Online citations, reference lists, and bibliographies.

The Influence Of The Microstructure Of High Noble Gold-platinum Dental Alloys On Their Corrosion And Biocompatibility In Vitro

M. Colic, Dragomir Stamenković, I. Anžel, G. Lojen, R. Rudolf
Published 2009 · Materials Science

Cite This
Download PDF
Analyze on Scholarcy
Share
The aim of this work was to compare the microstructures of two high noble experimental Au-Pt alloys with similar composition with their corrosion and biocompatibility in vitro. We showed that Au-Pt II alloy, composed of 87.3 wt.% Au, 9.9 wt.% Pt, 1.7 wt.% Zn and 0.5 wt.% Ir + Rh + In, although possessing better mechanical properties than the Au-Pt I alloy (86.9 wt.% Au, 10.4 wt.% Pt, 1.5 wt.% Zn and 0.5 wt.% Ir + Rh + In), exerted higher adverse effects on the viability of L929 cells and the suppression of rat thymocyte functions, such as proliferation activity, the production of Interleukin-2 (IL-2), expression of IL-2 receptor and activation — induced apoptosis after stimulation of the cells with Concanavalin-A. These results correlated with the higher release of Zn ions in the culture medium. As Zn2+, at the concentrations which were detected in the alloy’s culture media, showed a lesser cytotoxic effect than the Au-Pt conditioning media, we concluded that Zn is probably not the only element responsible for alloy cytotoxicity. Microstructural characterization of the alloys, performed by means of scanning electron microscopy in addition to energy dispersive X-ray and X-ray diffraction analyses, showed that Au-Pt I is a two-phase alloy containing a dominant Au-rich α1 phase and a minor Pt-rich α2 phase. On the other hand, the Au-Pt II alloy additionally contained three minor phases: AuZn3, Pt3Zn and Au1.4Zn0.52. The highest content of Zn was identified in the Pt3Zn phase. After conditioning, the Pt3Zn and AuZn3 phases disappeared, suggesting that they are predominantly responsible for Zn loss, lower corrosion stability and subsequent lower biocompatibility of the Au-Pt II alloy.
This paper references
10.1016/J.ABB.2007.04.015
Stimulation of phosphoinositide 3-kinase/Akt signaling by copper and zinc ions: mechanisms and consequences.
A. Barthel (2007)
10.1023/A:1020603110255
The role of intracellular zinc in modulation of life and death of Hep-2 cells
E. Rudolf (2004)
10.1007/S10856-006-8225-Y
Ion release from gold/platinum dental alloy: could release of other elements be accountable in the contact allergy attributed to the gold?
A. Čelebić (2006)
10.1002/(SICI)1097-0320(19981101)33:3<333::AID-CYTO7>3.0.CO;2-H
Flow cytometric analysis of mitochondrial activity in situ: application to acetylceramide-induced mitochondrial swelling and apoptosis.
Macouillard-Poulletier de Gann (1998)
10.7326/0003-4819-125-2-199607150-00012
Zinc: The Biology and Therapeutics of an Ion
A. Prasad (1996)
Long-term cytotoxicity of dental casting alloys.
J. Wataha (1999)
10.1016/0022-1759(95)00072-I
A novel assay for apoptosis. Flow cytometric detection of phosphatidylserine expression on early apoptotic cells using fluorescein labelled Annexin V.
I. Vermes (1995)
10.1046/j.1440-1711.1999.00825.x
Regulation of caspase activation and apoptosis by cellular zinc fluxes and zinc deprivation: A review
F. Chai (1999)
10.1289/ehp.941025
Zinc: health effects and research priorities for the 1990s.
C. Walsh (1994)
Elements released from dental casting alloys and their cytotoxic effects.
A. S. Al-Hiyasat (2002)
10.1016/S0109-5641(01)00058-6
Effect of small additions of Ir on properties of a binary Au-Ti alloy.
J. Fischer (2002)
10.1016/S0192-0561(99)00077-6
Modulatory effect of 7-thia-8-oxoguanosine on proliferation of rat thymocytes in vitro stimulated with concanavalin A.
M. Čolić (2000)
10.1016/S0048-9697(01)00843-9
In vitro suppression of thymocyte apoptosis by metal-rich complex environmental mixtures: potential role of zinc and cadmium excess.
A. B. Chukhlovi (2001)
10.1017/S0885715600009830
Powder diffraction data for the intermetallic compounds RhAl2.63, IrAl2.75, and AuZn3
K. Gotzmann (1997)
10.1002/JCP.1041640206
Preferential induction of apoptosis in mouse CD4+CD8+αβTCRIoCD3εIo thymocytes by zinc
W. Telford (1995)
10.1016/S0109-5641(96)80020-0
In vitro models of biocompatibility: a review.
C. T. Hanks (1996)
10.1016/S0109-5641(00)00099-3
Elemental release from dental casting alloys into biological media with and without protein.
J. Wataha (2001)
10.1007/BF03215496
Gold in dentistry: Alloys, uses and performance
H. Knosp (2003)
10.1016/0022-5088(70)90151-7
Über die struktur der mischung platin-kupfer-zink
Y. Khan (1970)
10.1007/BF03214859
Homogeneous gold catalysts and alkynes: A successful liaison
A. S. Hashmi (2003)
Prevention of anti-CD3 monoclonal antibody-induced thymic apoptosis by protein tyrosine kinase inhibitors.
K. Migita (1994)
10.1111/J.1348-0421.1998.TB02325.X
Induction of apoptosis and tyrosine phosphorylation of cellular proteins in T cells and non-T cells by stimulation with concanavalin A.
F. Nagase (1998)
10.1177/00220345900690081801
Cytotoxicity of Experimental Casting Alloys Evaluated by Cell Culture Tests
R. Craig (1990)
10.1007/s00204-005-0009-5
Zinc: a multipurpose trace element
M. Stefanidou (2005)
10.1063/1.89819
Spinodal decomposition in amorphous Au‐implanted Pt
S. P. Singhal (1978)
10.1016/S0952-7915(00)00227-2
Activation-induced cell death.
R. Budd (2001)
10.1016/0022-3913(90)90259-F
Metal ceramic compatibility: a review of the literature.
M. Bagby (1990)
10.1006/TAAP.2000.8921
Possible role of caspase-3 inhibition in cadmium-induced blockage of apoptosis.
C. Yuan (2000)
10.1006/TAAP.2000.8911
Induction of rat hepatic aryl sulfotransferase (SULT1A1) gene expression by triamcinolone acetonide: impact on minoxidil-mediated hypotension.
Z. Duanmu (2000)
10.1177/00220345980770100401
Cytotoxicity of Dental Alloy Extracts and Corresponding Metal Salt Solutions
G. Schmalz (1998)



