Online citations, reference lists, and bibliographies.
← Back to Search

The Multiple Facets Of Periostin In Bone Metabolism

B. Merle, P. Garnero
Published 2012 · Medicine

Save to my Library
Download PDF
Analyze on Scholarcy Visualize in Litmaps
Share
Reduce the time it takes to create your bibliography by a factor of 10 by using the world’s favourite reference manager
Time to take this seriously.
Get Citationsy
Periostin is a matricellular glutamate-containing protein expressed during ontogenesis and in adult connective tissues submitted to mechanical strains including bone and, more specifically, the periosteum, periodontal ligaments, tendons, heart valves, or skin. It is also expressed in neoplastic tissues, cardiovascular and fibrotic diseases, and during wound repair. Its biological functions are extensively investigated in fields such as cardiovascular physiology or oncology. Despite its initial identification in bone, investigations of periostin functions in bone-related physiopathology are less abundant. Recently, several studies have analyzed the potential role of periostin in bone biology and suggest that periostin may be an important regulator of bone formation. The aim of this article is to provide an extensive review on the implications of periostin in bone biology and its potential use in benign and metabolic bone diseases.
This paper references
10.1042/BJ2940271
Osteoblast-specific factor 2: cloning of a putative bone adhesion protein with homology with the insect protein fasciclin I.
S. Takeshita (1993)
10.1006/PREP.1995.1040
Expression and characterization of murine osteoblast-specific factor 2 (OSF-2) in a baculovirus expression system.
T. Sugiura (1995)
10.1002/JOR.1100140310
Expression of syndecan‐3 and tenascin‐C: Possible involvement in periosteum development
E. Koyama (1996)
10.1359/jbmr.1999.14.7.1239
Identification and Characterization of a Novel Protein, Periostin, with Restricted Expression to Periosteum and Periodontal Ligament and Increased Expression by Transforming Growth Factor β
K. Horiuchi (1999)
Identification and characterization of a novel protein, periostin, with restricted expression to periosteum and periodontal ligament and increased expression by transforming growth factor beta.
K. Horiuchi (1999)
10.1074/jbc.M000074200
Regulation of Cyclooxygenase-2 and Periostin by Wnt-3 in Mouse Mammary Epithelial Cells*
M. Haertel-Wiesmann (2000)
10.1161/01.RES.86.9.939
Altered patterns of gene expression in response to myocardial infarction.
L. Stanton (2000)
10.1016/S0925-4773(01)00356-2
Periostin (an osteoblast-specific factor) is expressed within the embryonic mouse heart during valve formation
A. Kruzynska-Frejtag (2001)
10.1359/jbmr.2001.16.10.1846
Effects of Daily Treatment with Parathyroid Hormone on Bone Microarchitecture and Turnover in Patients with Osteoporosis: A Paired Biopsy Study *
D. Dempster (2001)
10.1002/jcb.10156
Leptin stimulates human osteoblastic cell proliferation, de novo collagen synthesis, and mineralization: Impact on differentiation markers, apoptosis, and osteoclastic signaling
J. Gordeladze (2002)
10.1002/jcb.10272
A novel mechanism for the regulation of osteoblast differentiation: Transcription of periostin, a member of the fasciclin I family, is regulated by the bHLH transcription factor, twist
A. Oshima (2002)
10.1007/s00441-002-0664-2
The divergent expression of periostin mRNA in the periodontal ligament during experimental tooth movement
J. Wilde (2003)
10.1210/JC.2003-030470
Effects of an excess and a deficiency of endogenous parathyroid hormone on volumetric bone mineral density and bone geometry determined by peripheral quantitative computed tomography in female subjects.
Q. Chen (2003)
10.1152/PHYSIOLGENOMICS.00056.2003
Transcriptional profiling and regulation of the extracellular matrix during muscle regeneration.
S. Goetsch (2003)
10.1161/01.HYP.0000074905.22908.A6
Effects of Pressure Overload on Extracellular Matrix Expression in the Heart of the Atrial Natriuretic Peptide–Null Mouse
D. Wang (2003)
10.1210/ER.2002-0023
Bone morphogenetic proteins, their antagonists, and the skeleton.
