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Role Of Optical Coherence Tomography In Glaucoma

A. Akman
Published 2018 · Medicine

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Retinal ganglion cells (RGCs) are the ultimate target of glaucomatous damage. Optical Coherence Tomography (OCT) revolutionized the diagnosis and monitoring of glaucoma as it can detect RGC damage objectively and quantitatively. OCT can demonstrate changes related to RGC damage in three anatomical domains. Retinal nerve fiber layer (RNFL) analysis has been a primary outcome of interest and can establish loss of RGC axons. Macular ganglion cell analysis can demonstrate thinning of the RGC axonal complex directly at the macula. Optic nerve head analysis measures changes in the RGC axons at the level of the neuroretinal rim. The use of these three approaches together increases the chances of detecting glaucomatous damage in very early stages. In an individual patient, any of these parameters might be affected earlier than the other two, and hence, measuring the RNFL, neuroretinal rim and macula simultaneously increases the odds for identifying early glaucoma. The aim of this chapter is to summarize the role of these three approaches in clinical practice for diagnosis of glaucoma.
This paper references
10.1016/j.preteyeres.2012.08.003
Glaucomatous damage of the macula
D. Hood (2013)
10.1126/science.1957169
Optical coherence tomography
D. Huang (1991)
10.1167/TVST.1.1.3
The Nature of Macular Damage in Glaucoma as Revealed by Averaging Optical Coherence Tomography Data.
D. Hood (2012)
10.1167/iovs.10-5572
Three-dimensional imaging of macular inner structures in glaucoma by using spectral-domain optical coherence tomography.
Yuriko Kotera (2011)
10.1177/004947558701700407
Diagnosis of Primary Open Angle Glaucoma
A. Foster (1987)
10.1016/j.ajo.2013.04.016
From clinical examination of the optic disc to clinical assessment of the optic nerve head: a paradigm change.
B. Chauhan (2013)
10.1007/s00417-005-0094-4
Ten-year results: detection of long-term progressive optic disc changes with confocal laser tomography
H. Philippin (2005)
10.5455/medarh.2014.68.113-116
Correlation Between Retinal Nerve Fiber Layer and Disc Parameters in Glaucoma Suspected Eyes
S. Kasumovic (2014)
10.1167/iovs.16-19933
Clinical Utility of Optical Coherence Tomography in Glaucoma
Z. Dong (2016)
Inter-Visit and Inter-Instrument Variability for Cirrus HD-OCT Peripapillary Retinal Nerve Fiber Layer Thickness Measurements
Merle Horne (2008)
10.1167/iovs.10-5222
Reproducibility of peripapillary retinal nerve fiber layer thickness and optic nerve head parameters measured with cirrus HD-OCT in glaucomatous eyes.
Jean-Claude Mwanza (2010)
10.1016/j.ophtha.2015.06.015
Estimating Lead Time Gained by Optical Coherence Tomography in Detecting Glaucoma before Development of Visual Field Defects.
Tammy M. Kuang (2015)
10.1016/j.ophtha.2009.04.013
Retinal nerve fiber layer imaging with spectral-domain optical coherence tomography: a variability and diagnostic performance study.
C. Leung (2009)
10.1002/cne.903000103
Topography of ganglion cells in human retina
C. Curcio (1990)
10.1167/iovs.13-13310
Automated segmentation of optic nerve head structures with optical coherence tomography.
F. Almobarak (2014)
10.1136/bjophthalmol-2012-301845
Macular assessment using optical coherence tomography for glaucoma diagnosis
K. Sung (2012)
10.1167/TVST.4.6.4
Central Glaucomatous Damage of the Macula Can Be Overlooked by Conventional OCT Retinal Nerve Fiber Layer Thickness Analyses.
Diane L. Wang (2015)
10.1016/S0161-6420(92)32018-4
An evaluation of optic disc and nerve fiber layer examinations in monitoring progression of early glaucoma damage.
H. Quigley (1992)
10.1007/s00417-010-1585-5
Diagnostic ability of retinal ganglion cell complex, retinal nerve fiber layer, and optic nerve head measurements by Fourier-domain optical coherence tomography
A. Schulze (2010)
10.1016/j.preteyeres.2007.08.001
A framework for comparing structural and functional measures of glaucomatous damage
D. Hood (2007)
10.1001/archophthalmol.2009.276
Prediction of functional loss in glaucoma from progressive optic disc damage.
F. Medeiros (2009)
10.1016/j.ophtha.2012.03.044
Retinal nerve fiber layer imaging with spectral-domain optical coherence tomography: patterns of retinal nerve fiber layer progression.
C. Leung (2012)
10.1097/ICU.0000000000000024
Diagnosing glaucoma progression with optical coherence tomography.
Christopher Kai-shun Leung (2014)
10.1016/j.ophtha.2012.09.055
Enhanced detection of open-angle glaucoma with an anatomically accurate optical coherence tomography-derived neuroretinal rim parameter.
B. Chauhan (2013)
10.1016/j.ophtha.2011.09.054
Optic disc margin anatomy in patients with glaucoma and normal controls with spectral domain optical coherence tomography.
Alexandre S C Reis (2012)
10.1001/archopht.1982.01030030137016
Optic nerve damage in human glaucoma. III. Quantitative correlation of nerve fiber loss and visual field defect in glaucoma, ischemic neuropathy, papilledema, and toxic neuropathy.
H. Quigley (1982)
10.1016/j.ophtha.2010.01.026
