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Lack Of Algesic Effect Of Substance P On Paravascular Pain Receptors

F. Lembeck, R. Gamse
Published 2004 · Chemistry, Medicine

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Summary1.Substance P (synthetic or extracted from intestine or central nervous system) is devoid of an algesic effect on paravascular pain receptors.2.The algesic effect of a SP-containing acetone HCl-extract from spinal cord is explained by its high content of potassium ions.3.SP-containing preparations which include an ammonium sulphate precipitation in the extraction procedure are algesic due to content of this salt.4.SP-containing extract from intestine were found to be contaminated with a bradykinin-like peptide of high algesic potency.5.These findings are discussed with regard to the restricted value of earlier results about central actions of SP-containing tissue extracts and with regard to the role of SP as a possible neurotransmitter.
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