Online citations, reference lists, and bibliographies.

Effects Of Aging On The Structural And Permeability Characteristics Of Cerebrovasculature In Normotensive And Hypertensive Strains Of Rats

C. A. Knox, R. Yates, I. Chen, P. M. Klara
Published 1980 · Biology, Medicine

Cite This
Download PDF
Analyze on Scholarcy
Share
SummaryThis study demonstrates that markedly different patterns of age-related changes in blood pressure and body weight occur among normotensive Wistar-Kyoto (WKY) and Sprague-Dawley (SD) rats and spontaneously hypertensive rats (SHR). In addition, a variety of age-related structural alterations occurred in the walls of arterioles, capillaries, and venules of the frontal cortex. These changes include: (1) an increase in the thickness of the vascular wall by deposits of collagen and basal lamina which, in some cases, extended into the surrounding neuropil; (2) the presence of a flocculent material in the adventitia of intracerebral arterioles; (3) vesicular inclusions in perivascular macrophages, pericytes and smooth muscle cells which were labelled with i.v. administered horseradish peroxidase (HRP); (4) fragmentation of smooth muscle cells; and (5) accumulation of lipofuscin-like pigments in perivascular glial processes. The hypertensive rats exhibited these changes, but they were more advanced and more widely distributed throughout the cerebral cortex. The aged hypertensive rats occasionally had large bundles of 10 nm diameter, intermediate filaments in the endothelial cells. Whereas no change in blood-brain barrier permeability to HRP was observed in the aged normotensive rats, all age groups of the hypertensive rats exhibited increased permeability to HRP in the initial segment of penetrating arterioles in laminae I and II of the cerebral cortex.
This paper references
Cerebellar cortex: cytology and organization
S. Palay (1974)
10.1007/BF00691695
The blood-brain barrier to horseradish peroxidase under normal and experimental conditions
E. Westergaard (1977)
10.1016/S0140-6736(54)91821-8
The pathogenesis of hypertensive encephalopathy and its relation to the malignant phase of hypertension; experimental evidence from the hypertensive rat.
F. Byrom (1954)
10.1016/S0022-5320(76)80141-4
Observations on the blood-brain barrier in hypertensive rats, with particular reference to phagocytic pericytes
B. Deurs (1976)
10.1007/BF00543548
Morphogenesis of plasmatic arterionecrosis as the cause of hypertensive intracerebral hemorrhage
G. Ooneda (1973)
10.1007/BF00427707
An electron microscopic study of plasmatic arterionecrosis in the human cerebral arteries
H. Shinkai (2004)
Quantitative assessment of changing in neuron and glia cell packing density and lipofuscin accumulation with age in the cerebral cortex of a nonhuman primate (Macaca mulatta)
KR Brizzee (1976)
10.1007/BF00691213
Electron microscope studies of cerebral swelling
Eiichi Tani (1965)
10.1253/jcj.39.611
Experimental studies on the pathogenesis and prophylaxis of stroke in stroke-prone spontaneously hypertensive rats (SHR).(1) Quantitative estimation of cerebrovascular permeability.
Y. Yamori (1975)
10.1016/S0014-4835(77)80008-0
Morphology of blood-brain interfaces.
M. Brightman (1977)
Thickness of aortic media in hypertension
HT Karsner (1938)
10.1097/00005072-194910000-00006
IROX AND CALCIUM DKPOSITS IN THE BRAIN; THEIR PATHOLOGIC SIGNIFICANCE
G. Strassmann (1949)
Morphology and permeability of the aging cerebral cortex in normotensive and hypertensive strains of rats
CA Knox (1979)
10.1007/BF00691070
Lafora-like inclusion bodies in the CNS of aged dogs
Y. Suzuki (2004)
Etude anatomopathologique sur le cerveau de chien senile
E Osetowska (1965)
The effect of age upon the influx of glucose into the brain.
P. Daniel (1978)
10.1007/978-1-4684-3093-6_11
Immune Reactions in Aging Brain and Senile Dementia
K. Nandy (1977)
10.1093/geronj/34.5.642
Thinning of capillary walls and declining numbers of endothelial mitochondria in the cerebral cortex of the aging primate, Macaca nemestrina.
