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Functional Chitosan: Drug Delivery And Biomedical Applications
Sougata Jana, Subrata Jana
Published 2019 ·
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Chitosan is a nontoxic, biodegradable, biocompatible natural aminopolysachharide with diverse applications. Chitosan can be easily modified into different forms such as membranes, sponges, gels, scaffolds, microparticles, nanoparticles, and nanofiber for drug delivery, gene therapy, tissue engineering, and wound healing in biomedical application. Recently, chitosan-based molecularly imprinted polymers have gained considerable attention and showed significant potential in fields, such as environmental remediation, medicine, as well as various industrial applications. However, the performance of the chitosan-based products in various applications is influenced by many factors including the source of chitin, extraction process, molecular weight, degree of deacetylation, pH, ionic strength, concentration, and temperature. This chapter will provide a brief overview of chitosan in molecular imprinting technique as a functional polymer or supporting matrix because of its low cost and high content of amino and hydroxyl functional groups as well as the computational modeling for the designing of chitosan-based material for desired application. Rational designing of chitosan-based derivatives using computational modeling is not only fast and economic but also a greener approach, which helps understanding various thermodynamic and spectroscopic aspects at molecular level. This chapter also discusses diverse applications of chitosan for biomedical, industrial, and environmental
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Revisiting ceramics for medical applications.
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Advances in Development of Antimicrobial Peptidomimetics as Potential Drugs
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Chitosan-based nanoparticles for survivin targeted siRNA delivery in breast tumor therapy and preventing its metastasis
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Trial of Intravesical DTA-H19/PEI in Patients With Intermediate-Risk Superficial Bladder Cancer -Full Text View -ClinicalTrials
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Nanocapsule formation by interfacial polymer deposition following solvent displacement
H. Fessi (1989)
Tissue engineering: advances in in vitro cartilage generation.
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Biological and medical significance of calcium phosphates.
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Vancomycin loaded superparamagnetic MnFe2O4 nanoparticles coated with PEGylated chitosan to enhance antibacterial activity.
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Fabrication of Chitosan/Silk Fibroin Composite Nanofibers for Wound-dressing Applications
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Effects of the Degree of Deacetylation on the Physicochemical Properties and Schwann Cell Affinity of Chitosan Films
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Miscibility, mechanical characteristic and platelet adhesion of 6-O-carboxymethylchitosan/polyurethane semi-IPN membranes
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Block copolymer micelles: preparation, characterization and application in drug delivery.
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Drug/Dye-Loaded, Multifunctional PEG-Chitosan-Iron Oxide Nanocomposites for Methotraxate Synergistically Self-Targeted Cancer Therapy and Dual Model Imaging.
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Serum 25-Hydroxyvitamin D Levels and Dry Eye Syndrome: Differential Effects of Vitamin D on Ocular Diseases
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Degradation of Partially Oxidized Alginate and Its Potential Application for Tissue Engineering
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A randomized, controlled study to investigate the efficacy and safety of a topical gentamicin-collagen sponge in combination with systemic antibiotic therapy in diabetic patients with a moderate or severe foot ulcer infection
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Antibacterial Effects of Chitosan/Cationic Peptide Nanoparticles
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Progress and prospects: naked DNA gene transfer and therapy
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Viral chemistry: the chemical functionalization of viral architectures to create new technology.
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Nanocomposite microemulsions study of single-walled carbon nanotubes in arteries: Applications of nanocomposite materials in drug delivery
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Synthesis and characterization of water-soluble chitosan derivate and its antibacterial activity
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Ex vivo skin permeation and retention studies on chitosan-ibuprofen-gellan ternary nanogel prepared by in situ ionic gelation technique--a tool for controlled transdermal delivery of ibuprofen.
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Enhancement of Serum Lysozyme Activity by Injecting a Mixture of Chitosan Oligosaccharides Intravenously in Rabbits
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Treatment with LL‐37 is safe and effective in enhancing healing of hard‐to‐heal venous leg ulcers: a randomized, placebo‐controlled clinical trial
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Iodinated Echogenic Glycol Chitosan Nanoparticles for X-ray CT/US Dual Imaging of Tumor
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Carboxymethyl chitosan-folic acid-conjugated Fe3O4@SiO2 as a safe and targeting antitumor nanovehicle in vitro
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Designing multifunctional quantum dots for bioimaging, detection, and drug delivery.
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Short- and long-term stability of lyophilised melatonin-loaded lecithin/chitosan nanoparticles.
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Synthesis, characterization, and properties of poly(vinyl acetate)‐ and poly(vinyl alcohol)‐grafted chitosan
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Novel Combination BMP7 and HGF Gene Therapy Instigates Selective Myofibroblast Apoptosis and Reduces Corneal Haze In Vivo
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Micafungin in the treatment of candiduria: A case series
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Recent Advances in Biosensor Technology for Potential Applications – An Overview
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Pegylated poly-l-arginine derivatives of chitosan for effective delivery of siRNA.
