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Morphology And Immunology Of The Human Palatine Tonsil

H. Nave, A. Gebert, R. Pabst
Published 2001 · Biology, Medicine

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At the surface of the respiratory and digestive organs the organism first comes into contact nasally and orally with various foreign agents and substances in the air and in food. The palatine tonsils are located at the centre of this strategic region. Immunological processes, both humoral and cellular, are initiated in the different specialised compartments of the palatine tonsils, such as the crypt epithelium, lymphoid follicles and extrafollicular region. Each compartment has a typical composition of lymphocytes and dendritic cell subsets. This review summarises current data on the anatomy, histology, and pathology of the human palatine tonsils, describes their fundamental immunological functions, and provides insight into the various interactions involved in the initiation of immune responses. The palatine tonsil is the only easily accessible human lymphoid organ and is often taken as an example for lymphoid organs. Although affections of the palatine tonsils constitutes an essential part in the clinical routine, it is still controversial whether tonsillectomy is of general benefit. This is of increasing importance since it has been discovered in the last few years that the palatine tonsils are reservoir and replication sites of HIV.
This paper references
Cytokine expression and production by tonsillar lymphocytes.
Y. Harabuchi (1996)
10.3109/00016488809125002
Computerized three-dimensional reconstruction of the crypt system of the palatine tonsil.
K. Abbey (1988)
Active replication of HIV-1 at the lymphoepithelial surface of the tonsil.
S. Frankel (1997)
The tonsil and adenoid controversy.
Witt Rl (1989)
10.1038/377740A0
Follicular dendritic cells and human immunodeficiency virus infectivity
S. Heath (1995)
Culture characterization of differentiated high endothelial venule cells from human tonsils.
E. S. Baekkevold (1999)
10.1126/science.272.5258.115
Replication of HIV-1 in Dendritic Cell-Derived Syncytia at the Mucosal Surface of the Adenoid
S. Frankel (1996)
10.3109/00016488809125041
Immunological basis of indications for tonsillectomy and adenoidectomy.
M. Ying (1988)
10.1016/S0002-9440(10)61694-X
Phenotypic characterization of five dendritic cell subsets in human tonsils.
K. Summers (2001)
10.1155/1998/68382
Development and Maintenance of the Gut-Associated Lymphoid Tissue (Galt): the Roles of Enteric Bacteria and Viruses
J. Cebra (1998)
10.1097/00000478-199605000-00004
Lymphoid changes of the nasopharyngeal and palatine tonsils that are indicative of human immunodeficiency virus infection. A clinicopathologic study of 12 cases.
B. Wenig (1996)
10.1016/0167-5699(92)90106-H
Is BALT a major component of the human lung immune system?
R. Pabst (1992)
10.1136/jcp.45.8.668
Human tonsil intraepithelial B cells: a marginal zone-related subpopulation.
M. Morente (1992)
10.1016/0167-5699(95)80023-9
High endothelial venules (HEVs): specialized endothelium for lymphocyte migration.
J. Girard (1995)
10.1016/S0092-8674(00)80106-3
Epithelial M Cells: Gateways for Mucosal Infection and Immunization
M. Neutra (1996)
Microanatomical distribution of dendritic cells in normal tonsils.
B. Noble (1996)
10.1007/s004419900172
Follicular dendritic cells in vitro modulate the expression of Fas and Bcl-2 on germinal center B cells
R. Tsunoda (2000)
10.1679/AOHC.53.41
Differentiation of crypt epithelium in human palatine tonsils: the microenvironment of crypt epithelium as a lymphoepithelial organ.
Y. Sato (1990)
10.1046/j.1365-2249.1999.00850.x
Age‐dependent altered proportions in subpopulations of tonsillar lymphocytes
W. Bergler (1999)
10.1177/014107689008300216
Immunology of the Tonsil: A Review
G. Scadding (1990)
10.1084/JEM.192.11.1553
Cxc Chemokine Receptor 5 Expression Defines Follicular Homing T Cells with B Cell Helper Function
P. Schaerli (2000)
10.1073/PNAS.88.21.9838
Lymphoid organs function as major reservoirs for human immunodeficiency virus.
G. Pantaleo (1991)
Age-related changes of IgA immunocytes and serum and salivary IgA after tonsillectomy.
K. Jung (1996)
10.1007/978-1-4615-2492-2_49
Five human mature B cell subsets.
Y. Liu (1994)
10.1016/S0167-5699(98)01413-3
Regional specialization in the mucosal immune system: what happens in the microcompartments?
