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Mitochondria In Health And In Sickness
A. Urbani, M. Babu, P. Bottoni, R. Scatena, Alessio Soggiu, P. Roncada, L. Bonizzi
Published 2019 ·
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Given the role of mitochondria in modulating many cellular functions, it is not surprising that they can play a crucial role also in molecular pathophysiology of cancer. In particular, the discovery in recent decades of a link between cancer metabolic processes, alterations of mitochondrial DNA, oncogenes and tumor suppressors has led not only to a renaissance of interest in Warburg’s pioneering work, but also to a reexamination of his original observations above all in relation to the current knowledge in cancer cell metabolism. It follows that, although mitochondrial contribution to the pathogenesis of cancer has historically tended to be neglected, it is now evident that reprogrammed mitochondria can contribute to a complex bioenergetic adjustment that sustains not only tumor formation but also its progression. Most importantly, cancer cell metabolism seems to have a role in diversified aspects related to cancer pathophysiology (i.e., aggressiveness, recurrence, metastatic dissemination). Hence, it is imperative to always consider cancer cell metabolism, its adaptability, its influences but, above all, its functional heterogeneity in a single tumor, for a really rational and valid approach towards molecular biology of cancer.
This paper references
Engineered AAA+ proteases reveal principles of proteolysis at the mitochondrial inner membrane
Hui Shi (2016)
A Global Analysis of the Receptor Tyrosine Kinase-Protein Phosphatase Interactome.
Z. Yao (2017)
Current strategies towards therapeutic manipulation of mtDNA heteroplasmy.
C. Pereira (2017)
Inefficient coupling between proton transport and ATP synthesis may be the pathogenic mechanism for NARP and Leigh syndrome resulting from the T8993G mutation in mtDNA.
G. Sgarbi (2006)
The absolute quantification strategy: a general procedure for the quantification of proteins and post-translational modifications.
D. Kirkpatrick (2005)
Mitochondrial Nucleoid: Shield and Switch of the Mitochondrial Genome
S. R. Lee (2017)
Leigh syndrome: Clinical features and biochemical and DNA abnormalities
S. Rahman (1996)
Electron Cryomicroscopy Structure of a Membrane-anchored Mitochondrial AAA Protease*
Sukyeong Lee (2010)
The mitochondrial genome: structure, transcription, translation and replication.
J. Taanman (1999)
Design and selection of novel Cys2His2 zinc finger proteins.
C. Pabo (2001)
A truncated form of DNA topoisomerase IIbeta associates with the mtDNA genome in mammalian mitochondria.
R. L. Low (2003)
Phosphorylation of human TFAM in mitochondria impairs DNA binding and promotes degradation by the AAA+ Lon protease.
B. Lu (2013)
Mitochondrial quality control and communications with the nucleus are important in maintaining mitochondrial function and cell health☆☆☆
Vassilios N. Kotiadis (2014)
Purifying selection of mtDNA and its implications for understanding evolution and mitochondrial disease
J. B. Stewart (2008)
Turn up the power – pharmacological activation of mitochondrial biogenesis in mouse models
J. Komen (2014)
Purification of mitochondria by sucrose step density gradient centrifugation.
D. Clayton (2014)
Modification of cysteine residues by alkylation. A tool in peptide mapping and protein identification.
Salvatore Sechi (1998)
Phenotypic heterogeneity in m.3243A>G mitochondrial disease: The role of nuclear factors
S. J. Pickett (2018)
Mass spectrometry based biomarker discovery, verification, and validation — Quality assurance and control of protein biomarker assays
C. Parker (2014)
A Glutathione S-Transferase π-Activated Prodrug Causes Kinase Activation Concurrent with S-Glutathionylation of Proteins
D. Townsend (2006)
The core human mitochondrial transcription initiation complex
T. Shutt (2011)
Role of the N-terminal domain of the chaperone ClpX in the recognition and degradation of lambda phage protein O.
Guillaume Thibault (2012)
Import of Proteins and Nucleic Acids into Mitochondria
N. Verechshagina (2018)
Activators of cylindrical proteases as antimicrobials: identification and development of small molecule activators of ClpP protease.
