Online citations, reference lists, and bibliographies.
Please confirm you are human
(Sign Up for free to never see this)
← Back to Search

Axotomy Affects The Retrograde Labeling Of Cervical And Lumbar-cord-projecting Rubrospinal Neurons Differently

G. Tseng, Yueh-Jan Wang, Min-E Hu
Published 2004 · Medicine

Save to my Library
Download PDF
Analyze on Scholarcy
Share
The effect of axotomy at cervical and lumbar spinal levels upon the ability of rubrospinal neurons to retrogradely transport tracer was compared. Unilateral rubrospinal tractotomy was performed first at C5 and, after a few days, at C2 vertebral levels. Different retrograde tracers were applied at the lesioned sites right after tractotomy. Tracer applied at C5 labeled both cervical and lumbar-cord-projecting neurons. Tracer applied at C2 also labeled both groups of neurons if performed 2 days after that at C5; however, only cervical-cord-projecting neurons were labeled when it was performed 3 or 5 days after that at C5. In another set of experiments, a T10 tractotomy without tracer application was performed 2 or 5 days prior to the C5/C2 series of tract lesions. When preceded by a T10 lesion 2 days in advance, tracer applied at C5 labeled both cervical and lumbar-cord-projecting neurons. However, a T10 lesion 5 days in advance resulted in the labeling of only cervical-cord-projecting neurons by the tracer applied at C5. In either case, tracer applied at C2 consistently labeled only cervical-cord-projecting neurons, irrespective of the intervals — 2, 3, or 5 days — allowed between C5 and C2 lesions. Most neurons labeled from C2 were also double-labeled by the tracer applied at C5. Thus, unlike lumbar-cord-projecting counterparts, cervical-cord-projecting rubrospinal neurons retain the ability to uptake and/or transport retrograde tracer several days following axotomy. This implies that cervical-cord-projecting rubrospinal neurons survive in a different functional state from their lumbar-cord-projecting counterparts following axonal injury.
This paper references
10.1523/JNEUROSCI.11-08-02528.1991
Response of facial and rubrospinal neurons to axotomy: changes in mRNA expression for cytoskeletal proteins and GAP-43
W. Tetzlaff (1991)
Prela - beled red nucleus and sensorimotor cortex neurons of the rat survive 10 and 20 weeks alter spinal cord transection
RL McBride (1989)
10.1002/CNE.902140303
Cell death and changes in the retrograde transport of horseradish peroxidase in rubrospinal neurons following spinal cord hemisection in the adult rat
H. Goshgarian (1983)
10.1152/JN.1996.75.1.248
Structural and functional alterations in rat corticospinal neurons after axotomy.
G. Tseng (1996)
10.1007/BF00234928
Spinal branching of corticospinal axons in the cat
Y. Shinoda (2004)
10.1212/WNL.34.8.1002
Histologic evidence for death of cortical neurons after spinal cord transaction
E. R. Feringa (1984)
10.1016/0006-8993(75)90482-5
A study of the dynamics of retrograde transport and accumulation of horseradish peroxidase in injured neurons
J. Halperin (1975)
10.1212/WNL.33.4.478
Retrograde transport in corticospinal neurons after spinal cord transection
E. R. Feringa (1983)
10.1007/BF01215644
Cytoplasmic constriction and vesiculation after axotomy in the squid giant axon
P. Gallant (1995)
10.1097/00005072-198909000-00007
Prelabeled Red Nucleus and Sensorimotor Cortex Neurons of the Rat Survive 10 and 20 Weeks After Spinal Cord Transection
R. McBride (1989)
10.1007/BF01148324
Regeneration of long spinal axons in the rat
P. Richardson (1984)
10.1016/0304-3940(79)95337-0
Origin of the rubrospinal tract of the rat
H. M. Murray (1979)
10.1083/JCB.119.1.123
Axonal and dendritic endocytic pathways in cultured neurons.
R. Parton (1992)
10.1016/0006-8993(72)90224-7
Retrograde transport of protein tracer in the rabbit hypoglossal nerve during regeneration.
K. Kristensson (1972)
10.1002/CNE.902140108
Origin of the rubrospinal tract in neonatal, developing, and mature rats
J. Y. Shieh (1983)
10.1016/0006-8993(81)90153-0
Quantitative differences in collateralization of the descending spinal pathways from red nucleus and other brain stem cell groups in rat as demonstrated with the multiple fluorescent retrograde tracer technique
A. Huisman (1981)
10.1007/BF00187823
A time-dependent loss of retrograde transport ability in distally axotomized rubrospinal neurons
G. Tseng (2004)
10.1016/0165-0270(91)90122-G
Double-labelling with rhodamine beads and biocytin: a technique for studying corticospinal and other projection neurons in vitro
G. Tseng (1991)
10.1007/BF00237251
Spinal branching of rubrospinal axons in the cat
Y. Shinoda (1977)
10.1007/BF01176997
Uptake and retrograde axonal transport of horseradish peroxidase in regenerating facial motor neurons of the mouse
T. Olsson (1978)
10.1111/j.1471-4159.1976.tb01563.x
RETROGRADE AXONAL TRANSPORT OF RAPIDLY MIGRATING LABELLED PROTEINS AND GLYCOPROTEINS IN REGENERATING PERIPHERAL NERVES
M. Frizell (1976)
10.1016/0006-8993(95)01418-7
Perineuronal microglial reactivity following proximal and distal axotomy of rat rubrospinal neurons
G. Tseng (1996)
10.1002/CNE.902960313
Cell death of corticospinal neurons is induced by axotomy before but not after innervation of spinal targets
M. Merline (1990)



This paper is referenced by
10.1007/s00429-003-0361-2
The proximity of the lesion to cell bodies determines the free radical risk induced in rat rubrospinal neurons subjected to axonal injury
P.-H. Liu (2003)
10.1089/NEU.2004.21.1624
Spinal axonal injury induces brief downregulation of ionotropic glutamate receptors and no stripping of synapses in cord-projection central neurons.
Yueh-Jan Wang (2004)
10.1089/089771504323004629
Spinal axonal injury transiently elevates the level of metabotropic glutamate receptor 5, but not 1, in cord-projection central neurons.
Yueh-Jan Wang (2004)
10.1089/089771502320914714
Fate of the soma and dendrites of cord-projection central neurons after proximal and distal spinal axotomy: an intracellular dye injection study.
Yueh-Jan Wang (2002)
10.1111/jnc.13102
AAV‐mediated expression of BAG1 and ROCK2‐shRNA promote neuronal survival and axonal sprouting in a rat model of rubrospinal tract injury
Malleswari Challagundla (2015)
10.1007/s00429-002-0250-0
Parvalbumin-containing neurons mediate the feedforward inhibition of rat rubrospinal neurons
Chuen-Lan Liu (2002)
10.1002/dneu.22083
Androgen action at the target musculature regulates brain‐derived neurotrophic factor protein in the spinal nucleus of the bulbocavernosus
T. Verhovshek (2013)
10.1006/exnr.2002.8057
Close Axonal Injury of Rubrospinal Neurons Induced Transient Perineuronal Astrocytic and Microglial Reaction That Coincided with Their Massive Degeneration
P. Liu (2003)
10.1002/jnr.10787
Treatment of chronically injured spinal cord with neurotrophic factors stimulates βII‐tubulin and GAP‐43 expression in rubrospinal tract neurons
P. Storer (2003)
Semantic Scholar Logo Some data provided by SemanticScholar