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Zinc Signals In Cellular Functions And Disorders
T. Fukada, T. Kambe
Published 2014 · Chemistry
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Zinc plays an indispensable role in life. It regulates a great number of protein functions including transcription factors, enzymes, adapters, receptors, and growth factors as a structural or catalytic factor. Recently, a further function of zinc has received extensive interest and attention because of its potential importance as a signaling mediator. Zinc plays a dynamic role as an extracellular and intracellular signaling factor, which enables communication between cells in an autocrine, paracrine, or endocrine fashion, conversion of extracellular stimuli to intracellular responses, and regulation of various intracellular signaling pathways. These zinc functions are recognized as “zinc signaling,” which has critical roles in physiology, and thus their imbalance can cause a variety of problems with regard to human health. This book extensively reviews the field from the basic aspects to the crucial roles of zinc signaling in biological processes, discussing the future directions and questions at both the molecular and the physiological level.
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Modulation of inhibitory and excitatory amino acid receptor ion channels by zinc
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Modulation of mitochondrial function by endogenous Zn2+ pools
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ZnT1 is a major Zn transporter on the plasma membrane and may participate in cytosolic Zn homeostasis in neurons by transporting Zn from the somata to the extracellular space (Sekler et al
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requirement for elevated zinc availability (Bernhardt et al
Metallothioneins (MT) play an important role in zinc
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Another neutrophil granulocyte
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Zinc is also critical for immune system function
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Pim Family Kinases Enhance Tumor Growth of Prostate Cancer Cells
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Developmental regulation of the growth plate
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M. Puertollano (2011)
Negative regulation of Toll-like receptor-mediated immune responses
F. Liew (2005)
GPR39 signaling is stimulated by zinc ions but not by obestatin.
B. Holst (2007)
Behavior in the forced swim test and neurochemical changes in the hippocampus in young rats after 2-week zinc deprivation
Haruna Tamano (2009)
Serum copper and zinc concentrations in serum from patients with cancer and cardiovascular disease.
F. Martín-Lagos (1997)
Effects on the endocrine pancreas in Chinese hamsters fed zinc deficient diets.
L. Boquist (1969)
Initial and cyclic recruitment of ovarian follicles.
E. Mcgee (2000)
Zinc transporter ZIP8 (SLC39A8) and zinc influence IFN‐γ expression in activated human T cells
T. B. Aydemir (2009)
Zinc and diarrheal disease: current status and future perspectives
Angus G. Scrimgeour (2008)
The SLC39 family of zinc transporters.
Jeeyon Jeong (2013)
The blood–brain barrier: an overview: Structure, regulation, and clinical implications
P. Ballabh (2004)
Deficiencies of hippocampal Zn and ZnT3 accelerate brain aging of Rat.
T. Saito (2000)
2008), is responsible for the activation of multiple signaling pathways
13 Role and Regulation of Copper and Zinc Transport Proteins in the Central Nervous System
C. Levenson (2007)
SLC39A8 ZIP8 Mutation Impaired multiorgan organogenesis and hematopoiesis
Tissue plasminogen activator, a secreted serine protease, is excitotoxic and increases lysosomal sequestration of the increased Zn
Research on zinc homeostasis has focused on intestinal
Genetically encoded copper(I) reporters with improved response for use in imaging.
J. Liu (2013)
Impact of S100A8/A9 Expression on Prostate Cancer Progression In Vitro and In Vivo
Sina Grebhardt (2014)
Adipokines in inflammation and metabolic disease
N. Ouchi (2011)
Amino terminal domain regulation of NMDA receptor function.
G. A. Herin (2004)
Nutritional regulation of IGF-I and IGFBPs.
U. Le (1996)
Altered gastrointestinal and metabolic function in the GPR39-obestatin receptor-knockout mouse.
D. Moechars (2006)
Regulation of glucagon secretion by zinc: lessons from the β cell‐specific Znt8 knockout mouse model
A. Hardy (2011)
Zinc and Prostate Cancer: A Critical Scientific, Medical, and Public Interest Issue (United States)
L. Costello (2005)
Down’s syndrome, neuroinflammation, and Alzheimer neuropathogenesis
D. Wilcock (2013)
Wee1B, Myt1, and Cdc25 function in distinct compartments of the mouse oocyte to control meiotic resumption
J. Oh (2010)
Phosphodiesterase: overview of protein structures, potential therapeutic applications and recent progress in drug development
Y. H. Jeon (2005)
NKCC1 and KCC2 prevent hyperexcitability in the mouse hippocampus
L. Zhu (2008)
The connection between the extracellular stimulus and ZIP7 activation
Furthermore, oxidation of cysteine residues alters the number of metal-binding sites, thus connecting redox and zinc metabolism
Zinc deficiency impairs neuronal precursor cell proliferation and induces apoptosis via p53-mediated mechanisms
Rikki S. Corniola (2008)
Hippocampal zinc infusion delays the development of afterdischarges and seizures in a kindling model of epilepsy
Siegward-M Elsas (2009)
Inflammation, genes and zinc in Alzheimer's disease
S. Vasto (2008)
Glucagon‐like peptide 1(GLP‐1) in biology and pathology
J. Meier (2005)
Inhibition of Clathrin-Mediated Endocytosis Selectively Attenuates Specific Insulin Receptor Signal Transduction Pathways
B. P. Ceresa (1998)
The effect of zinc supplementation on the treatment of chronic hepatitis C patients with interferon and ribavirin.
