5-HT 2A Receptors And BDNF Regulation: Implications For Psychopathology
Minal Jaggar, Vidita A. Vaidya
Published 2018 · Medicine
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Serotonin2A (5-HT2A) receptors are implicated in the pathophysiology of mood disorders and schizophrenia, as well as in mediating the effects of hallucinogens. 5-HT2A receptors also serve as drug targets for specific classes of antidepressants and atypical antipsychotics. Preclinical and clinical studies have identified an important role for brain derived neurotrophic factor (BDNF) in the pathogenesis of depression and schizophrenia, and in the therapeutic actions of antidepressants and antipsychotics. 5-HT2A receptors have been reported to regulate BDNF expression within key limbic neurocircuits, including the prefrontal cortex and hippocampus. Further, alterations in BDNF directly impact 5-HT2A receptor expression, signaling and function. In this book chapter, we have extensively reviewed the current understanding of the regulation of BDNF by 5-HT2A receptors at multiple levels spanning from transcriptional regulation to modulation of BDNF signaling. We have also discussed the impact of perturbations in BDNF on 5-HT2A receptors, primarily focusing on studies from BDNF mouse mutant models. These studies highlight a reciprocal relationship between 5-HT2A receptors and BDNF, and suggest that such a crosstalk may play an important role in the actions of stress, antidepressant and atypical antipsychotic treatments, and in mediating hallucinogenic responses. We also highlight specific open questions hitherto unexplored in understanding the nature of interaction between 5-HT2A receptors and BDNF, and the implications of such a relationship to psychopathology.
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BDNF Release Is Required for the Behavioral Actions of Ketamine
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Distinct signaling pathways of precursor BDNF and mature BDNF in cultured cerebellar granule neurons
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Evidence for the Preferential Involvement of 5-HT2A Serotonin Receptors in Stress- and Drug-Induced Dopamine Release in the Rat Medial Prefrontal Cortex
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TrkB Regulates Hippocampal Neurogenesis and Governs Sensitivity to Antidepressive Treatment
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Enhanced BDNF Signaling is Associated with an Antidepressant-like Behavioral Response and Changes in Brain Monoamines
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Functional Role of BDNF Production from Unique Promoters in Aggression and Serotonin Signaling
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Activation of the Trk Signaling Pathway by Extracellular Zinc
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Serotonin-induced MMP-13 Production Is Mediated via Phospholipase C, Protein Kinase C, and ERK1/2 in Rat Uterine Smooth Muscle Cells*
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Mechanism of the 5-hydroxytryptamine 2A receptor-mediated facilitation of synaptic activity in prefrontal cortex
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Inhibition of parvalbumin-expressing interneurons results in complex behavioral changes
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Variant Brain-Derived Neurotrophic Factor Val66Met Polymorphism Alters Vulnerability to Stress and Response to Antidepressants
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Blockade of 5-HT2 Receptor Selectively Prevents MDMA-Induced Verbal Memory Impairment
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Differential Regulation of Mitogen-Activated Protein Kinases ERK1/2 and ERK5 by Neurotrophins, Neuronal Activity, and cAMP in Neurons
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BDNF protects against stress-induced impairments in spatial learning and memory and LTP.
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GABAergic interneuron origin of schizophrenia pathophysiology
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Stress and glucocorticoids affect the expression of brain-derived neurotrophic factor and neurotrophin-3 mRNAs in the hippocampus
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Truncated TrkB-T1 mediates neurotrophin-evoked calcium signalling in glia cells
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Brain-Derived Neurotrophic Factor and Neuropsychiatric Disorders
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Stimulation of 5-HT(2) receptors in prefrontal pyramidal neurons inhibits Ca(v)1.2 L type Ca(2+) currents via a PLCbeta/IP3/calcineurin signaling cascade.
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Behavioral and serotonergic consequences of decreasing or increasing hippocampus brain-derived neurotrophic factor protein levels in mice
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Lasting Epigenetic Influence of Early-Life Adversity on the BDNF Gene
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Serotonin-Induced Increases in Adult Cell Proliferation and Neurogenesis are Mediated Through Different and Common 5-HT Receptor Subtypes in the Dentate Gyrus and the Subventricular Zone
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Immunohistochemical localization of brain-derived neurotrophic factor in adult rat brain
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Progesterone Pretreatment Enhances Serotonin-Stimulated BDNF Gene Expression in Rat C6 Glioma Cells Through Production of 5α-Reduced Neurosteroids
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BDNF Val66Met Impairs Fluoxetine-Induced Enhancement of Adult Hippocampus Plasticity
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Developmental regulation of brain-derived neurotrophic factor messenger RNAs transcribed from different promoters in the rat brain
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BDNF and VEGF in the pathogenesis of stress-induced affective diseases: an insight from experimental studies.
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5-Hydroxytryptamine 2A receptor antagonists as potential treatment for psychiatric disorders
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Repeated treatment with mirtazapine induces brain-derived neurotrophic factor gene expression in rats
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Reduced brain-derived neurotrophic factor is associated with a loss of serotonergic innervation in the hippocampus of aging mice.
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Effects of brain-derived neurotrophic factor (BDNF) on glial cells and serotonergic neurones during development.
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The molecular neurobiology of depression
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Brain-Derived Neurotrophic Factor Induces Long-Term Potentiation in Intact Adult Hippocampus: Requirement for ERK Activation Coupled to CREB and Upregulation of Arc Synthesis
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Converging translational evidence for the involvement of the serotonin 2A receptor gene in major depressive disorder
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Brain-Derived Neurotrophic Factor Expands Ocular Dominance Columns in Visual Cortex in Monocularly Deprived and Nondeprived Kittens But Does Not in Adult Cats
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Altered Brain-Derived Neurotrophic Factor Expression in the Ventral Tegmental Area, but not in the Hippocampus, Is Essential for Antidepressant-Like Effects of Electroconvulsive Therapy
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Increased expression of brain-derived neurotrophic factor mRNA in rat hippocampus is associated with improved spatial memory and enriched environment
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The mGlu2/3 Receptor Agonists LY354740 and LY379268 Differentially Regulate Restraint-Stress-Induced Expression of c-Fos in Rat Cerebral Cortex
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The role of neurotrophic factors in adult hippocampal neurogenesis, antidepressant treatments and animal models of depressive-like behavior.
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Group II mGlu receptor agonists inhibit behavioural and electrophysiological effects of DOI in mice
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Biphasic change in BDNF gene expression following antidepressant drug treatment explained by differential transcript regulation
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BDNF-TRKB signaling system of the dorsal periaqueductal gray matter is implicated in the panicolytic-like effect of antidepressant drugs
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Brain-derived neurotrophic factor and trkB are essential for cAMP-mediated induction of the serotonergic neuronal phenotype.
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Influence of thyroid hormone on 5-HT1A and 5-HT2A receptor-mediated regulation of hippocampal BDNF mRNA expression
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Increased neurogenesis and the ectopic granule cells after intrahippocampal BDNF infusion in adult rats
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Suppression of piriform cortex activity in rat by corticotropin-releasing factor 1 and serotonin 2A/C receptors
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Bi-phasic change in BDNF gene expression following antidepressant drug treatment
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Schizophrenia-Related Neural and Behavioral Phenotypes in Transgenic Mice Expressing Truncated Disc1
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