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The Relationship Between Plasma Potassium, Muscle Membrane Excitability And Force Following Quadriceps Fatigue

W. West, A. Hicks, Robert McKelvie, J O'Brien
Published 2009 · Medicine, Chemistry
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To examine the simultaneous changes in plasma [K+], muscle excitability and force during fatigue, ten male adults (mean age = 22 ± 0.5 years) held an isometric contraction of their right quadriceps muscle at an intensity of 30% maximum voluntary contraction (MVC) for 3 min. Femoral venous and brachial arterial [K+] were determined from serial samples drawn before, during, and for 15 min following the 3-min contraction. Each blood sample was synchronized with a maximal stimulation of the right femoral nerve to evoke a twitch and compound muscle action potential (M-wave). Immediately post-exercise, twitch torque was only 42% of baseline and femoral venous plasma [K+] had increased significantly from 4.02 ± 0.08 mmol/l to 5.9 ± 0.22 mmol/1. Femoral venous plasma lactate rose to a peak level of 10.0 ± 0.8 mmol/1 at 1 min post exercise. The recovery of the twitch torque was exponentially related to the recovery of femoral venous plasma [K+] (r2 = 0.93, P < 0.01). There was no evidence for any loss of muscle membrane excitability during the period of increased extracellular [K+], in fact, the M-waves tended to be potentiated in the early phases of the recovery period. These results suggest that muscle membrane excitability is maintained in spite of increased extracellular [K+] following fatigue induced by a sustained submaximal quadriceps contraction. However, the strong relationship between twitch torque and femoral venous plasma [K+] suggests that K+ may be exerting its effect distal to surface membrane action potential propagation, most likely in the T-tubular region.
This paper references
Central nervous changes in fatigue induced by local work
B Maton (1991)
10.1007/BF01875427
Density and apparent location of the sodium pump in frog sartorius muscle
Roque A Venosa (2005)
10.1152/ajpregu.1985.248.2.R190
Water and ion shifts in skeletal muscle of humans with intense dynamic knee extension.
Gisela Sjøgaard (1985)
10.2165/00007256-199111060-00004
Potassium Regulation during Exercise and Recovery
Michael I Lindinger (1991)
10.1152/jappl.1989.67.5.1835
Impulse propagation and muscle activation in long maximal voluntary contractions.
Christine K. Thomas (1989)
10.1007/BF00240408
The relationship between voluntary electromyogram, endurance time and intensity of effort in isometric handgrip exercise
W. West (1995)
10.1016/0014-4886(79)90280-2
Excitation frequency and muscle fatigue: Electrical responses during human voluntary and stimulated contractions
B. Bigland-ritchie (1979)
10.1111/j.1748-1716.1988.tb08478.x
Muscle energy metabolism and electrolyte shifts during low-level prolonged static contraction in man.
Gisela Sjøgaard (1988)
10.1152/physrev.1986.66.3.542
Regulation of active Na+-K+ transport in skeletal muscle.
Torben Clausen (1986)
10.1249/00003677-198600140-00004
The physiology of static exercise.
Jerrold Scott Petrofsky (1986)
10.1007/BF00583367
Potassium and sodium shifts during in vitro isometric muscle contraction, and the time course of the ion-gradient recovery
Carsten Juel (2004)
10.1007/BF02584013
Spatial gradients of intracellular calcium in skeletal muscle during fatigue
Håkan Westerblad (2007)
10.1016/0013-4694(72)90058-2
Discharge frequency and discharge pattern of human motor units during voluntary contraction of muscle.
R. Person (1972)
Epinephrine and some other hormonal responses to exercise in man: with special reference to physical training.
Michael Kjaer (1989)
10.1007/BF00580975
Extracellular K+ concentration and K+ Balance of the gastrocnemius muscle of the dog during exercise
Hansjürgen Hirche (1980)
10.1152/jappl.1981.51.5.1131
Extent of motor unit activation during effort.
A Y Bélanger (1981)
10.1113/jphysiol.1989.sp017691
Increased sodium pump activity following repetitive stimulation of rat soleus muscles.
Audrey L. Hicks (1989)
10.1152/jappl.1988.64.3.1084
Failure of neuromuscular propagation during human maximal voluntary contraction.
François Bellemare (1988)
10.1113/jphysiol.1982.sp014340
The absence of neuromuscular transmission failure in sustained maximal voluntary contractions.
B. Bigland-ritchie (1982)
10.1113/jphysiol.1972.sp009691
Fatigue of maintained voluntary muscle contraction in man.
John A. Stephens (1972)
10.1152/jappl.1994.76.6.2411
Behavior of motor units in human biceps brachii during a submaximal fatiguing contraction.
S. J. Garland (1994)
10.1007/BF00656721
The measurement of Ke+ concentration changes in human muscles during volitional contractions
Frantisek Vyskocil (2004)
Work induced potassium loss from skeletal muscles and its physiological implications, lnt
P Hnik (1986)
10.1113/jphysiol.1952.sp004718
The components of membrane conductance in the giant axon of Loligo.
Alan Lloyd Hodgkin (1952)
10.1152/jappl.1989.66.6.2606
M wave potentiation during and after muscle activity.
Audrey L. Hicks (1989)
10.1038/ki.1989.1
Regulation of the Na,K-pump in skeletal muscle.
Torben Clausen (1989)
10.2165/00007256-199213020-00009
The Roles of Ionic Processes in Muscular Fatigue During Intense Exercise
Michael J. McKenna (1992)
10.1152/ajpregu.1988.254.1.R117
Ion fluxes during tetanic stimulation in isolated perfused rat hindlimb.
Michael I Lindinger (1988)
10.1113/jphysiol.1970.sp009158
On the relationships between membrane potential, calcium transient and tension in single barnacle muscle fibres.
