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Zinc Signals In Cellular Functions And Disorders

T. Fukada, T. Kambe
Published 2014 · Chemistry

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Zinc plays an indispensable role in life. It regulates a great number of protein functions including transcription factors, enzymes, adapters, receptors, and growth factors as a structural or catalytic factor. Recently, a further function of zinc has received extensive interest and attention because of its potential importance as a signaling mediator. Zinc plays a dynamic role as an extracellular and intracellular signaling factor, which enables communication between cells in an autocrine, paracrine, or endocrine fashion, conversion of extracellular stimuli to intracellular responses, and regulation of various intracellular signaling pathways. These zinc functions are recognized as “zinc signaling,” which has critical roles in physiology, and thus their imbalance can cause a variety of problems with regard to human health. This book extensively reviews the field from the basic aspects to the crucial roles of zinc signaling in biological processes, discussing the future directions and questions at both the molecular and the physiological level.
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