E. Canalis (2003)
10.1016/S0006-291X(02)02904-2
EMI domains are widespread and reveal the probable orthologs of the Caenorhabditis elegans CED-1 protein.
I. Callebaut (2003)
10.1016/S0014-4827(03)00213-1
Inorganic phosphate regulates multiple genes during osteoblast differentiation, including Nrf2.
G. Beck (2003)
Identification of novel genes of the bone-specific transcription factor Runx2.
M. Stock (2004)
10.1002/dvdy.10453
Periostin is expressed within the developing teeth at the sites of epithelial–mesenchymal interaction
A. Kruzynska-Frejtag (2004)
10.1016/S1535-6108(04)00081-9
Periostin potently promotes metastatic growth of colon cancer by augmenting cell survival via the Akt/PKB pathway.
S. Bao (2004)
10.1359/jbmr.2004.19.6.959
Identification of Novel Target Genes of the Bone‐Specific Transcription Factor Runx2
M. Stock (2004)
10.1023/A:1021899904332
Elevated Serum Periostin Levels in Patients with Bone Metastases from Breast but not Lung Cancer
H. Sasaki (2003)
10.1016/J.ORTHRES.2003.10.007
Gene expression of periostin in the early stage of fracture healing detected by cDNA microarray analysis
T. Nakazawa (2004)
10.1002/jcb.20115
Expression and function of periostin‐isoforms in bone
J. Litvin (2004)
10.1152/JAPPLPHYSIOL.01311.2003
Hypoxia-responsive growth factors upregulate periostin and osteopontin expression via distinct signaling pathways in rat pulmonary arterial smooth muscle cells.
Peng Li (2004)
10.1128/MCB.25.24.11131-11144.2005
periostin Null Mice Exhibit Dwarfism, Incisor Enamel Defects, and an Early-Onset Periodontal Disease-Like Phenotype
H. Rios (2005)
10.1002/ijc.21120
Periostin is down‐regulated in high grade human bladder cancers and suppresses in vitro cell invasiveness and in vivo metastasis of cancer cells
C. J. Kim (2005)
10.1002/jcb.20438
Molecular profile of catabolic versus anabolic treatment regimens of parathyroid hormone (PTH) in rat bone: An analysis by DNA microarray
J. Onyia (2005)
10.1210/EN.2005-0239
Chronic elevation of parathyroid hormone in mice reduces expression of sclerostin by osteocytes: a novel mechanism for hormonal control of osteoblastogenesis.
T. Bellido (2005)
10.1359/JBMR.050812
Sympathetic Nervous System Does Not Mediate the Load‐Induced Cortical New Bone Formation
R. D. de Souza (2005)
10.1016/J.ARCHORALBIO.2005.04.002
Messenger RNA expression of periostin and Twist transiently decrease by occlusal hypofunction in mouse periodontal ligament.
Elaine Afanador (2005)
10.1161/01.ATV.0000149141.81230.c6
Vascular Injury Induces Expression of Periostin: Implications for Vascular Cell Differentiation and Migration
V. Lindner (2004)
10.1093/CARCIN/BGI034
Periostin induction in tumor cell line explants and inhibition of in vitro cell growth by anti-periostin antibodies.
I. Tai (2005)
10.1002/ART.20811
Fibroblast-like synoviocytes derived from patients with rheumatoid arthritis show the imprint of synovial tissue heterogeneity: evidence of a link between an increased myofibroblast-like phenotype and high-inflammation synovitis.
Pia V Kasperkovitz (2005)
10.1210/ER.2004-0001
Transforming Growth Factor- 1 to the Bone
K. Janssens (2005)
10.1111/j.0105-2896.2005.00332.x
Fos/AP‐1 proteins in bone and the immune system
E. Wagner (2005)
10.1016/J.BONE.2005.03.018
SOST is a target gene for PTH in bone.