Elisa Leung (2011)
Microhomology-mediated end joining is the principal mediator of double-strand break repair during mitochondrial DNA lesions
S. Tadi (2016)
Mitochondrial DNA mutations in human disease
L. Greaves (2006)
Keeping mtDNA in Shape between Generations
J. B. Stewart (2014)
Mitochondrial disorders in children: toward development of small‐molecule treatment strategies
W. J. Koopman (2016)
The Impact of Base Excision DNA Repair in Age-Related Neurodegenerative Diseases
G. Leandro (2015)
Metabolic syndrome and mitochondrial function: Molecular replacement and antioxidant supplements to prevent membrane peroxidation and restore mitochondrial function
G. Nicolson (2007)
Gene therapy for progeny of mito-mice carrying pathogenic mtDNA by nuclear transplantation.
A. Sato (2005)
Evidence for the presence of 5S rRNA in mammalian mitochondria.
P. J. Magalhães (1998)
Live Birth Derived From Oocyte Spindle Transfer to Prevent Mitochondrial Disease
J. Zhang (2017)
Production and use of stable isotope-labeled proteins for absolute quantitative proteomics.
Dorothée Lebert (2011)
Mutant POLG2 disrupts DNA polymerase gamma subunits and causes progressive external ophthalmoplegia.
M. Longley (2006)
The neurology of mitochondrial DNA disease
R. McFarland (2002)
100 – Arrhythmia in Neurological Disease
Tarek Zghaib (2018)
Identification of mammalian mitochondrial proteins that interact with IAPs via N-terminal IAP binding motifs
A. Verhagen (2007)
Multiplexed absolute quantification in proteomics using artificial QCAT proteins of concatenated signature peptides
R. Beynon (2005)
G8363A Mutation in the Mitochondrial DNA Transfer Ribonucleic Acid Lys Gene: Another Cause of Leigh Syndrome
A. Shtilbans (2000)
Identification of Protein Interactions Involved in Cellular Signaling
J. Westermarck (2013)
Mitochondrial DNA mutations and human disease.
H. Tuppen (2010)
Inhibition of Lon blocks cell proliferation, enhances chemosensitivity by promoting apoptosis and decreases cellular bioenergetics of bladder cancer: potential roles of Lon as a prognostic marker and therapeutic target in baldder cancer
Yongzhang Liu (2014)
Imprinting disorders and assisted reproductive technology.
S. Manipalviratn (2009)
Twinkle and POLG defects enhance age-dependent accumulation of mutations in the control region of mtDNA.
S. Wanrooij (2004)
Maternal germ-line transmission of mutant mtDNAs from embryonic stem cell-derived chimeric mice.
J. Sligh (2000)
Oxygen in mitochondrial disease: can there be too much of a good thing?
V. K. Mootha (2018)
University of Groningen An In Vivo Magnetic Resonance Spectroscopy Study of the Effects of Caloric and Non-Caloric Sweeteners on Liver Lipid Metabolism in Rats
Sharon Janssens (2017)
Pore loops of the AAA+ ClpX machine grip substrates to drive translocation and unfolding
A. Martin (2008)
Sequence-specific modification of mitochondrial DNA using a chimeric zinc finger methylase
M. Minczuk (2006)
ER-mitochondria contacts couple mtDNA synthesis with mitochondrial division in human cells
S. C. Lewis (2016)
Transfer of chloramphenicol‐resistant mitochondrial DNA into the chimeric mouse
S. Levy (2004)
Alterations in mtDNA: a qualitative and quantitative study associated with cervical cancer development.
A. Warowicka (2013)
Transfection of mitochondria: strategy towards a gene therapy of mitochondrial DNA diseases
P. Seibel (1995)
F. Mavilio (1993)
Progressive increase in mtDNA 3243A>G heteroplasmy causes abrupt transcriptional reprogramming
M. Picard (2014)
Phenotypic heterogeneity of the 8344A>G mtDNA “MERRF” mutation
M. Mancuso (2013)
A Census of Human Soluble Protein Complexes
P. Havugimana (2012)
Mitochondrial DNA mutation associated with Leber's hereditary optic neuropathy.
