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Substance P As Neurogenic Mediator Of Antidromic Vasodilation And Neurogenic Plasma Extravasation
F. Lembeck, P. Holzer
Published 2004 · Chemistry, Medicine
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Summary1.Antidromic vasodilation and neurogenic plasma extravasation were induced by antidromic stimulation of the saphenous nerve in guanethidine-treated rats. Vasodilation was measured by the change of outflow from the femoral vein and plasma extravasation was determined by Evans blue exudation.2.Antidromic vasodilation was reduced by 85% in adult rats which were pretreated with capsaicin on the second day of life.3.Antidromic vasodilation was inhibited by 46% after pretreatment with cimetidine plus mepyramine and by 64% after pretreatment with compound 48/80, but was not affected by pretreatment with cimetidine, atropine, methysergide, or indomethacin. Similarly, neurogenic plasma extravasation was reduced by 50% after pretreatment with cimetidine plus mepyramine, and by 88% after pretreatment with compound 48/80, but was not altered after pretreatment with indomethacin.4.Infusion of substance P into the femoral artery dose-dependently produced vasodilation (threshold: 0.1 pmol min−1) and plasma extravasation (threshold: 0.5 pmol·min−1). Vasodilation induced by substance P was inhibited by 47% after pretreatment with cimetidine plus mepyramine and by 58% after pretreatment with compound 48/80. Plasma extravasation induced by substance P was reduced by 61% after pretreatment with cimetidine plus mepyramine and by 81% after pretreatment with compound 48/80. Pretreatment with indomethacin had no influence on substance P-induced vasodilation and plasma extravasation.5.It is concluded that vasodilation and plasma extravasation following antidromic stimulation of sensory nerves are initiated by peripheral release of substance P from chemosensitive pain fibres. The actions of substance P include, besides direct effects, release of histamine from mast cells.
This paper references
Observations relating to vasodilatation arising from antidromic impulses , to herpes zoster and trophic effects
T. Lewis (1927)
Substance P and sensory nerve endings
Interactions of substance P with putative mediators of inflammation and ATP.
L. Chahl (1977)
謙一 河村 (1937)
MODIFICATION BY CAPSAICIN AND COMPOUND 48/80 OF DYE LEAKAGE INDUCED BY IRRITANTS IN THE RAT
P. T. Arvier (1977)
The central and peripheral ends of the substance P-containing sensory neurones in the rat trigeminal system
A. Cuello (1978)
The nature and the distribution of afferent fibres provided with the axon reflex arrangement.
O. Celander (1953)
Release of substance P-like immunoreactivity into the antral lumen of cats.
K. Uvnäs‐Wallensten (1978)
Effect of substance P on various vascular beds in the dog.
D. Hallberg (1975)
Pharmacology and Nerve Endings
H. Dale (1935)
Release of Histamine from Mast Cells by Vasoactive Peptides 1
A. Johnson (1973)
Substance P: release on trigeminal nerve stimulation, effects in the eye.
A. Bill (1979)
Zur Frage der zentralen Übertragung afferenter Impulse
F. Lembeck (2004)
THE COMPONENT OF THE DORSAL ROOT MEDIATING VASODILATATION AND THE SHERRINGTON CONTRACTURE
J. Hinsey (1930)
Direct evidence for neurogenic inflammation and its prevention by denervation and by pretreatment with capsaicin.
N. Jancsó (1967)
Lack of algesic effect of substance P on paravascular pain receptors
F. Lembeck (2004)
Flare and itch induced by substance P in human skin.
O. Haegermark (1978)
Uber die Beziehung der sensiblen Nervenendigungen zum Entzündungsvorgang
A. N. Bruce (1910)
FORMATION OF A FACTOR INCREASING VASCULAR PERMEABILITY DURING ELECTRICAL STIMULATION OF THE SAPHENOUS NERVE IN RATS
J. Leme (1974)
Substance P and excitatory transmitter of primary sensory neurons.
M. Otsuka (1976)
Pharmacologically induced selective degeneration of chemosensitive primary sensory neurones
G. Jancsó (1977)
Pharmacology and Nerve-Endings
H. Dale (1935)
Effects of substance P on functionally identified units in cat spinal cord
J. Henry (1976)
Release of a humoral vasodilator substance during neurogenic vasodilatation.
D. Ballard (1970)
A pharmacological approach to elucidation of the role of different nerve fibres and receptor endings in mediation of pain.
J. Szolcsányi (1977)
Release of substance P-like immunoreactivity from the dental pulp.
L. Olgart (1977)
SUBSTANCE P: A NATURALLY OCCURRING TRANSMITTER IN HUMAN SPINAL CORD
A. Cuello (1976)
[Crossed tachyphylaxis of peptides].