P. Brandtzaeg (1999)
10.3109/00016489109138388
The Waldeyer ring equivalent in the rat. A model for analysis of oronasopharyngeal immune responses.
P. Koornstra (1991)
Immunoglobulin systems of human tonsils. I. Control subjects of various ages: quantification of Ig-producing cells, tonsillar morphometry and serum Ig concentrations.
P. Brandtzaeg (1978)
10.1007/978-1-4615-2492-2_36
The differences in survival and phenotype between centroblasts and centrocytes.
Y. Liu (1994)
10.1046/j.1365-3083.1996.d01-38.x
Blood Leucocyte Subsets of the Rat: Expression of Adhesion Molecules and Localization Within High Endothelial Venules
J. Westermann (1996)
Concomitant in vivo production of 19 different cytokines in human tonsils.
J. Andersson (1994)
10.1016/0165-2478(86)90016-7
Isolation of follicular dendritic cells from human tonsils and adenoids. V. Effect on lymphocyte proliferation and differentiation.
N. Cormann (1986)
10.1084/JEM.180.1.329
Analysis of somatic mutation in five B cell subsets of human tonsil
V. Pascual (1994)
Long-term effects of intensive therapy combined with tonsillectomy in patients with IgA nephropathy.
O. Hotta (1996)
10.1016/0167-5699(88)91223-6
The lymph follicle: a hard nut to crack.
E. Heinen (1988)
Tonsillar (Waldyer's ring equivalent) lymphoid tissue in the rat: lymphocyte subset binding to high endothelial venules (HEV) and in situ distribution.
P. Koornstra (1992)
10.1002/(SICI)1097-0185(199605)245:1<102::AID-AR15>3.0.CO;2-T
Tonsils of the soft palate of young pigs: Crypt structure and lymphoepithelium
G. T. Belz (1996)
10.1111/j.1600-065X.1997.tb00963.x
Germinal center development
Y. Liu (1997)
10.1111/j.1365-2249.1995.tb03132.x
Increased dimeric IgA‐producing B cells in tonsils in IgA nephropathy determined by in situ hybridization for J chain mRNA
S. Harper (1995)
A study of apoptosis in the human palatine tonsil.
K. Kuki (1996)
The specialised structure of crypt epithelium in the human palatine tonsil and its functional significance.
Perry Me (1994)
10.3109/00016489209100794
Distribution of lymphoid cells in tonsillar compartments in relation to infection and age. A quantitative study using image analysis.
N. Yamanaka (1992)
10.1016/0167-5699(90)90160-B
Lymphocyte subsets in the blood: a diagnostic window on the lymphoid system?
J. Westermann (1990)
10.1007/s004290050143
Intercellular and lymphatic pathways associated with tonsils of the soft palate in young pigs
G. T. Belz (1998)
10.1046/j.1365-3083.1998.00371.x
Differentiation of T Lymphocytes in the Human Adenoid as Measured by the Expression of CD45 Isoforms
Mattila (1998)
10.1128/IAI.63.3.853-857.1995
Induction of compartmentalized B-cell responses in human tonsils.
M. Quiding-Järbrink (1995)
The B-cell development in tonsillar lymphoid follicles.
P. Brandtzaeg (1996)
10.1002/EJI.1830270106
Human T lymphocytes bind to germinal centers of human tonsils via integrin α4/VCAM‐1 and LFA‐1/ICAM−1 and −2
F. Schriever (1997)
M-cells in the epithelium of the nasopharyngeal tonsil.
T. Karchev (1984)
10.1007/s004180050186
The role of M cells in the protection of mucosal membranes
A. Gebert (1997)
10.1002/PATH.1711300205
Scanning and transmission electron microscopy on the epithelium of human palatine tonsils
A. Howie (1980)
10.1111/j.1365-2249.1993.tb07970.x
Immunohistochemical detection of co‐localizing cytokine and antibody producing cells in the extrafollicular area of human palatine tonsils
S. Hoefakker (1993)
10.1111/j.1365-3083.1981.tb00136.x
Influence of Tonsillar Disease on the Expression of J Chain by Immunoglobulin‐producing Cells in Human Palatine and Nasopharyngeal Tonsils
F. Korsrud (1981)
10.1111/j.1699-0463.1991.tb01278.x
Association between keratin staining patterns and the structural and functional aspects of palatine tonsil epithelium
J. Reibel (1991)
10.1016/S0167-5699(99)01498-X
Regionalized immune function of tonsils and adenoids.