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Development and evaluation of a novel biodegradable film made from chitosan and cinnamon essential oil with low affinity toward water
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Real-time and non-invasive optical imaging of tumor-targeting glycol chitosan nanoparticles in various tumor models.
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Changes in microbial flora of Pacific oysters (Crassostrea gigas) during refrigerated storage and its shelf-life extension by chitosan.
R. Cao (2009)
Functionalized Graphene Oxide with Chitosan for Protein Nanocarriers to Protect against Enzymatic Cleavage and Retain Collagenase Activity
Fatemeh Emadi (2017)
Gold nanocages: from synthesis to theranostic applications.
Y. Xia (2011)
Antimicrobial peptides and their interaction with biofilms of medically relevant bacteria.
G. Batoni (2016)
Chitin and chitosan polymers: Chemistry, solubility and fiber formation
C. K. S. Pillai (2009)
Actively targeted delivery of anticancer drug to tumor cells by redox-responsive star-shaped micelles.
Chunli Shi (2014)
Bioactive Packaging Materials from Edible Chitosan Polymer—Antimicrobial Activity Assessment on Dairy‐Related Contaminants
V. Coma (2003)
Evaluation of the mucoadhesive properties of chitosan nanoparticles prepared using different chitosan to tripolyphosphate (CS:TPP) ratios.
Ezzeddin M A Hejjaji (2018)
Alkaline chitosan solutions.
C. Muzzarelli (2003)
Ethosomes: new prospects in transdermal delivery.
B. Godin (2003)
Tumor Regression by Targeted Gene Delivery to the Neovasculature
J. Hood (2002)
Use of adeno-associated virus as a mammalian DNA cloning vector: transduction of neomycin resistance into mammalian tissue culture cells.
P. Hermonat (1984)
Poly(vinyl alcohol) physical hydrogels: new vista on a long serving biomaterial.
Marie-Helene Alves (2011)
Factors influencing the transfection efficiency of ultra low molecular weight chitosan/hyaluronic acid nanoparticles.
Nicolas Duceppe (2009)
Acetylation degree, a key parameter modulating chitosan rheological, thermal and film-forming properties
M. Hamdi (2019)
Magnetofection: enhancing and targeting gene delivery by magnetic force in vitro and in vivo
Friedrich Scherer (2002)
Controlled preparation of physically crosslinked chitosan‐g‐poly(vinyl alcohol) hydrogel
Congming Xiao (2010)
Adsorption of dyes and heavy metal ions by chitosan composites: A review
W. Ngah (2011)
The effects of crosslinking of scaffolds engineered from cartilage ECM Cross Mark on the chondrogenic differentiation of MSCs
C R Rowland (2013)
The reaction mechanism of GA cross-link CS-LBG IPN
The TGF-β pathway is a common target of drugs that prevent experimental diabetic retinopathy
G Chaira (2009)
Pain free blunt needle injection technology
P Crocker (2001)
The antiviral activity of chitosan
S N Chirkov (2002)
Phenylboronic acid-installed polymeric micelles for targeting sialylated epitopes in solid tumors.
Stéphanie Deshayes (2013)
Chitosan based micro- and nanoparticles for colon-targeted delivery of vancomycin prepared by alternative processing methods.
T. Cerchiara (2015)
Ultrapure chitosan oligomers as carriers for corneal gene transfer.
E. Klausner (2010)
An Overview of Chitosan Nanoparticles and Its Application in Non-Parenteral Drug Delivery
M. Mohammed (2017)
Chitosan: A potential biopolymer for wound management.
I. Bano (2017)
Development and characterization of surface modified PLGA nanoparticles for nasal vaccine delivery: effect of mucoadhesive coating on antigen uptake and immune adjuvant activity.
Dilip Pawar (2013)
Preparation, characterization, and potential application of chitosan, chitosan derivatives, and chitosan metal nanoparticles in pharmaceutical drug delivery
T. Ahmed (2016)
The structure of alpha-chitin.
R. Minke (1978)
Evaluation of the antimicrobial activity of chitosan and its quaternized derivative on E. coli and S. aureus growth
R. Goy (2016)
An overview of drug delivery vehicles for cancer treatment: Nanocarriers and nanoparticles including photovoltaic nanoparticles.
Silvia Chowdhury (2016)
hBD‐1: a novel β‐defensin from human plasma
K. W. Bensch (1995)
Fluorescent imino and secondary amino chitosans as potential sensing biomaterials.
Sorel Jatunov (2015)
Viral and nonviral delivery systems for gene delivery
Nouri Nayerossadat (2012)
Tissue engineering: generation of differentiated artificial tissues for biomedical applications
W. W. Minuth (1997)
Alginate polycation microcapsules. I. Interaction between alginate and polycation.