Christopher C. Ashley (1970)
10.1113/jphysiol.1949.sp004388
The effect of temperature on the electrical activity of the giant axon of the squid.
Alan Lloyd Hodgkin (1949)
10.1113/jphysiol.1986.sp016263
Reflex origin for the slowing of motoneurone firing rates in fatigue of human voluntary contractions.
B R Bigland-Ritchie (1986)
10.1113/jphysiol.1990.sp018241
Reflex inhibition of human soleus muscle during fatigue.
S Jayne Garland (1990)
Exercise-induced muscle fatigue: the significance of potassium.
Gisela Sjøgaard (1990)
Water and electrolyte fluxes during exercise and their relation to muscle fatigue.
Gisela Sjøgaard (1986)
10.1002/mus.880070902
Changes in muscle contractile properties and neural control during human muscular fatigue.
B. Bigland-ritchie (1984)
10.1113/jphysiol.1993.sp019486
Impairment of neuromuscular propagation during human fatiguing contractions at submaximal forces.
Andrew J. Fuglevand (1993)
10.1113/jphysiol.1990.sp017935
Plasma potassium changes with high intensity exercise.
J I Medbø (1990)
10.1139/y92-172
Effects of K+ on the twitch and tetanic contraction in the sartorius muscle of the frog, Rana pipiens. Implication for fatigue in vivo.
J M Renaud (1992)
10.1159/000414701
Na,K Homeostasis of Skeletal Muscle during Activation
Ole M Sejersted (1987)
10.1002/mus.880020404
Amplitude of the surface electromyogram during fatiguing isometric contractions.
Alexander Lind (1979)



This paper is referenced by
10.1152/japplphysiol.01539.2012
Comparison of neuromuscular adjustments associated with sustained isometric contractions of four different muscle groups.
Daria Neyroud (2013)
10.1249/MSS.0b013e318245cc4d
Mechanisms of fatigue and task failure induced by sustained submaximal contractions.
Daria Neyroud (2012)
in habitual and nonhabitual caffeine consumers Caffeine potentiates low frequency skeletal muscle force
Mark A Tarnopolsky (2013)
10.1111/j.1440-1681.2008.05021.x
Mechanisms of fatigue induced by isometric contractions in exercising humans and in mouse isolated single muscle fibres.
Nicolas Place (2009)
10.1136/bcr-2016-214798
Renal tubular acidosis type 4 in pregnancy
Adam Daniel Jakes (2016)
10.1016/j.brainres.2009.12.023
Influence of activity-induced axonal hypoexcitability on transmission of descending and segmental signals
Alessandro Rossi (2010)
Neuromuscular performance and exercise stress associated with the stabilisation of synovial joints
Claire. Minshull (2003)
muscle groups with sustained isometric contractions of four different Comparison of neuromuscular adjustments associated
Nicola A. Maffiuletti (2013)
10.1016/j.pneurobio.2004.03.005
Cerebral perturbations provoked by prolonged exercise
Lars Nybo (2004)
10.1007/s00421-017-3553-9
Different recoveries of the first and second phases of the M-wave after intermittent maximal voluntary contractions
Javier Rodríguez-Falces (2017)
Mechanisms of fatigue induced by isometric contractions in exercising humans and in isolated mouse single muscle fibres
Nicolas Place (2008)
Influence des mécanismes de régulation de la fatigue neuromusculaire sur la performance motrice
Guillaume P Ducrocq (2017)
Endurance performance : the integrative physiology of resisting fatigue
Yolande Xanthe Rocille Harley (2004)
10.4025/jphyseduc.v29i1.2915
TRADITIONAL MODELS OF FATIGUE AND PHYSICAL PERFORMANCE
Felipe de Russi de Lima (2018)
force in habitual and nonhabitual caffeine consumers Caffeine potentiates low frequency skeletal muscle
Cynthia Cupido (2015)
10.1007/s00421-017-3788-5
Determinants, analysis and interpretation of the muscle compound action potential (M wave) in humans: implications for the study of muscle fatigue
Javier Rodríguez-Falces (2017)
10.1016/j.jelekin.2019.102385
Recovery of the first and second phases of the M wave after prolonged maximal voluntary contractions.
Javier Rodríguez-Falces (2019)
10.1016/j.rehab.2011.01.001
Neuromuscular fatigue in healthy muscle: underlying factors and adaptation mechanisms.
Sébastien Boyas (2011)
10.1002/mus.23856
Twitch and M-wave potentiation induced by intermittent maximal voluntary quadriceps contractions: differences between direct quadriceps and femoral nerve stimulation.
Javier Rodríguez-Falces (2013)
10.1519/JSC.0b013e3181a518f1
Time Course of Postactivation Potentiation During Intermittent Submaximal Fatiguing Contractions in Endurance- and Power-Trained Athletes
Claire Morana (2009)
10.1152/physrev.00015.2007
Skeletal muscle fatigue: cellular mechanisms.
David G Allen (2008)
10.1002/cphy.c160009
Muscle and Limb Mechanics.
George A. Tsianos (2017)
10.1080/17461391.2010.521582
Peripheral alterations after two different concentric power protocols
Katja Tomažin (2011)
10.1152/japplphysiol.01144.2014
M-wave potentiation after voluntary contractions of different durations and intensities in the tibialis anterior.
Javier Rodríguez-Falces (2015)
10.1007/s10974-017-9484-6
Changes in contractile and metabolic parameters of skeletal muscle as rats age from 3 to 12 months
Hongyang Xu (2017)
10.1007/s00421-010-1480-0
Muscle fatigue: from observations in humans to underlying mechanisms studied in intact single muscle fibres
Nicolas Place (2010)
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