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Effect Of Estrogen–Progestogen Hormonal Replacement Therapy On Periurethral And Bladder Vessels

R. M. Endo, M. Girão, M. Sartori, M. J. Simões, E. Baracat, G. Rodrigues de Lima
Published 2000 · Medicine

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Abstract: This study assessed the effect of hormone replacement therapy using estrogens and/or progestogens on the number of vessels in the proximal and distal urethra, vesicourethral junction and bladder of castrated adult female rats. Forty-five virgin adult rats (Rattus norvegicus albinus) castrated for at least 30 days were used. They were assigned to five groups; group I (control) received no medication; the others received via the subcutaneous route, respectively, 17-β-estradiol (group II), medroxyprogesterone acetate (group III), a maize oil and benzyl acid solution – placebo (group IV) and 17-β-estradiol combined with medroxyprogesterone acetate (group V), for a minimum of 28 days. Increased vascularization throughout the urinary tract, except in the distal urethra, was found following estrogen replacement alone. In the group that received combined estrogens and progestogens, no increase was found. It was concluded that estrogen replacement in castrated rats significantly increased the number of vessels in the lower urinary tract.
This paper references
The vascular component in the production of intraurethral pressure.
S. Raz (1972)
Distúrbiosurogenitaisdasmulheresmenopausadas: fisiopatologiae aspectosclı́nicos.J Bras Ginecol1992;102:3–6
JM Aldrighi (1992)
Evaluation of the urethral mucosa before and after oestrogen treatment in postmenopausal women with a new sampling technique.
U. Ulmsten (1987)
The use of intravaginal oestrogen cream in genuine stress incontinence
P. Hilton (1983)
Parathyroid hormone is more effective than estrogen or bisphosphonates for restoration of lost bone mass in ovariectomized rats.
T. Wronski (1993)
Effects of estrogen on urethral function in women with urinary incontinence.
N. Bhatia (1989)
Aspects on the anatomy of the female urethra with special relation to urinary continence.
A. B. Huisman (1983)
The effect of progesterone on the adrenergic receptors of the urethra.
S. Raz (1973)
E. Weibel (1966)
Treatment of stress incontinence with estrogen in postmenopausal women.
P. Faber (1977)
The Effects of Estrogens and Gestagens on the Urethral Pressure Profile in Urinary Continent and Stress Incontinent Women
T. Rud (1980)
Distúrbios urogenitais das mulheres menopausadas : fisiopatologia e aspectos clı́nicos
JM Aldrighi (1992)
Sexhormonesandthe femaleurinary tract
A Miodrag (1988)
Considerações sobre a sı́ndrome do climatério
G RodriguesDeLima (1989)
AmorosoJJG,VassermanJ. Considerac ̧õessobrea sı́ndromedo climatério
G RodriguesDe Lima (1989)
Nonparametricstatisticalmethods.New York: JohnWiley
HollanderM (1973)
Effects of estrogenon urethral function in women with urinary incontinence.Am
NN Bhatia (1989)
Menopausal genuine stress urinary incontinence treated with conjugated estrogens plus progestogens
M. Sartori (1995)
Effect of oestrogen and progesterone on the blood flow in the lower urinary tract of the rabbit.
S. Batra (1985)
The vascularcomponentiin the productionof intra-urethralpressure.J Urol 1972;108:93–96
S Raz (1972)
Estrogen Therapy in the Management of Urinary Incontinence in Postmenopausal Women: A Meta-Analysis. First Report of the Hormones and Urogenital Therapy Committee
J. A. Fantl (1994)
Menopausalgenuinestressurinary incontinencetreatedwith conjugatedestrogensplusprogestogen
SartoriMGF (1995)
Effect of gestational sex steroid exposure on limb development and endochondral ossification in the pregnant C57Bl/6J mouse: I. Medroxyprogesterone acetate.
J. P. Carbone (1990)
Sı́ndromedo climatério
BaracatEC (1989)
Nonparametric Statistical Methods
M. Hollander (1973)
Factors maintaining urethral pressurein women
T Rud (1980)
Effects of estrogenson urethral function in women with urinary incontinence.Am
NN Bhatia (1989)
Effects of Estrogen on Urethral Function with Urinary Incontinence in Women
N. Bhatia (1989)
Treatmentof stressincontinencewith estrogenin postmenopausal woman.Urol Int 1977;32:221–223
P Faber (1977)
Parathyroidhormoneis more effective thanestrogenor bisphosphonates for restorationof lost bonemassin ovariectomizedrats.Endocrinology1993;132:823
TJ Wronski (1993)
Evaluationof theurethralmucosabefore andafter oestrogentreatmentin postmenopausal womenwith a newsamplingtechnique.GynecolObstetInvest1987;24:208–211
UlmstenU (1987)
Effectsof gestationalsex steroid exposure on limb development and endochondral ossificationin pregnantC57BI/6JMouse:I
CarboneJP (1990)