B. Thu (1996)
Antibacterial action of chitosan
Nadathur R. Sudarshan (1992)
Effect of Zn/ZnO integration with hydroxyapatite: a review
Varun Saxena (2018)
The basic science of gene therapy.
R. Mulligan (1993)
Chitin deacetylation by enzymatic means: monitoring of deacetylation processes
A. Martinou (1995)
Release Behavior of 5-Fluorouracil from Chitosan-Gel Nanospheres Immobilizing 5-Fluorouracil Coated with Polysaccharides and Their Cell Specific Cytotoxicity
Y. Ohya (1994)
Chitin regulation of immune responses: an old molecule with new roles.
C. Lee (2008)
Selective probing and imaging of cells with single walled carbon nanotubes as near-infrared fluorescent molecules.
Kevin Welsher (2008)
The effect of processing variables on the morphology of electrospun nanofibers and textiles
J. Deitzel (2001)
Transdermal skin delivery: predictions for humans from in vivo, ex vivo and animal models.
B. Godin (2007)
Local delivery of chitosan/VEGF siRNA nanoplexes reduces angiogenesis and growth of breast cancer in vivo.
E. Salva (2012)
A novel pH-sensitive membrane from chitosan--TEOS IPN; preparation and its drug permeation characteristics.
S. Park (2001)
The Road from Host-Defense Peptides to a New Generation of Antimicrobial Drugs
A. Boto (2018)
Mesoporous silica nanoparticles as cutting‐edge theranostics: Advancement from merely a carrier to tailor‐made smart delivery platform
P. Kumar (2018)
Synthesis and characterization of novel aromatic azo bond-containing pH-sensitive and hydrolytically cleavable IPN hydrogels.
Padmanabh Chivukula (2006)
Preparation and important functional properties of water-soluble chitosan produced through Maillard reaction.
Y. Chung (2005)
Stability of Chitosan—A Challenge for Pharmaceutical and Biomedical Applications
E. Szymańska (2015)
Polymer nanoparticles composed with gallic acid grafted chitosan and bioactive peptides combined antioxidant, anticancer activities and improved delivery property for labile polyphenols
B. Hu (2015)
Novel alginate-enclosed chitosan-calcium phosphate-loaded iron-saturated bovine lactoferrin nanocarriers for oral delivery in colon cancer therapy.
J. Kanwar (2012)
Fabrication of heparinized nano ZnO/poly(vinylalcohol)/carboxymethyl cellulose bionanocomposite hydrogels using artificial neural network for wound dressing application
Alireza Joorabloo (2019)
Polymeric micelle stability
S. Owen (2012)
The Human Cathelicidin Antimicrobial Peptide LL-37 and Mimics are Potential Anticancer Drugs
K. Kuroda (2015)
Chitosan: A Promising Biopolymer in Drug Delivery Applications
Chinmayee Saikia (2015)
Ocular drug delivery systems: An overview.
Ashaben Patel (2013)
Dual docetaxel/superparamagnetic iron oxide loaded nanoparticles for both targeting magnetic resonance imaging and cancer therapy.
You Ling (2011)
Polymer-based nanocapsules for drug delivery.
C. E. Mora-Huertas (2010)
Preparation and antibacterial activity of chitosan nanoparticles.
Lifeng Qi (2004)
Effective use of transdermal drug delivery in children.
M. B. Delgado-Charro (2014)
Inhibiting the Evolution of Antibiotic Resistance
Mark N. Ragheb (2019)
Biomedical Activity of Chitin/Chitosan Based Materials—Influence of Physicochemical Properties Apart from Molecular Weight and Degree of N-Acetylation
J. Kumirska (2011)
Overview of Glycoconjugate Analysis
A. Varki (2009)
Oral colon cancer targeting by chitosan nanocomposites
A. Bose (2018)
Antimicrobial Activity of Gallic Acid-Grafted-Chitosan Against Fish Pathogens
D. Kim (2015)
Thyroxin releasing chitosan/collagen based smart hydrogels to stimulate neovascularization
Abdur Raheem Aleem (2017)
Preparation and characterization of mPEG grafted chitosan micelles as 5-fluorouracil carriers for effective antitumor activity
D-J Fu (2014)
From basic research to clinics
G Guidotti (2017)
ed) Gene therapy -tools and potential applications
A Rodriguez (2013)
Anticancer activities of Ganoderma lucidum: active ingredients and pathways. Funct Food
Hjk Chi (2013)
Transdermal delivery using low frequency sonophoresis
S Mitragotri (1996)
P Dong (2019)
TRA) under TEQIP Phase II Project. She has two book chapters to her credit
The Multifaceted Antibacterial Mechanisms of the Pioneering Peptide Antibiotics Tyrocidine and Gramicidin S
Michaela Wenzel (2018)
Injectable in situ cross-linking chitosan-hyaluronic acid based hydrogels for abdominal tissue regeneration
Youming Deng (2017)
Opportunities and challenges of carbon-based nanomaterials for cancer therapy.
