← Back to Search
The Role Of Tight Junctions And Aquaporins In Skin Dryness
Published 2012 · Chemistry
Save to my Library
Download via 🐼 PaperPanda Download via oaDOI Download via OAB Download via LibKey Download via Google Google ScholarAnalyze on Scholarcy Visualize in Litmaps
Reduce the time it takes to create your bibliography by a factor of 10 by using the world’s favourite reference manager
Time to take this seriously.
The maintenance of optimum water content in the skin and especially in the epidermis is provided by many orchestrated mechanisms. Water uptake into the dermis/epidermis, paracellular and transcellular water transport through the epidermis and water retention as well as controlled water loss in the stratum corneum have to be coordinated. Unbalance of these mechanisms results in dry skin. Following its paracellular route, water has to pass tight junctions before it can get into contact with the stratum corneum. For the transcellular route water channels, formed by so-called aquaporins, are of importance. Here, I will summarize our current knowledge of the involvement of aquaporin-formed pores and tight junctions in epidermal water homeostasis – as well as in other functions – and their putative roles in skin dryness.
This paper references
Intercellular spaces of the human epidermis as demonstrated with lanthanum.
K. Hashimoto (1971)
The Merkel cell.
R. Winkelmann (1972)
Tetrameric assembly of CHIP28 water channels in liposomes and cell membranes: a freeze-fracture study
J. Verbavatz (1993)
Molecular cloning and expression of a member of the aquaporin family with permeability to glycerol and urea in addition to water expressed at the basolateral membrane of kidney collecting duct cells.
K. Ishibashi (1994)
Molecular mechanisms of photoaging and its prevention by retinoic acid: ultraviolet irradiation induces MAP kinase signal transduction cascades that induce Ap-1-regulated matrix metalloproteinases that degrade human skin in vivo.
G. Fisher (1998)
Defective stratum corneum and early neonatal death in mice lacking the gene for transglutaminase 1 (keratinocyte transglutaminase).
M. Matsuki (1998)
Low humidity stimulates epidermal DNA synthesis and amplifies the hyperproliferative response to barrier disruption: implication for seasonal exacerbations of inflammatory dermatoses.
M. Denda (1998)
Subcellular distribution of tight junction-associated proteins (occludin, ZO-1, ZO-2) in rodent skin.
K. Morita (1998)
Physiological mechanism for enhancement of paracellular drug transport.
M. Hayashi (1999)
Water Channel Protein AQP3 Is Present in Epithelia Exposed to the Environment of Possible Water Loss
Toshiyuki Matsuzaki (1999)
Complex phenotype of mice lacking occludin, a component of tight junction strands.
M. Saitou (2000)
Nicotinamide increases biosynthesis of ceramides as well as other stratum corneum lipids to improve the epidermal permeability barrier
O. Tanno (2000)
Epidermal tight junctions: ZO-1 and occludin are expressed in mature, developing, and affected skin and in vitro differentiating keratinocytes.
K. Pummi (2001)
Altered expression of occludin and tight junction formation in psoriasis
Y. Yoshida (2001)
Defective urinary concentrating ability due to a complete deficiency of aquaporin-1.
L. King (2001)
Osmotic stress up-regulates aquaporin-3 gene expression in cultured human keratinocytes.
Y. Sugiyama (2001)
Tight junctions and compositionally related junctional structures in mammalian stratified epithelia and cell cultures derived therefrom.
L. Langbein (2002)
Permeability barrier dysfunction in transgenic mice overexpressing claudin 6.
K. Turksen (2002)
Functional requirement of aquaporin-5 in plasma membranes of sweat glands
L. N. Nejsum (2002)
Functional expression of AQP3 in human skin epidermis and reconstructed epidermis.
R. Sougrat (2002)
Impaired Stratum Corneum Hydration in Mice Lacking Epidermal Water Channel Aquaporin-3*
T. Ma (2002)
Claudin-based tight junctions are crucial for the mammalian epidermal barrier
M. Furuse (2002)
AQP3 Deficiency in Humans and the Molecular Basis of a Novel Blood Group System, GIL*
N. Roudier (2002)
Selectively Reduced Glycerol in Skin of Aquaporin-3-deficient Mice May Account for Impaired Skin Hydration, Elasticity, and Barrier Recovery*
M. Hara (2002)
Organization and formation of the tight junction system in human epidermis and cultured keratinocytes.