Wang-Sheng Ko (2005)
Identification and cloning of a beta-cell-specific zinc transporter, ZnT-8, localized into insulin secretory granules.
F. Chimienti (2004)
Inhibitory function of zinc against excitation of hippocampal glutamatergic neurons
A. Takeda (2003)
and non-receptor tyrosine kinase
Zinc homeostatic proteins in the CNS are regulated by crosstalk between extracellular and intracellular zinc
N. Karol (2010)
G. Fosmire (1990)
Genome-level expression profiles in pediatric septic shock indicate a role for altered zinc homeostasis in poor outcome.
H. Wong (2007)
Blood-brain barrier flux of aluminum, manganese, iron and other metals suspected to contribute to metal-induced neurodegeneration.
R. Yokel (2006)
A specific laboratory test for the diagnosis of melancholia. Standardization, validation, and clinical utility.
B. Carroll (1981)
A novel member of a zinc transporter family is defective in acrodermatitis enteropathica.
K. Wang (2002)
NFAT proteins: key regulators of T-cell development and function
F. Macian (2005)
Zinc homeostasis in humans.
J. King (2000)
Trace-metal analysis of cancerous and noncancerous human tissues.
I. Mulay (1971)
A fresh look at the role of CaMKII in hippocampal synaptic plasticity and memory.
C. Rongo (2002)
Insights into Zn2+ homeostasis in neurons from experimental and modeling studies.
R. A. Colvin (2008)
An approach to assay calcineurin activity and the inhibitory effect of zinc ion.
Junyi Huang (2008)
Neurobiology of zinc and zinc-containing neurons.
C. J. Frederickson (1989)
Oocyte-dependent activation of mitogen-activated protein kinase (ERK1/2) in cumulus cells is required for the maturation of the mouse oocyte-cumulus cell complex.
You-Qiang Su (2003)
A case-control study on selenium, zinc, and copper in plasma and hair of subjects affected by breast and lung cancer
L. Piccinini (2007)
Evaluation of zinc status in whole blood and scalp hair of female cancer patients.
A. Memon (2007)
Metalloproteomes: a bioinformatic approach.
C. Andreini (2009)
Growth and zinc homeostasis in the severely Zn-deficient rat.
R. Giugliano (1984)
Syndrome of iron deficiency anemia, hepatosplenomegaly, hypogonadism, dwarfism and geophagia.
A. Prasad (1961)
Synaptic Zn homeostasis and its significance
A Takeda (2013)
Elevated plasmz zinc: a heritable anomaly.
J. C. Smith (1976)
Zip4 (Slc39a4) Expression is Activated in Hepatocellular Carcinomas and Functions to Repress Apoptosis, Enhance Cell Cycle and Increase Migration
Benjamin P. Weaver (2010)
Induction of cytokines by zinc ions in human peripheral blood mononuclear cells and separated monocytes.
C. Driessen (1994)
Zn(2+) induces stimulation of the c-Jun N-terminal kinase signaling pathway through phosphoinositide 3-Kinase.
S. J. Eom (2001)
Diet and prostatic cancer: a case-control study in Hawaii.
L. Kolonel (1988)
The Constitutively Active Orphan G-protein-coupled Receptor GPR39 Protects from Cell Death by Increasing Secretion of Pigment Epithelium-derived Growth Factor*
Sonja Dittmer (2008)
Measurement of Intracellular Free Zinc in Living Cortical Neurons: Routes of Entry
S. Sensi (1997)
Tamoxifen resistance in breast cancer cells is accompanied by an enhanced motile and invasive phenotype: Inhibition by gefitinib (`Iressa', ZD1839)
S. Hiscox (2004)
Body zinc distribution profile during N-methyl-N-nitrosourea-induced mammary tumorigenesis in rats at various levels of dietary zinc intake
W. Woo (2007)
Mechanisms and Regulation of the Gene-Expression Response to Sepsis
T. Cornell (2010)
Hepatic removal of insulin in normal man: dose response to endogenous insulin secretion.
