← Back to Search

# Succinate Accumulation In Man During Exercise

P. W. Hochachka, R. Dressendorfer
Published 1976 · Biology, Medicine

Reduce the time it takes to create your bibliography by a factor of 10 by using the world’s favourite reference manager
Time to take this seriously.
SummaryIt has been demonstrated in several diving vertebrates that succinate, a component of the Krebs cycle, accumulates in blood during breath-hold dives. The production of succinate is thought to result from amino acid catabolism. Our purpose was to determine whether succinate accumulation occurs in man during muscular activity requiring anaerobic energy contribution. Experiments using an endurance athlete included apneic work on an underwater ergometer and treadmill running to exhaustion. During 1 min breath-hold “dives” in cold water while exercising at a work rate equivalent to 62% of $$\dot V$$ O2max, venous succinate increased from 42 Μmoles/l (M×10−6) at rest to 125 M×10−6. The treadmill run elicited $$\dot V$$ O2max and increased succinate from a similar resting value to 93 M×10−6. Increases in alanine, lactate, and pyruvate were observed for both types of exercise. The findings confirm that succinate accumulation also occurs in man. It was suggested that amino acid catabolism may provide a source of anaerobic energy production in addition to glycolysis. However, the importance of the proposed energy pathway remains to be quantified.
This paper references

This paper is referenced by
Some data provided by SemanticScholar