D. Wallace (1988)
Transcription could be the key to the selection advantage of mitochondrial deletion mutants in aging
A. Kowald (2014)
Role of peroxisome proliferator-activated receptor-gamma and its coactivator DRIP205 in cellular responses to CDDO (RTA-401) in acute myelogenous leukemia.
T. Tsao (2010)
Mitochondrial DNA Variation in Human Radiation and Disease
D. Wallace (2015)
Mutant mitochondrial helicase Twinkle causes multiple mtDNA deletions and a late-onset mitochondrial disease in mice.
H. Tyynismaa (2005)
Mitochondrial biogenesis in the metabolic syndrome and cardiovascular disease
J. Ren (2010)
Advances in methods for reducing mitochondrial DNA disease by replacing or manipulating the mitochondrial genome
P. K. Rai (2018)
Modifier genes for hypertrophic cardiomyopathy.
A. Marian (2002)
Phase I study of the syn- thetic triterpenoid, 2-cyano-3, 12-dioxoolean-1, 9-dien-28-oic acid (CDDO), in advanced solid tumors
G Speranza (2012)
PGC-1alpha/beta induced expression partially compensates for respiratory chain defects in cells from patients with mitochondrial disorders.
S. Srivastava (2009)
Proteome analysis of human substantia nigra in Parkinson's disease
M. Basso (2004)
Selected reaction monitoring for quantitative proteomics: a tutorial
V. Lange (2008)
Accumulation of pathogenic DeltamtDNA induced deafness but not diabetic phenotypes in mito-mice.
Kazuto Nakada (2004)
Germline mtDNA mutations aggravate ageing and can impair brain development
Jaime M Ross (2013)
mtDNA Variation and Analysis Using Mitomap and Mitomaster
M. Lott (2013)
Prediction of missed proteolytic cleavages for the selection of surrogate peptides for quantitative proteomics.
C. Lawless (2012)
YME1L controls the accumulation of respiratory chain subunits and is required for apoptotic resistance, cristae morphogenesis, and cell proliferation
L. Stiburek (2012)
Acyldepsipeptide antibiot- ics induce the formation of a structured axial channel in ClpP: a model for the ClpX/ClpA- bound state of ClpP
DH Li (2010)
Identification of Analytical Factors Affecting Complex Proteomics Profiles Acquired in a Factorial Design Study with Analysis of Variance: Simultaneous Component Analysis.
Vikram Mitra (2016)
Super-resolution microscopy reveals that mammalian mitochondrial nucleoids have a uniform size and frequently contain a single copy of mtDNA
Christian Kukat (2011)
Mitochondria and Mitophagy: The Yin and Yang of Cell Death Control
D. Kubli (2012)
The BioPlex Network: A Systematic Exploration of the Human Interactome
E. Huttlin (2015)
Rescue of a deficiency in ATP synthesis by transfer of MTATP6, a mitochondrial DNA-encoded gene, to the nucleus
G. Manfredi (2002)
Genetic and Clinical Features of Sensorineural Hearing Loss Associated With the 1555 Mitochondrial Mutation
S. Usami (1997)
Sequential Treatment of SH‐SY5Y Cells with Retinoic Acid and Brain‐Derived Neurotrophic Factor Gives Rise to Fully Differentiated, Neurotrophic Factor‐Dependent, Human Neuron‐Like Cells
M. Encinas (2000)
The use of proteotypic peptide libraries for protein identification.
R. Craig (2005)
Suppression of mutations in mitochondrial DNA by tRNAs imported from the cytoplasm.
Olga A. Kolesnikova (2000)
A new mtDNA mutation in the tRNA(Lys) gene associated with myoclonic epilepsy and ragged-red fibers (MERRF).
G. Silvestri (1992)
Import of fluorescent RNA into mitochondria of living cells
Jaroslav Zelenka (2012)
Mitochondrial DNA mutations associated with the 11778 mutation in Leber's disease
澤野 徹 (1996)
Gene targeting using zinc finger nucleases
M. Porteus (2005)
Mitochondria: In Sickness and in Health
J. Nunnari (2012)
Using MCL to extract clusters from networks.
S. van Dongen (2012)
Persistent damage induces mitochondrial DNA degradation.