A. Bianco (2008)
Direct electrochemistry and electrocatalysis of hemoglobin entrapped in semi-interpenetrating polymer network hydrogel based on polyacrylamide and chitosan.
Xiandong Zeng (2007)
Implantable Biodegradable Sponges: Effect of Interpolymer Complex Formation of Chitosan With Gelatin on the Release Behavior of Tramadol Hydrochloride
N. Foda (2007)
pH Effects on solubility, zeta potential, and correlation between antibacterial activity and molecular weight of chitosan.
Shun-Hsien Chang (2015)
Anti-ulcer effects of chitin and chitosan, healthy foods, in rats.
M. Itō (2000)
Functionalization of Fe3O4 nanoparticles with biodegradable chitosan-grafted-mPEG for paclitaxel delivery
D. Hoang (2016)
Designing Supermacroporous Cryogels Based on Polyacrylonitrile and a Polyacrylamide–Chitosan Semi-interpenetrating Network
Era Jain (2009)
Oral gene delivery with chitosan–DNA nanoparticles generates immunologic protection in a murine model of peanut allergy
K. Roy (1999)
Efficacy of vaccination and nisin Z treatments to eliminate intramammary Staphylococcus aureus infection in lactating cows
R. Guan (2017)
Procion Green H-4G immobilized on a new IPN hydrogel membrane composed of poly(2-hydroxyethylmethacrylate)/chitosan: preparation and its application to the adsorption of lysozyme
Gulay Bayramoglu (2002)
Recovery of Direct Dye and Acid Dye by Adsorption on Chitosan Fiber – Equilibria
H. Yoshida (1991)
Large-scale pattern growth of graphene films for stretchable transparent electrodes
K. Kim (2009)
Grafting : a versatile means to modify polymers Techniques , factors and applications
A. Bhattacharyaa (1978)
Antimicrobial peptides: new drugs for bad bugs?
J. Steckbeck (2014)
Factors affecting the susceptibility of Staphylococcus aureus CCRC 12657 to water soluble lactose chitosan derivative
Yu-Lu Chen (2005)
Comparison of the mucoadhesive properties of various polymers.
V. Grabovac (2005)
In vitro and in vivo antibacterial activity of shrimp chitosan against some intestinal bacteria
G. Tsai (2004)
Understanding antibiotic resistance via outer membrane permeability
I. Ghai (2018)
Chitosan grafted methoxy poly(ethylene glycol)-poly(ε-caprolactone) nanosuspension for ocular delivery of hydrophobic diclofenac
Shuai Shi (2015)
The potential application of hyaluronic acid coated chitosan nanoparticles in ocular delivery of dexamethasone.
M. A. Kalam (2016)
In vitro evaluation and modification of pectinate gel beads containing trimethyl chitosan, as a multi-particulate system for delivery of water-soluble macromolecules to colon
F. Atyabi (2005)
Use of ultrasound contrast agents for gene or drug delivery in cardiovascular medicine.
R. Bekeredjian (2005)
Effect of molecular structure of chitosan on protein delivery properties of chitosan nanoparticles.
Y. Xu (2003)
Synthesis and study of water-soluble chitosan-O-poly(ethylene glycol) graft copolymers
N. Gorochovceva (2004)
Antimicrobial Activity of Bee Venom and Melittin against Borrelia burgdorferi
K. M. Socarras (2017)
A novel sensing platform based on periodate-oxidized chitosan
Y. Feng (2010)
Antimicrobial and optical properties of PET chemically modified and grafted with borane compounds
Monika Benkocká (2018)
High concentration honey chitosan electrospun nanofibers: biocompatibility and antibacterial effects.
Wessam A Sarhan (2015)
Physical properties and antibacterial activity of quaternized chitosan/carboxymethyl cellulose blend films
Dongying Hu (2016)
Near-infrared photonic energy penetration: can infrared phototherapy effectively reach the human brain?
Theodore A. Henderson (2015)
Perspectives for chitosan based antimicrobial films in food applications
P. Dutta (2009)
Glibenclamide Nanocrystals in a Biodegradable Chitosan Patch for Transdermal Delivery: Engineering, Formulation, and Evaluation.
Hany S M Ali (2017)
Physicochemical properties of mucus and their impact on transmucosal drug delivery.
J. Leal (2017)
Advancing biomaterials of human origin for tissue engineering.
F. Chen (2016)
An in vitro cytotoxicity study of 5-fluorouracil encapsulated chitosan/gold nanocomposites towards MCF-7 cells
E. Nivethaa (2015)
Novel antibacterial fibers of quaternized chitosan and poly(vinyl pyrrolidone) prepared by electrospinning
M. Ignatova (2007)
Magnetic nanofactories: localized synthesis and delivery of quorum-sensing signaling molecule autoinducer-2 to bacterial cell surfaces.