R. Eaton (1983)
The Ig-related killer cell inhibitory receptor binds zinc and requires zinc for recognition of HLA-C on target cells.
S. Rajagopalan (1995)
Geophagia in Turkey: iron and zinc deficiency, iron and zinc absorption studies and response to treatment with zinc in geophagia cases.
A. Çavdar (1983)
The neurobiology of zinc in health and disease
C. Frederickson (2005)
Clusterin and chemoresistance.
J. Djeu (2009)
The ZnR/GPR39 Interacts With the CaSR to Enhance Signaling in Prostate and Salivary Epithelia
H. Asraf (2014)
Mechanisms of tamoxifen resistance.
A. Ring (2004)
Regulation and function of Zip4, the acrodermatitis enteropathica gene.
G. Andrews (2008)
Agonist-Driven Maturation and Plasma Membrane Insertion of Calcium-Sensing Receptors Dynamically Control Signal Amplitude
M. P. Grant (2011)
Insulin crystallization depends on zinc transporter ZnT8 expression, but is not required for normal glucose homeostasis in mice
K. Lemaire (2009)
Undernutrition as an underlying cause of malaria morbidity and mortality in children less than five years old.
L. Caulfield (2004)
Vitamin and mineral supplement use is associated with reduced risk of prostate cancer.
A. Kristal (1999)
Transient Increase in Zn2+ in Hippocampal CA1 Pyramidal Neurons Causes Reversible Memory Deficit
A. Takeda (2011)
Zinc treatment for 5 or 10 days is equally efficacious in preventing diarrhea in the subsequent 3 months among Bangladeshi children.
D. Alam (2011)
Severe Anemia and Neutropenia Associated With Hyperzincemia and Hypercalprotectinemia
S. Fessatou (2005)
Fluorescence-based quantitative scratch wound healing assay demonstrating the role of MAPKAPK-2/3 in fibroblast migration.
Manoj B. Menon (2009)
Longitudinal changes in zinc transport kinetics, metallothionein and zinc transporter expression in a blood-brain barrier model in response to a moderately excessive zinc environment.
D. J. Bobilya (2008)
The structure and mechanism of protein phosphatases: insights into catalysis and regulation.
D. Barford (1998)
Extracellular zinc ions induces mitogen-activated protein kinase activity and protein tyrosine phosphorylation in bombesin-sensitive Swiss 3T3 fibroblasts.
A. Hansson (1996)
Zinc deficiency and effects of zinc supplementation on sickle cell anemia subjects.
A. Prasad (1981)
Intracellular free zinc and zinc buffering in human red blood cells
T. J. Simons (2005)
Zinc Signals Are Essential for Lipopolysaccharide-Induced Signal Transduction in Monocytes1
H. Haase (2008)
The clinical relevance of the metabolism of prostate cancer; zinc and tumor suppression: connecting the dots
L. Costello (2006)
Host factors affecting the growth of carcinogen-induced rat mammary carcinomas: a review and tribute to Charles Brenton Huggins.
C. Welsch (1985)
SLC39A9 (ZIP9) Regulates Zinc Homeostasis in the Secretory Pathway: Characterization of the ZIP Subfamily I Protein in Vertebrate Cells
W. Matsuura (2009)
The role of zinc in wound healing.
M. Andrews (1999)
Role of corticosteroid hormones in the dentate gyrus.
M. Joëls (2007)
Bloc A (2005) Two SUR1-specific histidine residues mandatory for zinc-induced activation of the rat
V Bancila (2005)
PI arrest of isolated oocytes can be maintained in vitro
A Dominant Negative Heterozygous G87R Mutation in the Zinc Transporter, ZnT-2 (SLC30A2), Results in Transient Neonatal Zinc Deficiency
Inbal Lasry (2012)
The role of prohormone convertases in insulin biosynthesis: evidence for inherited defects in their action in man and experimental animals.
D. Steiner (1996)
Low serum Zn concentrations
survivors Wong (2007)
Postnatal Development of Zinc-Rich Terminal Fields in the Brain of the Rat
T. Valente (2002)
Reduction in duration of common colds by zinc gluconate lozenges in a double-blind study.
G. Eby (1984)
thereby having a high potential to migrate and metastasize. A simplified schematic illustration of this mechanism
oocyte meiotic maturation in vitro
J Chen (2009)
Biochemical Characterization of Human ZIP13 Protein
Bum-Ho Bin (2011)
The involvement of zinc in DNA repair
Zinc and the zinc proteome.