E. M. Burns (1979)
Connections of the cerebral cortex . 1 . Albino rat . A . Topography of the cortical areas
Krieg WJS (1946)
10.1083/jcb.35.1.213
THE ULTRASTRUCTURAL BASIS OF CAPILLARY PERMEABILITY STUDIED WITH PEROXIDASE AS A TRACER
M. Karnovsky (1967)
An examination of cerebral cortex and brain stem aging
H Brody (1976)
The cellular pathology of experimental hypertension. V. Increased permeability of cerebral arterial vessels.
F. Giacomelli (1970)
Morphological evaluations of tissues embedded in LX112 (an epon replacement) and in LX 112/araldite combination
JA Mascorro (1979)
Senile plaques and cerebral amyloidosis in aged dogs. A histochemical and ultrastructural study.
H. Wisniewski (1970)
10.1679/aohc1950.38.299
An electron microscope study on permeability in cerebral venules in the rats with hypertensive encephalopathy.
T. Eto (1975)
10.1093/geronj/34.2.162
Blood-brain barrier permeability in senescent rats.
S. Rapoport (1979)
Contractile protein in endothelial cells of cerebral arteries and arterioles: comparison of normotensive and malignant hypertensive states. Circulation
CG Becker (1973)
10.1007/978-3-642-92847-5_12
Pathologische Befunde an den Hirngefäßen bei Tieren
E. Dahme (1962)
10.1002/path.1711210209
Vascular changes in the brain of spontaneously hypertensive rats: hyaline and fibrinoid degeneration.
S. Amano (1977)
Pathology of cerebrovascular diseases in spontaneously hypertensive rats
F Hazama (1975)
Pathology and pathogenesis of cerebrovascular lesions in spontaneously hypertensive rats
S Amano (1976)
10.1177/26.8.80419
Palladium chloride as a stain for elastin at the ultrastructural level.
S. Morris (1978)
Pathology of the cerebral blood vessels
W. E. Stehbens (1972)
10.1002/aja.1001170204
The distribution within the brain of ferritin injected into cerebrospinal fluid compartments. II. Parenchymal distribution.
M. Brightman (1965)
Age-related changes in the permeability of the blood-brain barrier and protein metabolism in the cerebellum and pons variolii
KA Getsel (1973)
Contractile protein in endothelial cells of cerebral arteries and arterioles : comparison of normotensive and malignant hypertensive states
F Luthy (1973)
10.1093/geronj/29.1.20
Significance of an aging-linked neuron binding gamma globulin fraction of human sera.
C. R. Ingram (1974)
10.1002/aja.1001000306
Electron microscopy of the vascular bed of rat cerebral cortex.
E. A. Maynard (1957)
10.1159/000211955
Ultrastructure of the ageing retinal vascular system, with special reference to quantitative and qualitative changes of capillary basement membranes.
P. Leuenberger (1973)
The role of the vascular factor in the distribution of senile changes in the cerebral cortex
E Appel (1965)
The early stages of absorption of injected horseradish peroxidase in the proximal tubules of mouse kidney: ultrastructural cytochemistry by a new technique
RC Graham (1966)



This paper is referenced by
10.1038/s41598-018-28985-8
Relationship between Systemic Vascular Characteristics and Retinal Nerve Fiber Layer Loss in Patients with Type 2 Diabetes
Soo Ji Jeon (2018)
10.3233/JAD-132504
Cerebral blood volume and vasodilation are independently diminished by aging and hypertension: a near infrared spectroscopy study.
Merav E. Shaul (2014)
10.1152/ajpregu.00104.2007
A warmer ambient temperature increases the passage of interleukin-1beta into the brains of old rats.