J. Brandner (2002)
Expression patterns of tight junction proteins in Merkel cell carcinoma
N. Haass (2003)
Immunohistological distribution of the tight junction components ZO‐1 and occludin in regenerating human epidermis
M. Malminen (2003)
Expression of claudin‐5 in dermal vascular endothelia
K. Morita (2003)
AQP1 and AQP3, Psoriasin, and Nitric Oxide Synthases 1–3 are Inflammatory Mediators in Erythema Toxicum Neonatorum
G. Marchini (2003)
Aquaporin 3 colocates with phospholipase d2 in caveolin-rich membrane microdomains and is downregulated upon keratinocyte differentiation.
X. Zheng (2003)
Tight junction-related structures in the absence of a lumen: occludin, claudins and tight junction plaque proteins in densely packed cell formations of stratified epithelia and squamous cell carcinomas.
L. Langbein (2003)
Glycerol replacement corrects defective skin hydration, elasticity, and barrier function in aquaporin-3-deficient mice
M. Hara (2003)
Expression and localization of tight junction-associated proteins in human hair follicles
J. Brandner (2003)
Glycerol regulates stratum corneum hydration in sebaceous gland deficient (asebia) mice.
J. Fluhr (2003)
Transepidermal Water Loss in Developing Rats: Role of Aquaporins in the Immature Skin
J. Ågren (2003)
The tight junction: a multifunctional complex.
E. Schneeberger (2004)
Claudin-1 gene mutations in neonatal sclerosing cholangitis associated with ichthyosis: a tight junction disease.
S. Hadj-Rabia (2004)
Junctional adhesion molecules (JAMs): more molecules with dual functions?
K. Ebnet (2004)
Tight junction‐associated proteins (occludin, ZO‐1, claudin‐1, claudin‐4) in squamous cell carcinoma and Bowen's disease
K. Morita (2004)
Sealing the live part of the skin: the integrated meshwork of desmosomes, tight junctions and curvilinear ridge structures in the cells of the uppermost granular layer of the human epidermis.
H. Schlüter (2004)
Molecular mechanisms and drug development in aquaporin water channel diseases: structure and function of aquaporins.
M. Yasui (2004)
Progressive Adipocyte Hypertrophy in Aquaporin-7-deficient Mice
M. Hara-Chikuma (2005)
The epidermal barrier function is dependent on the serine protease CAP1/Prss8
C. Leyvraz (2005)
Loss of claudin‐1 expression in tumor‐associated vessels correlates with acquisition of metastatic phenotype in melanocytic neoplasms
M. L. Cohn (2005)
[Structure and function of water channels].
Y. Fujiyoshi (2002)
Up-regulated expression of zonula occludens protein-1 in human melanoma associates with N-cadherin and contributes to invasion and adhesion.
K. Smalley (2005)
E‐cadherin is essential for in vivo epidermal barrier function by regulating tight junctions
Judith A Tunggal (2005)
Junctional adhesion molecules (JAM)-B and -C contribute to leukocyte extravasation to the skin and mediate cutaneous inflammation.
R. Ludwig (2005)
More than just water channels: unexpected cellular roles of aquaporins
A. Verkman (2005)
The Rac activator Tiam1 controls tight junction biogenesis in keratinocytes through binding to and activation of the Par polarity complex
A. Mertens (2005)
Tight junction: a co‐ordinator of cell signalling and membrane trafficking
K. Köhler (2005)
Are Sweat Glands an Alternate Penetration Pathway? Understanding the Morphological Complexity of the Axillary Sweat Gland Apparatus
K. Wilke (2005)
Delayed epidermal permeability barrier formation and hair follicle aberrations in Inv-Cldn6 mice
T. Troy (2005)
EGFR-mediated expression of aquaporin-3 is involved in human skin fibroblast migration.
C. Cao (2006)
Expression and function of aquaporins in human skin: Is aquaporin-3 just a glycerol transporter?
M. Boury-Jamot (2006)
Claudins and epithelial paracellular transport.
C. V. Van Itallie (2006)
Confirmation of the origin of NISCH syndrome
L. Feldmeyer (2006)
Increased expression of aquaporin 3 in atopic eczema
M. Olsson (2006)
Hyaluronan-CD44 interaction stimulates keratinocyte differentiation, lamellar body formation/secretion, and permeability barrier homeostasis.