W. Maret (2013)
ZnT8 is responsible for transporting zinc into insulin
Obestatin, a Peptide Encoded by the Ghrelin Gene, Opposes Ghrelin's Effects on Food Intake
J. Zhang (2005)
Dual nanomolar and picomolar Zn(II) binding properties of metallothionein.
A. Krężel (2007)
Zinc transporters and cancer: a potential role for ZIP7 as a hub for tyrosine kinase activation.
C. Hogstrand (2009)
Exocytosis of Vesicular Zinc Reveals Persistent Depression of Neurotransmitter Release during Metabotropic Glutamate Receptor Long-Term Depression at the Hippocampal CA3–CA1 Synapse
J. Qian (2006)
Zinc as adjunct treatment in infants aged between 7 and 120 days with probable serious bacterial infection: a randomised, double-blind, placebo-controlled trial
S. Bhatnagar (2012)
Structure of the Zinc Transporter YiiP
M. Lu (2007)
INPP4B: the New Kid on the PI3K Block
I. Agoulnik (2011)
Adult hippocampal neurogenesis buffers stress responses and depressive behavior
J. S. Snyder (2011)
Zinc deficiency induces membrane barrier damage and increases neutrophil transmigration in Caco-2 cells.
A. Finamore (2008)
The involvement of calcium in the activation of mammalian oocytes.
D. Whittingham (1978)
Zinc deficiency adversely influences interleukin-4 and interleukin-6 signaling.
K. Gruber (2013)
Measuring steady-state and dynamic endoplasmic reticulum and Golgi Zn2+ with genetically encoded sensors
Yan Qin (2011)
Metal site occupancy and allosteric switching in bacterial metal sensor proteins.
Alfredo J. Guerra (2012)
p38 Activation Is Required Upstream of Potassium Current Enhancement and Caspase Cleavage in Thiol Oxidant-Induced Neuronal Apoptosis
B. McLaughlin (2001)
Expression of Ca2+-Permeable AMPA Receptor Channels Primes Cell Death in Transient Forebrain Ischemia
S. Liu (2004)
Structure-function analysis of HKE4, a member of the new LIV-1 subfamily of zinc transporters.
K. Taylor (2004)
The Neurophysiology and Pathology of Brain Zinc
S. Sensi (2011)
Zinc modulation of insulin-like growth factor's effect in osteoblastic MC3T3-E1 cells
T. Matsui (1995)
Zinc metabolism in patients with the syndrome of iron deficiency anemia, hepatosplenomegaly, dwarfism, and hypognadism.
A. Prasad (1963)
Contribution by synaptic zinc to the gender-disparate plaque formation in human Swedish mutant APP transgenic mice
J. Lee (2002)
Extracellular zinc and zinc-citrate, acting through a putative zinc-sensing receptor, regulate growth and survival of prostate cancer cells.
Noga Dubi (2008)
Targeting of the mouse Slc39a2 (Zip2) gene reveals highly cell‐specific patterns of expression, and unique functions in zinc, iron, and calcium homeostasis
Jennifer L Peters (2007)
Localization in rat brain of the trace metals, zinc and manganese, after intracerebroventricular injection
A. Takeda (1994)
T-lymphocytes: a target for stimulatory and inhibitory effects of zinc ions.
A. Hönscheid (2009)
Mouse ZIP1 and ZIP3 genes together are essential for adaptation to dietary zinc deficiency during pregnancy
Jodi Dufner-Beattie (2006)
In silico identification and expression of SLC30 family genes: An expressed sequence tag data mining strategy for the characterization of zinc transporters' tissue expression
M. Seve (2004)
Zinc and immune function: the biological basis of altered resistance to infection.
A. Shankar (1998)
Splice isoforms as therapeutic targets for colorectal cancer.
K. Miura (2012)
Differential modulation of zinc-stimulated p21(Cip/WAF1) and cyclin D1 induction by inhibition of PI3 kinase in HT-29 colorectal cancer cells
So-young Oh (2002)
Interrelationships between zinc and immune function.
P. Fraker (1986)
The dynamic link between the integrity of the immune system and zinc status.
P. Fraker (2000)
Quantitative Phosphoproteomics Reveals Widespread Full Phosphorylation Site Occupancy During Mitosis
J. V. Olsen (2010)
Acute dietary zinc deficiency before conception compromises oocyte epigenetic programming and disrupts embryonic development.
X. Tian (2013)
Return to homeostasis: downregulation of NF-κB responses
J. Ruland (2011)
Disruption of G protein-coupled receptor 39 impairs insulin secretion in vivo.