R. Fernandes (2007)
Cell age, suspending medium and metal ion influence the susceptibility of Escherichia coli O157:H7 to water-soluble maltose chitosan derivative.
T. Yang (2007)
Microparticles based on chitosan/carboxymethylcellulose polyelectrolyte complexes for colon delivery of vancomycin.
T. Cerchiara (2016)
Enhancing drug absorption using lipids: a case study presenting the development and pharmacological evaluation of a novel lipid-based oral amphotericin B formulation for the treatment of systemic fungal infections.
K. Sachs-Barrable (2008)
pH and Glucose Dual-Responsive Injectable Hydrogels with Insulin and Fibroblasts as Bioactive Dressings for Diabetic Wound Healing.
L. Zhao (2017)
Hexanoyl-Chitosan-PEG Copolymer Coated Iron Oxide Nanoparticles for Hydrophobic Drug Delivery.
Meng-Hsuan Hsiao (2015)
Development of Polymeric Functionally Graded Scaffolds: A Brief Review
R. Scaffaro (2017)
Chemoprevention of Colon Cancer in a Rat Carcinogenesis Model Using a Novel Nanotechnology-Based Combined Treatment System
Abhishek V. Chaudhary (2011)
5-flourouracil loaded N,O-carboxymethyl chitosan nanoparticles as an anticancer nanomedicine for breast cancer.
A. Anitha (2012)
STUDIES ON A BACTERICIDAL AGENT EXTRACTED FROM A SOIL BACILLUS
R. Dubos (1939)
Biopolymer-Based Antimicrobial Packaging: A Review
D. Cha (2004)
Hydrogels for tissue engineering: scaffold design variables and applications.
Jeanie L Drury (2003)
Study on the mechanisms of chitosan and its derivatives used as transdermal penetration enhancers.
W. He (2009)
Polymersomes: a new multifunctional tool for cancer diagnosis and therapy
D H Levine (2008)
Incorporated AMP into NPs (121 nm) enhanced the activity of the peptide against S. aureus and significantly reduced hemolysis and cytotoxicity
Antibacterial polymer composite coatings with synthesized silver nanoparticles
Yılmaz Atay (2015)
Design and production of nanoparticles formulated from nanoemulsion templates-a review
N Anton (2008)
Drug delivery with upconversion nanoparticles for multi-functional targeted cancer cell imaging and therapy.
Chao Wang (2011)
Progress in the development of interpenetrating polymer network hydrogels.
D. Myung (2008)
Development and characterization of an LDPE/chitosan composite antimicrobial film for chilled fish storage.
K. Reesha (2015)
Membrane targeting cationic antimicrobial peptides.
Daniela Ciumac (2019)
Genesis and regulation of the heart automaticity.
M. Mangoni (2008)
Beneficial properties for insulin absorption using superporous hydrogel containing interpenetrating polymer network as oral delivery vehicles.
Lichen Yin (2008)
Development of biomaterials for gene therapy.
S. Han (2000)
pH-sensitive freeze-dried chitosan-polyvinyl pyrrolidone hydrogels as controlled release system for antibiotic delivery.
M. Risbud (2000)
Synthesis, characteristic and antibacterial activity of N,N,N-trimethyl chitosan and its carboxymethyl derivatives
T. Xu (2010)
Antiproliferation and apoptosis induced by curcumin in human ovarian cancer cells
Mingxin Shi (2006)
Curcumin nanomedicine: a road to cancer therapeutics.
Murali M Yallapu (2013)
Positively charged nanoparticles for improving the oral bioavailability of cyclosporin-A.
M. H. El-Shabouri (2002)
Preliminary report: the short-term effects of direct p53 DNA injection in primary hepatocellular carcinomas.
N. Habib (1996)
The threshold for brain damage in rabbits induced by bursts of ultrasound in the presence of an ultrasound contrast agent (Optison).
K. Hynynen (2003)
Ligand-targeted therapeutics in anticancer therapy
T. Allen (2002)
“The Good, the Bad and the Ugly” of Chitosans
B. Bellich (2016)
Chitosan-coated PLGA nanoparticles for DNA/RNA delivery: effect of the formulation parameters on complexation and transfection of antisense oligonucleotides.
N. Nafee (2007)
Preparation of bioactive glass-polyvinyl alcohol hybrid foams by the sol-gel method
M. Pereira (2005)
Effects of molecular weight and deacetylation degree of chitin/chitosan on wound healing
Tatsuya Minagawa (2007)
Attachment of stem cells on porous chitosan scaffold crosslinked by Na5P3O10
H. Lin (2007)
Chitosan nanoparticles as a novel delivery system for ammonium glycyrrhizinate.
