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G×E Interaction Influences Trajectories Of Hand Grip Strength
I. Petersen, N. Pedersen, T. Rantanen, W. Kremen, W. Johnson, M. Panizzon, L. Christiansen, C. Franz, M. McGue, K. Christensen, N. Hamdi, R. Krueger, C. Reynolds
Published 2016 · Biology, Medicine
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Age-related decline in grip strength predicts later life disability, frailty, lower well-being and cognitive change. While grip strength is heritable, genetic influence on change in grip strength has been relatively ignored, with non-shared environmental influence identified as the primary contributor in a single longitudinal study. The extent to which gene-environment interplay, particularly gene-environment interactions, contributes to grip trajectories has yet to be examined. We considered longitudinal grip strength measurements in seven twin studies of aging in the Interplay of Genes and Environment across Multiple Studies consortium. Growth curve parameters were estimated for same-sex pairs, aged 34–99 (N = 10,681). Fisher’s test for mixture distribution of within-monozygotic twin-pair differences (N = 1724) was performed on growth curve parameters. We observed significant gene-environment interaction on grip strength trajectories. Finally, we compared the variability of within-pair differences of growth curve parameters by APOE haplotypes. Though not statistically significant, the results suggested that APOE ɛ2ɛ2/ɛ2ɛ3 haplotypes might buffer environmental influences on grip strength trajectories.
This paper references
Screening for C9orf72 repeat expansions in Chinese amyotrophic lateral sclerosis patients
Z. Zou (2013)
Validity and usefulness of hand-held dynamometry for measuring muscle strength in community-dwelling older persons.
P. Abizanda (2012)
The short-term reliability of grip strength measurement and the effects of posture and grip span.
T. Watanabe (2005)
Do the MN and Jk systems influence environmental variability in serum lipid levels?
N. Martin (1983)
Associations between APOE and low-density lipoprotein cholesterol genotypes and cognitive and physical capability: the HALCyon programme
Tamuno Alfred (2014)
Association between APOE epsilon 2/epsilon 3/epsilon 4 polymorphism and disability severity in a national long-term care survey sample.
A. Kulminski (2008)
Is grip strength a useful single marker of frailty?
H. Syddall (2003)
Genotypeenvironment interactions: cognitive aging and social factors
CA Reynolds (2007)
The Swedish Adoption Twin Study of Aging: an update.
N. Pedersen (1991)
Blom , Gunnar : statistical estimates and transformed betavariables
NG Martin (1961)
VETSA: the Vietnam Era Twin Study of Aging.
W. Kremen (2013)
Understanding sarcopenia as a geriatric syndrome
A. Cruz-Jentoft (2010)
Sexual orientation in a U.S. national sample of twin and nontwin sibling pairs.
K. Kendler (2000)
Bayesian longitudinal plateau model of adult grip strength
R. W. Nahhas (2010)
Genetic and Environmental Influences on Decline in Biobehavioral Markers of Aging
D. Finkel (2003)
Muscle strength and body mass index as long-term predictors of mortality in initially healthy men.
T. Rantanen (2000)
Age trajectories of grip strength: cross-sectional and longitudinal data among 8,342 Danes aged 46 to 102.
H. Frederiksen (2006)
Apolipoprotein E and Measured Physical and Pulmonary Function in Older Taiwanese Adults
Sarinnapha Vasunilashorn (2013)
Heredity links natural hazards and human health: Apolipoprotein E gene moderates the health of earthquake survivors.
M. Daly (2011)
Apolipopro - tein E epsilon 4 and laterlife decline in cognitive function and grip strength
D Carmelli (2013)
Aslan AKD (2015a) Factors associated with grip strength decline in older adults
New horizons in the pathogenesis, diagnosis and management of sarcopenia
A. Sayer (2013)
Dementia in Swedish Twins: Predicting Incident Cases
M. Gatz (2010)
Grip Strength and Cognitive Abilities: Associations in Old Age.
O. Sternäng (2016)
Stata: release 13. Statistical software. StataCorp LP: College Station Physical capability in mid-life and survival over 13 years of follow-up: British birth cohort study
College Station (2013)
Substantial genetic influence on cognitive abilities in twins 80 or more years old.
G. Mcclearn (1997)
Factors associated with grip strength decline in older adults.
O. Sternäng (2015)
Physical capability in mid-life and survival over 13 years of follow-up: British birth cohort study
R. Cooper (2014)
Physical function as predictor for the persistence of depressive and anxiety disorders.