L. Bourguignon (2006)
Identification of a keratinocarcinoma cell line expressing AQP3
M. Nakakoshi (2006)
DHCR24 gene knockout mice demonstrate lethal dermopathy with differentiation and maturation defects in the epidermis.
R. Mirza (2006)
The aquaporin water channels.
P. Agre (2006)
Tight junctions: molecular architecture and function.
S. Aijaz (2006)
Claudins in occluding junctions of humans and flies.
M. Furuse (2006)
Skin hydration: a review on its molecular mechanisms
S. Verdier-Sévrain (2007)
Changes in the distribution pattern of Claudin tight junction proteins during the progression of mouse skin tumorigenesis
A. Arabzadeh (2007)
A topical lipophilic niacin derivative increases NAD, epidermal differentiation and barrier function in photodamaged skin
E. Jacobson (2007)
The role of junctional adhesion molecules in vascular inflammation
C. Weber (2007)
Role of aPKC isoforms and their binding partners Par3 and Par6 in epidermal barrier formation.
I. Helfrich (2007)
Tight junction components occludin, ZO‐1, and claudin‐1, ‐4 and ‐5 in active and healing psoriasis
S. Peltonen (2007)
Altered claudin expression is a feature of chronic plaque psoriasis
R. Watson (2007)
Tight junctions/adherens junctions: basic structure and function.
C. Niessen (2007)
The targeted overexpression of a Claudin mutant in the epidermis of transgenic mice elicits striking epidermal and hair follicle abnormalities
T. Troy (2007)
Aquaporin-3 facilitates epidermal cell migration and proliferation during wound healing
M. Hara-Chikuma (2008)
Hydrating skin by stimulating biosynthesis of aquaporins.
M. Dumas (2007)
A potential role for the phospholipase D2-aquaporin-3 signaling module in early keratinocyte differentiation: production of a phosphatidylglycerol signaling lipid.
W. Bollag (2007)
Tight junction proteins in keratinocytes: localization and contribution to barrier function
T. Yuki (2007)
Langerhans cells and lymph node dendritic cells express the tight junction component claudin-1.
S. Zimmerli (2007)
Claudin-1 overexpression in melanoma is regulated by PKC and contributes to melanoma cell motility
P. D. Leotlela (2007)
Defective glycerol metabolism in aquaporin 9 (AQP9) knockout mice
A. Rojek (2007)
Prevention of Skin Tumorigenesis and Impairment of Epidermal Cell Proliferation by Targeted Aquaporin-3 Gene Disruption
M. Hara-Chikuma (2007)
All‐trans retinoic acid attenuates ultraviolet radiation‐induced down‐regulation of aquaporin‐3 and water permeability in human keratinocytes
C. Cao (2008)
Increased expression of aquaporin‐3 in the epidermis of DHCR24 knockout mice
R. Mirza (2008)
Glycerol and the skin: holistic approach to its origin and functions
J.W. Fluhr (2008)
Retinoic acid increases aquaporin 3 expression in normal human skin.
G. Bellemère (2008)
Effect of RNA interference of tight junction-related molecules on intercellular barrier function in cultured human keratinocytes
Takuya Yamamoto (2008)
Human epidermal Langerhans cells express the tight junction protein claudin‐1 and are present in human genetic claudin‐1 deficiency (NISCH syndrome)
S. Zimmerli (2007)
Phosphorylation of claudin-4 is required for tight junction formation in a human keratinocyte cell line.
S. Aono (2008)
Histological variation of Japanese skin with aging
M. Dumas (2008)
Regulation of epidermal tight-junctions (TJ) during infection with exfoliative toxin-negative Staphylococcus strains.
U. Ohnemus (2008)
Nicotinamide attenuates aquaporin 3 overexpression induced by retinoic acid through inhibition of EGFR/ERK in cultured human skin keratinocytes.
Xiuzu Song (2008)
Dermatitis and Aging-Related Barrier Dysfunction in Transgenic Mice Overexpressing an Epidermal-Targeted Claudin 6 Tail Deletion Mutant
T. Troy (2009)
Aquaporins: translating bench research to human disease
A. Verkman (2009)
External antigen uptake by Langerhans cells with reorganization of epidermal tight junction barriers
A. Kubo (2009)
Alteration of tight junction proteins is an early event in psoriasis: putative involvement of proinflammatory cytokines.
