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Expression Of Peroxiredoxin 1, 2, 3, And 6 Genes In Cancer Cells During Drug Resistance Formation

E. Kalinina, T. Berezov, A. Shtil, N. Chernov, V. Glazunova, M. Novichkova, N. Nurmuradov
Published 2012 · Biology, Medicine

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We studied the expression of peroxiredoxin genes (PRDX1, PRDX2, PRDX3, and PRDX6) in human erythroleukemia K652, human breast carcinoma MCF-7, and human ovarian carcinoma SKOV-3 cells during cisplatin resistance development. It was found that drug resistance formation was accompanied by a significant increase in the expression of PRDX1, PRDX2, PRDX3, PRDX6 genes in all cancer cell strains, which confirms the important contribution of redox-dependent mechanisms into the development of cisplatin resistance of cancer cells.
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