DOI: 10.1007/bf01833331
Expression Of IGF-I And IGF-II MRNA In Breast Tissue
S. Paik
Published 2005 · Biology, Medicine
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Email SummaryExpression of IGF-I and IGF-II was studied in human breast cancer tissues by in situ hybridization. IGF-I mRNA was detected only in stromal cells adjacent to normal breast epithelial cells. Stromal cells associated with the tumor cells did not contain IGF-I, nor did malignant or benign breast epithelial cells. In contrast, IGF-II mRNA was found in both the malignant epithelial cells and their adjacent stromal cells. These data imply that stromal cells associated with breast epithelium may switch expression from IGF-I to IGF-II during breast cancer evolution. This appearance of IGF-II expression may identify cancer-associated stromal cells that have a fetal phenotype.
This paper references
Insulin-like growth factor II mRNA expression in human breast cancer.
D. Yee (1988)
Gelsolin modulation in epithelial and stromal cells of mammary carcinoma.
C. Chaponnier (1989)
Growth factor messenger RNA expression by human breast fibroblasts from benign and malignant lesions.
K. Cullen (1991)
The insulin-like growth factor II (IGF-II)/mannose 6-phosphate receptor mediates IGF-II-induced motility in human rhabdomyosarcoma cells.
C. Minniti (1992)
10.1002/ijc.2910470603
Comparative analysis of the expression of the extracellular matrix protein tenascin in normal human fetal, adult and tumor tissues
P. G. Natali (1991)
10.1210/mend-3-3-509
Analysis of insulin-like growth factor I gene expression in malignancy: evidence for a paracrine role in human breast cancer.
D. Yee (1989)
Expression of IGF - II mRNA in fetal kidney and Wilms ' tumor ; an in - situ hybridization study
S Paik
This paper is referenced by
10.1007/BF00666055
Effect of two 4-hydroxyandrostenedione doses on serum insulin-like growth factor I levels in advanced breast cancer
L. Ferrari (1994)
10.1177/172460081002500305
Igf-Ii Mrna Expression in Breast Cancer: Predictive Value and Relationship to Other Prognostic Factors
Emilio Fiore (2010)
10.1530/ERC-11-0074
Insulin receptor and cancer.
A. Belfiore (2011)
Endocrine-Related Cancer ( 2011 ) 18 R 125 – R 147 Insulin receptor and cancer
A. Belfiore (2011)
10.1007/978-1-4020-8526-0_5
Influence of the Tumour Microenvironment
Rosemary A. Walker (2009)
10.1158/0008-5472.CAN-14-2041
Wnt/β-Catenin Small-Molecule Inhibitor CWP232228 Preferentially Inhibits the Growth of Breast Cancer Stem-like Cells.
Gyu-Beom Jang (2015)
Insulin-like Growth Factor Binding Protein 1 Expression Inhibits Insulin-like Growth Factor I Action in MCF-7 Breast Cancer Cells 1
Douglas (2005)
10.1053/J.SEMINONCOL.2003.08.014
Potential therapeutic strategies to interrupt insulin-like growth factor signaling in breast cancer.
S. Byron (2003)
Apoptosis: Physiology and Pathology
J. C. Reed (2011)
Angiogenic Growth Factors in Preinvasive Breast Disease 1
Sue C. Heffelfinger (1999)
10.1210/en.2008-1473
Insulin-like growth factor type 1 receptor and insulin receptor isoform expression and signaling in mammary epithelial cells.
A. M. Rowzee (2009)
10.3233/BD-2003-17109
IGFBPs and breast cancer.
C. Perks (2003)
10.1210/ER.2006-0001
The role of the IGF system in cancer growth and metastasis: overview and recent insights.
A. Samani (2007)
A molecular analysis of the oestrogen receptor and surrounding chromosomal region in early breast cancer
S. Chappell (1997)
10.1186/1741-7015-8-1
IGF-I induced genes in stromal fibroblasts predict the clinical outcome of breast and lung cancer patients
M. Rajski (2010)
Advances in Brief Pregnancy-dependent Growth of Mammary Tumors Is Associated with Overexpression of Insulin-like Growth Factor II 1
Hung Quoc Huynh (2006)
10.1007/S10540-006-9002-3
Mannose-6-phosphate/Insulin-like Growth Factor II Receptor Expression and Tumor Development
E. Hebert (2006)
10.1186/s12885-020-07183-8
Methylation of WT1, CA10 in peripheral blood leukocyte is associated with breast cancer risk: a case-control study
Anqi Ge (2020)
10.1007/978-1-4419-9911-5
Insulin Resistance and Cancer: Epidemiology, Cellular and Molecular Mechanisms and Clinical Implications
I. G. Fantus (2011)
Polymorphisms and circulating levels in the insulin-like growth factor system and risk of breast cancer: a systematic review.
O. Fletcher (2005)
10.1023/B:BREA.0000018384.64326.dd
Mitogenic Properties of Insulin-Like Growth Factors I and II, Insulin-like Growth Factor Binding Protein-3 and Epidermal Growth Factor on Human Breast Stromal Cells in Primary Culture
Karen S. Strange (2004)
IGF2 Promotes Activation of Estrogen Receptors in Basal-like Breast Cancer Cells
A. Richardson (2011)
10.1677/ERC.0.0100331
Interactions between estrogen and insulin-like growth factor signaling pathways in human breast tumor cells.
I. H. Hamelers (2003)
10.1007/BF00666209
The insulin-like growth factor system as a target in breast cancer
D. Yee (2004)
10.1007/BF01807035
IGF-II mRNA and protein are expressed in the stroma of invasive breast cancers: Anin situ hybridization and immunohistochemistry study
C. Giani (2005)
10.1111/acer.13139
Tumor Phenotype and Gene Expression During Early Mammary Tumor Development in Offspring Exposed to Alcohol In Utero.
Catina Crismale-Gann (2016)
10.1186/bcr3423
The expression and significance of insulin-like growth factor-1 receptor and its pathway on breast cancer stem/progenitors
W. Chang (2012)
Tyrosine Kinase Receptor Inhibitors : A New Target for Anticancer Drug Development
Surana Adhikari S (2013)
10.5451/unibas-005213593
Tumor-stroma derived gene expression patterns as prognosticators in breast cancer
M. Rajski (2010)
10.1007/s10911-008-9102-8
IGF Ligand and Receptor Regulation of Mammary Development
A. M. Rowzee (2008)
Endocrine-Related Cancer ( 2003 ) 10 331 – 345 Interactions between estrogen and insulin-like growth factor signaling pathways in human breast tumor cells
I. H. Hamelers (2003)
10.18632/oncotarget.6524
IGF-I induces upregulation of DDR1 collagen receptor in breast cancer cells by suppressing MIR-199a-5p through the PI3K/AKT pathway
R. Matà (2016)
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