This paper is referenced by
10.1007/s13404-017-0200-5
High-temperature oxidation behaviors and surface oxide color of Pd-free, Au-Pt-based metal-ceramic alloys for dental applications
Takanobu Shiraishi (2017)
10.2298/AVB0906641S
The effect of repeated casting on the biocompatibility of a dental gold alloy
Dragoslav Stamenković (2009)
10.1111/eos.12267
Corrosion behavior of dental alloys used for retention elements in prosthodontics.
Judith Nierlich (2016)
10.1007/BF03214986
Recent progress in gold nanoparticle-based non-volatile memory devices
J. Lee (2010)
10.1504/IJIS.2010.034903
The response of peripheral blood mononuclear cells to shape memory alloys
Rebeka Rudolf (2010)
10.1016/J.PROENG.2013.10.003
RETRACTED: Microstructure and Biocompatibility of Gold-lanthanum Nanostrips
Rebeka Rudolf (2014)
10.1007/s13404-014-0150-0
Microstructure and biocompatibility of gold–lanthanum strips
R. Rudolf (2014)
10.1007/S12540-010-1211-4
Microstructural analyses of two high noble gold-platinum alloys before and after conditioning in a cell culture medium
Rebeka Rudolf (2010)
10.1533/9780857099051.1.37
Biocompatibility of precious metals for medical applications
A. Johnson (2014)
10.1177/0885328210377536
Cytotoxicity of Gold Nanoparticles Prepared by Ultrasonic Spray Pyrolysis
R. Rudolf (2012)
10.1007/978-3-319-74814-6_7
Platinum in Biomedical Applications
O. Sinitsyna (2018)
10.1186/s40824-019-0176-8
Electrical stimulation as a novel tool for regulating cell behavior in tissue engineering
Cen Chen (2019)
10.1016/j.actbio.2009.06.027
Relationship between microstructure, cytotoxicity and corrosion properties of a Cu-Al-Ni shape memory alloy.
M. Čolić (2010)
10.1002/jbm.a.34225
The effect of grain size on the biocompatibility, cell-materials interface, and mechanical properties of microwave-sintered bioceramics.
Djordje N Veljovic (2012)
Semantic Scholar Logo Some data provided by SemanticScholar