080/03007995.2020.1860923
Curcuminoids and Boswellia serrata extracts combination decreases tendinopathy symptoms: findings from an open-label post-observational study
Y. Henrotin (2020)
10.1055/S-0043-118938
Evidenz und Tradition am Beispiel der Phytopharmaka
R. Juette (2017)
10.3390/antiox9060529
Terpenoids as Potential Geroprotectors
E. Proshkina (2020)
10.1080/13697137.2019.1679110
Cranberry, D-mannose and anti-inflammatory agents prevent lower urinary tract symptoms in women undergoing prolapse surgery
E. Russo (2019)
10.13171/MJC74181121-CSUK
Hydroxylated boswellic and glycyrrhetinic acid derivatives: synthesis and cytotoxicity
Immo Serbian (2018)
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