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A Simple And Regioselective One-pot Procedure For The Direct N-acylation Of Some Purine And Pyrimidine Nucleobases Via Carboxylic Acids Using Cyanuric Chloride

M. N. Soltani Rad, S. Behrouz, Z. Asrari, A. Khalafi-nezhad
Published 2014 · Chemistry

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A facile and selective one-pot N-acylation of nucleobases via carboxylic acids using cyanuric chloride (2,4,6-trichloro-1,3,5-triazine) is described. In this protocol, the reaction of diverse carboxylic acids with pyrimidine and/or purine nucleobases is efficiently achieved in the presence of cyanuric chloride and NaH/Et3N in DMF/MeCN (1:1, v/v) to afford the corresponding N-acyl nucleobases in good yields.Graphical Abstract
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