Yan Wu (2005)
Preparation of sub-micrometer porous membrane from chitosan/polyethylene glycol semi-IPN
Minfeng Zeng (2004)
Chitosan Based Systems for Tissue Engineering Part II: Soft Tissues
H. Çiǧdem (2010)
Chitosan/cyclodextrin nanoparticles can efficiently transfect the airway epithelium in vitro.
D. Teijeiro-Osorio (2009)
Water absorption, retention and the swelling characteristics of cassava starch grafted with polyacrylic acid.
J. R. Witono (2014)
The fabrication and characterization of Cu-nanoparticle immobilization on a hybrid chitosan derivative-carbon support as a novel electrochemical sensor: application for the sensitive enzymeless oxidation of glucose and reduction of hydrogen peroxide.
A. A. Ensafi (2014)
In vitro degradation and release behavior of porous poly(lactic acid) scaffolds containing chitosan microspheres as a carrier for BMP-2-derived synthetic peptide
X. Niu (2009)
Antibacterial activity of chitosan grafting nisin: Preparation and characterization
Xiaoming Zhu (2015)
Enhanced cellular uptake and phototoxicity of Verteporfin-conjugated gold nanoparticles as theranostic nanocarriers for targeted photodynamic therapy and imaging of cancers.
Linlin Zhao (2016)
Design and characterization of a chitosan physical gel promoting wound healing in mice
L. Mayol (2014)
Ultrasmall Chitosan-Genipin Nanocarriers Fabricated from Reverse Microemulsion Process for Tumor Photothermal Therapy in Mice.
X. Song (2015)
Preparation and characterization of cross-linked chitosan/palladium nanocomposites for catalytic and antibacterial activity
S. Dhanavel (2018)
Preparations of biodegradable nanospheres of water-soluble and insoluble drugs with D, L-lactide/glycolide copolymer by a novel spontaneous emulsification solvent diffusion method, and the drug release behavior.
pDNA bioparticles: comparative heterogeneity, surface, binding, and activity analyses.
P. Medberry (2004)
The Cushion Method: A New Technique for the Recovery of Hydrophilic Nanocarriers.
W. He (2016)
Combined near-IR photothermal therapy and chemotherapy using gold-nanorod/chitosan hybrid nanospheres to enhance the antitumor effect.
Rui Chen (2013)
Improved antifungal activity and stability of chitosan nanofibers using cellulose nanocrystal on banknote papers.
Leila Mohammadi Amirabad (2018)
The Mechanical and Biological Properties of Chitosan Scaffolds for Tissue Regeneration Templates Are Significantly Enhanced by Chitosan from Gongronella butleri
N. Nwe (2009)
pH-responsive polymers for drug delivery applications
E. Ratemi (2018)
A multiple emulsion method for loading 5‐fluorouracil into a magnetite‐loaded nanocapsule: a physicochemical investigation
M. Ashjari (2012)
Interactions of phospholipid bilayer with chitosan: effect of molecular weight and pH.
N. Fang (2001)
Calcium phosphates as substitution of bone tissues
M. Vallet-Regí (2004)
Breast Cancer: Conventional Diagnosis and Treatment Modalities and Recent Patents and Technologies
M. I. Nounou (2015)
Iron-Oxide-Based Nanovector for Tumor Targeted siRNA Delivery in an Orthotopic Hepatocellular Carcinoma Xenograft Mouse Model.
K. Wang (2016)
Mucoadhesive microsphere of propanol HCl for nasal delivery
P M Dandangi (2007)
A novel method of grafting modification of chitosan via REFT polymerization agent
D Hua (2008)
Chitosan Nanoparticle Penetration into Shrimp Muscle and its Effects on the Microbial Quality
Alexander Chouljenko (2016)
The history of electrically-assisted transdermal drug delivery ("iontophoresis").
A. Helmstädter (2001)
Carbopol gel containing chitosan-egg albumin nanoparticles for transdermal aceclofenac delivery.
Sougata Jana (2014)
Functional graphene oxide as a nanocarrier for controlled loading and targeted delivery of mixed anticancer drugs.
L. Zhang (2010)
An efficient and flexible system for construction of adenovirus vectors with insertions or deletions in early regions 1 and 3.
A. Bett (1994)
Dynamic Self-Assembly of Gold/Polymer Nanocomposites: pH-Encoded Switching between 1D Nanowires and 3D Nanosponges.
Q. Zhang (2017)
Thermo-sensitive chitosan based semi-IPN hydrogels for high loading and sustained release of anionic drugs.
G. Li (2012)
Food applications of chitin and chitosans
F. Shahidi (1999)
Synergism of Antimicrobial Frog Peptides Couples to Membrane Intrinsic Curvature Strain
R. Leber (2018)
Chitosan hybrid nanoparticles as a theranostic platform for targeted doxorubicin/VEGF shRNA co-delivery and dual-modality fluorescence imaging
H. Yang (2016)
Main properties and current applications of some polysaccharides as biomaterials
M. Rinaudo (2008)
Effects of chitosan molecular weight on its antioxidant and antimutagenic properties.