F. Tremblay (2009)
Identification of novel genes that co-cluster with estrogen receptor alpha in breast tumor biopsy specimens, using a large-scale real-time reverse transcription-PCR approach.
S. Tozlu (2006)
p38 and EGF receptor kinase-mediated activation of the phosphatidylinositol 3-kinase/Akt pathway is required for Zn2+-induced cyclooxygenase-2 expression.
W. Wu (2005)
Acid sensing by visceral afferent neurones
P. Holzer (2011)
Beta-Arrestins: new roles in regulating heptahelical receptors' functions.
P. McDonald (2001)
Protective effects of metallothionein on streptozotocin-induced diabetes in rats.
J. Yang (1994)
Biological half-lives of zinc and manganese in rat brain
A. Takeda (1995)
Video image analysis of labile zinc in viable pancreatic islet cells using a specific fluorescent probe for zinc.
P. Zalewski (1994)
Differential expression of hZnT‐4 in Human prostate tissues
F. Beck (2004)
Decreased zinc and downregulation of ZIP3 zinc uptake transporter in the development of pancreatic adenocarcinoma
L. Costello (2011)
The ZnT transporters reduce cytosolic zinc
The randomized comparative pediatric critical illness stress-induced immune suppression (CRISIS) prevention trial*
J. Carcillo (2012)
Low intracellular zinc induces oxidative DNA damage, disrupts p53, NFκB, and AP1 DNA binding, and affects DNA repair in a rat glioma cell line
E. Ho (2002)
Zinc-induced cortical neuronal death with features of apoptosis and necrosis: Mediation by free radicals
Y. Kim (1999)
hZip2 and hZip3 zinc transporters are down regulated in human prostate adenocarcinomatous glands
M. Desouki (2007)
Peroxynitrite-Induced Neuronal Apoptosis Is Mediated by Intracellular Zinc Release and 12-Lipoxygenase Activation
Yumin Zhang (2004)
A ratiometric and targetable fluorescent sensor for quantification of mitochondrial zinc ions.
L. Xue (2012)
Cellular zinc homeostasis is a regulator in monocyte differentiation of HL‐60 cells by 1α,25‐dihydroxyvitamin D3
S. Dubben (2010)
The SLC39 family of metal ion transporters
D. Eide (2004)
Zinc and depression. An update.
G. Nowak (2005)
The mouse acrodermatitis enteropathica gene Slc39a4 (Zip4) is essential for early development and heterozygosity causes hypersensitivity to zinc deficiency.
Jodi Dufner-Beattie (2007)
Zinc deficiency in patients with sickle cell disease.
A. S. Prasad (2002)
Intracellular Zinc Release, 12-Lipoxygenase Activation and MAPK Dependent Neuronal and Oligodendroglial Death
Yumin Zhang (2007)
The role of four oestrogen-responsive genes, pLIV1, pS2, pSYD3 and pSYD8, in predicting responsiveness to endocrine therapy in primary breast cancer.
D. L. Manning (1993)
Collectively, ZIP13 has indispensable roles for the proper
Zinc transporters. In: Rink L (ed) Zinc in human health
RJ Cousins (2011)
Zinc is indispensable for a multitude of normal cellular functions and organ systems, having roles in processes as diverse as DNA synthesis, cognitive function, growth, development, and immunity
Abrogation of Nuclear Factor-κB Activation Is Involved in Zinc Inhibition of Lipopolysaccharide-Induced Tumor Necrosis Factor-α Production and Liver Injury
Z. Zhou (2004)
Zinc inhibits glutamate release via activation of pre‐synaptic KATP channels and reduces ischaemic damage in rat hippocampus
V. Bancila (2004)
GPR39 splice variants versus antisense gene LYPD1: expression and regulation in gastrointestinal tract, endocrine pancreas, liver, and white adipose tissue.
K. Egerod (2007)
Measuring picomolar intracellular exchangeable zinc in PC-12 cells using a ratiometric fluorescence biosensor.
Rebecca A. Bozym (2006)
CEACAM1 regulates insulin clearance in liver
M. Poy (2002)
Zinc signalling and subcellular distribution: emerging targets in type 2 diabetes.
E. Mocchegiani (2008)
Activation of the IκB Kinase Complex by TRAF6 Requires a Dimeric Ubiquitin-Conjugating Enzyme Complex and a Unique Polyubiquitin Chain
Li Deng (2000)
The root of reduced fertility in aged women and possible therapentic options: current status and future perspects.
J. Qiao (2014)
Pulsatile insulin secretion dictates systemic insulin delivery by regulating hepatic insulin extraction in humans.
