The Relationship Between Plasma Potassium, Muscle Membrane Excitability And Force Following Quadriceps Fatigue
W. West, A. Hicks, Robert McKelvie, J O'Brien
Published 2009 · Medicine, Chemistry
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To examine the simultaneous changes in plasma [K+], muscle excitability and force during fatigue, ten male adults (mean age = 22 ± 0.5 years) held an isometric contraction of their right quadriceps muscle at an intensity of 30% maximum voluntary contraction (MVC) for 3 min. Femoral venous and brachial arterial [K+] were determined from serial samples drawn before, during, and for 15 min following the 3-min contraction. Each blood sample was synchronized with a maximal stimulation of the right femoral nerve to evoke a twitch and compound muscle action potential (M-wave). Immediately post-exercise, twitch torque was only 42% of baseline and femoral venous plasma [K+] had increased significantly from 4.02 ± 0.08 mmol/l to 5.9 ± 0.22 mmol/1. Femoral venous plasma lactate rose to a peak level of 10.0 ± 0.8 mmol/1 at 1 min post exercise. The recovery of the twitch torque was exponentially related to the recovery of femoral venous plasma [K+] (r2 = 0.93, P < 0.01). There was no evidence for any loss of muscle membrane excitability during the period of increased extracellular [K+], in fact, the M-waves tended to be potentiated in the early phases of the recovery period. These results suggest that muscle membrane excitability is maintained in spite of increased extracellular [K+] following fatigue induced by a sustained submaximal quadriceps contraction. However, the strong relationship between twitch torque and femoral venous plasma [K+] suggests that K+ may be exerting its effect distal to surface membrane action potential propagation, most likely in the T-tubular region.
This paper references
Central nervous changes in fatigue induced by local work
B Maton (1991)
Density and apparent location of the sodium pump in frog sartorius muscle
Roque A Venosa (2005)
Water and ion shifts in skeletal muscle of humans with intense dynamic knee extension.
Gisela Sjøgaard (1985)
Potassium Regulation during Exercise and Recovery
Michael I Lindinger (1991)
Impulse propagation and muscle activation in long maximal voluntary contractions.
Christine K. Thomas (1989)
The relationship between voluntary electromyogram, endurance time and intensity of effort in isometric handgrip exercise
W. West (1995)
Excitation frequency and muscle fatigue: Electrical responses during human voluntary and stimulated contractions
B. Bigland-ritchie (1979)
Muscle energy metabolism and electrolyte shifts during low-level prolonged static contraction in man.
Gisela Sjøgaard (1988)
Regulation of active Na+-K+ transport in skeletal muscle.
Torben Clausen (1986)
The physiology of static exercise.
Jerrold Scott Petrofsky (1986)
Potassium and sodium shifts during in vitro isometric muscle contraction, and the time course of the ion-gradient recovery
Carsten Juel (2004)
Spatial gradients of intracellular calcium in skeletal muscle during fatigue
Håkan Westerblad (2007)
Discharge frequency and discharge pattern of human motor units during voluntary contraction of muscle.
R. Person (1972)
Epinephrine and some other hormonal responses to exercise in man: with special reference to physical training.
Michael Kjaer (1989)
Extracellular K+ concentration and K+ Balance of the gastrocnemius muscle of the dog during exercise
Hansjürgen Hirche (1980)
Extent of motor unit activation during effort.
A Y Bélanger (1981)
Increased sodium pump activity following repetitive stimulation of rat soleus muscles.
Audrey L. Hicks (1989)
Failure of neuromuscular propagation during human maximal voluntary contraction.
François Bellemare (1988)
The absence of neuromuscular transmission failure in sustained maximal voluntary contractions.
B. Bigland-ritchie (1982)
Fatigue of maintained voluntary muscle contraction in man.
John A. Stephens (1972)
Behavior of motor units in human biceps brachii during a submaximal fatiguing contraction.
S. J. Garland (1994)
The measurement of Ke+ concentration changes in human muscles during volitional contractions
Frantisek Vyskocil (2004)
Work induced potassium loss from skeletal muscles and its physiological implications, lnt
P Hnik (1986)
The components of membrane conductance in the giant axon of Loligo.
Alan Lloyd Hodgkin (1952)
M wave potentiation during and after muscle activity.
Audrey L. Hicks (1989)
Regulation of the Na,K-pump in skeletal muscle.
Torben Clausen (1989)
The Roles of Ionic Processes in Muscular Fatigue During Intense Exercise
Michael J. McKenna (1992)
Ion fluxes during tetanic stimulation in isolated perfused rat hindlimb.