N. Kirschner (2009)
Oxygen deprivation inhibits basal keratinocyte proliferation in a model of human skin and induces regio‐specific changes in the distribution of epidermal adherens junction proteins, aquaporin‐3, and glycogen
J. Straseski (2009)
Tumor necrosis factor-alpha decreases aquaporin-3 expression in DJM-1 keratinocytes.
I. Horie (2009)
Water channel proteins (later called aquaporins) and relatives: Past, present, and future
G. Benga (2009)
Tight junctions and tight junction proteins in mammalian epidermis.
J. Brandner (2009)
Tight junctions and the regulation of gene expression.
M. Balda (2009)
Effect of green Coffea arabica L. seed oil on extracellular matrix components and water‐channel expression in in vitro and ex vivo human skin models
Maria Del Carmen Velazquez Pereda (2009)
The expression of differentiation markers in aquaporin-3 deficient epidermis
M. Hara-Chikuma (2009)
Tight junctions: is there a role in dermatology?
N. Kirschner (2010)
TGF-beta1 causes epithelial-mesenchymal transition in HaCaT derivatives, but induces expression of COX-2 and migration only in benign, not in malignant keratinocytes.
Kati Räsänen (2010)
Reduced aquaporin3 expression and survival of keratinocytes in the depigmented epidermis of vitiligo.
Nan-Hyung Kim (2010)
Fibroblast growth factor receptors 1 and 2 in keratinocytes control the epidermal barrier and cutaneous homeostasis
Jingxuan Yang (2010)
Epidermal Permeability Barrier Recovery Is Delayed in Vitiligo-Involved Sites
J. Liu (2010)
Perturbation of lamellar granule secretion by sodium caprate implicates epidermal tight junctions in lamellar granule function.
Shohei Kuroda (2010)
Trans-Zeatin attenuates ultraviolet induced down-regulation of aquaporin-3 in cultured human skin keratinocytes.
Chao Ji (2010)
Tight junctions form a barrier in human epidermis.
N. Kirschner (2010)
The TRPV4 Channel Contributes to Intercellular Junction Formation in Keratinocytes*♦
T. Sokabe (2010)
Expression of differential genes involved in the maintenance of water balance in human skin by Piptadenia colubrina extract
Maria Del Carmen Velazquez Pereda (2010)
Aquaporin‐3 gene and protein expression in sun‐protected human skin decreases with skin ageing
Ji Li (2010)
Somatostatin regulates tight junction function and composition in human keratinocytes
Matthias Vockel (2010)
Tight junction regulates epidermal calcium ion gradient and differentiation.
M. Kurasawa (2011)
Characterization of tight junctions and their disruption by UVB in human epidermis and cultured keratinocytes.
T. Yuki (2011)
Impact of AQP3 inducer treatment on cultured human keratinocytes, ex vivo human skin and volunteers
N. Garcia (2011)
Resolved psoriasis lesions retain expression of a subset of disease-related genes.
M. Suárez-Fariñas (2011)
CD44 regulates tight-junction assembly and barrier function.
N. Kirschner (2011)
Upregulation of aquaporin-3 is involved in keratinocyte proliferation and epidermal hyperplasia.
Kyoko Nakahigashi (2011)
Abnormal aquaporin-3 protein expression in hyperproliferative skin disorders
K. E. Voss (2011)
Compartmentalization of the human stratum corneum by persistent tight junction‐like structures
M. Haftek (2011)
Tight junctions in the stratum corneum explain spatial differences in corneodesmosome degradation
S. Igawa (2011)
Homo‐ and heterotypic cell–cell contacts in Merkel cells and Merkel cell carcinomas: heterogeneity and indications for cadherin switching
A. Werling (2011)
Lysophospholipids improve skin moisturization by modulating of calcium‐dependent cell differentiation pathway
S. Yahagi (2011)
Tight junction defects in patients with atopic dermatitis.
A. De Benedetto (2011)
Byakkokaninjinto prevents body water loss by increasing the expression of kidney aquaporin‐2 and skin aquaporin‐3 in KKAy mice
Takashi Aburada (2011)
Filaggrin genotype in ichthyosis vulgaris predicts abnormalities in epidermal structure and function.
R. Gruber (2011)
This paper is referenced by
Contribution of tight junction proteins to ion, macromolecule, and water barrier in keratinocytes.
N. Kirschner (2013)