← Back to Search
Apolipoprotein E Is Associated With Age At Onset Of Amyotrophic Lateral Sclerosis
Yi-Ju Li, M. Pericak-Vance, J. Haines, N. Siddique, D. McKenna-Yasek, W. Hung, P. Sapp, C. I. Allen, Wenjie Chen, B. Hosler, A. Saunders, L. Dellefave, R. Brown, T. Siddique
Published 2004 · Medicine
Save to my Library
Download via 🐼 PaperPanda Download via oaDOI Download via OAB Download via LibKey Download via Google Google ScholarAnalyze on Scholarcy Visualize in Litmaps
Reduce the time it takes to create your bibliography by a factor of 10 by using the world’s favourite reference manager
Time to take this seriously.
Apolipoprotein E (APOE) is a confirmed risk factor for Alzheimer disease. APOE is also involved in several other neurodegenerative disorders, including Parkinson disease and multiple sclerosis. Previous studies of amyotrophic lateral sclerosis (Lou Gehrig disease, ALS) have investigated the effect of APOE on the risk of developing ALS, age at onset, site of onset, and duration of the disease. The results have been inconsistent, possibly due to small sample sizes and complete reliance on case-control data. No family-based association studies were performed. To address these limitations, we investigated the relationship between APOE functional polymorphisms and age at onset of ALS in a large set of 508 families. We treated age at onset as a quantitative trait and performed family-based association analysis using the TDT Q5 method. APOE-2 is protective against earlier onset ( P =0.001) with an average age at onset of APOE-2 carriers approximately 3 years later than that of non-APOE-2 carriers. Similar to our previous report, we did not find APOE associated with ALS risk. Our findings suggest that APOE may express its strongest effect through age at onset rather than on risk.
This paper references
Population subdivision with respect to multiple alleles
C. Li (1969)
Linkage of a gene causing familial amyotrophic lateral sclerosis to chromosome 21 and evidence of genetic-locus heterogeneity.
T. Siddique (1991)
Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis
D. Rosen (1993)
Linkage analysis in familial Alzheimer disease: Description of the Duke and Boston data sets
M. Pericak-Vance (1993)
Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families.
E. Corder (1993)
Association of apolipoprotein E allele epsilon 4 with late-onset familial and sporadic Alzheimer's disease.
A. M. Saunders (1993)
Linkage of recessive familial amyotrophic lateral sclerosis to chromosome 2q33–q35
A. Hentati (1994)
Apolipoprotein E epsilon 4 allele is not associated with earlier age at onset in amyotrophic lateral sclerosis.
S. Mui (1995)
Apolipoprotein E ϵ4 allele is not associated with earlier age at onset in amyotrophic lateral sclerosis
S. Mui (1995)
PEDIGENE : a comprehensive data management system to facilitate efficient and rapid disease gene mapping
C Haynes (1995)
PEDIGENE: a comprehensive data management system to facilitate efficient and rapid disease gene
C Haynes (1995)
Apolipoprotein E epsilon 4 in bulbar-onset motor neuron disease.
R. Smith (1996)
Apolipoprotein E ɛ4 in bulbar-onset motor neuron disease
R. Smith (1996)
Association of apolipoprotein E ∈4 allele with bulbar-onset motor neuron disease
A. Al-Chalabi (1996)
Apolipoprotein E genotyping in sporadic amyotrophic lateral sclerosis: evidence for a major influence on the clinical presentation and prognosis
B. Moulard (1996)
A transmission disequilibrium test for quantitative trait loci.
D. Rabinowitz (1997)
Lack of association of apolipoprotein E ϵ4 allele with bulbar‐onset motor neuron disease
R. Bachus (1997)
Modulation of the age at onset of Parkinson's disease by apolipoprotein E genotypes
S. Zareparsi (1997)
Clinical neurophysiology in the diagnosis of amyotrophic lateral sclerosis: The Lambert and the El Escorial criteria
A. Wilbourn (1998)
Linkage of a commoner form of recessive amyotrophic lateral sclerosis to chromosome 15q15-q22 markers
A. Hentati (1998)
Lack of association between apolipoprotein E genotype and sporadic amyotrophic lateral sclerosis
T. Siddique (1998)
Refined mapping and characterization of the recessive familial amyotrophic lateral sclerosis locus (ALS2) on chromosome 2q33
B. Hosler (1998)
PedCheck: a program for identification of genotype incompatibilities in linkage analysis.
J. O'Connell (1998)
Re - fined mapping and characterization of the recessive familial amyotrophic lateral sclerosis locus ( ALS 2 ) on chromosome 2 q 33
BA Hosler (1998)
The collection of biological samples for DNA analysis. In: Haines JL, Pericak-Vance MA (eds) Approaches to gene mapping in complex human diseases
JM Vance (1998)
DataTracker: comprehensive software for data quality control protocols in complex disease studies
JB Rimmler (1999)
A general test of association for quantitative traits in nuclear families.
G. Abecasis (2000)
Linkage of familial amyotrophic lateral sclerosis with frontotemporal dementia to chromosome 9q21-q22.
B. Hosler (2000)
A test for linkage and association in general pedigrees: the pedigree disequilibrium test.
E. Martin (2000)
Association of APOE ε4 allele with survival in amyotrophic lateral sclerosis
V. Drory (2001)
Association of APOE epsilon4 allele with survival in amyotrophic lateral sclerosis.