Michael I Lindinger (1988)
On the relationships between membrane potential, calcium transient and tension in single barnacle muscle fibres.
Christopher C. Ashley (1970)
The effect of temperature on the electrical activity of the giant axon of the squid.
Alan Lloyd Hodgkin (1949)
Reflex origin for the slowing of motoneurone firing rates in fatigue of human voluntary contractions.
B R Bigland-Ritchie (1986)
Reflex inhibition of human soleus muscle during fatigue.
S Jayne Garland (1990)
Exercise-induced muscle fatigue: the significance of potassium.
Gisela Sjøgaard (1990)
Water and electrolyte fluxes during exercise and their relation to muscle fatigue.
Gisela Sjøgaard (1986)
Changes in muscle contractile properties and neural control during human muscular fatigue.
B. Bigland-ritchie (1984)
Impairment of neuromuscular propagation during human fatiguing contractions at submaximal forces.
Andrew J. Fuglevand (1993)
Plasma potassium changes with high intensity exercise.
J I Medbø (1990)
Effects of K+ on the twitch and tetanic contraction in the sartorius muscle of the frog, Rana pipiens. Implication for fatigue in vivo.
J M Renaud (1992)
Na,K Homeostasis of Skeletal Muscle during Activation
Ole M Sejersted (1987)
Amplitude of the surface electromyogram during fatiguing isometric contractions.
Alexander Lind (1979)
This paper is referenced by
Comparison of neuromuscular adjustments associated with sustained isometric contractions of four different muscle groups.
Daria Neyroud (2013)
Mechanisms of fatigue and task failure induced by sustained submaximal contractions.
Daria Neyroud (2012)
in habitual and nonhabitual caffeine consumers Caffeine potentiates low frequency skeletal muscle force
Mark A Tarnopolsky (2013)
Mechanisms of fatigue induced by isometric contractions in exercising humans and in mouse isolated single muscle fibres.
Nicolas Place (2009)
Renal tubular acidosis type 4 in pregnancy
Adam Daniel Jakes (2016)
Influence of activity-induced axonal hypoexcitability on transmission of descending and segmental signals
Alessandro Rossi (2010)
Neuromuscular performance and exercise stress associated with the stabilisation of synovial joints
Claire. Minshull (2003)
muscle groups with sustained isometric contractions of four different Comparison of neuromuscular adjustments associated
Nicola A. Maffiuletti (2013)
Cerebral perturbations provoked by prolonged exercise
Lars Nybo (2004)
Different recoveries of the first and second phases of the M-wave after intermittent maximal voluntary contractions
Javier Rodríguez-Falces (2017)
Mechanisms of fatigue induced by isometric contractions in exercising humans and in isolated mouse single muscle fibres
Nicolas Place (2008)
Influence des mécanismes de régulation de la fatigue neuromusculaire sur la performance motrice
Guillaume P Ducrocq (2017)
Endurance performance : the integrative physiology of resisting fatigue
Yolande Xanthe Rocille Harley (2004)
TRADITIONAL MODELS OF FATIGUE AND PHYSICAL PERFORMANCE
Felipe de Russi de Lima (2018)
force in habitual and nonhabitual caffeine consumers Caffeine potentiates low frequency skeletal muscle
Cynthia Cupido (2015)
Determinants, analysis and interpretation of the muscle compound action potential (M wave) in humans: implications for the study of muscle fatigue
Javier Rodríguez-Falces (2017)
Recovery of the first and second phases of the M wave after prolonged maximal voluntary contractions.
Javier Rodríguez-Falces (2019)
Neuromuscular fatigue in healthy muscle: underlying factors and adaptation mechanisms.
Sébastien Boyas (2011)
Twitch and M-wave potentiation induced by intermittent maximal voluntary quadriceps contractions: differences between direct quadriceps and femoral nerve stimulation.
Javier Rodríguez-Falces (2013)
Time Course of Postactivation Potentiation During Intermittent Submaximal Fatiguing Contractions in Endurance- and Power-Trained Athletes
Claire Morana (2009)
Skeletal muscle fatigue: cellular mechanisms.
David G Allen (2008)
Muscle and Limb Mechanics.
George A. Tsianos (2017)
Peripheral alterations after two different concentric power protocols
Katja Tomažin (2011)
M-wave potentiation after voluntary contractions of different durations and intensities in the tibialis anterior.
Javier Rodríguez-Falces (2015)
Changes in contractile and metabolic parameters of skeletal muscle as rats age from 3 to 12 months
Hongyang Xu (2017)
Muscle fatigue: from observations in humans to underlying mechanisms studied in intact single muscle fibres
Nicolas Place (2010)