J. Meier (2005)
In this study, the intracellular zinc
Although it is plausible that alterations in Zn homeostasis in the brain may contribute to AD pathogenesis, the molecular mechanisms that account for these disturbances remain to be identified
The concentrations of free Mg2+ and free Zn2+ in equine blood plasma.
G. R. Magneson (1987)
Designed Inhibitors of Insulin-Degrading Enzyme Regulate the Catabolism and Activity of Insulin
M. Leissring (2010)
Role of MAP kinase and myosin light chain kinase in chromosome-induced development of mouse egg polarity.
Manqi Deng (2005)
Zinc permeates mouse muscle ACh receptor channels expressed in BOSC 23 cells and affects channel function
D. Ragozzino (2000)
Clusterin: the missing link in the calcium-dependent resistance of cancer cells to apoptogenic stimuli.
B. Pająk (2006)
Metal Ion Site Engineering Indicates a Global Toggle Switch Model for Seven-transmembrane Receptor Activation*
C. E. Elling (2006)
Cortical neurons lacking KCC2 expression show impaired regulation of intracellular chloride.
L. Zhu (2005)
Trace elements and cancer risk: a review of the epidemiologic evidence
S. Silvera (2006)
Zinc signaling through glucocorticoid and glutamate signaling in stressful circumstances
A. Takeda (2010)
Zn2+ currents are mediated by calcium‐permeable AMPA/Kainate channels in cultured murine hippocampal neurones
Y. Jia (2002)
Zinc requirements and the risks and benefits of zinc supplementation.
W. Maret (2006)
A Case of Hyperzincemia with Functional Zinc Depletion: A New Disorder?
B. Sampson (1997)
Interaction between protein kinase C and regulatory ligand is enhanced by a chelatable pool of cellular zinc.
I. Forbes (1990)
Antioxidant effect of zinc in humans.
A. Prasad (2004)
A combination of calcium ionophore and puromycin effectively produces human parthenogenones with one haploid pronucleus.
K. Nakagawa (2001)
Zinc deficiency and child development.
M. Black (1998)
Cognitive Loss in Zinc Transporter-3 Knock-Out Mice: A Phenocopy for the Synaptic and Memory Deficits of Alzheimer's Disease?
P. Adlard (2010)
Inhibition of presynaptic activity by zinc released from mossy fiber terminals during tetanic stimulation
A. Minami (2006)
Interleukin 1 regulates secretion of zinc-thymulin by human thymic epithelial cells and its action on T-lymphocyte proliferation and nuclear protein kinase C.
J. A. Coto (1992)
A comparison of zinc metabolism, inflammation, and disease severity in critically ill infected and noninfected adults early after intensive care unit admission.
B. Besecker (2011)
Obesity is associated with macrophage accumulation in adipose tissue.
S. Weisberg (2003)
The molecular foundations of the maternal to zygotic transition in the preimplantation embryo.
R. Schultz (2002)
Egg activation can also be achieved artificially
activation Saunders (2002)
Kinetic analysis of zinc metabolism and its regulation in normal humans.
M. Wastney (1986)
3NB, UK e-mail: firstname.lastname@example.org © Springer Japan
[The Ehlers-Danlos syndrome].
B. Duperrat (1965)
Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR Inhibitors: Rationale and Importance to Inhibiting These Pathways in Human Health
W. Chappell (2011)
Zinc Supplementation Tightens “Leaky Gut” in Crohn’s Disease
G. Sturniolo (2001)
Molecular mechanism of Zn2+ agonism in the extracellular domain of GPR39
L. Storjohann (2008)
Stress and adult neurogenesis
C. Mirescu (2006)
Hyperzincemia with systemic inflammation: a heritable disorder of calprotectin metabolism with rheumatic manifestations?
Y. Saito (2002)
Generation of a Slc39a8 hypomorph mouse: markedly decreased ZIP8 Zn²⁺/(HCO₃⁻)₂ transporter expression.
B. Wang (2011)
Metallothionein proteins also regulate labile intracellular zinc levels (Blindauer and Leszczyszyn
In contrast to the two other examples just discussed, Zn binding also results in a blue shift of both excitation and emission spectra, allowing ratiometric detection
Insulin crystallization depends on zinc
K Lemaire (2009)
Zinc ions and cation diffusion
JJ 173677–702 Bruinsma (2002)
Dynamic imaging of cytosolic zinc in Arabidopsis roots combining FRET sensors and RootChip technology.
V. Lanquar (2014)
Zinc improves the development of human CD34+ cell progenitors towards Natural Killer cells and induces the expression of GATA-3 transcription factor.
M. Muzzioli (2007)
Overview of mammalian zinc transporters
T. Kambe (2003)
Zinc and diabetes--clinical links and molecular mechanisms.
