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Antitumor And Antimetastatic Activity Of Fucoidan, A Sulfated Polysaccharide Isolated From The Okhotsk Sea Fucus Evanescens Brown Alga
T. V. Alekseyenko, S. Y. Zhanayeva, A. A. Venediktova, T. Zvyagintseva, T. Kuznetsova, N. Besednova, T. Korolenko
Published 2007 · Chemistry, Medicine
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Antitumor and antimetastatic activities of fucoidan, a sulfated polysaccharide isolated from Fucus evanescens (brown alga in Okhotsk sea), was studied in C57Bl/6 mice with transplanted Lewis lung adenocarcinoma. Fucoidan after single and repeated administration in a dose of 10 mg/kg produced moderate antitumor and antimetastatic effects and potentiated the antimetastatic, but not antitumor activities of cyclophosphamide. Fucoidan in a dose of 25 mg/kg potentiated the toxic effect of cyclophosphamide.
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