B. V. van Milligen (2012)
The Swedish Twin Registry: a unique resource for clinical, epidemiological and genetic studies
P. Lichtenstein (2002)
Longitudinal changes in physical functional performance among the oldest old: insight from a study of Swedish twins
D. Proctor (2006)
Apolipoprotein E genotype and memory in the sixth decade of life
M. R. Schultz (2008)
Poor correlation between handgrip strength and isokinetic performance of knee flexor and extensor muscles in community‐dwelling elderly women
Diogo Carvalho Felicio (2014)
Muscle Strength and Physical Performance as Predictors of Mortality, Hospitalization, and Disability in the Oldest Old
D. Legrand (2014)
Genotype-environment interactions: cognitive aging and social factors.
C. Reynolds (2007)
Handgrip Strength and Cause‐Specific and Total Mortality in Older Disabled Women: Exploring the Mechanism
T. Rantanen (2003)
Age trajectories of grip strength: crosssectional and longitudinal data among 8,342 Danes aged
H Frederiksen (2006)
Heritability of body size and muscle strength in young adulthood: a study of one million Swedish men
K. Silventoinen (2008)
IGEMS: the consortium on Interplay of Genes and Environment across Multiple Studies.
N. Pedersen (2013)
Sortilin receptor 1 predicts longitudinal cognitive change
C. Reynolds (2013)
Identification of high-risk individuals for the development of disability in activities of daily living. A tenyear follow-up study
ME den Ouden (2013)
Handgrip strength as a predictor of functional, psychological and social health. A prospective population-based study among the oldest old.
D. Taekema (2010)
Blom, Gunnar: Statistical estimates and transformed beta‐variables. Wiley/New York, Almquist und Wiksell/Stockholm 1958; 176 S., Kr. 20,—
O. Ludwig, (1961)
Midlife hand grip strength as a predictor of old age disability.
T. Rantanen (1999)
Handgrip strength at admission and time to discharge in medical and surgical inpatients.
J. Mendes (2014)
The Danish Twin Registry: 127 birth cohorts of twins.
A. Skytthe (2002)
The Minnesota Twin Registry: current status and future directions.
R. Krueger (2002)
The Resemblance between Twins, a Statistical Examination of Lauterbach's Measurements.
R. Fisher (1925)
Apolipoprotein E ε4 and later-life decline in cognitive function and grip strength.
P. Batterham (2013)
Sarcopenia: European consensus on definition and diagnosis
A. Cruz-Jentoft (2010)
A Danish Population-Based Twin Study on General Health in the Elderly
K. Christensen (1999)
Heritability of maximal isometric muscle strength in older female twins.
K. Tiainen (2004)
Identification of high-risk individuals for the development of disability in activities of daily living. A ten-year follow-up study
M. E. M. Ouden (2013)
Hand grip strength: A phenotype suitable for identifying genetic variants affecting mid‐ and late‐life physical functioning
H. Frederiksen (2002)
The joint effect of apolipoprotein E epsilon4 and MRI findings on lower-extremity function and decline in cognitive function.
D. Carmelli (2000)
Age- and sex-differences in the validity of questionnaire-based zygosity in twins.
L. Christiansen (2003)
The Danish Twin Registry: linking surveys, national registers, and biological information.
A. Skytthe (2013)
Midlife muscle strength and human longevity up to age 100 years: a 44-year prospective study among a decedent cohort
T. Rantanen (2011)
European working group on sarcopenia in older people. Sarcopenia: European consensus on definition and diagnosis: report of the European working group on sarcopenia in older people
A. Cruz-Jentoft (2010)
Growing Old but Not Growing Apart: Twin Similarity in the Latter Half of the Lifespan
M. McGue (2013)
:A Ten-year Follow-up Study
A. Sasaki (1981)
This paper is referenced by
Apolipoprotein E ε4 and cognitive function after surgery in middle-aged and elderly Danish twins
U. Dokkedal (2020)
Coming to grips with economic development: Variation in adult hand grip strength during health transition in Vanuatu.
K. M. Olszowy (2018)
A mutation associated with stress resistance in mice is associated with human grip strength and mortality.
Breanne L Newell-Stamper (2020)
Genetic Influences on Functional Capacities in Aging.
A. Foebel (2016)
IGEMS: The Consortium on Interplay of Genes and Environment Across Multiple Studies - An Update.
N. Pedersen (2019)