J. Jansen (2009)
A novel gene involved in zinc transport is deficient in the lethal milk mouse
L. Huang (1997)
Body-mass index and
A Berrington de Gonzalez (2010)
Syndrome of hepatic cirrhosis, dystonia, polycythemia, and hypermanganesemia caused by mutations in SLC30A10, a manganese transporter in man.
K. Tuschl (2012)
The role of nutrition in children's neurocognitive development, from pregnancy through childhood
Anett Nyaradi (2013)
Reduced hepatic insulin extraction in response to gastric inhibitory polypeptide compensates for reduced insulin secretion in normal-weight and normal glucose tolerant first-degree relatives of type 2 diabetic patients.
N. Rudovich (2004)
The metaphase II arrest in mouse oocytes is controlled through microtubule‐dependent destruction of cyclin B in the presence of CSF.
J.Z. Kubiak (1993)
Increase in blood-brain barrier permeability by altitude decompression.
C. Chryssanthou (1987)
Functional significance of zinc-related signaling pathways in immune cells.
H. Haase (2009)
Structure-function analysis of LIV-1, the breast cancer-associated protein that belongs to a new subfamily of zinc transporters.
K. Taylor (2003)
NZ 2008 Cvijanovich (2009)
The Importance of Zinc in Human Nutrition and Estimation of the Global Prevalence of Zinc Deficiency
K. Brown (2001)
Mossy fiber Zn2+ spillover modulates heterosynaptic N-methyl-d-aspartate receptor activity in hippocampal CA3 circuits
S. Ueno (2002)
Vglut1 and ZnT3 co-targeting mechanisms regulate vesicular zinc stores in PC12 cells
G. Salazar (2005)
Zinc Sensing Receptor Signaling, Mediated by GPR39, Reduces Butyrate-Induced Cell Death in HT29 Colonocytes via Upregulation of Clusterin
Limor Cohen (2012)
Acute Stress Increases Depolarization-Evoked Glutamate Release in the Rat Prefrontal/Frontal Cortex: The Dampening Action of Antidepressants
L. Musazzi (2010)
The Physiological Effects of Deleting the Mouse Slc30a8 Gene Encoding Zinc Transporter-8 Are Influenced by Gender and Genetic Background
L. Pound (2012)
R. Thomas (1991)
Zinc dyshomeostasis: a key modulator of neuronal injury.
M. Capasso (2005)
Parthenogenetic activation of oocytes in c-mos-deficient mice
N. Hashimoto (1994)
Hippocampal formation volume, memory dysfunction, and cortisol levels in patients with Cushing's syndrome
M. Starkman (1992)
Acrodermatitis enteropathica secondary to Crohn's disease.
M. Krasovec (1996)
Overexpression of glutathione peroxidase with two isoforms of superoxide dismutase protects mouse islets from oxidative injury and improves islet graft function.
T. Mysore (2005)
Negative regulation of T-cell receptor signalling by tyrosine protein kinase p50csk
L. Chow (1993)
Zinc homeostasis in the brain of adult rats fed zinc‐deficient diet
A. Takeda (2001)
Differential Effects of Mucosal pH on Human (Caco-2) Intestinal Epithelial Cell Motility, Proliferation, and Differentiation
D. A. Perdikis (2004)
In vivo and in vitro studies of thymulin in marginally zinc‐deficient mice
M. Dardenne (1984)
Zinc inhibition of γ-aminobutyric acid transporter 4 (GAT4) reveals a link between excitatory and inhibitory neurotransmission
Einav Cohen-Kfir (2005)
The Meiosis I-to-Meiosis II Transition in Mouse Oocytes Requires Separase Activity
M.Emilie Terret (2003)
Roles for cell death in zinc deficiency.
P. Fraker (2005)
The Essential Toxin: Impact of Zinc on Human Health
L. M. Plum (2010)
Low-molecular-weight constituents of isolated insulin-secretory granules. Bivalent cations, adenine nucleotides and inorganic phosphate.
J. Hutton (1983)
Diabetes-linked zinc transporter ZnT8 is a homodimeric protein expressed by distinct rodent endocrine cell types in the pancreas and other glands.
C. Murgia (2009)
New sensors for quantitative measurement of mitochondrial Zn(2+).
J. Park (2012)
Zinc Requirement During Meiosis I–Meiosis II Transition in Mouse Oocytes Is Independent of the MOS-MAPK Pathway1
Miranda L Bernhardt (2011)
Evidence for a Zinc Uptake Transporter in Human Prostate Cancer Cells Which Is Regulated by Prolactin and Testosterone*
L. Costello (1999)
Zinc in Human Health: Effect of Zinc on Immune Cells
A. Prasad (2008)
Alcoholism causes alveolar macrophage zinc deficiency and immune dysfunction.