F. Lembeck (1967)
J. Gaddum (1953)
DECREASE OF SUBSTANCE P IN PRIMARY AFFERENT NEURONES AND IMPAIRMENT OF NEUROGENIC PLASMA EXTRAVASATION BY CAPSAICIN
R. Gamse (1980)
Effect of substance P in cat dorsal horn neurones activated by noxious stimuli
M. Randić (1977)
The capillary dilator substances in dry powders of spinal roots; a possible role of adenosine triphosphate in chemical transmission from nerve endings
F. Holton (1954)
Experimental immunohistochemical studies on the localization and distribution of substance P in cat primary sensory neurons
T. Hökfelt (1975)
Mitochondrial alterations in the spinal ganglion cells of the rat accompanying the long-lasting sensory disturbance induced by capsaicin.
F. Joó (1969)
Zur Frage der zentralen bertragung afferenter Impulse: III. Mitteilung. Das Vorkommen und die Bedeutung der Substanz P in den dorsalen Wurzeln des Rckenmarks
F. Lembeck (1953)
Effects of substance P oll functionally identified units in cat spinal cord
J. L. Henry (1976)
Vasodilator response to histamine: dependence upon the site of administration.
T. Galeno (1979)
Gekreuzte Tachyphylaxie von Peptiden
F. Lembeck (2004)
On the origin from the spinal cord of the vaso‐dilator fibres of the hind‐limb, and on the nature of these fibres 1
W. Bayliss (1901)
On the transmitter responsible for antidromic vasodilatation in the rabbit's ear
P. Holton (1951)
Untersuchungen fiber die GefS . 3 wurzeln des Ischiadicus
S. Stricker (1876)
A pharmacological and histological investigation of the involvement of mast cells in cutaneous axon reflex vasodilatation.
J. Kiernan (1975)
This paper is referenced by
Capsaicin and potassium evoked substance P release from the nucleus tractus solitarius and spinal trigeminal nucleus in vitro.
C. Helke (1981)
Nonadrenergic neural vasodilator mechanisms.
J. Bevan (1987)
Influence of Anaesthesia on Blood Flow to the Calves During Surgery
B. Lindström (1984)
Neurogenic inflammation caused by wool fabric in the rat; Possible mediation by substance P
R. Helme (1986)
A study of the cutaneous sensory reinnervation after burn injury using antibodies to neurofilament
A. Hermanson (2004)
Effect of antianaphylactic agents on substance-P induced histamine release from rat peritoneal mast cells
H. Hachisuka (2004)
Neuropeptides, inflammation, and motility
E. Mayer (2005)
Substance P-induced increase in vascular permeability in the rat trachea does not depend on neutrophils or other components of circulating blood.
R. Bethel (1988)
Neuropeptides and the Skin
S. Brain (1989)
Functions of peptidergic nerves
L. Olgart (1990)
Mediators of substance P-induced inflammation in the rat knee joint
F. F. Lam (2005)
Inhibition by substance P of activity of an angiotensin-converting enzyme in human blood serum
N. Komissarova (2004)
Neuronal substance P in the esophagus. Distribution and effects on motor activity.
S. Leander (1982)
Activation of macrophages by substance P: induction of oxidative burst and thromboxane release.
H. Hartung (1983)
Neuronal Interaction with Mast Cells
J. Bienenstock (1991)
Time course and characteristics of the capacity of sensory nerves to reinnervate skin territories outside their normal innervation zones.
E. Kinnman (1993)
Altered vascular permeability responses to substance P in diabetic rats: interactions with a nitric oxide synthesis inhibitor.
R. Mathison (1993)
Evidence for a intimate relationship between mast cells and nerve fibers in the tongue of the frog,Rana esculenta
G. Baccari (1997)
Diminished Flare Response in Neuropathic Diabetic Patients: Comparison of Effects of Substance P, Histamine, and Capsaicin
N. Aronin (1987)
Peptides and the primary afferent nociceptor
J. Levine (1993)
Correlation between local vascular and sensory changes following tissue inflammation induced by repetitive application of topical capsaicin
P. Mohammadian (1998)
1. Pathophysiology of skin tests
Activation of neurokinin NK(2) receptors by tachykinin peptides causes contraction of uterus in pregnant women near term.
E. Patak (2000)
An examination of neurogenic mechanisms involved in mustard oil-induced inflammation in the mouse.
A. Grant (2005)
Substance P induces degranulation of mast cells and leukocyte adhesion to venular endothelium
H. Suzuki (1995)
Ionic Mechanisms of Peptide-Induced Responses in Vascular Endothelial Cells
Jianben Song (1996)
Inferior functional sensory regeneration after suture of sciatic neurotomy in newborns compared with mature rats
T. Hansson (1996)
Effect of chronic sciatic nerve lesion on the neurogenic inflammatory response in intact and acutely injured denervated rat skin
M. Bassirat (2005)
Peripheral Blood Perfusion Induced By Electrical Stimulation Of The Anterior Cingulate Cortex
J. He (2007)
Primary afferent neuropeptide mRNA regulation in experimental periodontitis in the rat
S. A. El-Aleem (2008)
New Targets in Migraine Therapy
B. Schueren (2009)
The role of perivascular adipose tissue-derived sensory nerves in influencing vascular regulation.
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