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Chitosan Nanoparticles As Carrier For Anticancer Drugs: An Overview

Raj Kumar Salar, Naresh Kumar
Published 2018 · Chemistry

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Cancer is the leading cause of death worldwide. Chemotherapy and radiotherapy have been used to treat cancer; however, these methods have serious side effects. Nanomedicine has emerged as a hope for cancer patients in the recent past. Various nanomedical carriers such as liposomal nanoparticles, polymeric nanoparticles, etc. have been developed to carry anticancer drugs to target site. Among these, polymeric nanoparticles have been used extensively due to their unique properties. Of various natural and synthetic polymers, chitosan is most suitable as a carrier of anticancer drugs. It is a natural polymer obtained from deacetylation of chitin. Researchers have worked on the anticancer drug encapsulation in chitosan nanoparticles and its targeted drug delivery. Chitosan nanoparticles are safe and biodegradable and can release drugs at controlled rates to the target site. Chitosan nanoparticles can be synthesized by various methods such as ionic gelation method, emulsion polymerization method, etc. Although research is going on worldwide, more research is needed in the area of anticancer drug encapsulation in chitosan nanoparticles and its delivery to target sites.
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