H. Keller (2005)
10.1074/jbc.M602308200
Wnt/β-Catenin Signaling Is a Normal Physiological Response to Mechanical Loading in Bone*
J. A. Robinson (2006)
10.1002/jcb.20958
Regulation of osteoblast differentiation by transcription factors
T. Komori (2006)
10.1016/J.BONE.2005.11.017
Matricellular proteins: Extracellular modulators of bone development, remodeling, and regeneration.
A. Alford (2006)
10.1002/dvdy.20717
Twist1 dimer selection regulates cranial suture patterning and fusion
J. Connerney (2006)
10.1158/1078-0432.CCR-06-0931
Clinical Features of Metastatic Bone Disease and Risk of Skeletal Morbidity
R. Coleman (2006)
10.1016/J.ATHEROSCLEROSIS.2005.11.002
Phosphatidylinositol-3-kinase signaling mediates vascular smooth muscle cell expression of periostin in vivo and in vitro.
G. Li (2006)
10.1074/jbc.M509205200
Up-regulation of the Wnt, Estrogen Receptor, Insulin-like Growth Factor-I, and Bone Morphogenetic Protein Pathways in C57BL/6J Osteoblasts as Opposed to C3H/HeJ Osteoblasts in Part Contributes to the Differential Anabolic Response to Fluid Shear*
K. W. Lau (2006)
10.1016/J.JACI.2006.02.046
Periostin: a novel component of subepithelial fibrosis of bronchial asthma downstream of IL-4 and IL-13 signals.
G. Takayama (2006)
10.1007/s00774-006-0716-x
αVβ3 Integrin ligands enhance volume-sensitive calcium influx in mechanically stretched osteocytes
A. Miyauchi (2006)
10.1210/JC.2005-1766
Clinical Review: Sex steroids and the periosteum--reconsidering the roles of androgens and estrogens in periosteal expansion.
D. Vanderschueren (2006)
10.1016/J.BBRC.2006.02.016
Periostin is an extracellular matrix protein required for eruption of incisors in mice.
I. Kii (2006)
AlphaVbeta3 integrin ligands enhance volume-sensitive calcium influx in mechanically stretched osteocytes.
A. Miyauchi (2006)
10.1359/jbmr.060904
Bone Fragility: Failure of Periosteal Apposition to Compensate for Increased Endocortical Resorption in Postmenopausal Women
P. Szulc (2006)
10.1080/08977190701398977
Differential effect of FGF and PDGF on cell proliferation and migration in osteoblastic cells
S. Kim (2007)
10.1016/J.BIOCEL.2007.06.004
TGFBIp/βig-h3 protein: A versatile matrix molecule induced by TGF-β
N. Thapa (2007)
10.14670/HH-22.1167
Periostin: novel diagnostic and therapeutic target for cancer.
Y. Kudo (2007)
10.1038/sj.onc.1210009
Periostin promotes invasiveness and resistance of pancreatic cancer cells to hypoxia-induced cell death: role of the β4 integrin and the PI3k pathway
P. Baril (2007)
10.1002/jcb.21224
Periostin regulates collagen fibrillogenesis and the biomechanical properties of connective tissues
R. Norris (2007)
10.1016/J.YDBIO.2006.09.048
Periostin promotes atrioventricular mesenchyme matrix invasion and remodeling mediated by integrin signaling through Rho/PI 3-kinase.
J. Butcher (2007)
10.1186/1476-4598-6-80
Human periostin gene expression in normal tissues, tumors and melanoma: evidences for periostin production by both stromal and melanoma cells
G. Tilman (2007)
10.1016/J.BIOMATERIALS.2007.08.031
The tooth attachment mechanism defined by structure, chemical composition and mechanical properties of collagen fibers in the periodontium.
Sunita P. Ho (2007)
10.1007/s00441-007-0439-x
Association of TIMP-2 with extracellular matrix exposed to mechanical stress and its co-distribution with periostin during mouse mandible development
N. Yoshiba (2007)
10.1038/nm1619
Periostin induces proliferation of differentiated cardiomyocytes and promotes cardiac repair
B. Kühn (2007)
10.1053/J.GASTRO.2007.01.031
Periostin creates a tumor-supportive microenvironment in the pancreas by sustaining fibrogenic stellate cell activity.