J. B. Buchanan (2008)
10.1016/0047-6374(92)90083-P
Formation of cerebrovascular anomalies in the ageing rat is delayed by chronic nimodipine application
G. I. D. Jong (1992)
10.1007/s002219900219
Density of perfused brain capillaries in the aged rat during the wake-sleep cycle
G. Zoccoli (1999)
10.1016/S0197-4580(00)00225-6
Calcium antagonists decrease capillary wall damage in aging hypertensive rat brain
E. Farkas (2001)
10.1007/978-1-59259-105-3_17
The Blood-Brain Barrier in the Aging Brain
G. Rascher (2002)
10.1007/BF00685243
Capillary junctions of the rat are not affected by osmotic opening of the blood-brain barrier
C. Farrell (1984)
10.1111/j.1471-4159.1993.tb09825.x
Altered Composition of Cerebral Microvessel Membrane Phosphoglycerides from Senescent Mouse
W. Williams (1993)
10.1007/BF00690532
Cerebral microangiopathy in stroke-prone spontaneously hypertensive rats
K. Fredriksson (2004)
10.1111/J.1749-6632.1994.TB44427.X
Cerebrovascular, neuronal, and behavioral effects of long-term Ca2+ channel blockade in aging normotensive and hypertensive rat strains.
P. Luiten (1994)
10.1161/01.RES.66.6.1747
Effects of aging on mechanics and composition of cerebral arterioles in rats.
M. Hajdu (1990)
10.3171/JNS.2005.103.4.0687
Influence of age on stroke outcome following transient focal ischemia.
C. Rosen (2005)
10.1016/j.neurobiolaging.2005.10.021
Altered pericyte–endothelial relations in the rat retina during aging: Implications for vessel stability
S. Hughes (2006)
10.1259/bjr.20140704
T1ρ relaxation time in brain regions increases with ageing: an experimental MRI observation in rats.
F. Zhao (2016)
10.1081/CEH-120023545
Arterial Hypertension and Brain Damage—Evidence from Animal Models (Review)
F. Amenta (2003)
10.1016/S1568-1637(02)00064-8
Microvascular plasticity in aging
D. Riddle (2003)
10.1016/j.brainres.2009.05.042
Plasminogen activator inhibitor type 1 derived peptide, EEIIMD, diminishes cortical infarct but fails to improve neurological function in aged rats following middle cerebral artery occlusion
Zhenjun Tan (2009)
Microvascular changes in estrogen-alpha sensitive brainstem structures of aging female hamsters
Henk de Weerda (2018)
Composition of Cerebral Arterioles in Rats
Michael A. Hajdu (2005)
10.1002/CPHY.CP020411
The Cerebral Microcirculation
R. Tuma (2011)
The role of blood-brain barrier disruption in spontaneous intracerebral haemorrhage and small vessel disease
Whitney M Freeze (2014)
10.1007/BF00687224
Brain aging in normotensive and hypertensive strains of rats
C. A. Knox (1980)
10.1007/BF00690585
Effects of aging and chronic arterial hypertension on the cell populations in the neocortex and archicortex of the rat
C. A. Knox (1982)
10.1016/B978-0-7020-3519-7.00002-4
Chapter 2 – Wistar and Sprague–Dawley rats
E. Mcinnes (2012)
Alterations in JAK /STAT signaling pathway and blood -brain barrier function: Mechanisms underlying worsened outcome following stroke in the aged rat
V. A. Dinapoli (2008)
10.1016/j.neures.2010.04.010
Microvascular changes in estrogen-α sensitive brainstem structures of aging female hamsters
P. Gerrits (2010)
10.1016/S0197-4580(01)00213-5
Ultrastructural and permeability features of microvessels in the hippocampus, cerebellum and pons of senescence-accelerated mice (SAM)
M. Ueno (2001)
10.1161/01.HYP.13.5.475
Ploidy in Mesenteric Vessels of Aged Spontaneously Hypertensive and Wistar‐Kyoto Rats
D. M. Lombardi (1989)
Effects of Early Onset of Nimodipine Treatment on Microvascular Integrity in the Aging Rat Brain
G. D. De Jong (1990)
10.1007/s00401-004-0845-z
Blood-brain barrier is impaired in the hippocampus of young adult spontaneously hypertensive rats
M. Ueno (2004)
10.1093/GERONA/55.3.B135
Age-dependent increase in infarct volume following photochemically induced cerebral infarction: putative role of astroglia.
A. Kharlamov (2000)
See more
Semantic Scholar Logo Some data provided by SemanticScholar