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Therapie Des Malignen Pleuramesothelioms

H. Huwer, A. Bücker
Published 2009 · Medicine

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ZusammenfassungDie chirurgischen Maßnahmen zur Behandlung des malignen Pleuramesothelioms sind Pleurektomie mit Dekortikation und extrapleurale Pneumonektomie. Die extrapleurale Pneumonektomie, historisch mit einer hohen Letalität verbunden, wird heutzutage in erfahrenen Zentren mit der gleichen Letalität wie eine Standardpneumonektomie durchgeführt. Dieser Artikel beschreibt beide Operationen und diskutiert postoperative Komplikationen, klinische Resultate und Rezidivmuster nach den entsprechenden operativen Maßnahmen. Zusätzlich werden das Stagingsystem der International Mesothelioma Interest Group (IMIG) und andere prognostische Parameter dargestellt; pathologische und epidemiologische Besonderheiten des malignen Pleuramesothelioms werden erwähnt.AbstractThe principal surgical options for the treatment of malignant pleural mesothelioma are pleurectomy and decortication or extrapleural pneumonectomy. Although previously associated with high lethality rates, extrapleural pneumonectomy can be performed today at experienced centers with the same risk of lethality as standard pneumonectomy. This article provides a description of both surgical procedures and discusses complications, clinical results and recurrence patterns. In addition, the staging system proposed by the International Mesothelioma Interest Group (IMIG) and other prognostic parameters are detailed. Mention is also made of the pathological and epidemiological characteristics of malignant plural mesothelioma.
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