V. Drory (2001)
Correcting for a potential bias in the pedigree disequilibrium test.
E. Martin (2001)
Transmission/disequilibrium tests for quantitative traits
X. Zhu (2001)
A novel locus for familial amyotrophic lateral sclerosis, on chromosome 18q.
C. K. Hand (2002)
Association of polymorphisms in the apolipoprotein E region with susceptibility to and progression of multiple sclerosis.
S. Schmidt (2002)
Multiple Sclerosis GG (2002) Association of polymorphisms in the apolipoprotein e region with susceptibility to and progression of multiple sclerosis
S Schmidt (2002)
Identification of two novel loci for dominantly inherited familial amyotrophic lateral sclerosis.
P. Sapp (2003)
A new familial amyotrophic lateral sclerosis locus on chromosome 16q12.1-16q12.2.
H. Abalkhail (2003)
Two families with familial amyotrophic lateral sclerosis are linked to a novel locus on chromosome 16q.
D. Ruddy (2003)
Genotype‐based association test for general pedigrees: The genotype‐PDT
E. Martin (2003)
Apolipoprotein E controls the risk and age at onset of Parkinson disease
Y. Li (2004)
X-linked dominant locus for late-onset familial amyotrophic lateral sclerosis
T Siddique (2004)
Exact tests for association between alleles at arbitrary numbers of loci
D. Zaykin (2005)
This paper is referenced by
Diabetes Mellitus and Amyotrophic Lateral Sclerosis: A Systematic Review
Laura Ferri (2021)
From Multi-Omics Approaches to Precision Medicine in Amyotrophic Lateral Sclerosis
Giovanna Morello (2020)
Correlation between Apolipoprotein E genotype and brain metabolism in amyotrophic lateral sclerosis
A. Canosa (2018)
Apolipoprotein E isoforms and susceptibility to genetic generalized epilepsies
J. Chaves (2019)
Polygenic Risk Scores in Neurodegenerative Diseases: a Review
L. Ibañez (2019)
Genetic Variation in the Ontario Neurodegenerative Disease Research Initiative
Allison A. Dilliott (2019)
Younger age of onset in familial amyotrophic lateral sclerosis is a result of pathogenic gene variants, rather than ascertainment bias
P. Mehta (2018)
Decreased Levels of Foldase and Chaperone Proteins Are Associated with an Early-Onset Amyotrophic Lateral Sclerosis
Melania Filareti (2017)
Apolipoprotein E and Alzheimer’s disease: the influence of apolipoprotein E on amyloid-β and other amyloidogenic proteins
T. Huynh (2017)
Is Apolipoprotein E ε2 Associated with Delayed Onset of Non-Lesional Temporal Lobe Epilepsy?
D. Sporiš (2017)
Implication of Epigenetic Modifications in Neurodegenerative Disorders:Traces and Imprints
R. Singh (2016)
To Dement or Not to Dement, That Is the Question.
B. Traynor (2016)
Apolipoprotein epsilon 4 genotype is associated with less improvement in cognitive function five years after cardiac surgery: a retrospective cohort study
K. Bartels (2015)
Role of apolipoprotein E polymorphism as a prognostic marker in traumatic brain injury and neurodegenerative disease: a critical review.
T. Maiti (2015)
Motor Neuron Disease.
M. Dimachkie (2015)
Targeted Exon Capture and Sequencing in Sporadic Amyotrophic Lateral Sclerosis
Julien Couthouis (2014)
Study of Cyclophilin A Function in Models of Amyotrophic Lateral Sclerosis
Eliana Lauranzano (2013)
Chapter 132 – Motor Neuron Disease
T. Siddique (2013)
Age of onset of amyotrophic lateral sclerosis is modulated by a locus on 1p34.1
K. Ahmeti (2013)
Neuroinflammation: modulation by flavonoids and mechanisms of action.
J. Spencer (2012)
Heterogeneity in multiple sclerosis; a bio-marker approach
J. Zwemmer (2011)
ApoE E4 is a Susceptibility Factor in Amnestic But Not Aphasic Dementias
E. Rogalski (2011)
Genetic Risk Factors: Their Function and Comorbidities in Alzheimer's Disease
M. Hiltunen (2011)
Does apolipoprotein E genotype modify the clinical expression of ALS?
A. Jawaid (2011)
Mutant ApoA-1 Amyloidosis in a Family of Five Siblings With Motor Neuron Disease and Dementia
M. Vrethem (2011)
ApoE isoform-specific regulation of regeneration in the peripheral nervous system.
L. Comley (2011)
APOE ε4 allele is associated with an increased risk of bulbar‐onset amyotrophic lateral sclerosis in men
J. Praline (2011)
Function and Comorbidities of Apolipoprotein E in Alzheimer's Disease
Valérie Leduc (2011)
Alzheimer's disease as homeostatic responses to age-related myelin breakdown
G. Bartzokis (2011)
Clinical genetics of amyotrophic lateral sclerosis: what do we really know?
P. Andersen (2011)
Apolipoprotein E in Alzheimer's disease and other neurological disorders
P. Verghese (2011)
A decrease in body mass index is associated with faster progression of motor symptoms and shorter survival in ALS
A. Jawaid (2010)See more