I. Shokolenko (2013)
Manipulating mitochondrial DNA heteroplasmy by a mitochondrially targeted restriction endonuclease.
S. Srivastava (2001)
Mitochondrial Protein Interaction Mapping Identifies Regulators of Respiratory Chain Function.
Brendan J Floyd (2016)
Existence of nuclear‐encoded 5S‐rRNA in bovine mitochondria
S. Yoshionari (1994)
Quantitative Map of β-Lactone-Induced Virulence Regulation.
J. Krysiak (2017)
Spontaneous and specific chemical cross-linking in live cells to capture and identify protein interactions
B. Yang (2017)
Reciprocal Degradation of YME1L and OMA1 Adapts Mitochondrial Proteolytic Activity during Stress.
T. K. Rainbolt (2016)
The RNase P Associated with HeLa Cell Mitochondria Contains an Essential RNA Component Identical in Sequence to That of the Nuclear RNase P
R. S. Puranam (2001)
Transmitochondrial mice carrying resistance to chloramphenicol on mitochondrial DNA: Developing the first mouse model of mitochondrial DNA disease
D. Marchington (1999)
The importance of the digest: proteolysis and absolute quantification in proteomics.
Philip Brownridge (2011)
NATURALLY OCCURRING MITOCHONDRIAL DNA HAPLOTYPES EXHIBIT METABOLIC DIFFERENCES: INSIGHT INTO FUNCTIONAL PROPERTIES OF MITOCHONDRIA
N. Pichaud (2012)
Structures of ClpP in complex with acyldepsipeptide antibiotics reveal its activation mechanism
Byung-Gil Lee (2010)
Mitochondrial Gene Replacement in Primate Offspring and Embryonic Stem Cells
M. Tachibana (2009)
Options and considerations when selecting a quantitative proteomics strategy
B. Domon (2010)
Germ-line deletions of mtDNA in mitochondrial myopathy.
J. Poulton (1991)
Linear mitochondrial DNA is rapidly degraded by components of the replication machinery
V. Peeva (2018)
The m.3243A>G mitochondrial DNA mutation and related phenotypes. A matter of gender?
M. Mancuso (2013)
Premature ageing in mice expressing defective mitochondrial DNA polymerase
A. Trifunović (2004)
Mitochondrial DNA Mutations, Oxidative Stress, and Apoptosis in Mammalian Aging
G. Kujoth (2005)
Identical mitochondrial DNA deletion in a woman with ocular myopathy and in her son with pearson syndrome.
S. Shanske (2002)
Mitochondria in cybrids containing mtDNA from persons with mitochondriopathies
R. Swerdlow (2007)
Panorama of ancient metazoan macromolecular complexes
Cuihong Wan (2015)
The m-AAA protease processes cytochrome c peroxidase preferentially at the inner boundary membrane of mitochondria.
I. E. Suppanz (2009)
Running‐wheel activity delays mitochondrial respiratory flux decline in aging mouse muscle via a post‐transcriptional mechanism
Sarah Stolle (2018)
Base Excision Repair in the Mitochondria
A. Prakash (2015)
Multiple effects of 2,2',5,5'-tetrachlorobiphenyl on oxidative phosphorylation in rat liver mitochondria.
V. Mildažienė (2002)
A panel of regulated proteins in serum from patients with cervical intraepithelial neoplasia and cervical cancer.
Alexander P. Boichenko (2014)
Intracellular Targets for DNA Delivery: Nuclei and Mitochondria
V. Torchilin (2002)
Clinical Heterogeneity Associated with the Mitochondrial DNA T8993C Point Mutation
F. Santorelli (1996)
Dynamics of the ClpP serine protease: A model for self-compartmentalized proteases
K. Liu (2014)
mitoTev‐TALE: a monomeric DNA editing enzyme to reduce mutant mitochondrial DNA levels
C. Pereira (2018)
Down-Regulating Overexpressed Human Lon in Cervical Cancer Suppresses Cell Proliferation and Bioenergetics
X. Nie (2013)
A compendium of human mitochondrial gene expression machinery with links to disease
T. Shutt (2010)
Blastocyst preimplantation genetic diagnosis (PGD) of a mitochondrial DNA disorder.
