Online citations, reference lists, and bibliographies.

Musculoskeletal And Integumentary Systems

I. Bentov, M. Reed
Published 2018 · Medicine

Cite This
Download PDF
Analyze on Scholarcy
Share
Anesthesia and surgery directly affect the musculoskeletal and integumentary systems and expose the patient to potential risks of nerve injury, pressure ulcers, and surgical site infection. Older age is a risk factor for all of them. Aging is accompanied by changes to the structure and function of the skin that negatively impact the three stages of incisional wound healing, inflammation, tissue formation, and remodeling, leading to an increased risk of surgical wound infection. Surgical wound infection is associated with considerable suffering and leads to an increase in costs, morbidity, and mortality. Anesthesiologists provide clinical interventions that can improve wound healing and reduce the risk of surgical site infections. Interventions include preoperative consulting for smoking cessation and physical activity, administration of antibiotics and oxygen, and management of blood glucose, body temperature, and fluids. It is also possible that choice of anesthetic technique and drugs may also influence wound healing. Aging is also associated with sarcopenia (loss of muscle mass) and osteoarthritis, which are important to recognize in order to reduce the incidence of perioperative pressure ulcers and nerve injuries.
This paper references
10.1086/421095
Antimicrobial prophylaxis for surgery: an advisory statement from the National Surgical Infection Prevention Project.
D. Bratzler (2004)
10.1097/ALN.0000000000001515
Perioperative Hyperglycemia Management: An Update
Elizabeth W. Duggan (2017)
10.1097/01.sla.0000167850.49819.ea
Preoperative Antibiotics and Mortality in the Elderly
J. Silber (2005)
10.2147/CIA.S55842
Prevention and optimal management of sarcopenia: a review of combined exercise and nutrition interventions to improve muscle outcomes in older people
H. Denison (2015)
Mesenchymal cell activation is the rate-limiting step of granulation tissue induction.
S. McClain (1996)
10.1097/ALN.0b013e3181e2c1c3
Anesthetic Management and Surgical Site Infections in Total Hip or Knee Replacement: A Population-based Study
C. Chang (2010)
10.1016/0022-4804(79)90155-0
Local anesthetics and wound healing.
M. Chvapil (1979)
10.1097/00000539-199705000-00014
The Threshold for Thermoregulatory Vasoconstriction During Nitrous Oxide/Sevoflurane Anesthesia Is Reduced in the Elderly
M. Ozaki (1997)
10.1016/j.clindermatol.2010.07.001
Clinical aspects and molecular diagnostics of skin aging.
C. Zouboulis (2011)
10.1016/0923-1811(93)90764-G
The effect of aging and arteriosclerosis on human skin blood flow.
Y. Tsuchida (1993)
10.1038/NM1197-1209
Estrogen accelerates cutaneous wound healing associated with an increase in TGF-β1 levels
G. Ashcroft (1997)
10.2337/diacare.20.2.135
Altered Hierarchy of Protective Responses Against Severe Hypoglycemia in Normal Aging in Healthy Men
K. Matyka (1997)
10.1067/MJW.2003.132
The Link Between Tissue Oxygen and Hydration in Nursing Home Residents With Pressure Ulcers: Preliminary Data
N. Stotts (2003)
10.1056/NEJM199909023411006
Cutaneous wound healing.
A. Singer (1999)
10.1001/JAMA.294.16.2035
Supplemental perioperative oxygen and the risk of surgical wound infection: a randomized controlled trial.
F. Belda (2005)
10.1042/BJ3180379
Regulation of reactive-oxygen-species generation in fibroblasts by Rac1.
M. Sundaresan (1996)
10.1046/j.1365-2133.2002.04991.x
Is skin ageing in the elderly caused by sun exposure or smoking?
W. Leung (2002)
10.1056/NEJM197803232981205
Oxygen-Dependent Microbial Killing by Phagocytes
B. Babior (1978)
10.1001/JAMA.297.22.2481
Preoperative hematocrit levels and postoperative outcomes in older patients undergoing noncardiac surgery.
W. Wu (2007)
10.1001/archsurg.2012.5
Wound healing and infection in surgery. The clinical impact of smoking and smoking cessation: a systematic review and meta-analysis.
L. Sørensen (2012)
10.1213/00000539-199301000-00002
Postoperative ulnar nerve palsy--is it a preventable complication?
R. Stoelting (1993)
Gross tissue weights in the human body by cadaver dissection.
J. Clarys (1984)
10.1097/CCM.0b013e318298a849
Intraoperative Risk Factors Associated With Postoperative Pressure Ulcers in Critically Ill Patients: A Retrospective Observational Study*
D. O'Brien (2014)
10.1371/journal.pone.0083743
A Systematic Review of Risk Factors Associated with Surgical Site Infections among Surgical Patients
E. Korol (2013)
10.1097/01.SLA.0000094387.50865.23
Effects of intravenous fluid restriction on postoperative complications: comparison of two perioperative fluid regimens: a randomized assessor-blinded multicenter trial.