M. Erkan (2007)
10.1096/fj.07-8080com
The activin A‐follistatin system: potent regulator of human extracellular matrix mineralization
M. Eijken (2007)
10.1007/s00198-007-0329-9
The periosteum—a surface for all seasons
E. Seeman (2007)
TGFBIp/betaig-h3 protein: a versatile matrix molecule induced by TGF-beta.
N. Thapa (2007)
10.1074/jbc.M705194200
Determination of Dual Effects of Parathyroid Hormone on Skeletal Gene Expression in Vivo by Microarray and Network Analysis*
X. Li (2007)
10.1016/j.ydbio.2008.01.003
Periostin regulates atrioventricular valve maturation.
R. Norris (2008)
10.1083/JCB1802OIA7
Periostin is essential for cardiac healing after acute myocardial infarction
M. Shimazaki (2008)
10.1016/j.bbamcr.2008.01.013
Tenascin-C induction by cyclic strain requires integrin-linked kinase.
S. Maier (2008)
10.1369/jhc.7A7321.2007
Immunolocalization of Periostin-like Factor and Periostin During Embryogenesis
Shimei Zhu (2008)
10.3892/IJO.32.1.161
Role of alternative splicing of periostin in human bladder carcinogenesis.
C. J. Kim (2008)
10.1074/jbc.M705092200
Mechanical Stimulation of Bone in Vivo Reduces Osteocyte Expression of Sost/Sclerostin*
A. Robling (2008)
10.1902/jop.2008.070624
Periostin is essential for the integrity and function of the periodontal ligament during occlusal loading in mice.
H. Rios (2008)
10.1210/en.2008-0369
Differentiation and proliferation of periosteal osteoblast progenitors are differentially regulated by estrogens and intermittent parathyroid hormone administration.
Mami Ogita (2008)
10.1074/jbc.M708029200
Periostin, a Member of a Novel Family of Vitamin K-dependent Proteins, Is Expressed by Mesenchymal Stromal Cells*
D. Coutu (2008)
10.1016/S0083-6729(07)00016-7
Vitamin K and bone health in adult humans.
S. Bügel (2008)
10.1007/s12079-008-0023-5
Functional role of periostin in development and wound repair: implications for connective tissue disease
D. W. Hamilton (2008)
10.1074/jbc.M109.051961
Incorporation of Tenascin-C into the Extracellular Matrix by Periostin Underlies an Extracellular Meshwork Architecture*
I. Kii (2009)
10.1002/jcb.22214
Role of hypoxia in the hallmarks of human cancer
Kai Ruan (2009)
10.1186/1471-2407-10-273
Periostin is up-regulated in high grade and high stage prostate cancer
V. Tischler (2010)
10.1074/jbc.M109.060335
The Matricellular Protein Periostin Is Required for Sost Inhibition and the Anabolic Response to Mechanical Loading and Physical Activity*
N. Bonnet (2009)
10.1007/s00256-009-0849-9
The periosteum: what is it, where is it, and what mimics it in its absence?
J. Dwek (2010)
10.1016/j.canlet.2009.02.030
Upregulated expression of periostin by hypoxia in non-small-cell lung cancer cells promotes cell survival via the Akt/PKB pathway.
G. Ouyang (2009)
10.1016/j.bone.2008.11.012
Periostin-like-factor and Periostin in an animal model of work-related musculoskeletal disorder.
S. Rani (2009)
10.1074/jbc.M109.024125
Fibronectin Binds and Enhances the Activity of Bone Morphogenetic Protein 1*
G. Huang (2009)
10.1007/s11626-009-9214-5
Mechanical loading promotes Lewis lung cancer cell growth through periostin
D. Ma (2009)
10.1186/1476-4598-9-13
Gene expression profiling of cholangiocarcinoma-derived fibroblast reveals alterations related to tumor progression and indicates periostin as a poor prognostic marker
Kusumawadee Utispan (2010)
10.1016/j.humpath.2008.07.008
Periostin, a novel marker of intramembranous ossification, is expressed in fibrous dysplasia and in c-Fos-overexpressing bone lesions.