N. Treff (2012)
Oligomycin Induces a Decrease in the Cellular Content of a Pathogenic Mutation in the Human Mitochondrial ATPase 6 Gene*
G. Manfredi (1999)
Mitochondrial Replacement: Ethics and Identity
A. Wrigley (2015)
Widespread Macromolecular Interaction Perturbations in Human Genetic Disorders
Nidhi Sahni (2015)
A Human Interactome in Three Quantitative Dimensions Organized by Stoichiometries and Abundances
M. Y. Hein (2015)
Bandsma RH (2016) Malnutrition-associated liver steatosis and ATP depletion is caused by per- oxisomal and mitochondrial dysfunction
T van Zutphen (2016)
Towards germline gene therapy of inherited mitochondrial diseases
M. Tachibana (2013)
G7731A mutation in mouse mitochondrial tRNALys regulates late-onset disorders in transmitochondrial mice.
A. Shimizu (2015)
Peroxiredoxin-6 protects against mitochondrial dysfunction and liver injury during ischemia-reperfusion in mice.
T. Eismann (2009)
Global Survey of Organ and Organelle Protein Expression in Mouse: Combined Proteomic and Transcriptomic Profiling
T. Kislinger (2006)
Comparative mitochondrial proteomics: perspective in human diseases
Y. Jiang (2012)
Emerging therapies for mitochondrial disorders
H. Nightingale (2016)
A Lentiviral Functional Proteomics Approach Identifies Chromatin Remodeling Complexes Important for the Induction of Pluripotency*
Anthony B. Mak (2010)
Can Mitochondrial DNA be CRISPRized: Pro and Contra
Romuald Loutre (2018)
Selective mitochondrial DNA degradation following double-strand breaks
Amandine Moretton (2017)
Core human mitochondrial transcription apparatus is a regulated two-component system in vitro
T. Shutt (2010)
Mesenchymal stem cells alleviate oxidative stress–induced mitochondrial dysfunction in the airways
X. Li (2018)
Phenotypic variability in a family with a mitochondrial DNA T8993C mutation.
Y. Suzuki (1998)
NARP-MILS syndrome caused by 8993 T > G mitochondrial DNA mutation: a clinical, genetic and neuropathological study
A. Rojo (2006)
The epidemiology of mitochondrial disorders--past, present and future.
A. Schaefer (2004)
Lon Peptidase 1 (LONP1)-dependent Breakdown of Mitochondrial 5-Aminolevulinic Acid Synthase Protein by Heme in Human Liver Cells*
Q. Tian (2011)
Hsp90 Is a Novel Target Molecule of CDDO-Me in Inhibiting Proliferation of Ovarian Cancer Cells
Dong-jun Qin (2015)
A direct repeat is a hotspot for large-scale deletion of human mitochondrial DNA.
E. Schon (1989)
What causes mitochondrial DNA deletions in human cells?
K. J. Krishnan (2008)
Heterogeneity of six children and their mothers with mitochondrial DNA 3243 A>G mutation
Yanyan Ma (2013)
Metalloproteases of the Inner Mitochondrial Membrane.
Roman M. Levytskyy (2017)
Glutathione S-transferases as regulators of kinase pathways and anticancer drug targets.
D. Townsend (2005)
Nucleotide Binding and Conformational Switching in the Hexameric Ring of a AAA+ Machine
B. M. Stinson (2013)
Defining the Human Deubiquitinating Enzyme Interaction Landscape
M. Sowa (2009)
Global landscape of protein complexes in the yeast Saccharomyces cerevisiae
N. Krogan (2006)
Parkin modulates heteroplasmy of truncated mtDNA in Caenorhabditis elegans.
Itay Valenci (2015)
Mitochondrial DNA mutations in disease and aging
D. Wallace (2010)
Human mitochondrial topoisomerase I
H. Zhang (2001)
Delivering healthy mitochondria for the therapy of mitochondrial diseases and beyond.
Chin-San Liu (2014)
Mitochondrial DNA depletion, mitochondrial mutations and high TFAM expression in hepatocellular carcinoma
Lihua Qiao (2017)
Delivery of mtZFNs into Early Mouse Embryos.