Y. Mintz (2004)
10.1053/APMR.2001.24305
Tai Chi Chuan training to enhance microcirculatory function in healthy elderly men.
J. Wang (2001)
10.1086/428626
The effect of increasing age on the risk of surgical site infection.
K. Kaye (2005)
10.1016/S0140-6736(10)60576-4
Effect of intensive treatment of hyperglycaemia on microvascular outcomes in type 2 diabetes: an analysis of the ACCORD randomised trial
F. Ismail-Beigi (2010)
10.1097/00000542-199309000-00008
The Threshold for Thermoregulatory Vasoconstriction during Nitrous Oxide/Isoflurane Anesthesia Is Lower in Elderly Than in Young Patients
A. Kurz (1993)
10.1097/00000542-199008000-00002
Nerve injury associated with anesthesia.
D. A. Kroll (1990)
10.1097/ALN.0000000000000036
Anesthesia, Microcirculation, and Wound Repair in Aging
I. Bentov (2014)
10.1097/00000542-200004000-00011
The Effect of Anesthetic Technique on Postoperative Outcomes in Hip Fracture Repair
D. O'hara (2000)
10.1161/HC3701.096099
A 30-Year Follow-Up of the Dallas Bed Rest and Training Study: II. Effect of Age on Cardiovascular Adaptation to Exercise Training
D. McGuire (2001)
10.1097/01.sla.0000094300.36689.ad
The Role of Epidural Anesthesia and Analgesia in Surgical Practice
R. Moraca (2003)
Age-related differences in repair of dermal wounds and myocardial infarcts attenuate during the later stages of healing.
M. Reed (2006)
10.1006/MVRE.1998.2078
Growth factors reverse the impaired sprouting of microvessels from aged mice.
W. Arthur (1998)
10.1007/s00701-015-2489-2
The dependence of age on ulnar nerve conductive study parameter adaptation after compressive ulnar neuropathy operations in the elbow
Novotná Radka (2015)
10.1056/NEJMoa0808939
Preventing surgical-site infections in nasal carriers of Staphylococcus aureus.
L. G. Bode (2010)
10.1097/00000542-199208000-00005
Epidural versus general anesthesia, ambient operating room temperature, and patient age as predictors of inadvertent hypothermia.
S. Frank (1992)
10.1016/j.cger.2010.03.002
Age-related changes in the musculoskeletal system and the development of osteoarthritis.
R. Loeser (2010)
Effect of age on wound healing in healthy human beings.
D. R. Holt (1992)
10.1136/bmj.315.7113.909
Intraoperative intravascular volume optimisation and length of hospital stay after repair of proximal femoral fracture: randomised controlled trial
S. Sinclair (1997)
10.1126/science.157.3791.927
Collagen Proline Hydroxylase in Wound Healing, Granuloma Formation, Scurvy, and Growth
E. Mussini (1967)
10.1002/14651858.CD001735.pub4
Support surfaces for pressure ulcer prevention.
E. McInnes (2011)
10.1213/01.ANE.0000196511.48033.0B
CON: Fluid restriction for cardiac patients during major noncardiac surgery should be replaced by goal-directed intravascular fluid administration.
D. Spahn (2006)
10.1001/ARCHSURG.138.3.314
Risk factors for postoperative infectious complications in noncolorectal abdominal surgery: a multivariate analysis based on a prospective multicenter study of 4718 patients.
P. Pessaux (2003)
10.1213/ANE.0000000000001422
Lidocaine Impairs Proliferative and Biosynthetic Functions of Aged Human Dermal Fibroblasts
I. Bentov (2016)
10.1016/S0003-4975(99)00014-4
Continuous intravenous insulin infusion reduces the incidence of deep sternal wound infection in diabetic patients after cardiac surgical procedures.
A. Furnary (1999)
10.1056/NEJMOA003069
Intranasal mupirocin to prevent postoperative Staphylococcus aureus infections.
T. Perl (2002)
10.1111/j.1549-8719.2000.tb00135.x
Microcirculatory Dysfunction Induced by Cigarette Smoking
H. Lehr (2000)
10.1001/jama.2009.1452
Effect of high perioperative oxygen fraction on surgical site infection and pulmonary complications after abdominal surgery: the PROXI randomized clinical trial.
C. S. Meyhoff (2009)
10.1172/JCI23506
How does blood glucose control with insulin save lives in intensive care
G. Berghe (2004)
10.1097/SLA.0b013e31818990d1
Relationship of Perioperative Hyperglycemia and Postoperative Infections in Patients Who Undergo General and Vascular Surgery
M. Ramos (2008)
10.1161/01.CIR.99.1.111
Age-dependent impairment of angiogenesis.