T. Kashima (2009)
10.1152/physiolgenomics.00078.2009
Lack of periostin leads to suppression of Notch1 signaling and calcific aortic valve disease.
T. Tkatchenko (2009)
10.1186/1471-2148-10-30
Periostin shows increased evolutionary plasticity in its alternatively spliced region
S. Hoersch (2010)
10.1002/jcp.21633
Periostin‐like‐factor in osteogenesis
Shimei Zhu (2009)
10.1016/j.joca.2008.07.010
Differential transcriptome analysis of intraarticular lesional vs intact cartilage reveals new candidate genes in osteoarthritis pathophysiology.
M. Geyer (2009)
10.1002/pros.20988
The increased expression of periostin during early stages of prostate cancer and advanced stages of cancer stroma
T. Tsunoda (2009)
10.1074/jbc.M109.088864
Interaction between Periostin and BMP-1 Promotes Proteolytic Activation of Lysyl Oxidase*
Takumi Maruhashi (2010)
10.1016/j.matbio.2010.07.001
Periostin is a collagen associated bone matrix protein regulated by parathyroid hormone.
D. Fortunati (2010)
10.1177/0022034510378684
TGF-β1 and FAK Regulate Periostin Expression in PDL Fibroblasts
W. Wen (2010)
10.1371/journal.pone.0012234
Periostin Associates with Notch1 Precursor to Maintain Notch1 Expression under a Stress Condition in Mouse Cells
H. Tanabe (2010)
10.1016/j.atherosclerosis.2009.07.046
Periostin mediates vascular smooth muscle cell migration through the integrins alphavbeta3 and alphavbeta5 and focal adhesion kinase (FAK) pathway.
Guohong Li (2010)
10.1007/s00223-010-9391-y
Development of a New ELISA for Serum Periostin: Evaluation of Growth-Related Changes and Bisphosphonate Treatment in Mice
Sylvain Contié (2010)
10.1002/jcp.22208
Role of TNF alpha and PLF in bone remodeling in a rat model of repetitive reaching and grasping
S. Rani (2010)
10.1016/j.archoralbio.2010.11.001
Oestrogen regulates proliferation, osteoblastic differentiation, collagen synthesis and periostin gene expression in human periodontal ligament cells through oestrogen receptor beta.
A. Mamalis (2011)
10.1371/journal.pone.0018410
Delayed Re-Epithelialization in Periostin-Deficient Mice during Cutaneous Wound Healing
T. Nishiyama (2011)
10.1002/ijc.25591
Increased expression and serum levels of the stromal cell‐secreted protein periostin in breast cancer bone metastases
Sylvain Contié (2011)
10.1007/s00018-011-0784-5
Periostin in fibrillogenesis for tissue regeneration: periostin actions inside and outside the cell
A. Kudo (2011)



This paper is referenced by
10.2147/IJGM.S335296
Association of Serum Periostin Level with Classical Bone Turnover Markers and Bone Mineral Density in Shanghai Chinese Postmenopausal Women with Osteoporosis
Ran Li (2021)
10.53064/jrad.2021.12.4.13
Periostin a Game-changer in Periodontal Health and Disease: A Review
Priyanka S. Padalkar (2021)
10.3389/fmed.2021.694800
Periostin: An Emerging Molecule With a Potential Role in Spinal Degenerative Diseases
Daxue Zhu (2021)
10.1038/s41551-020-00672-y
Microneedle patch for the ultrasensitive quantification of protein biomarkers in interstitial fluid
Zheyu Wang (2021)
10.1016/j.lfs.2021.119620
MicroRNA-489-3p promotes adipogenesis by targeting the Postn gene in 3T3-L1 preadipocytes.