This paper is referenced by
Efeitos da Corticosteroidoterapia na Uretra e na Bexiga de Ratas Castradas antes e durante Reposição Estrogênica
J. D. S. Júnior (2000)
Sexual steroids in urogynecology
M. Sartori (2011)
Isoflavone regulates vascular endothelial growth factor expression in urinary tract of castrated rats.
M. D. D. Sampaio (2009)
Relationship between serum estradiol and follicle-stimulating hormone levels and urodynamic results in women with stress urinary incontinence
K. H. Ahn (2011)
Expression of vascular endothelial growth factor in the lower urinary tract in rats after castration and estrogen administration
E. V. M. Zucchi (2006)
Estrous influences on micturition thresholds of the female rat before and after bladder inflammation.
O. L. Johnson (2002)
Estrogen therapy influence on periurethral vessels in postmenopausal incontinent women using Dopplervelocimetry analysis.
S. Kobata (2008)
Hormonal influence on periurethral vessels in postmenopausal incontinent women using Doppler velocimetry analysis.
Z. I. K. Jármy-Di Bella (2007)
Citologia Hormonal do Trato Urinário Baixo e da Vagina de Mulheres na Pós- menopausa, antes e durante Estrogenioterapia Oral e Transdérmica
Áurea Belas Lustosa (2002)
Three‐dimensional power Doppler measurement of perfusion of the periurethral tissue in incontinent women – a preliminary report
C. Liang (2006)
Estrogen and ghrelin increase number of submucosal urethral and anal canal blood vessels in ovariectomized rats.
D. Rizk (2005)
Estrogen and urinary incontinence
K. Hirai (2009)
Short-term functional and neuroregenerative response of the urethra to ovariectomy and vaginal distension in female rats
Corri L. Ferguson (2004)
Influence of estrogen replacement and aging on the expression of nerve growth factor in the urethra of female rats
E. Zucchi (2012)
Sulfated glycosaminoglycans of periurethral tissue in pre- and postmenopausal women.
P. C. Feldner (2008)
Changes in Urethral Connective Tissue after Estrogen Replacement Therapy in Ovariectomized Rats
M. Dündar (2002)
Kadin İşeme Bozukluklari ve Prolaps Tedavisinde Östrojen'in Yeri
Murat Akand (2014)
The pharmacological treatment of urinary incontinence
Andersson (1999)
Glycosaminoglycan profile in bladder and urethra of castrated rats treated with estrogen, progestogen, and raloxifene.
J. D. de Deus (2003)
Doppler Velocimetry Parameters of Periurethral Vessels in Postmenopausal Incontinent Women Receiving Estrogen Replacement
M. Girão (2001)
Postmenopausal Hormone Therapy: Does It Cause Incontinence?
J. Steinauer (2005)
The postmenopausal bladder
T. Hillard (2010)
Effects of tamoxifen on Doppler velocimetry parameters of periurethral vessels in postmenopausal women
C. A. Faria (2004)
Estrogen therapy and urinary incontinence: what is the evidence and what do we tell our patients?
L. E. Waetjen (2006)
The controversies regarding the role of estrogens in urogynecology.
T. Rechberger (2007)
Current Pharmacologic Treatment of Lower Urinary Tract Symptoms
K. Andersson (2014)
Effects of Soy Isoflavone extract treatment on Morphology and Morphometry of the Urinary Tract of Overiectomised Female Sprague Dawley Rats
E. Mwandiringana (2014)
Análise dos Vasos do Trato Urinário Inferior de Ratas Durante e Após a Prenhez
José Vicente Kosmiskas (2002)
Effects of ovariectomy and hormone replacement on collagen and blood vessels of the urethral submucosa of rats
D. Rizk (2003)
The role of local estrogen therapy in the management of pelvic floor disorders
T. Tzur (2016)
Histomorphometric analysis of a rat bladder after electrical stimulation.
Gisela Rosa Franco (2011)
The effects of hormones on urinary incontinence in postmenopausal women
S. Quinn (2009)
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