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A Biospecific Polymeric Carrier For Polypeptide Drugs

L. I. Valuev, G. Sytov, I. L. Valuev, M. V. Ul’yanova, L. Vanchugova, N. A. Platé
Published 2004 · Chemistry

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Polymeric systems for targeting polypeptide medicinal drugs onto the wall of the small intestine after oral administration were synthesized. These systems are composed of particles of ovomucoid-modified polyacrylamide hydrogel with insulin physically immobilized in its bulk. In vitro experiments have demonstrated the enhanced stability of the immobilized polypeptide against proteolysis and the affinity of polymeric particles to lectin-containing surfaces. The efficiency of the systems obtained was demonstrated in experiments with animals and diabetes patients. The effrct of these systems upon oral administration was qualitatevely similar to that of subcutaneously administered native insulin.
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