Shun-Hsien Chang (2018)
Overview of Agents Used for Emergency Hemostasis
H. Khoshmohabat (2016)
Mucoadhesive Buccal Tablets Based on Chitosan/Gelatin Microparticles for Delivery of Propranolol Hydrochloride.
A. Abruzzo (2015)
Membrane Active Antimicrobial Peptides: Translating Mechanistic Insights to Design
J. Li (2017)
Polyionic hydrocolloids for the intestinal delivery of protein drugs: alginate and chitosan--a review.
M. George (2006)
Porosity of 3D biomaterial scaffolds and osteogenesis.
V. Karageorgiou (2005)
Heterogeneous N-deacetylation of chitin in alkaline solution
K. Chang (1997)
Development of a topical polymeric mucoadhesive ocular delivery system for azithromycin.
L. Bowman (2009)
Motivational interviewing to improve adherence behaviours for the prevention of diabetic foot ulceration
Jodi Binning (2019)
Development of novel ultrashort antimicrobial peptide nanoparticles with potent antimicrobial and antibiofilm activities against multidrug-resistant bacteria
Ammar M. Almaaytah (2017)
Sensitive voltammetric determination of tryptophan using an acetylene black paste electrode modified with a Schiff's base derivative of chitosan.
Peihong Deng (2011)
Chitosan - Locust bean gum interpenetrating polymeric network nanocomposites for delivery of aceclofenac.
Sougata Jana (2017)
Nanostructured lipid carriers system: Recent advances in drug delivery
M. A. Iqbal (2012)
Chitosan for Gene Delivery and Orthopedic Tissue Engineering Applications
R. Raftery (2013)
Hydrogels for biomedical applications.
A. Hoffman (2002)
Nanoencapsulation I. Methods for preparation of drug-loaded polymeric nanoparticles.
C. Reis (2006)
Nanoparticle-based theragnostics: Integrating diagnostic and therapeutic potentials in nanomedicine.
Chen Fang (2010)
Interpenetrating polymer network blend microspheres of chitosan and hydroxyethyl cellulose for controlled release of isoniazid.
Sudha C. Angadi (2010)
N-PEG'ylation of chitosan via click chemistry reactions
Ruta Kulbokaite (2009)
Theranostic lipid nanoparticles for cancer medicine.
Danielle M. Charron (2015)
SP600125, an anthrapyrazolone inhibitor of Jun N-terminal kinase
B. Bennett (2001)
Influence of the degree of acetylation on some biological properties of chitosan films.
C. Châtelet (2001)
Chitosans for delivery of nucleic acids☆
M. Buschmann (2013)
Synthetic therapeutic peptides: science and market.
P. Vlieghe (2010)
Novel crosslinking methods to design hydrogels.
W. Hennink (2002)
Introduction of liposome-encapsulated SV40 DNA into cells.
R. Fraley (1980)
Studies on semi-interpenetrating polymer network beads of chitosan–poly(ethylene glycol) for the controlled release of drugs
K. Gupta (2001)
Arginine in α-Defensins
N. Schmidt (2012)
Preparation and characterization of antimicrobial chitosan-N-arginine with different degrees of substitution
B. Xiao (2011)
Anti-Microbial Dendrimers against Multidrug-Resistant P. aeruginosa Enhance the Angiogenic Effect of Biological Burn-wound Bandages
Philippe Abdel-Sayed (2016)
Oleoyl-chitosan nanoparticles inhibits Escherichia coli and Staphylococcus aureus by damaging the cell membrane and putative binding to extracellular or intracellular targets.
Ke Xing (2009)
Interpenetrating Polymer Networks And Related Materials
J. Junker (2016)
Advances in self-assembled chitosan nanomaterials for drug delivery.
Yu Yang (2014)
Fluorescent Bioactive Corrole Grafted-Chitosan Films.
Joana F. B. Barata (2016)
Photoinduced Graft Copolymerization onto Chitosan Under Heterogeneous Conditions
Samaneh Saber-Samandari (2012)
Cell penetrating peptides as an innovative approach for drug delivery; then, present and the future
Santosh K Bashyal (2016)
A study on the hemocompatibility of dendronized chitosan derivatives in red blood cells
Yanfang Zhou (2015)
Chitosan‐based Polyelectrolyte Complexes: Characteristics and Application in Formulation of Particulate Drug Carriers
B. Čalija (2015)
Y-shaped biotin-conjugated poly (ethylene glycol)-poly (epsilon-caprolactone) copolymer for the targeted delivery of curcumin.
