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Succinate Accumulation In Man During Exercise

P. W. Hochachka, R. Dressendorfer
Published 1976 · Biology, Medicine

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SummaryIt has been demonstrated in several diving vertebrates that succinate, a component of the Krebs cycle, accumulates in blood during breath-hold dives. The production of succinate is thought to result from amino acid catabolism. Our purpose was to determine whether succinate accumulation occurs in man during muscular activity requiring anaerobic energy contribution. Experiments using an endurance athlete included apneic work on an underwater ergometer and treadmill running to exhaustion. During 1 min breath-hold “dives” in cold water while exercising at a work rate equivalent to 62% of $$\dot V$$ O2max, venous succinate increased from 42 Μmoles/l (M×10−6) at rest to 125 M×10−6. The treadmill run elicited $$\dot V$$ O2max and increased succinate from a similar resting value to 93 M×10−6. Increases in alanine, lactate, and pyruvate were observed for both types of exercise. The findings confirm that succinate accumulation also occurs in man. It was suggested that amino acid catabolism may provide a source of anaerobic energy production in addition to glycolysis. However, the importance of the proposed energy pathway remains to be quantified.
This paper references
Experimental investigations on the respiratory function in diving mammals and birds
P. F. Scholander (1940)
10.1152/JAPPL.1962.17.6.938
Some effects of apneic underwater diving on blood gases, lactate, and pressure in man.
C. Olsen (1962)
10.1152/JAPPL.1962.17.2.184
Circulatory adjustment in pearl divers.
P. Scholander (1962)
10.1021/BI00903A023
ON THE MECHANISM OF OXIDATIVE PHOSPHORYLATION. VII. THE ENERGY-REQUIRING REDUCTION OF PYRIDINE NUCLEOTIDE BY SUCCINATE AND THE ENERGY-YIELDING OXIDATION OF REDUCED PYRIDINE NUCLEOTIDE BY FUMARATE.
D. Sanadi (1963)
10.1016/0304-4165(67)90135-3
Evidence of reduction of fumarate to succinate in perfused rat liver under conditions of reduced O2 tension.
H. D. Hoberman (1967)
10.1016/0076-6879(69)13072-4
[65] Assays of intermediates of the citric acid cycle and related compounds by fluorometric enzyme methods
J. Williamson (1969)
10.1515/BCHM2.1969.350.1.691
Intermediary metabolism of the liver fluke Fasciola hepatica, II. Hydrogen transport and phosphorylation.
L. W. De Zoeten (1969)
10.1042/BJ1180221
Anaerobic rat heart. Effects of glucose and tricarboxylic acid-cycle metabolites on metabolism and physiological performance.
D. Penney (1970)
10.1016/0005-2728(70)90158-1
The energy-yielding oxidation of NADH by fumarate in submitochondrial particles of rat tissues.
M. Wilson (1970)
10.1126/science.178.4065.1056
Invertebrate Facultative Anaerobiosis
P. Hochachka (1972)
Succinyl coenzyme A synthetase of Escherichia coli. Effects of phosphoenzyme formation and of substrate binding on the reactivity and stability of the enzyme.
F. J. Moffet (1972)
10.1172/JCI107112
Effect of insulin on muscle glutamate uptake. Whole blood versus plasma glutamate analysis.
T. Aoki (1972)
10.1093/ICB/13.2.543
Animal Life Without Oxygen: Basic Biochemical Mechanisms
P. Hochachka (1973)
Strategies of biochemical adaptation
P. Hochachka (1973)
Modification of a standard bicycle ergometer for underwater use.
J. F. Morlock (1974)
10.1016/0305-0491(75)90292-8
Multiple end products of anaerobiosis in diving vertebrates.
P. W. Hochachka (1975)



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10.1101/2021.02.10.430650
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10.3390/ijms22168636
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B. Astiarraga (2020)
10.17863/CAM.49510
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Fay M. Allen (2020)
10.1016/j.cell.2020.08.039
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10.1016/j.redox.2020.101733
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Alexander S. Milliken (2020)
10.1016/j.jshs.2019.12.003
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D. Nieman (2019)
10.14814/phy2.14630
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S. Ives (2020)
10.1101/2020.08.31.275438
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Alexander S. Milliken (2020)
10.1038/s41590-019-0372-7
SUCNR1 controls an anti-inflammatory program in macrophages to regulate the metabolic response to obesity
N. Keiran (2019)
10.1007/s00125-019-4947-5
The proposed systemic thermogenic metabolites succinate and 12,13-diHOME are inversely associated with adiposity and related metabolic traits: evidence from a large human cross-sectional study
S. Vasan (2019)
10.1007/s11154-019-09513-z
Gut microbiota-derived succinate: Friend or foe in human metabolic diseases?
S. Fernández-Veledo (2019)
10.15252/embr.201947892
Succinate induces skeletal muscle fiber remodeling via SUNCR1 signaling
(2019)
10.3390/nu11010025
The Role of Succinate in the Regulation of Intestinal Inflammation
J. Connors (2018)
10.1016/j.celrep.2018.04.104
Accumulation of Succinate in Cardiac Ischemia Primarily Occurs via Canonical Krebs Cycle Activity
Jimmy Zhang (2018)
10.1038/s41586-018-0353-2
Accumulation of succinate controls activation of adipose tissue thermogenesis
E. Mills (2018)
10.1016/j.cbpb.2018.02.002
50 years of comparative biochemistry: The legacy of Peter Hochachka.
L. Buck (2018)
Accumulation of systemic succinate controls activation of adipose tissue thermogenesis
E. Mills (2018)
10.1152/physrev.00042.2016
Physiology of Astroglia.
A. Verkhratsky (2018)
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L. T. Bucka (2018)
10.3324/haematol.2018.196097
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Franco Grimolizzi (2018)
10.3233/BSI-150132
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