A. Rivard (1999)
10.1093/BJACEACCP/MKR048
Perioperative peripheral nerve injuries
Abdul Ghaaliq Lalkhen (2012)
10.1046/J.0022-202X.2001.01539.X
Age-related alterations in the inflammatory response to dermal injury.
M. Swift (2001)
10.1213/01.ANE.0000063824.43113.DB
The Effects of Epidural and General Anesthesia on Tissue Oxygenation
T. Treschan (2003)
10.1097/00132586-200108000-00044
Practice Advisory for the Prevention of Perioperative Peripheral Neuropathies: A Report by the American Society of Anesthesiologists Task Force on Prevention of Perioperative Peripheral Neuropathies
C. Blitt (2000)
10.1007/s00268-003-7400-2
Oxygen in Wound Healing—More than a Nutrient
A. Tandara (2003)
10.1111/j.1524-475X.2009.00539.x
Increased fluid intake does not augment capacity to lay down new collagen in nursing home residents at risk for pressure ulcers: a randomized, controlled clinical trial.
N. Stotts (2009)
10.1189/jlb.70.6.881
Senescence in innate immune responses: reduced neutrophil phagocytic capacity and CD16 expression in elderly humans
S. Butcher (2001)
10.1001/archsurg.2009.1
Perioperative supplemental oxygen therapy and surgical site infection: a meta-analysis of randomized controlled trials.
M. Qadan (2009)
10.1002/14651858.CD006954.pub2
Local anaesthetic wound infiltration and abdominal nerves block during caesarean section for postoperative pain relief.
A. Bamigboye (2009)
10.1006/JSRE.2001.6330
Perioperative anemia: an independent risk factor for infection, mortality, and resource utilization in surgery.
J. Dunne (2002)
10.1001/ARCHSURG.1997.01430330063010
Wound tissue oxygen tension predicts the risk of wound infection in surgical patients.
H. Hopf (1997)
10.1111/j.1532-5415.2008.02053.x
The Effect of Surgical Site Infection on Older Operative Patients
K. Kaye (2009)
10.1053/rapm.2003.50050
Adverse Effects of Local Anesthetic Infiltration on Wound Healing
M. Brower (2003)
10.1067/MSY.2003.80
Supplemental perioperative fluid administration increases tissue oxygen pressure.
C. F. Arkiliç (2003)
10.1111/jgs.13332
Chronic Wound Repair and Healing in Older Adults: Current Status and Future Research
L. Gould (2015)
10.1016/S0140-6736(99)00874-0
Postoperative pain and subcutaneous oxygen tension
O. Akça (1999)
10.1136/oem.2006.029017
Heat-related and cold-related deaths in England and Wales: who is at risk?
S. Hajat (2007)
10.2741/3642
Aging and the control of human skin blood flow.
Lacy A. Holowatz (2010)
10.1213/ANE.0b013e31823fada8
The Role of Perioperative High Inspired Oxygen Therapy in Reducing Surgical Site Infection: A Meta-Analysis
B. Togioka (2012)
10.1002/art.23176
Estimates of the prevalence of arthritis and other rheumatic conditions in the United States. Part II.
R. Lawrence (2008)
10.1136/thx.2005.053058
Ageing, smoking and oxidative stress
J. Donohue (2006)
10.1007/s002689910111
Manipulation of the Metabolic Response in Clinical Practice
H. Kehlet (2000)
10.1093/AGEING/AFI199
Age-related differences in smoking cessation advice and support given to patients hospitalised with smoking-related illness.
A. Buckland (2005)
10.1152/JAPPLPHYSIOL.00347.2003
Invited review: Aging and sarcopenia.
T. Doherty (2003)
10.1093/GERONA/56.3.M146
Frailty in older adults: evidence for a phenotype.
L. Fried (2001)
10.1111/j.1365-2044.1986.tb13219.x
An investigation of factors affecting postoperative rewarming of adult patients
F. Carli (1986)
10.3389/fphys.2014.00012
Physical activity in the prevention of peripheral artery disease in the elderly
G. Schiattarella (2014)
10.1001/JAMA.281.11.1022
Is This Patient Hypovolemic
S. Mcgee (1999)
10.1016/J.RAPM.2007.06.398
Effect of a Continuous Peripheral Nerve Block on the Inflammatory Response in Knee Arthroplasty
H. Bagry (2008)
10.1161/01.CIR.101.25.2896
Physical activity prevents age-related impairment in nitric oxide availability in elderly athletes.