P. Brandtzaeg (1999)
10.1159/000421721
Immunology and Immunopathology of Tonsils1
P. Brandtzaeg (1992)
10.1097/00006454-200005001-00002
Mucosal immune response in the ear, nose and throat.
P. Ogra (2000)
10.1016/1074-7613(95)90048-9
Memory B cells from human tonsils colonize mucosal epithelium and directly present antigen to T cells by rapid up-regulation of B7-1 and B7-2.
Y. Liu (1995)
10.1016/S0167-5699(98)01307-3
Immunology of the tonsils.
M. Perry (1998)
10.1038/367425A0
How B and T cells talk to each other
E. Clark (1994)
10.1016/S0165-5876(99)00147-0
What is wrong in chronic adenoiditis/tonsillitis anatomical considerations.
M. Casselbrant (1999)
Role of gamma delta-T cells in the palatine tonsil.
N. Yamanaka (1996)
10.1007/s004290050055
M cells in the rabbit palatine tonsil: the distribution, spatial arrangement and membrane subdomains as defined by confocal lectin histochemistry
A. Gebert (1997)
10.3109/00016488809124999
Specialization of tonsils as analyzers of the human immune system.
T. Karchev (1988)
10.1016/S0074-7696(08)61346-7
M cells in Peyer's patches of the intestine.
A. Gebert (1996)
10.1016/S0025-7125(05)70088-2
Sore throat, tonsillitis, and adenoiditis.
M. A. Richardson (1999)
Tonsils and lympho-epithelial structures in the pharynx as immuno-barriers.
L. Surján (1987)
10.1002/STEM.5530120304
Molecular control of B Lymphocyte growth and differentiation
J. Banchereau (1994)
10.1177/44.9.8773569
M-cells in the rabbit tonsil exhibit distinctive glycoconjugates in their apical membranes.
A. Gebert (1996)
Immune systems of human nasopharyngeal and palatine tonsils: histomorphometry of lymphoid components and quantification of immunoglobulin-producing cells in health and disease.
F. Korsrud (1980)
Differences in the germinal centres of palatine tonsils and lymph nodes.
E. F. Brachtel (1996)
10.1016/0165-5876(82)90090-8
Electron-microscope observations on the tonsillar epithelium in children with recurrent tonsillitis.
T. Karchev (1982)
10.1084/JEM.193.9.1105
The Ccr7 Ligand ELC (Ccl19) Is Transcytosed in High Endothelial Venules and Mediates T Cell Recruitment
E. S. Baekkevold (2001)
The tonsil and adenoid controversy.
R. Witt (1989)
10.1182/BLOOD.V97.12.3992
Expression of macrophage inflammatory protein-3alpha, stromal cell-derived factor-1, and B-cell-attracting chemokine-1 identifies the tonsil crypt as an attractive site for B cells.
M. Casamayor-Pallejà (2001)
10.1046/j.1365-3083.2000.00681.x
Differences in Lymphocyte Subsets in the Wall of High Endothelial Venules and the Lymphatics of Human Palatine Tonsils
Zidan (2000)
Structure and function of bronchus-associated lymphoid tissue (BALT).
T. Sminia (1989)
10.1084/JEM.188.2.373
Selective Recruitment of Immature and Mature Dendritic Cells by Distinct Chemokines Expressed in Different Anatomic Sites
M. Dieu (1998)
Cell dynamics in the germinal center of the human tonsil.
H. Tabe (1996)
Immune functions and immunopathology of palatine and nasopharyngeal tonsils
P Brandtzaeg (1987)
Immune functions of human nasal mucosa and tonsils in health and disease
P Brandtzaeg (1984)
Immune functions of human nasal mucosa and tonsils in health and disease.