Beverly J. McCann (2018)
Transmission of human mtDNA heteroplasmy in the Genome of the Netherlands families: support for a variable-size bottleneck.
M. Li (2016)
Antibiotic acyldepsipeptides activate ClpP peptidase to degrade the cell division protein FtsZ
P. Sass (2011)
The Role of Mitochondrial DNA Copy Number in Mammalian Fertility1
T. Wai (2010)
TRIAP1/PRELI complexes prevent apoptosis by mediating intramitochondrial transport of phosphatidic acid.
Christoph Potting (2013)
Obtusilactone A and (−)‐sesamin induce apoptosis in human lung cancer cells by inhibiting mitochondrial Lon protease and activating DNA damage checkpoints
H. Wang (2010)
Mitochondrial biogenesis in health and disease. Molecular and therapeutic approaches.
F. Sanchis-Gomar (2014)
Transmitochondrial mice as models for primary prevention of diseases caused by mutation in the tRNALys gene
A. Shimizu (2014)
Parallel reaction monitoring using quadrupole‐Orbitrap mass spectrometer: Principle and applications
A. Bourmaud (2016)
A Map of Human Mitochondrial Protein Interactions Linked to Neurodegeneration Reveals New Mechanisms of Redox Homeostasis and NF-κB Signaling.
Ramy H. Malty (2017)
Low-dose rapamycin extends lifespan in a mouse model of mtDNA depletion syndrome
Stephanie E Siegmund (2017)
Development of a single-chain, quasi-dimeric zinc-finger nuclease for the selective degradation of mutated human mitochondrial DNA
M. Minczuk (2008)
Selective Elimination of Mitochondrial Mutations in the Germline by Genome Editing
P. Reddy (2015)
Structure of mammalian respiratory complex I
Jiapeng Zhu (2016)
Repair of oxidative DNA damage and cancer: recent progress in DNA base excision repair.
T. L. Scott (2014)
Parkin overexpression selects against a deleterious mtDNA mutation in heteroplasmic cybrid cells
Der-Fen Suen (2010)
Mitochondrial DNA genetics and the heteroplasmy conundrum in evolution and disease.
D. Wallace (2013)
Large-scale cDNA transfection screening for genes related to cancer development and progression.
Dafang Wan (2004)
Two direct repeats cause most human mtDNA deletions.
D. Samuels (2004)
Ketogenic treatment reduces deleted mitochondrial DNAs in cultured human cells
S. Santra (2004)
Cytoplasmic transfer of chloramphenicol resistance in human tissue culture cells
D. Wallace (1975)
Building the mitochondrial proteome
S. Da Cruz (2005)
Progress and prospects: gene therapy for mitochondrial DNA disease
D. S. Kyriakouli (2008)
Preferential amplification of a human mitochondrial DNA deletion in vitro and in vivo
O. M. Russell (2018)
Definition of a High-Confidence Mitochondrial Proteome at Quantitative Scale
Marcel Morgenstern (2017)
TWINKLE is an essential mitochondrial helicase required for synthesis of nascent D-loop strands and complete mtDNA replication
D. Milenkovic (2013)
In D-loop: 40years of mitochondrial 7S DNA
T. Nicholls (2014)
ATP-dependent Lon protease controls tumor bioenergetics by reprogramming mitochondrial activity.
Pedro M. Quiros (2014)
Mitochondrial transfer between cells can rescue aerobic respiration
J. Spees (2006)
The Mitochondrial Unfoldase-Peptidase Complex ClpXP Controls Bioenergetics Stress and Metastasis
J. H. Seo (2016)
Leigh syndrome associated with mitochondrial DNA 8993 T-->G mutation and ragged-red fibers.
S. C. Mak (1996)
A mitochondrial paradigm of metabolic and degenerative diseases, aging, and cancer: a dawn for evolutionary medicine.
D. Wallace (2005)
Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases
M. Lin (2006)
MicroRNA Directly Enhances Mitochondrial Translation during Muscle Differentiation
Xiaorong S. Zhang (2014)
Mitochondrial ROS in cancer: initiators, amplifiers or an Achilles' heel?