A. Mehta (2013)
treating male patients with a PLC mutation (Eldar-Geva et al
1976) or to an overexpression of calprotectin, a zinc-binding S100 protein (Fessatou et al
Trace elements in human physiology and pathology: zinc
KD Tew (2003)
Metal ionophores – An emerging class of anticancer drugs
Wei-Qun Ding (2009)
SOD1 as a molecular switch for initiating the homeostatic ER stress response under zinc deficiency.
K. Homma (2013)
Zinc metabolism in patients
AS Prasad (1963)
Formation of the Ovarian Follicular Antrum and Follicular Fluid1
R. Rodgers (2010)
Too much of a good thing: the role of protein kinase CK2 in tumorigenesis and prospects for therapeutic inhibition of CK2.
J. Duncan (2008)
Protein Tyrosine Phosphatases as Targets of the Combined Insulinomimetic Effects of Zinc and Oxidants
H. Haase (2005)
Polymorphonuclear leukocyte chemotaxis induced by zinc, copper and nickel in vitro.
E. Hujanen (1995)
Snail, Zeb and bHLH factors in tumour progression: an alliance against the epithelial phenotype?
H. Peinado (2007)
Calcium-Binding Proteins S100A8 and S100A9 as Novel Diagnostic Markers in Human Prostate Cancer
Alexander Hermani (2005)
GPR39 receptor expression in the mouse brain
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Report of the International Society for Zinc Biology 5th Meeting, in Collaboration with Zinc-Net (COST Action TD1304)—UCLan Campus, Pyla, Cyprus
N. Lowe (2017)
Zinc Signals and Immunity
M. Maywald (2017)
Molecular pathogenesis of Spondylocheirodysplastic Ehlers-Danlos syndrome caused by mutant ZIP13 proteins
Bum-Ho Bin (2014)
The zinc transporter ZIP9 (Slc39a9) regulates zinc dynamics essential to egg activation in zebrafish
Aubrey Converse (2020)
Absorption Mechanisms of Iron, Copper, and Zinc: An Overview.
Yukina Nishito (2018)
Zinc-Chelating Small Molecules Preferentially Accumulate and Function within Pancreatic β Cells.
Timothy M. Horton (2019)
The influence of dietary energy and zinc source and concentration on performance, trace mineral status, and gene expression of beef steers
Remy N Carmichael-Wyatt (2020)
The contribution of zinc to platelet behaviour during haemostasis and thrombosis.
K. A. Taylor (2016)
L-Type Calcium Channel-Mediated Zinc Wave Is Involved in the Regulation of IL-6 by Stimulating Non-IgE with LPS and IL-33 in Mast Cells and Dendritic Cells.
Ryota Uchida (2019)
Potential ecological risk of metal pollution in lead smelter-contaminated agricultural soils in Khulna, Bangladesh
Md Ali Akber (2019)
Bactericidal ZnO glass-filled thermoplastic polyurethane and polydimethyl siloxane composites to inhibit biofilm-associated infections
B. Cabal (2019)
The Physiological, Biochemical, and Molecular Roles of Zinc Transporters in Zinc Homeostasis and Metabolism.
T. Kambe (2015)
Zinc Metabolism and Metallothioneins
Abdulkerim Kasim Baltaci (2017)
Genetic Study of Zinc Transporters and Zinc Signaling
T. Fukada (2017)
Mast cells play role in wound healing through the ZnT2/GPR39/IL-6 axis
K. Nishida (2019)
Zinc as a Signal to Stimulate Red Blood Cell Formation in Fish
Yen-Hua Chen (2017)
Recent Advances in the Role of SLC39A/ZIP Zinc Transporters In Vivo
Teruhisa Takagishi (2017)
Progressive structural modification to a zinc-actuated photoinduced electron transfer (PeT) switch in the context of intracellular zinc imaging.
Miguel Macias-Contreras (2017)
Roles of Zinc Transporters in Cellular Transport of Cadmium and Manganese
S. Himeno (2017)
The direct modulatory activity of zinc toward ion channels
Sujin Noh (2015)
Role of probiotics to combat viral infections with emphasis on COVID-19
Aravind Sundararaman (2020)
Role of Zinc Signaling in the Regulation of Mast Cell-, Basophil-, and T Cell-Mediated Allergic Responses
K. Nishida (2018)
Zinc as a Gatekeeper of Immune Function
Inga Wessels (2017)
Zinc in Cellular Regulation: The Nature and Significance of “Zinc Signals”
W. Maret (2017)See more