P. Brandzaeg (1984)
Lymphocyte trafficking
R Pabst (1998)
Die Gaumentonsillen als Teil des lymphatischen Systems . Ein - und Ausstrom neugebildeter Lymphozyten
E Nowara (1986)



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Sanjana Balachandra (2020)
10.1101/2020.08.06.239574
Generation of tonsil organoids as an ex vivo model for SARS-CoV-2 infection
H. K. Kim (2020)
10.1101/2020.10.20.20216101
MYC, BCL2 and BCL6 co-localisation patterns at single-cell resolution underlie their prognostic significance in diffuse large B-cell lymphoma
M. Hoppe (2020)
10.1038/s41598-020-69981-1
Cytokine production in patients with recurrent acute tonsillitis: analysis of tonsil samples and blood
Katharina Geißler (2020)
10.12775/JEHS.2020.10.05.028
Resistance of the mucous membrane of the oral cavity during hypertrophy of the lingual tonsil
A. V. Аndreev (2020)
10.47210/bjohns.2020.v28i1.21
A Clinical Study of Serum Vitamin D Levels in Chronic Tonsillitis among Paediatric Age Group
Sudhakar Rao M.S (2020)
10.1007/s00247-020-04650-z
Normal FDG uptake in the adenoids and palatine tonsils in children on PET/MRI
Sachin S. Kumbhar (2020)
10.1038/s41598-020-58675-3
Prevalence of palatine tonsilloliths in Dominican patients of varying social classes treated in university clinics
J. Aragoneses (2020)
10.33899/mmed.2020.164164
Histological and Immunohistochemical Analysis of Special Compartments of Palatin Tonsils in Relation to Tonsillar Diseases
Zahraa A. Tabou (2020)
10.3329/bjo.v24i1.45330
Role of intranasal fluticasone furoate spray in modifying quality of life of children with adenoid hypertrophy
Mazharul Islam (2020)
10.1684/ecn.2015.0368
Poly-functional T helper cells in human tonsillar mononuclear cells
S. Yu (2019)
10.1016/j.anl.2018.06.004
Radiographic and histologic characterization of tongue base tissues obtained by transoral robotic surgery in patients with obstructive sleep apnea.
J. Kim (2019)
The microbiome in primary Sjögren ’ s syndrome
V. Meulen (2019)
10.1038/s41587-019-0207-y
Immuno-SABER enables highly multiplexed and amplified protein imaging in tissues
Sinem K Saka (2019)
10.1101/719807
Mining the human tonsillar microbiota as autoimmune modulator
J. Li (2019)
10.1007/s00441-019-03135-2
Histological characterization of the lingual tonsils of the one-humped camel (Camelus dromedarius)
M. Zidan (2019)
10.1016/J.BJORL.2018.12.013
Comparison of postoperative morbidity between conventional cold dissection and bipolar electrocautery tonsillectomy: which technique is better?
M. Mofatteh (2019)
10.1002/ar.24001
Yak (Bos grunniens) Tonsils: Morphological Description and Expression of IgA and IgG
J. Sun (2019)
10.1186/s12917-019-2166-4
Detection of live M. bovis BCG in tissues and IFN-γ responses in European badgers (Meles meles) vaccinated by oropharyngeal instillation or directly in the ileum
S. Lesellier (2019)
10.1538/expanim.18-0142
Fetal and early postnatal development of the porcine tonsils of the soft palate
S. Suzuki (2019)
Exp. Anim
Shunichi Suzuki (2019)
10.1038/s41398-019-0568-5
Association of chronic and acute inflammation of the mucosa-associated lymphoid tissue with psychiatric disorders and suicidal behavior
J. Isung (2019)
10.1016/j.anl.2018.04.009
Steroid pulse therapy transiently destroys the discriminative histological structure of tonsils in IgA nephropathy: Tonsillectomy should be performed before or just after steroid pulse therapy.
M. Adachi (2018)
10.30841/2307-5112.3.2018.146896
Treatment of hypertrophy of adenoids. Balancing between adenotomy and medication
Ф. Б. Юрочко (2018)
10.1097/MD.0000000000011040
Determinants of physiological uptake of 18F-fluorodeoxyglucose in palatine tonsils
Emily Birkin (2018)
10.29252/QUMS.22.4.4
The study of serum and tissue cholesterol levels in children undergoing tonsillectomy
M. Shaaker (2018)
10.1186/s41199-018-0039-3
HPV-driven oropharyngeal cancer: current knowledge of molecular biology and mechanisms of carcinogenesis
C. Pan (2018)
10.1002/lary.27002
Oral sampling methods are associated with differences in immune marker concentrations
C. Fakhry (2018)
10.1016/j.ijporl.2018.01.041
Human beta defensin-1 is involved in the susceptibility to adeno-tonsillar hypertrophy.
L. Zupin (2018)
10.1016/j.archoralbio.2018.08.020
Differential cellular composition of human palatine and pharyngeal tonsils.
Luke Stanisce (2018)
10.1128/JVI.00131-18
In Vitro Measles Virus Infection of Human Lymphocyte Subsets Demonstrates High Susceptibility and Permissiveness of both Naive and Memory B Cells
B. Laksono (2018)
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