S. Taddei (2000)
10.7326/0003-4819-146-7-200704030-00004
Prevalence of Neutropenia in the U.S. Population: Age, Sex, Smoking Status, and Ethnic Differences
M. Hsieh (2007)
10.1093/ageing/afs197
Prevalence of sarcopenia in community-dwelling older people in the UK using the European Working Group on Sarcopenia in Older People (EWGSOP) definition: findings from the Hertfordshire Cohort Study (HCS)
H. Patel (2013)
10.1111/j.1365-2133.1990.tb16127.x
Structural changes in ageing skin
W. Montagna (1990)
10.1093/GERONA/60.11.1432
Exercise accelerates wound healing among healthy older adults: a preliminary investigation.
C. Emery (2005)
10.1016/S0140-6736(01)06071-8
Effects of preoperative warming on the incidence of wound infection after clean surgery: a randomised controlled trial
A. Melling (2001)
10.1111/j.1365-2125.1977.tb00759.x
Lignocaine kinetics in cardiac patients and aged subjects.
Roger L. Nation (1977)
10.1097/ALN.0b013e318182c2a1
Antiinflammatory Effect of Peripheral Nerve Blocks after Knee Surgery: Clinical and Biologic Evaluation
F. Martin (2008)
10.1093/ajcp/67.1.49
Granulocyte adherence in the elderly.
E. Silverman (1977)
10.1185/03007990902860325
Prevalence of anemia in elderly patients in primary care: impact on 5-year mortality risk and differences between men and women
H. G. Endres (2009)
10.1002/JCP.1041580121
TGF‐β1 induces the expression of type I collagen and SPARC, and enhances contraction of collagen gels, by fibroblasts from young and aged donors
M. Reed (1994)
10.1016/j.mvr.2015.04.004
The effect of aging on the cutaneous microvasculature.
I. Bentov (2015)
10.1097/ALN.0000000000000393
Prehabilitation versus Rehabilitation: A Randomized Control Trial in Patients Undergoing Colorectal Resection for Cancer
C. Gillis (2014)
10.1161/CIRC.104.12.1350
A 30-Year Follow-Up of the Dallas Bed Rest and Training Study: I. Effect of Age on the Cardiovascular Response to Exercise
D. McGuire (2001)
10.1093/GERONA/50A.1.B40
Effects of aging and caloric restriction on extracellular matrix biosynthesis in a model of injury repair in rats.
K. Reiser (1995)
10.1152/JAPPL.1994.77.1.11
Maximal skin blood flow is decreased in elderly men.
G. Rooke (1994)
10.1111/J.1524-4725.1993.TB00413.X
Basics of cutaneous wound repair.
R. A. Clark (1993)
10.1183/09031936.96.09122573
Pulmonary gas exchange in elderly subjects.
H. Guénard (1996)
10.1016/S0889-8537(05)70151-6
Choosing general versus regional anesthesia for the elderly.
R. Roy (2000)
Pressure ulcers: avoidable or unavoidable? Results of the National Pressure Ulcer Advisory Panel Consensus Conference.
J. Black (2011)
10.1189/jlb.69.4.513
Chemokines in cutaneous wound healing
R. Gillitzer (2001)
10.1056/NEJM199706123362407
Mild perioperative hypothermia.
D. Sessler (1997)
10.1056/NEJM200001203420303
Supplemental perioperative oxygen to reduce the incidence of surgical-wound infection.
R. Greif (2000)
10.1007/s00268-012-1886-4
Effect of Preoperative Exercise on Cardiorespiratory Function and Recovery After Surgery: a Systematic Review
Daniel P. Lemanu (2012)
10.1097/ALN.0b013e31824babfe
Antiproliferative Effects of Local Anesthetics on Mesenchymal Stem Cells: Potential Implications for Tumor Spreading and Wound Healing
E. Lucchinetti (2012)
10.1111/j.1744-1609.2011.00227.x
Effectiveness of strategies for the management and/or prevention of hypothermia within the adult perioperative environment.
Sandeep Moola (2011)
10.1001/JAMA.291.1.79
Surgical site infection and the routine use of perioperative hyperoxia in a general surgical population: a randomized controlled trial.
K. Pryor (2004)
10.1056/NEJMOA011300
Intensive insulin therapy in critically ill patients.
G. Van den Berghe (2001)
10.1016/S0140-6736(05)66630-5
Obesity, cigarette smoking, and telomere length in women
A.M. Valdes (2005)
10.1001/JAMA.296.8.974
Preventing pressure ulcers: a systematic review.
M. Reddy (2006)
10.1046/J.1524-475X.1996.40307.X
Biochemical analysis of acute and chronic wound environments.
R. Tarnuzzer (1996)
10.1097/00000542-199512000-00005
Shivering Threshold during Spinal Anesthesia Is Reduced in Elderly Patients
N. Vassilieff (1995)
10.1080/10739680600618793
Capillary Hemodynamics and Oxygen Pressures in the Aging Microcirculation
D. Poole (2006)



Semantic Scholar Logo Some data provided by SemanticScholar