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A Biospecific Polymeric Carrier For Polypeptide Drugs

L. I. Valuev, G. Sytov, I. L. Valuev, M. V. Ul’yanova, L. Vanchugova, N. A. Platé
Published 2004 · Chemistry

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Polymeric systems for targeting polypeptide medicinal drugs onto the wall of the small intestine after oral administration were synthesized. These systems are composed of particles of ovomucoid-modified polyacrylamide hydrogel with insulin physically immobilized in its bulk. In vitro experiments have demonstrated the enhanced stability of the immobilized polypeptide against proteolysis and the affinity of polymeric particles to lectin-containing surfaces. The efficiency of the systems obtained was demonstrated in experiments with animals and diabetes patients. The effrct of these systems upon oral administration was qualitatevely similar to that of subcutaneously administered native insulin.
This paper references
10.3109/02652049409040461
Liposomes as a carrier for oral administration of insulin: effect of formulation factors.
K. B. Choudhari (1994)
10.1016/S0378-5173(99)00365-8
Chitosan and its derivatives: potential excipients for peroral peptide delivery systems.
A. Bernkop-Schnürch (2000)
10.1081/DDC-120003452
Effect of Bioadhesive Polymers, Sodium Salicylate, Polyoxyethylene-9-lauryl Ether, and Method of Preparation on the Relative Hypoglycemia Produced by Insulin Enteric-Coated Capsules in Diabetic Beagle Dogs
E. Hosny (2002)
[Interaction of ovomucoid from duck egg white with serine proteinases].
L. V. Vanchugova (1988)
10.1016/S1773-2247(04)50028-X
On the possible mechanism of enhanced absorption of oral immobilized insulin preparations
I. L. Valuev (2004)
10.1126/SCIENCE.3526553
A new approach to the oral administration of insulin and other peptide drugs.
M. Saffran (1986)
10.3109/03639049009074381
Effects of Gastrointestinal Administration of Human Insulin and a Human Insulin-Deae-Dextran Complex Entrapped in Different Compound Liposomes on Blood Glucose in Rats
A. Manosroi (1990)
10.1211/0022357011776522
Transport studies of insulin across rat jejunum in the presence of chicken and duck ovomucoids
V. Agarwal (2001)
10.1016/S0142-9612(01)00294-0
Mucoadhesive polymers with immobilized proteinase inhibitors for oral administration of protein drugs.
N. Platé (2002)
10.1248/CPB.38.1983
Hypoglycemic effect of intestinally administered monosaccharide-modified insulin derivatives in rats.
M. Haga (1990)
10.1042/BST0180752
Biodegradable azopolymer coating for oral delivery of peptide drugs.
M. Saffran (1990)
10.1081/DDC-100105182
Bioadhesive Characteristics of Chitosan Microspheres to the Mucosa of Rat Small Intestine
J. Shimoda (2001)
10.1016/S0168-3659(97)01627-1
Modified mucoadhesive polymers for the peroral administration of mainly elastase degradable therapeutic (poly)peptides
A. Bernkop-Schnürch (1997)
10.1016/0300-9629(88)90437-9
Harper's Biochemistry
R. Murray (1993)
10.1016/S0939-6411(03)00145-0
Development of acrylic-based copolymers for oral insulin delivery.
Aaron C Foss (2004)
10.1016/0168-3659(92)90070-8
Polymers for colon-specific drug delivery
J. Kopeček (1992)
10.1002/ADMA.19900020904
Chemical modification of polymeric materials by physiologically active substances
L. I. Valuev (1990)
10.1080/02652040110081406
The effect of oral absorption enhancers on the in vivo performance of insulin-loaded poly(ethylcyanoacrylate) nanospheres in diabetic rats
M. A. Radwan (2002)
10.2337/diacare.13.9.911
Insulin Administration via Liposomes
R. S. Spangler (1990)
10.1106/088532802028583
Stimuli Sensitive Polymethacrylic Acid Microparticles (PMAA) – Oral Insulin Delivery
S. P. Victor (2002)
10.1016/J.METABOL.2003.07.021
Oral modified insulin (HIM2) in patients with type 1 diabetes mellitus: results from a phase I/II clinical trial.
S. Clement (2004)
10.1016/0168-3659(92)90113-6
The colon as a site for drug delivery
R. Mrsny (1992)
10.1016/S0378-5173(01)00579-8
Liposomes with phosphatidylethanol as a carrier for oral delivery of insulin: studies in the rat.
M. Kisel (2001)
10.1016/0168-3659(90)90013-J
Nanocapsules as carriers for oral peptide delivery
C. Damgé (1990)



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