Retinal nerve fiber layer imaging with spectral-domain optical coherence tomography: analysis of the retinal nerve fiber layer map for glaucoma detection.
C. Leung (2010)
10.1097/IJG.0b013e3181f3eb64
Reproducibility of Retinal Nerve Fiber Layer Thickness Measurements Using Spectral Domain Optical Coherence Tomography
H. Wu (2011)
10.1136/bjo.83.3.290
Detection of optic disc change with the Heidelberg retina tomograph before confirmed visual field change in ocular hypertensives converting to early glaucoma
D. Kamal (1999)
10.1167/iovs.12-9979
Structural and functional abnormalities of retinal ganglion cells measured in vivo at the onset of optic nerve head surface change in experimental glaucoma.
B. Fortune (2012)
10.1167/iovs.11-7962
Macular ganglion cell-inner plexiform layer: automated detection and thickness reproducibility with spectral domain-optical coherence tomography in glaucoma.
Jean-Claude Mwanza (2011)
10.1016/J.AJO.2004.08.069
Evaluation of retinal nerve fiber layer, optic nerve head, and macular thickness measurements for glaucoma detection using optical coherence tomography.
F. Medeiros (2005)
10.1016/j.ophtha.2015.06.001
Bruch's Membrane Opening Minimum Rim Width and Retinal Nerve Fiber Layer Thickness in a Normal White Population: A Multicenter Study.
B. Chauhan (2015)
10.1167/iovs.13-13482
Structure-function relationships with spectral-domain optical coherence tomography retinal nerve fiber layer and optic nerve head measurements.
F. Pollet-Villard (2014)
10.1167/iovs.13-11676
Comparison of different spectral domain OCT scanning protocols for diagnosing preperimetric glaucoma.
Renato Lisboa (2013)
10.1167/iovs.12-9673
Detection of localized retinal nerve fiber layer defects with posterior pole asymmetry analysis of spectral domain optical coherence tomography.
J. Seo (2012)
10.1097/IJG.0b013e3181efb358
A 12-week, Double-masked, Parallel-group Study of the Safety and Efficacy of Travoprost 0.004% Compared With Pilocarpine 1% in Chinese Patients With Primary Angle-closure and Primary Angle-closure Glaucoma
Ling-ling Wu (2011)
10.1001/jamaophthalmol.2013.7656
Prevalence and nature of early glaucomatous defects in the central 10° of the visual field.
Ilana Traynis (2014)
10.1371/journal.pone.0125957
Diagnostic Ability of Macular Ganglion Cell Inner Plexiform Layer Measurements in Glaucoma Using Swept Source and Spectral Domain Optical Coherence Tomography
Z. Yang (2015)
10.1016/S0161-6420(96)30410-7
Reproducibility of nerve fiber layer thickness measurements using optical coherence tomography.
J. Schuman (1996)
10.1001/archopht.1991.01080010079037
Clinically detectable nerve fiber atrophy precedes the onset of glaucomatous field loss.
A. Sommer (1991)
10.1097/IJG.0b013e3182071cdd
Comparison of Retinal Nerve Fiber Layer Measurement Between 2 Spectral Domain OCT Instruments
B. B. Tan (2012)
10.1097/IJG.0b013e318220dbb7
Glaucoma Diagnostic Capabilities of Optic Nerve Head Parameters as Determined by Cirrus HD Optical Coherence Tomography
K. Sung (2012)
10.1136/BJOPHTHALMOL-2012-301845
Macular assessment using optical coherence tomography for glaucoma diagnosis
김찬윤 (2012)
10.1016/J.AJO.2006.07.043
Assessment of retinal nerve fiber layer using optical coherence tomography and scanning laser polarimetry in progressive glaucomatous optic neuropathy.
M. Sehi (2006)
10.1001/archophthalmol.2011.242
Novel software strategy for glaucoma diagnosis: asymmetry analysis of retinal thickness.
S. Asrani (2011)
10.1038/eye.2010.139
Diagnostic accuracy of nerve fibre layer, macular thickness and optic disc measurements made with the RTVue-100 optical coherence tomograph to detect glaucoma
A. Garas (2011)
10.1167/iovs.13-13130
Early glaucoma involves both deep local, and shallow widespread, retinal nerve fiber damage of the macular region.
D. Hood (2014)
10.1167/tvst.5.2.15
The 24-2 Visual Field Test Misses Central Macular Damage Confirmed by the 10-2 Visual Field Test and Optical Coherence Tomography
Lola M. Grillo (2016)
10.1016/J.OPHTHA.2007.08.011
Mapping of macular substructures with optical coherence tomography for glaucoma diagnosis.
O. Tan (2008)
10.1167/IOVS.05-1584
Optic disc and visual field progression in ocular hypertensive subjects: detection rates, specificity, and agreement.
N. Strouthidis (2006)
10.1016/j.ophtha.2010.01.031
Comparison of different spectral domain optical coherence tomography scanning areas for glaucoma diagnosis.
H. Rao (2010)
10.1016/j.ophtha.2017.04.021
24-2 Visual Fields Miss Central Defects Shown on 10-2 Tests in Glaucoma Suspects, Ocular Hypertensives, and Early Glaucoma.
C. G. De Moraes (2017)
10.1016/j.ophtha.2009.05.025
Detection of macular ganglion cell loss in glaucoma by Fourier-domain optical coherence tomography.
O. Tan (2009)
10.1001/ARCHOPHT.123.4.464
Optical coherence tomography longitudinal evaluation of retinal nerve fiber layer thickness in glaucoma.
G. Wollstein (2005)
10.1016/j.ophtha.2011.12.014
Glaucoma diagnostic accuracy of ganglion cell-inner plexiform layer thickness: comparison with nerve fiber layer and optic nerve head.
Jean-Claude Mwanza (2012)
10.1136/bjo.2009.163493
Comparative study of retinal nerve fibre layer measurement by RTVue OCT and GDx VCC
X. Wang (2010)



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