R. Qi (2021)
10.1096/fj.202101045RR
Mechanical loading alleviated the inhibition of β2‐adrenergic receptor agonist terbutaline on bone regeneration
(2021)
10.3390/biomedicines9040404
Vascular Calcification in Chronic Kidney Disease: Diversity in the Vessel Wall
Prabhatchandra R. Dube (2021)
10.3389/fcell.2021.615098
Transcriptome Analysis of Dnmt3l Knock-Out Mice Derived Multipotent Mesenchymal Stem/Stromal Cells During Osteogenic Differentiation
Chih-Yi Yang (2021)
10.1007/s00774-020-01200-3
Plasma periostin as a biomarker of osteoporosis in postmenopausal women with type 2 diabetes
Junyan Li (2021)
10.21873/anticanres.14557
Promotion of Chondrosarcoma Cell Survival, Migration and Lymphangiogenesis by Periostin
Ji-Yun Jeong (2020)
10.1016/j.jormas.2019.12.016
Bone regeneration and mineralization was promoted during distraction osteogenesis by human periostin gene in rabbit mandibular model.
Xiao-wen Jiang (2020)
10.1038/s41598-020-74400-6
FAM20C directly binds to and phosphorylates Periostin
Ju-hsien Lin (2020)
10.1007/978-3-030-40146-7_1
The Tumor Microenvironment: Focus on Extracellular Matrix.
N. N. Rigoglio (2020)
10.1038/s41598-020-64683-0
Oxytocin and bone quality in the femoral neck of rats in periestropause
Fernanda Fernandes (2020)
10.14740/jocmr4279
Chronic Pancreatitis Is Characterized by Elevated Circulating Periostin Levels Related to Intra-Pancreatic Fat Deposition
Juyeon Ko (2020)
10.1093/rheumatology/kez647
The role of biochemical markers of joint tissue remodelling to predict progression and treatment efficacy in inflammatory rheumatic diseases.
P. Garnero (2020)
10.1016/b978-0-12-814841-9.00078-6
Bone turnover markers
Patrick Garnero (2020)
10.1002/JPER.20-0030
Soft tissue healing around platform-switching and platform-matching single implants: A randomized clinical trial.
Guo-Liang Cheng (2020)
10.3389/fphar.2020.00757
The Bone Extracellular Matrix in Bone Formation and Regeneration
Xiao Lin (2020)
10.1016/b978-0-12-811907-5.00029-4
Vitamin K2 is a key regulator of clinically relevant molecular processes
M. Fusaro (2020)
10.3803/EnM.2020.35.1.55
Potential Biomarkers to Improve the Prediction of Osteoporotic Fractures
Beom-Jun Kim (2020)
10.1021/acsabm.0c00233
Intramembranous Ossification Imitation Scaffold with the Function of Macrophage Polarization for Promoting Critical Bone Defect Repair
Y. Tang (2020)
10.12932/AP-010620-0868
Serum periostin levels in adolescents.
Yosuke Nakamura (2020)
10.1016/j.molmet.2019.11.003
Adipocyte-derived Periostin mediates glucocorticoid-induced hepatosteatosis in mice
Jian Wan (2019)
10.1098/rsos.191172
The biomolecular characterization of a finger ring contextually dated to the emergence of the Early Neolithic from Syltholm, Denmark
Theis Zetner Trolle Jensen (2020)
10.1093/icvts/ivy339
Mechanical stress alters the expression of calcification-related genes in vascular interstitial and endothelial cells.
A. Rutkovskiy (2019)
10.1016/j.bbrc.2018.11.097
Self-healing and injectable hybrid hydrogel for bone regeneration of femoral head necrosis and defect.
Yingjie Wang (2019)
10.1016/j.lfs.2019.117184
Periostin reverses high glucose-inhibited osteogenesis of periodontal ligament stem cells via AKT pathway.
Yanzhe Yan (2019)
10.1016/j.archoralbio.2019.104635
Irisin promotes growth, migration and matrix formation in human periodontal ligament cells.
H. Pullisaar (2019)
Periostin - A biomarker in adults with asthma
Ruth Semprini (2019)
10.1002/jcp.29365
Two‐day‐treatment of Activin‐A leads to transient change in SV‐HFO osteoblast gene expression and reduction in matrix mineralization
Marta Baroncelli (2019)
10.1007/s10753-019-01129-4
Periostin Mediates Condylar Resorption via the NF-κB-ADAMTS5 Pathway
B. Fan (2019)
See more
Semantic Scholar Logo Some data provided by SemanticScholar