Wenxia Zhu (2015)
Synthesis and characterization of semi-interpenetrating polymer network hydrogel based on chitosan and poly(methacryloylglycylglycine)
M. Dash (2012)
Survey of the State of the Art in Biomaterials, Cells, Genes and Proteins Integrated into Micro- and Nanoscaffolds for Tissue Regeneration
Mohana Marimuthu and Sanghyo Kim (2009)
Physico-Chemical stability and drug retention of polymeric micelles for tumor-targeted drug delivery
Y Shi (2017)
Synthetic scheme for quaternary chitosan derivatives with antibacterial activity
She is currently working in the field of advanced drug delivery systems that are ideal carriers to deliver therapeutics for neurodegenerative disorders
DNA vaccines: immunology, application, and optimization*.
S. Gurunathan (2000)
Drug delivery and nanoparticles: Applications and hazards
W. D. de Jong (2008)
Efficacy assessment of a cell-mediated immunity HIV-1 vaccine (the Step Study): a double-blind, randomised, placebo-controlled, test-of-concept trial
S. Buchbinder (2008)
Flexible Substrate-Based Devices for Point-of-Care Diagnostics.
Shu-qi Wang (2016)
Enhanced Antibacterial Effect of Ceftriaxone Sodium-Loaded Chitosan Nanoparticles Against Intracellular Salmonella typhimurium
N. M. Zaki (2012)
Intracellular siRNA delivery dynamics of integrin-targeted, PEGylated chitosan-poly(ethylene imine) hybrid nanoparticles: A mechanistic insight.
H. Ragelle (2015)
Theranostic Applications of Nanomaterials in Cancer: Drug Delivery, Image-Guided Therapy, and Multifunctional Platforms
A. Fernandez-Fernandez (2011)
The development of bioengineered skin.
R. Kirsner (1998)
Naturally occurring scaffolds for soft tissue repair and regeneration.
J. Hodde (2002)
Nanotechnology Approaches for Ocular Drug Delivery
Qingguo Xu (2013)
Effect of alipogene tiparvovec (AAV1-LPL(S447X)) on postprandial chylomicron metabolism in lipoprotein lipase-deficient patients.
A. Carpentier (2012)
Polymer brushes via surface-initiated controlled radical polymerization: synthesis, characterization, properties, and applications.
Raphaël Barbey (2009)
Chitosan and Its Derivatives for Application in Mucoadhesive Drug Delivery Systems
Twana Mohammed M Ways (2018)
Assessing the in vitro and in vivo toxicity of superparamagnetic iron oxide nanoparticles.
M. Mahmoudi (2012)
Effect of argon-plasma treatment on proliferation of human-skin-derived fibroblast on chitosan membrane in vitro.
X. Zhu (2005)
Design and Development of Three-Dimensional Scaffolds for Tissue Engineering
C. Liu (2007)
Progress in Retinal and Eye Research
R. Molday (2012)
Polymeric micelles as nanocarriers for drug delivery
Liyan Qiu (2007)
Guar gum: Versatile natural polymer for drug delivery applications
Archana George (2019)
New Developments and Trends in Tissue Engineering: An Update
R. Horch (2012)
Pharmacokinetics and biodegradation of chitosan in rats
Hui Li (2015)
A comparison of shock wave and sinusoidal-focused ultrasound-induced localized transfection of HeLa cells.
P. Huber (1999)
Chitosan: A Promising Biomaterial for Tissue Engineering Scaffolds
P. K. Dutta (2011)
Protein separation using membrane chromatography: opportunities and challenges.
R. Ghosh (2002)
L. Hench (1988)
The taxol supply crisis. New NCI policies for handling the large-scale production of novel natural product anticancer and anti-HIV agents.
G. Cragg (1993)
Preparation of chitosan/SiO2-loaded graphene composite beads for efficient removal of bilirubin
J. Chen (2019)
Chitosan-modifications and applications: Opportunities galore
V. Mourya (2008)
Chitin and chitosan: Chemistry, properties and applications
P. Dutta (2004)
Influence of different collagen species on physico-chemical properties of crosslinked collagen matrices.
P. Angele (2004)
Carboxymethyl chitosan: Properties and biomedical applications.
Z. Shariatinia (2018)
Glycol chitosan nanoparticles as specialized cancer therapeutic vehicles: Sequential delivery of doxorubicin and Bcl-2 siRNA
H. Yoon (2014)
Why is chitosan mucoadhesive?
Ioannis A Sogias (2008)
Biocompatible nanocomposite scaffolds based on copolymer-grafted chitosan for bone tissue engineering with drug delivery capability.
Samaneh Saber-Samandari (2017)
Effects of hydroxyapatite reinforcement on the architecture and mechanical properties of freeze-dried collagen scaffolds.
Robert J. Kane (2012)
Scaffolds containing chitosan, gelatin and graphene oxide for bone tissue regeneration in vitro and in vivo.
S. Saravanan (2017)
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