Simran S Sabharwal (2014)
Selective degradation of mitochondria by mitophagy.
I. Kim (2007)
CONSeQuence: Prediction of Reference Peptides for Absolute Quantitative Proteomics Using Consensus Machine Learning Approaches*
C. Eyers (2011)
Correcting human mitochondrial mutations with targeted RNA import
Geng Wang (2012)
A LON-ClpP Proteolytic Axis Degrades Complex I to Extinguish ROS Production in Depolarized Mitochondria
K. R. Pryde (2016)
Whole-exome sequencing identifies homozygous AFG3L2 mutations in a spas- tic ataxia-neuropathy syndrome linked to mitochon- drial m-AAA proteases
TM Pierson (2011)
Mechanisms of tRNA import into yeast mitochondria: an overview.
I. Tarassov (1996)
Skyline: an open source document editor for creating and analyzing targeted proteomics experiments
B. MacLean (2010)
Transcriptional control of mitochondrial energy metabolism through the PGC1 coactivators.
B. Spiegelman (2007)
Human mitochondrial DNA replication machinery and disease.
Matthew J. Young (2016)
Preventing the transmission of mitochondrial DNA disorders using prenatal or preimplantation genetic diagnosis
Hubert J.M. Smeets (2015)
MtDNA-maintenance defects: syndromes and genes
C. Viscomi (2017)
Mitochondrial Fission, Fusion, and Stress
R. J. Youle (2012)
PGD for the m.14487 T>C mitochondrial DNA mutation resulted in the birth of a healthy boy
Suzanne C E H Sallevelt (2017)
An evaluation of the role of mitochondria in neurodegenerative diseases: mitochondrial mutations and oxidative pathology, protective nuclear responses, and cell death in neurodegeneration
D. S. Cassarino (1999)
Scoring proteomes with proteotypic peptide probes
B. Kuster (2005)
Oxygen-sensitive mitochondrial accumulation of cystathionine β-synthase mediated by Lon protease
Huajian Teng (2013)
Dual localization of human DNA topoisomerase IIIalpha to mitochondria and nucleus.
Y. Wang (2002)
Exploring mitochondrial system properties of neurodegenerative diseases through interactome mapping.
James Vlasblom (2014)
Concise Reviews: Assisted Reproductive Technologies to Prevent Transmission of Mitochondrial DNA Disease
J. Richardson (2015)
Proteomic identification of differentially‐expressed genes in human gastric carcinomas
R. Nishigaki (2005)
Nuclear transplantation in mouse embryos.
James H. McGrath (1983)
Targeting proteomics to investigate metastasis-associated mitochondrial proteins
H. Chou (2012)
Human cells lacking mtDNA: repopulation with exogenous mitochondria by complementation.
M. P. King (1989)
The AAA+ superfamily of functionally diverse proteins
J. Snider (2008)
A Phenotype-Driven Approach to Generate Mouse Models with Pathogenic mtDNA Mutations Causing Mitochondrial Disease
J. Kauppila (2016)
Mitochondrial DNA maintenance in vertebrates.
G. Shadel (1997)
Living on the edge: substrate competition explains loss of robustness in mitochondrial fatty-acid oxidation disorders
K. van Eunen (2016)
Twinkle, the Mitochondrial Replicative DNA Helicase, Is Widespread in the Eukaryotic Radiation and May Also Be the Mitochondrial DNA Primase in Most Eukaryotes
T. Shutt (2005)
Mitochondrial dysfunction in cardiovascular disease.
S. Ballinger (2005)
Novel Mechanisms for Heme-dependent Degradation of ALAS1 Protein as a Component of Negative Feedback Regulation of Heme Biosynthesis*
Y. Kubota (2016)
Spontaneous Kearns-Sayre/chronic external ophthalmoplegia plus syndrome associated with a mitochondrial DNA deletion: a slip-replication model and metabolic therapy.
J. Shoffner (1989)
Proteomic Challenges: Sample Preparation Techniques for Microgram-Quantity Protein Analysis from Biological Samples
Peter Feist (2015)
Systematic protein–protein interaction mapping for clinically relevant human GPCRs
Kate Sokolina (2017)
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